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57  structures 1351  species 0  interactions 35851  sequences 844  architectures

Family: C1_1 (PF00130)

Summary: Phorbol esters/diacylglycerol binding domain (C1 domain)

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "C1 domain". More...

C1 domain Edit Wikipedia article

Phorbol esters/diacylglycerol binding domain (C1 domain)
1ptr.png
C1 domain of PKC-delta (1ptr) Middle plane of the lipid bilayer - black dots. Boundary of the hydrocarbon core region - blue dots (cytoplasmic side). Layer of lipid phosphates - yellow dots.
Identifiers
SymbolC1
PfamPF00130
InterProIPR002219
SMARTC1
PROSITEPDOC00379
SCOPe2cpk / SUPFAM
OPM superfamily60
OPM protein1ptr
CDDcd00029

C1 domain (also known as phorbol esters/diacylglycerol binding domain) binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters.[1] Phorbol esters can directly stimulate protein kinase C, PKC. The N-terminal region of PKC, known as C1, has been shown[2]

Phorbol esters (such as PMA) are analogues of DAG and potent tumor promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC). Phorbol esters can directly stimulate PKC.

The N-terminal region of PKC, known as C1, binds PMA and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PMA-binding.

The DAG/PMA-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.

Human proteins containing this domain

AKAP13; ARAF; ARHGAP29; ARHGEF2; BRAF; CDC42BPA; CDC42BPB; CDC42BPG; CHN1; CHN2; CIT; DGKA; DGKB; DGKD; DGKE; DGKG; DGKH; DGKI; DGKK; DGKQ; DGKZ; GMIP; HMHA1; KSR1; KSR2; MYO9A; MYO9B; PDZD8; PRKCA; PRKCB1; PRKCD; PRKCE; PRKCG; PRKCH; PRKCI; PRKCN; PRKCQ; PRKCZ; PRKD1; PRKD2; PRKD3; RACGAP1; RAF1; RASGRP; RASGRP1; RASGRP2; RASGRP3; RASGRP4; RASSF1; RASSF5; ROCK1; ROCK2; STAC; STAC2; STAC3; TENC1; UNC13A; UNC13B; UNC13C; VAV1; VAV2; VAV3;

References

  1. ^ Azzi A, Boscoboinik D, Hensey C (1992). "The protein kinase C family". Eur. J. Biochem. 208 (3): 547–557. doi:10.1111/j.1432-1033.1992.tb17219.x. PMID 1396661.
  2. ^ Kikkawa U, Nishizuka Y, Igarashi K, Fujii T, Ono Y, Kuno T, Tanaka C (1989). "Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence". Proc. Natl. Acad. Sci. U.S.A. 86 (13): 4868–4871. doi:10.1073/pnas.86.13.4868. PMC 297516. PMID 2500657.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Phorbol esters/diacylglycerol binding domain (C1 domain) Provide feedback

This domain is also known as the Protein kinase C conserved region 1 (C1) domain.

Literature references

  1. Knighton DR, Zheng JH, Ten Eyck LF, Ashford VA, Xuong NH, Taylor SS, Sowadski JM; , Science. 1991;253:407-414.: Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. PUBMED:1862342 EPMC:1862342


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002219

Diacylglycerol (DAG) is an important second messenger. Phorbol esters (PE) are analogues of DAG and potent tumour promoters that cause a variety of physiological changes when administered to both cells and tissues. DAG activates a family of serine/threonine protein kinases, collectively known as protein kinase C (PKC) [ PUBMED:1396661 ]. Phorbol esters can directly stimulate PKC. The N-terminal region of PKC, known as C1, has been shown [ PUBMED:2500657 ] to bind PE and DAG in a phospholipid and zinc-dependent fashion. The C1 region contains one or two copies (depending on the isozyme of PKC) of a cysteine-rich domain, which is about 50 amino-acid residues long, and which is essential for DAG/PE-binding. The DAG/PE-binding domain binds two zinc ions; the ligands of these metal ions are probably the six cysteines and two histidines that are conserved in this domain.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan C1 (CL0006), which has the following description:

The members of this clan are all variations of the protein kinase C1 domain that is characterised by a rich cysteine and histidine content. The C1 domain is the N-terminal region of conservation found in protein kinase C domains. This domain is involved in binding many ligands, which include diacylglycerol, phorbol esters and zinc [1].

The clan contains the following 4 members:

C1_1 C1_2 C1_4 ZZ

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(44)
Full
(35851)
Representative proteomes UniProt
(61200)
RP15
(4516)
RP35
(11800)
RP55
(30364)
RP75
(41297)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(44)
Full
(35851)
Representative proteomes UniProt
(61200)
RP15
(4516)
RP35
(11800)
RP55
(30364)
RP75
(41297)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(44)
Full
(35851)
Representative proteomes UniProt
(61200)
RP15
(4516)
RP35
(11800)
RP55
(30364)
RP75
(41297)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: DAG_PE-bind; C1;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 44
Number in full: 35851
Average length of the domain: 52.60 aa
Average identity of full alignment: 31 %
Average coverage of the sequence by the domain: 7.45 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.5 26.5
Trusted cut-off 26.5 26.5
Noise cut-off 26.4 26.4
Model length: 53
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the C1_1 domain has been found. There are 57 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096UWG9 View 3D Structure Click here
A0A0G2KAU4 View 3D Structure Click here
A0A0G2KWM4 View 3D Structure Click here
A0A0G2L109 View 3D Structure Click here
A0A0R4IC22 View 3D Structure Click here
A0A0R4IDB7 View 3D Structure Click here
A0A0R4IHS8 View 3D Structure Click here
A0A0R4IPY3 View 3D Structure Click here
A0A140LG29 View 3D Structure Click here
A0A140LH08 View 3D Structure Click here
A0A1D5NSE1 View 3D Structure Click here
A0A1D6K5X0 View 3D Structure Click here
A0A286Y8W8 View 3D Structure Click here
A0A2R8PXG7 View 3D Structure Click here
A0A2R8Q067 View 3D Structure Click here
A0A2R8Q067 View 3D Structure Click here
A0A2R8Q3N3 View 3D Structure Click here
A0A2R8Q6S0 View 3D Structure Click here
A0A2R8Q6S0 View 3D Structure Click here
A0A2R8QA33 View 3D Structure Click here
A0A2R8QA79 View 3D Structure Click here
A0A2R8QAR8 View 3D Structure Click here
A0A2R8QC93 View 3D Structure Click here
A0A2R8QC93 View 3D Structure Click here
A0A2R8QIY5 View 3D Structure Click here
A0A2R8QIY5 View 3D Structure Click here
A0A2R8QJ48 View 3D Structure Click here
A0A2R8QJ48 View 3D Structure Click here
A0A2R8QMH0 View 3D Structure Click here
A0A2R8QNY1 View 3D Structure Click here
A0A2R8RM45 View 3D Structure Click here
A0A2R8RM45 View 3D Structure Click here
A0A2R8RZP8 View 3D Structure Click here
A0A2R8RZP8 View 3D Structure Click here
A1Z9I5 View 3D Structure Click here
A1Z9X0 View 3D Structure Click here
A1ZAN6 View 3D Structure Click here
A8JQ65 View 3D Structure Click here
A8JQ65 View 3D Structure Click here
A8QM12 View 3D Structure Click here
A9JR83 View 3D Structure Click here
A9JR83 View 3D Structure Click here
A9JTH6 View 3D Structure Click here
B0S4T7 View 3D Structure Click here
B0S6C8 View 3D Structure Click here
B1H1I7 View 3D Structure Click here
B1H1I7 View 3D Structure Click here
B2GV02 View 3D Structure Click here
B7YZL3 View 3D Structure Click here
B8A467 View 3D Structure Click here
B8A467 View 3D Structure Click here
B9EJ80 View 3D Structure Click here
C0PCE8 View 3D Structure Click here
D0IN10 View 3D Structure Click here
D3YWQ0 View 3D Structure Click here
D3YXJ0 View 3D Structure Click here
D3YXJ0 View 3D Structure Click here
D3Z837 View 3D Structure Click here
D3ZEY4 View 3D Structure Click here
D3ZEY4 View 3D Structure Click here
D3ZQN6 View 3D Structure Click here
D3ZSZ6 View 3D Structure Click here
D3ZSZ6 View 3D Structure Click here
D3ZXY2 View 3D Structure Click here
D3ZYG0 View 3D Structure Click here
D4A229 View 3D Structure Click here
D4A229 View 3D Structure Click here
E7EXR8 View 3D Structure Click here
E7F355 View 3D Structure Click here
E7F368 View 3D Structure Click here
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E7F3K5 View 3D Structure Click here
E7F4L5 View 3D Structure Click here
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E7F577 View 3D Structure Click here
E7F7C3 View 3D Structure Click here
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E7FEL8 View 3D Structure Click here
E7FFP7 View 3D Structure Click here
E9PUQ8 View 3D Structure Click here
E9PUQ8 View 3D Structure Click here
E9Q7N4 View 3D Structure Click here
E9Q7N4 View 3D Structure Click here
F1LN91 View 3D Structure Click here
F1LWB1 View 3D Structure Click here
F1LZW2 View 3D Structure Click here
F1LZW2 View 3D Structure Click here
F1M107 View 3D Structure Click here
F1M5T2 View 3D Structure Click here
F1M5T2 View 3D Structure Click here
F1M7Y5 View 3D Structure Click here
F1M9C3 View 3D Structure Click here
F1MAB7 View 3D Structure Click here
F1QJU6 View 3D Structure Click here
F1QJU6 View 3D Structure Click here
F1QMN5 View 3D Structure Click here
F1QRH8 View 3D Structure Click here
F1QRM7 View 3D Structure Click here
F1QRM7 View 3D Structure Click here
F1QRN2 View 3D Structure Click here
F1QVH9 View 3D Structure Click here
F1R506 View 3D Structure Click here
F1R506 View 3D Structure Click here
F1R561 View 3D Structure Click here
F1R561 View 3D Structure Click here
H2KYE1 View 3D Structure Click here
H2KYI9 View 3D Structure Click here
H2KZC9 View 3D Structure Click here
H2KZC9 View 3D Structure Click here
I1JZK2 View 3D Structure Click here
I1K533 View 3D Structure Click here
I1MT53 View 3D Structure Click here
K7L487 View 3D Structure Click here
O01583 View 3D Structure Click here
O08560 View 3D Structure Click here
O14795 View 3D Structure Click here
O35141 View 3D Structure Click here
O44588 View 3D Structure Click here
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O45720 View 3D Structure Click here
O45720 View 3D Structure Click here
O45818 View 3D Structure Click here
O45818 View 3D Structure Click here
O54874 View 3D Structure Click here
O75912 View 3D Structure Click here
O88673 View 3D Structure Click here
O88673 View 3D Structure Click here
O94806 View 3D Structure Click here
O94806 View 3D Structure Click here
O95267 View 3D Structure Click here
P04049 View 3D Structure Click here
P04627 View 3D Structure Click here
P05129 View 3D Structure Click here
P05129 View 3D Structure Click here
P05130 View 3D Structure Click here
P05130 View 3D Structure Click here
P05696 View 3D Structure Click here
P05696 View 3D Structure Click here
P05771 View 3D Structure Click here
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P09215 View 3D Structure Click here
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P09216 View 3D Structure Click here
P09216 View 3D Structure Click here
P09217 View 3D Structure Click here
P0C643 View 3D Structure Click here
P0C6P5 View 3D Structure Click here
P10398 View 3D Structure Click here
P11345 View 3D Structure Click here
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P13677 View 3D Structure Click here
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P13678 View 3D Structure Click here
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P14056 View 3D Structure Click here
P15056 View 3D Structure Click here
P15498 View 3D Structure Click here
P15882 View 3D Structure Click here
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P17252 View 3D Structure Click here
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P20444 View 3D Structure Click here
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P23298 View 3D Structure Click here
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P27715 View 3D Structure Click here
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P28867 View 3D Structure Click here
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P34125 View 3D Structure Click here
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P34885 View 3D Structure Click here
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P36582 View 3D Structure Click here
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P40809 View 3D Structure Click here
P41743 View 3D Structure Click here
P49619 View 3D Structure Click here
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P49621 View 3D Structure Click here
P49621 View 3D Structure Click here
P51556 View 3D Structure Click here
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P52429 View 3D Structure Click here
P52735 View 3D Structure Click here
P52757 View 3D Structure Click here
P52824 View 3D Structure Click here
P52824 View 3D Structure Click here
P54100 View 3D Structure Click here
P63318 View 3D Structure Click here
P63318 View 3D Structure Click here
P63319 View 3D Structure Click here
P63319 View 3D Structure Click here
P68403 View 3D Structure Click here
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P68404 View 3D Structure Click here
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P83099 View 3D Structure Click here
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P90980 View 3D Structure Click here
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P97306 View 3D Structure Click here
P97433 View 3D Structure Click here
Q01583 View 3D Structure Click here
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Q02111 View 3D Structure Click here
Q02111 View 3D Structure Click here
Q02156 View 3D Structure Click here
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Q02956 View 3D Structure Click here
Q03070 View 3D Structure Click here
Q03603 View 3D Structure Click here
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Q04759 View 3D Structure Click here
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Q05513 View 3D Structure Click here
Q05655 View 3D Structure Click here
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Q07292 View 3D Structure Click here
Q09103 View 3D Structure Click here
Q09103 View 3D Structure Click here
Q09746 View 3D Structure Click here
Q10024 View 3D Structure Click here
Q13574 View 3D Structure Click here
Q15139 View 3D Structure Click here
Q15139 View 3D Structure Click here
Q16760 View 3D Structure Click here
Q16760 View 3D Structure Click here
Q17860 View 3D Structure Click here
Q17860 View 3D Structure Click here
Q19266 View 3D Structure Click here
Q19770 View 3D Structure Click here
Q1L9A0 View 3D Structure Click here
Q1LYG2 View 3D Structure Click here
Q22744 View 3D Structure Click here
Q24171 View 3D Structure Click here
Q2QN70 View 3D Structure Click here
Q39017 View 3D Structure Click here
Q3UU96 View 3D Structure Click here
Q45FX5 View 3D Structure Click here
Q4KUS2 View 3D Structure Click here
Q4V8I4 View 3D Structure Click here
Q52LW3 View 3D Structure Click here
Q55DD4 View 3D Structure Click here
Q5ANK2 View 3D Structure Click here
Q5ANK2 View 3D Structure Click here
Q5EBH1 View 3D Structure Click here
Q5FAQ9 View 3D Structure Click here
Q5FBD1 View 3D Structure Click here
Q5KSL6 View 3D Structure Click here
Q5PQJ5 View 3D Structure Click here
Q5TZ37 View 3D Structure Click here
Q5TZ42 View 3D Structure Click here
Q5VT25 View 3D Structure Click here
Q5XIS9 View 3D Structure Click here
Q5XIS9 View 3D Structure Click here
Q60992 View 3D Structure Click here
Q62074 View 3D Structure Click here
Q62101 View 3D Structure Click here
Q62101 View 3D Structure Click here
Q62768 View 3D Structure Click here
Q62769 View 3D Structure Click here
Q62770 View 3D Structure Click here
Q64617 View 3D Structure Click here
Q64617 View 3D Structure Click here
Q66HV2 View 3D Structure Click here
Q6DBR6 View 3D Structure Click here
Q6DT37 View 3D Structure Click here
Q6NS52 View 3D Structure Click here
Q6NS52 View 3D Structure Click here
Q6NZH9 View 3D Structure Click here
Q6P3H8 View 3D Structure Click here
Q6P5E8 View 3D Structure Click here
Q6P5E8 View 3D Structure Click here
Q6PCS4 View 3D Structure Click here
Q6ZMT1 View 3D Structure Click here
Q6ZN54 View 3D Structure Click here
Q75GS0 View 3D Structure Click here
Q7K579 View 3D Structure Click here
Q7LDG7 View 3D Structure Click here
Q7SY24 View 3D Structure Click here
Q7SY24 View 3D Structure Click here
Q7T2C5 View 3D Structure Click here
Q7T2C5 View 3D Structure Click here
Q7TT49 View 3D Structure Click here
Q7TT50 View 3D Structure Click here
Q7ZUC5 View 3D Structure Click here
Q7ZUC5 View 3D Structure Click here
Q7ZUT6 View 3D Structure Click here
Q80UP3 View 3D Structure Click here
Q80UW5 View 3D Structure Click here
Q80XD1 View 3D Structure Click here
Q86A02 View 3D Structure Click here
Q86XP1 View 3D Structure Click here
Q86XP1 View 3D Structure Click here
Q8BTM9 View 3D Structure Click here
Q8BZ03 View 3D Structure Click here
Q8BZ03 View 3D Structure Click here
Q8BZ71 View 3D Structure Click here
Q8CGF1 View 3D Structure Click here
Q8IV61 View 3D Structure Click here
Q8K0T7 View 3D Structure Click here
Q8K1Y2 View 3D Structure Click here
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Q8NB66 View 3D Structure Click here
Q8NEN9 View 3D Structure Click here
Q8R1B0 View 3D Structure Click here
Q8R5I4 View 3D Structure Click here
Q8TDF6 View 3D Structure Click here
Q8WWW0 View 3D Structure Click here
Q90XF2 View 3D Structure Click here
Q91V57 View 3D Structure Click here
Q91WG7 View 3D Structure Click here
Q965N4 View 3D Structure Click here
Q96MF2 View 3D Structure Click here
Q99469 View 3D Structure Click here
Q99J78 View 3D Structure Click here
Q99MK9 View 3D Structure Click here
Q99N57 View 3D Structure Click here
Q9BZL6 View 3D Structure Click here
Q9BZL6 View 3D Structure Click here
Q9FFN7 View 3D Structure Click here
Q9H0H5 View 3D Structure Click here
Q9NHV9 View 3D Structure Click here
Q9QUG9 View 3D Structure Click here
Q9R0C8 View 3D Structure Click here
Q9R1C6 View 3D Structure Click here
Q9R1K8 View 3D Structure Click here
Q9UKW4 View 3D Structure Click here
Q9UPW8 View 3D Structure Click here
Q9VGH9 View 3D Structure Click here
Q9VTT9 View 3D Structure Click here
Q9W1B0 View 3D Structure Click here
Q9W4A9 View 3D Structure Click here
Q9WTQ0 View 3D Structure Click here
Q9WTQ0 View 3D Structure Click here
Q9WTQ1 View 3D Structure Click here
Q9WTQ1 View 3D Structure Click here
Q9WVM1 View 3D Structure Click here
Q9XUJ7 View 3D Structure Click here
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Q9XUS9 View 3D Structure Click here
Q9Y5S2 View 3D Structure Click here
Q9Y6T7 View 3D Structure Click here
Q9Y6T7 View 3D Structure Click here
Q9Z1N9 View 3D Structure Click here
Q9Z1S3 View 3D Structure Click here
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X1WHZ5 View 3D Structure Click here