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2628  structures 8617  species 0  interactions 22221  sequences 134  architectures

Family: ATP-synt_C (PF00137)

Summary: ATP synthase subunit C

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "ATP synthase subunit C". More...

ATP synthase subunit C Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ATP synthase subunit C Provide feedback

No Pfam abstract.

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002379

Transmembrane ATPases are membrane-bound enzyme complexes/ion transporters that use ATP hydrolysis to drive the transport of protons across a membrane. Some transmembrane ATPases also work in reverse, harnessing the energy from a proton gradient, using the flux of ions across the membrane via the ATPase proton channel to drive the synthesis of ATP.

There are several different types of transmembrane ATPases, which can differ in function (ATP hydrolysis and/or synthesis), structure (e.g., F-, V- and A-ATPases, which contain rotary motors) and in the type of ions they transport [ PUBMED:15473999 , PUBMED:15078220 ]. The different types include:

  • F-ATPases (ATP synthases, F1F0-ATPases), which are found in mitochondria, chloroplasts and bacterial plasma membranes where they are the prime producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts).
  • V-ATPases (V1V0-ATPases), which are primarily found in eukaryotes and they function as proton pumps that acidify intracellular compartments and, in some cases, transport protons across the plasma membrane [ PUBMED:20450191 ]. They are also found in bacteria [ PUBMED:9741106 ].
  • A-ATPases (A1A0-ATPases), which are found in Archaea and function like F-ATPases, though with respect to their structure and some inhibitor responses, A-ATPases are more closely related to the V-ATPases [ PUBMED:18937357 , PUBMED:1385979 ].
  • P-ATPases (E1E2-ATPases), which are found in bacteria and in eukaryotic plasma membranes and organelles, and function to transport a variety of different ions across membranes.
  • E-ATPases, which are cell-surface enzymes that hydrolyse a range of NTPs, including extracellular ATP.

The F-ATPases (or F1F0-ATPases) and V-ATPases (or V1V0-ATPases) are each composed of two linked complexes: the F1 or V1 complex contains the catalytic core that synthesizes/hydrolyses ATP, and the F0 or V0 complex that forms the membrane-spanning pore. The F- and V-ATPases all contain rotary motors, one that drives proton translocation across the membrane and one that drives ATP synthesis/hydrolysis [ PUBMED:11309608 , PUBMED:15629643 ].

In V-ATPases, there are three proteolipid subunits (c, c' and c'') that form part of the proton-conducting pore, each containing a buried glutamic acid residue that is essential for proton transport, and together they form a hexameric ring spanning the membrane [ PUBMED:15951435 , PUBMED:14635779 ].

Structurally, the c subunits consist of a two antiparallel transmembrane helices. Both helices of one c subunit are connected by a loop on the cytoplasmic side [ PUBMED:19783985 ].

This entry represents the V-ATPase proteolipid subunit C like domain found in the V-ATPase proteolipid subunit C and the F-ATP synthase subunit C.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(931)
Full
(22221)
Representative proteomes UniProt
(77741)
RP15
(3965)
RP35
(11060)
RP55
(19821)
RP75
(30270)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(931)
Full
(22221)
Representative proteomes UniProt
(77741)
RP15
(3965)
RP35
(11060)
RP55
(19821)
RP75
(30270)
Alignment:
Format:
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Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(931)
Full
(22221)
Representative proteomes UniProt
(77741)
RP15
(3965)
RP35
(11060)
RP55
(19821)
RP75
(30270)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Sonnhammer ELL
Number in seed: 931
Number in full: 22221
Average length of the domain: 61.30 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 63.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.0 24.0
Trusted cut-off 24.0 24.0
Noise cut-off 23.9 23.9
Model length: 60
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ATP-synt_C domain has been found. There are 2628 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0JKX3 View 3D Structure Click here
A0A0R0JZY7 View 3D Structure Click here
A0A1D6E5T9 View 3D Structure Click here
A0A1D6LI10 View 3D Structure Click here
A0A1D6MYY4 View 3D Structure Click here
A0A1D6MYY4 View 3D Structure Click here
A0A1D6P137 View 3D Structure Click here
A0A1D8PFL8 View 3D Structure Click here
A0A1D8PFL8 View 3D Structure Click here
A0A1D8PK00 View 3D Structure Click here
A0A1D8PK00 View 3D Structure Click here
A0A1X7YHF8 View 3D Structure Click here
A0A381MIF8 View 3D Structure Click here
A0A3B6U5Y6 View 3D Structure Click here
A1ZAL7 View 3D Structure Click here
A1ZAL7 View 3D Structure Click here
A4HZ75 View 3D Structure Click here
A4HZI5 View 3D Structure Click here
A4HZI5 View 3D Structure Click here
A4I051 View 3D Structure Click here
A4I051 View 3D Structure Click here
A4I3J4 View 3D Structure Click here
A4I3J4 View 3D Structure Click here
A4I657 View 3D Structure Click here
A4I657 View 3D Structure Click here
B0K022 View 3D Structure Click here
B0K022 View 3D Structure Click here
B4FZS8 View 3D Structure Click here
B4FZS8 View 3D Structure Click here
B6SK76 View 3D Structure Click here
B6SK76 View 3D Structure Click here
C0H4L0 View 3D Structure Click here
C0HLB3 View 3D Structure Click here
C0HLB3 View 3D Structure Click here
C0HLB4 View 3D Structure Click here
C0HLB4 View 3D Structure Click here
C6T3I8 View 3D Structure Click here
C6T3I8 View 3D Structure Click here
C6TBY6 View 3D Structure Click here
C6TBY6 View 3D Structure Click here
D3Z869 View 3D Structure Click here
F1QSP4 View 3D Structure Click here
F1QSP4 View 3D Structure Click here
F1QYM3 View 3D Structure Click here
F1QYM3 View 3D Structure Click here
G5EDB8 View 3D Structure Click here
G5EDB8 View 3D Structure Click here
I1J8N1 View 3D Structure Click here
I1J8N1 View 3D Structure Click here
I1JCJ3 View 3D Structure Click here
I1JCJ3 View 3D Structure Click here
I1LI00 View 3D Structure Click here
I1LI00 View 3D Structure Click here
I1LW89 View 3D Structure Click here
I1LW89 View 3D Structure Click here
K7MXS9 View 3D Structure Click here
M0R8M1 View 3D Structure Click here
M0R8M1 View 3D Structure Click here
O14046 View 3D Structure Click here
O14046 View 3D Structure Click here
P05496 View 3D Structure Click here
P0C301 View 3D Structure Click here
P0C519 View 3D Structure Click here
P0DH92 View 3D Structure Click here
P0DH92 View 3D Structure Click here
P0DH93 View 3D Structure Click here
P0DH93 View 3D Structure Click here
P0DH94 View 3D Structure Click here
P0DH94 View 3D Structure Click here
P21537 View 3D Structure Click here
P23380 View 3D Structure Click here
P23380 View 3D Structure Click here
P23968 View 3D Structure Click here
P23968 View 3D Structure Click here
P25515 View 3D Structure Click here
P25515 View 3D Structure Click here
P27449 View 3D Structure Click here
P27449 View 3D Structure Click here
P32842 View 3D Structure Click here
P32842 View 3D Structure Click here
P48201 View 3D Structure Click here
P50515 View 3D Structure Click here
P50515 View 3D Structure Click here
P54642 View 3D Structure Click here
P54642 View 3D Structure Click here
P56383 View 3D Structure Click here
P56384 View 3D Structure Click here
P56760 View 3D Structure Click here
P59228 View 3D Structure Click here
P59228 View 3D Structure Click here
P59229 View 3D Structure Click here
P59229 View 3D Structure Click here
P60112 View 3D Structure Click here
P61829 View 3D Structure Click here
P63081 View 3D Structure Click here
P63081 View 3D Structure Click here
P63082 View 3D Structure Click here
P63082 View 3D Structure Click here
P68699 View 3D Structure Click here
P69195 View 3D Structure Click here
P69421 View 3D Structure Click here
P69449 View 3D Structure Click here
P93278 View 3D Structure Click here
P9WPS1 View 3D Structure Click here
Q06055 View 3D Structure Click here
Q06645 View 3D Structure Click here
Q06646 View 3D Structure Click here
Q0IPT8 View 3D Structure Click here
Q0IPT8 View 3D Structure Click here
Q0IUB5 View 3D Structure Click here
Q0IUB5 View 3D Structure Click here
Q21898 View 3D Structure Click here
Q21898 View 3D Structure Click here
Q2G2F6 View 3D Structure Click here
Q304C3 View 3D Structure Click here
Q37315 View 3D Structure Click here
Q41773 View 3D Structure Click here
Q4CVQ9 View 3D Structure Click here
Q4CVQ9 View 3D Structure Click here
Q4CXI5 View 3D Structure Click here
Q4CXI5 View 3D Structure Click here
Q4D1H1 View 3D Structure Click here
Q4D1H1 View 3D Structure Click here
Q4D8T9 View 3D Structure Click here
Q4DAV7 View 3D Structure Click here
Q4DAV7 View 3D Structure Click here
Q4DBY2 View 3D Structure Click here
Q4DDG2 View 3D Structure Click here
Q4DFS0 View 3D Structure Click here
Q4DX70 View 3D Structure Click here
Q4DX70 View 3D Structure Click here
Q57674 View 3D Structure Click here
Q57674 View 3D Structure Click here
Q57674 View 3D Structure Click here
Q5AH00 View 3D Structure Click here
Q5AH00 View 3D Structure Click here
Q65XI1 View 3D Structure Click here
Q65XI1 View 3D Structure Click here
Q6IQN6 View 3D Structure Click here
Q6NN09 View 3D Structure Click here
Q6P041 View 3D Structure Click here
Q6P041 View 3D Structure Click here
Q6Z0Z9 View 3D Structure Click here
Q6Z0Z9 View 3D Structure Click here
Q71QT0 View 3D Structure Click here
Q71S46 View 3D Structure Click here
Q7ZVE5 View 3D Structure Click here
Q7ZYW7 View 3D Structure Click here
Q86AS7 View 3D Structure Click here
Q86AS7 View 3D Structure Click here
Q8I3R7 View 3D Structure Click here
Q8I3R7 View 3D Structure Click here
Q8IDF7 View 3D Structure Click here
Q8IDF7 View 3D Structure Click here
Q8IQG3 View 3D Structure Click here
Q8IQG3 View 3D Structure Click here
Q91V37 View 3D Structure Click here
Q91V37 View 3D Structure Click here
Q94DM9 View 3D Structure Click here
Q94DM9 View 3D Structure Click here
Q99437 View 3D Structure Click here
Q99437 View 3D Structure Click here
Q9AX79 View 3D Structure Click here
Q9AX79 View 3D Structure Click here
Q9B8D5 View 3D Structure Click here
Q9BKS0 View 3D Structure Click here
Q9CR84 View 3D Structure Click here
Q9SLA2 View 3D Structure Click here
Q9SLA2 View 3D Structure Click here
Q9SZY7 View 3D Structure Click here
Q9SZY7 View 3D Structure Click here
Q9URZ8 View 3D Structure Click here
Q9URZ8 View 3D Structure Click here
Q9VFE3 View 3D Structure Click here
Q9VFE3 View 3D Structure Click here
Q9VFE5 View 3D Structure Click here
Q9VFE5 View 3D Structure Click here
Q9VKQ8 View 3D Structure Click here
Q9VKQ8 View 3D Structure Click here
Q9VTI6 View 3D Structure Click here
Q9VTI6 View 3D Structure Click here