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581  structures 9268  species 0  interactions 110058  sequences 2061  architectures

Family: Metallophos (PF00149)

Summary: Calcineurin-like phosphoesterase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Calcineurin-like phosphoesterase Provide feedback

This family includes a diverse range of phosphoesterases [1] including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD P13457 or yeast MRE11 P32829. The most conserved regions in this superfamily centre around the metal chelating residues.

Literature references

  1. Aravind L, Koonin EV; , Nucleic Acids Res 1998;26:3746-3752.: Phosphoesterase domains associated with DNA polymerases of diverse origins. PUBMED:9685491 EPMC:9685491


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004843

This domain is found in a diverse range of phosphoesterases [ PUBMED:9685491 ], including bis(5'-nucleosyl)-tetraphosphatase (apaH), nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases, as well as nucleases such as bacterial SbcD or archaeal/yeast Mre11. The most conserved regions in this domain centre around the metal chelating residues.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Calcineurin (CL0163), which has the following description:

This clan contains the calcineurin-like phosphoesterases. This clan also includes the apparently inactive homologues from the small DNA polymerase subunits [1].

The clan contains the following 9 members:

DNA_pol_E_B FBPase_2 Metallophos Metallophos_2 Metallophos_3 PGA_cap PhoD PhoD_2 YmdB

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(324)
Full
(110058)
Representative proteomes UniProt
(371278)
RP15
(17994)
RP35
(52242)
RP55
(100806)
RP75
(159442)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(324)
Full
(110058)
Representative proteomes UniProt
(371278)
RP15
(17994)
RP35
(52242)
RP55
(100806)
RP75
(159442)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(324)
Full
(110058)
Representative proteomes UniProt
(371278)
RP15
(17994)
RP35
(52242)
RP55
(100806)
RP75
(159442)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Dlakic M
Previous IDs: STphosphatase;
Type: Domain
Sequence Ontology: SO:0000417
Author: Dlakic M
Number in seed: 324
Number in full: 110058
Average length of the domain: 209.30 aa
Average identity of full alignment: 14 %
Average coverage of the sequence by the domain: 47.62 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.5 21.5
Trusted cut-off 21.5 21.5
Noise cut-off 21.4 21.4
Model length: 205
Family (HMM) version: 30
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Metallophos domain has been found. There are 581 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LF50 View 3D Structure Click here
A0A0G2JYA4 View 3D Structure Click here
A0A0G2KPF8 View 3D Structure Click here
A0A0G2KPF8 View 3D Structure Click here
A0A0K3AU53 View 3D Structure Click here
A0A0N7KHQ6 View 3D Structure Click here
A0A0N7KPD1 View 3D Structure Click here
A0A0N7KQ48 View 3D Structure Click here
A0A0P0V918 View 3D Structure Click here
A0A0P0W5I6 View 3D Structure Click here
A0A0P0X1Z8 View 3D Structure Click here
A0A0P0XPV5 View 3D Structure Click here
A0A0P0XVP3 View 3D Structure Click here
A0A0P0XZH6 View 3D Structure Click here
A0A0P0Y702 View 3D Structure Click here
A0A0P0YDK3 View 3D Structure Click here
A0A0R0FJW7 View 3D Structure Click here
A0A0R0FVP8 View 3D Structure Click here
A0A0R0H044 View 3D Structure Click here
A0A0R0H385 View 3D Structure Click here
A0A0R0H3J2 View 3D Structure Click here
A0A0R0HHJ5 View 3D Structure Click here
A0A0R0HK88 View 3D Structure Click here
A0A0R0HM85 View 3D Structure Click here
A0A0R0HMI8 View 3D Structure Click here
A0A0R0HQB8 View 3D Structure Click here
A0A0R0IAM5 View 3D Structure Click here
A0A0R0IEQ9 View 3D Structure Click here
A0A0R0JHK6 View 3D Structure Click here
A0A0R0JPQ9 View 3D Structure Click here
A0A0R0K183 View 3D Structure Click here
A0A0R0K7V1 View 3D Structure Click here
A0A0R0KHP8 View 3D Structure Click here
A0A0R4IA80 View 3D Structure Click here
A0A0R4IF09 View 3D Structure Click here
A0A0R4ITV5 View 3D Structure Click here
A0A0R4IZT6 View 3D Structure Click here
A0A1D6DX51 View 3D Structure Click here
A0A1D6ECT6 View 3D Structure Click here
A0A1D6EDB5 View 3D Structure Click here
A0A1D6EK81 View 3D Structure Click here
A0A1D6EM47 View 3D Structure Click here
A0A1D6EVQ6 View 3D Structure Click here
A0A1D6FI23 View 3D Structure Click here
A0A1D6FMA8 View 3D Structure Click here
A0A1D6FUN0 View 3D Structure Click here
A0A1D6G9W1 View 3D Structure Click here
A0A1D6G9W5 View 3D Structure Click here
A0A1D6GLG2 View 3D Structure Click here
A0A1D6GNS6 View 3D Structure Click here
A0A1D6H1L3 View 3D Structure Click here
A0A1D6H716 View 3D Structure Click here
A0A1D6HB35 View 3D Structure Click here
A0A1D6HPT1 View 3D Structure Click here
A0A1D6HR19 View 3D Structure Click here
A0A1D6HR96 View 3D Structure Click here
A0A1D6HZI4 View 3D Structure Click here
A0A1D6I489 View 3D Structure Click here
A0A1D6I9U6 View 3D Structure Click here
A0A1D6IWU3 View 3D Structure Click here
A0A1D6J6K7 View 3D Structure Click here
A0A1D6JPZ4 View 3D Structure Click here
A0A1D6JVH6 View 3D Structure Click here
A0A1D6JXL2 View 3D Structure Click here
A0A1D6JY01 View 3D Structure Click here
A0A1D6KE93 View 3D Structure Click here
A0A1D6KGE2 View 3D Structure Click here
A0A1D6KKC7 View 3D Structure Click here
A0A1D6KME2 View 3D Structure Click here
A0A1D6KS94 View 3D Structure Click here
A0A1D6KVM0 View 3D Structure Click here
A0A1D6KX01 View 3D Structure Click here
A0A1D6L052 View 3D Structure Click here
A0A1D6LBV4 View 3D Structure Click here
A0A1D6LNP9 View 3D Structure Click here
A0A1D6LSM4 View 3D Structure Click here
A0A1D6LZA4 View 3D Structure Click here
A0A1D6M065 View 3D Structure Click here
A0A1D6MVF8 View 3D Structure Click here
A0A1D6N1P4 View 3D Structure Click here
A0A1D6N539 View 3D Structure Click here
A0A1D6NTT1 View 3D Structure Click here
A0A1D6P6J9 View 3D Structure Click here
A0A1D6P809 View 3D Structure Click here
A0A1D6PEB4 View 3D Structure Click here
A0A1D6PJC3 View 3D Structure Click here
A0A1D6PV53 View 3D Structure Click here
A0A1D6PZ13 View 3D Structure Click here
A0A1D6PZG4 View 3D Structure Click here
A0A1D6QAR4 View 3D Structure Click here
A0A1D6QM46 View 3D Structure Click here
A0A1D6QMD0 View 3D Structure Click here
A0A1D6QPY6 View 3D Structure Click here
A0A1D6QQF8 View 3D Structure Click here
A0A1D8PCA8 View 3D Structure Click here
A0A1D8PGZ0 View 3D Structure Click here
A0A1D8PJ80 View 3D Structure Click here
A0A1D8PJ89 View 3D Structure Click here
A0A1D8PMT0 View 3D Structure Click here
A0A1D8PNT7 View 3D Structure Click here
A0A1D8PP72 View 3D Structure Click here
A0A1D8PPT8 View 3D Structure Click here
A0A1D8PQA0 View 3D Structure Click here
A0A1D8PQT2 View 3D Structure Click here
A0A1D8PSJ8 View 3D Structure Click here
A0A1X7YEC1 View 3D Structure Click here
A0A1X7YHU4 View 3D Structure Click here
A0A286YA34 View 3D Structure Click here
A0A2R8Q7Q3 View 3D Structure Click here
A0A2R8QJS6 View 3D Structure Click here
A0A2R8RS59 View 3D Structure Click here
A1ZAU0 View 3D Structure Click here
A3C4N5 View 3D Structure Click here
A4HSD9 View 3D Structure Click here
A4HTW1 View 3D Structure Click here
A4HVT0 View 3D Structure Click here
A4HVT6 View 3D Structure Click here
A4HWC1 View 3D Structure Click here
A4HXD2 View 3D Structure Click here
A4HXP1 View 3D Structure Click here
A4I008 View 3D Structure Click here
A4I019 View 3D Structure Click here
A4I1H6 View 3D Structure Click here
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A4I2J0 View 3D Structure Click here
A4I2Z5 View 3D Structure Click here
A4I3E3 View 3D Structure Click here
A4I400 View 3D Structure Click here
A4I498 View 3D Structure Click here
A4I612 View 3D Structure Click here
A4I768 View 3D Structure Click here
A4I8C8 View 3D Structure Click here
A4I9P2 View 3D Structure Click here
A4IA54 View 3D Structure Click here
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A8DY95 View 3D Structure Click here
A8MQN4 View 3D Structure Click here
A8QI94 View 3D Structure Click here
A8WGP3 View 3D Structure Click here
A9JRC7 View 3D Structure Click here
B1WBP0 View 3D Structure Click here
B1WC86 View 3D Structure Click here
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B4FR72 View 3D Structure Click here
B4FS28 View 3D Structure Click here
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B6TE04 View 3D Structure Click here
B6TKI2 View 3D Structure Click here
B6TKL3 View 3D Structure Click here
B6U6X4 View 3D Structure Click here
B7FA26 View 3D Structure Click here
B9GEG4 View 3D Structure Click here
C0HHY2 View 3D Structure Click here
C0P5E1 View 3D Structure Click here
C6T9R4 View 3D Structure Click here
C6T9R7 View 3D Structure Click here
C6T9W2 View 3D Structure Click here
C6TAF5 View 3D Structure Click here
C6TAQ1 View 3D Structure Click here
C6TII4 View 3D Structure Click here
C6TK28 View 3D Structure Click here
C6TKR1 View 3D Structure Click here
C6TNW7 View 3D Structure Click here
C6ZS09 View 3D Structure Click here
C7G010 View 3D Structure Click here
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D3Z286 View 3D Structure Click here
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D3ZN69 View 3D Structure Click here
D4A120 View 3D Structure Click here
D6W4U0 View 3D Structure Click here
E2CWF0 View 3D Structure Click here
E7F169 View 3D Structure Click here
E7FFQ5 View 3D Structure Click here
E9AGF3 View 3D Structure Click here
E9AHS8 View 3D Structure Click here
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E9AHT0 View 3D Structure Click here
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E9AHU3 View 3D Structure Click here
F1Q6Z7 View 3D Structure Click here
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F1QD93 View 3D Structure Click here
F1QI59 View 3D Structure Click here
F1QPA6 View 3D Structure Click here
F1QUV1 View 3D Structure Click here
F4JMQ8 View 3D Structure Click here
F4JPS4 View 3D Structure Click here
F4KDK1 View 3D Structure Click here
F6NMN3 View 3D Structure Click here
F8W546 View 3D Structure Click here
G0T427 View 3D Structure Click here
G0T428 View 3D Structure Click here
G0T433 View 3D Structure Click here
G0T437 View 3D Structure Click here
G5EBX9 View 3D Structure Click here
G5EC18 View 3D Structure Click here
G5ECL6 View 3D Structure Click here
G5EE15 View 3D Structure Click here
G5EGK8 View 3D Structure Click here
G5EGR0 View 3D Structure Click here
H2FLJ4 View 3D Structure Click here
I1J5H1 View 3D Structure Click here
I1JB89 View 3D Structure Click here
I1JBU6 View 3D Structure Click here
I1JFE9 View 3D Structure Click here
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I1JJE9 View 3D Structure Click here
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I1JR93 View 3D Structure Click here
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I1JU50 View 3D Structure Click here
I1K0B0 View 3D Structure Click here
I1K593 View 3D Structure Click here
I1K6D8 View 3D Structure Click here
I1K7M5 View 3D Structure Click here
I1KC33 View 3D Structure Click here
I1KCA3 View 3D Structure Click here
I1KHK7 View 3D Structure Click here
I1KHL2 View 3D Structure Click here
I1KPF7 View 3D Structure Click here
I1KQM7 View 3D Structure Click here
I1KRQ6 View 3D Structure Click here
I1KRR2 View 3D Structure Click here
I1KSA8 View 3D Structure Click here
I1KXK7 View 3D Structure Click here
I1KXM8 View 3D Structure Click here
I1L2I7 View 3D Structure Click here
I1L5N5 View 3D Structure Click here
I1LBR4 View 3D Structure Click here
I1LUX6 View 3D Structure Click here
I1LZM0 View 3D Structure Click here
I1LZT0 View 3D Structure Click here
I1M3C5 View 3D Structure Click here
I1M6L3 View 3D Structure Click here
I1M8J6 View 3D Structure Click here
I1MBG0 View 3D Structure Click here
I1MQD9 View 3D Structure Click here
I1MY91 View 3D Structure Click here
I1N1B4 View 3D Structure Click here
I1N413 View 3D Structure Click here
I1NAM1 View 3D Structure Click here
I1NAY9 View 3D Structure Click here
I1NBW2 View 3D Structure Click here
I1NCD8 View 3D Structure Click here
I1ND52 View 3D Structure Click here
I1NI31 View 3D Structure Click here
I4DHV7 View 3D Structure Click here
I6X827 View 3D Structure Click here
I6YEE1 View 3D Structure Click here
K7K7T8 View 3D Structure Click here
K7KG04 View 3D Structure Click here
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K7KH75 View 3D Structure Click here
K7KMU1 View 3D Structure Click here
K7KQ43 View 3D Structure Click here
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K7L2E6 View 3D Structure Click here
K7LA10 View 3D Structure Click here
K7LC27 View 3D Structure Click here
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K7LK88 View 3D Structure Click here
K7LM16 View 3D Structure Click here
K7LM18 View 3D Structure Click here
K7LWB6 View 3D Structure Click here
K7M3M0 View 3D Structure Click here
K7MBV1 View 3D Structure Click here
K7MGP4 View 3D Structure Click here
K7MLC5 View 3D Structure Click here
K7MNR2 View 3D Structure Click here
K7MR42 View 3D Structure Click here
K7MRU1 View 3D Structure Click here
K7MW57 View 3D Structure Click here
K7MWX7 View 3D Structure Click here
K7MZ83 View 3D Structure Click here
K7N0G2 View 3D Structure Click here
K7TEL4 View 3D Structure Click here
K7TM89 View 3D Structure Click here
K7TQA6 View 3D Structure Click here
K7TVR5 View 3D Structure Click here
K7V620 View 3D Structure Click here
K7VI50 View 3D Structure Click here
K8FE09 View 3D Structure Click here
M0RCA8 View 3D Structure Click here
O00743 View 3D Structure Click here
O01320 View 3D Structure Click here
O02658 View 3D Structure Click here
O04951 View 3D Structure Click here
O13765 View 3D Structure Click here
O13781 View 3D Structure Click here
O14829 View 3D Structure Click here
O14830 View 3D Structure Click here
O15442 View 3D Structure Click here
O15757 View 3D Structure Click here
O16334 View 3D Structure Click here
O23244 View 3D Structure Click here
O35385 View 3D Structure Click here
O35655 View 3D Structure Click here
O42841 View 3D Structure Click here
O43049 View 3D Structure Click here
O44507 View 3D Structure Click here
O45001 View 3D Structure Click here
O48840 View 3D Structure Click here
O59759 View 3D Structure Click here
O62272 View 3D Structure Click here
O74480 View 3D Structure Click here
O74789 View 3D Structure Click here
O76932 View 3D Structure Click here
O82733 View 3D Structure Click here
O82734 View 3D Structure Click here
O97259 View 3D Structure Click here
P05637 View 3D Structure Click here
P07024 View 3D Structure Click here
P08331 View 3D Structure Click here
P0AEW4 View 3D Structure Click here
P0AG76 View 3D Structure Click here
P11612 View 3D Structure Click here
P12982 View 3D Structure Click here
P13681 View 3D Structure Click here
P13686 View 3D Structure Click here
P14747 View 3D Structure Click here
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P20604 View 3D Structure Click here
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P32829 View 3D Structure Click here
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P32945 View 3D Structure Click here
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P36614 View 3D Structure Click here
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P43341 View 3D Structure Click here
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P48528 View 3D Structure Click here
P48529 View 3D Structure Click here
P48578 View 3D Structure Click here
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P53041 View 3D Structure Click here
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