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498  structures 1575  species 0  interactions 47832  sequences 763  architectures

Family: UQ_con (PF00179)

Summary: Ubiquitin-conjugating enzyme

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Ubiquitin-conjugating enzyme". More...

Ubiquitin-conjugating enzyme Edit Wikipedia article

Ubiquitin—protein ligase
Identifiers
EC number6.3.2.19
CAS number74812-49-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Ubiquitin-conjugating enzyme, E2
Identifiers
SymbolUBQ-conjugat_E2
PfamPF00179
InterProIPR000608
SMARTSM00212
PROSITEPDOC00163
Membranome241

Ubiquitin-conjugating enzymes, also known as E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step in the ubiquitination reaction that targets a protein for degradation via the proteasome. The ubiquitination process covalently attaches ubiquitin, a short protein of 76 amino acids, to a lysine residue on the target protein. Once a protein has been tagged with one ubiquitin molecule, additional rounds of ubiquitination form a polyubiquitin chain that is recognized by the proteasome's 19S regulatory particle, triggering the ATP-dependent unfolding of the target protein that allows passage into the proteasome's 20S core particle, where proteases degrade the target into short peptide fragments for recycling by the cell.

Relationships

A ubiquitin-activating enzyme, or E1, first activates the ubiquitin by covalently attaching the molecule to its active site cysteine residue. The activated ubiquitin is then transferred to an E2 cysteine. Once conjugated to ubiquitin, the E2 molecule binds one of several ubiquitin ligases or E3s via a structurally conserved binding region. The E3 molecule is responsible for binding the target protein substrate and transferring the ubiquitin from the E2 cysteine to a lysine residue on the target protein.[1]

A particular cell usually contains only a few types of E1 molecule, a greater diversity of E2s, and a very large variety of E3s. The E3 molecules responsible for substrate identification and binding are thus the mechanisms of substrate specificity in proteasomal degradation. Each type of E2 can associate with many E3s.[2]

Isozymes

The following human genes encode ubiquitin-conjugating enzymes:

See also

References

  1. ^ Nandi D, Tahiliani P, Kumar A, Chandu D (2006). "The ubiquitin-proteasome system" (PDF). Journal of Biosciences. 31 (1): 137–55. doi:10.1007/BF02705243. PMID 16595883.
  2. ^ Risseeuw EP, Daskalchuk TE, Banks TW, Liu E, Cotelesage J, Hellmann H, Estelle M, Somers DE, Crosby WL (2003). "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis". The Plant Journal. 34 (6): 753–67. doi:10.1046/j.1365-313X.2003.01768.x. PMID 12795696.

External links


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Ubiquitin-conjugating enzyme Provide feedback

Proteins destined for proteasome-mediated degradation may be ubiquitinated. Ubiquitination follows conjugation of ubiquitin to a conserved cysteine residue of UBC homologues. TSG101 is one of several UBC homologues that lacks this active site cysteine [4, 5].

Literature references

  1. Cook WJ, Jeffrey LC, Sullivan ML, Vierstra RD; , J Biol Chem 1992;267:15116-15121.: Three-dimensional structure of a ubiquitin-conjugating enzyme (E2). PUBMED:1321826 EPMC:1321826

  2. Cook WJ, Jeffrey LC, Xu Y, Chau V; , Biochemistry 1993;32:13809-13817.: Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4. PUBMED:8268156 EPMC:8268156

  3. Cook WJ, Martin PD, Edwards BF, Yamazaki RK, Chau V; , Biochemistry 1997;36:1621-1627.: Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. PUBMED:9048545 EPMC:9048545

  4. Koonin EV, Abagyan RA; , Nat Genet 1997;16:330-331.: TSG101 may be the prototype of a class of dominant negative ubiquitin regulators. PUBMED:9241264 EPMC:9241264

  5. Ponting CP, Cai YD, Bork P , J Mol Med 1997;75:467-469.: The breast cancer gene product TSG101: a regulator of ubiquitination? PUBMED:9253709 EPMC:9253709

  6. Burroughs AM, Jaffee M, Iyer LM, Aravind L;, J Struct Biol. 2008;162:205-218.: Anatomy of the E2 ligase fold: implications for enzymology and evolution of ubiquitin/Ub-like protein conjugation. PUBMED:18276160 EPMC:18276160


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000608

Ubiquitin-conjugating enzymes (UBC or E2 enzymes) [ PUBMED:2193438 , PUBMED:1647207 , PUBMED:1656558 ] catalyse the covalent attachment of ubiquitin to target proteins. Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1, INTERPRO ), a ubiquitin-conjugating enzyme (E2), and a ubiquitin ligase (E3, INTERPRO , INTERPRO ), which work sequentially in a cascade [ PUBMED:14998368 ]. The E1 enzyme mediates an ATP-dependent transfer of a thioester-linked ubiquitin molecule to a cysteine residue on the E2 enzyme. The E2 enzyme ( EC ) then either transfers the ubiquitin moiety directly to a substrate, or to an E3 ligase, which can also ubiquitinylate a substrate.

There are several different E2 enzymes (over 30 in humans), which are broadly grouped into four classes, all of which have a core catalytic domain (containing the active site cysteine), and some of which have short N- and C-terminal amino acid extensions: class I enzymes consist of just the catalytic core domain (UBC), class II possess a UBC and a C-terminal extension, class III possess a UBC and an N-terminal extension, and class IV possess a UBC and both N- and C-terminal extensions. These extensions appear to be important for some subfamily function, including E2 localisation and protein-protein interactions [ PUBMED:15545318 ]. In addition, there are proteins with an E2-like fold that are devoid of catalytic activity (such as protein crossbronx from flies), but which appear to assist in poly-ubiquitin chain formation.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan UBC (CL0208), which has the following description:

This superfamily includes a diverse set of proteins that bind to ubiquitin [1].

The clan contains the following 13 members:

FANCL_d1 FANCL_d2 FANCL_d3 Knl1_RWD_C Prok-E2_A Prok-E2_B Prok-E2_C Prok-E2_D Prok-E2_E RWD UEV UFC1 UQ_con

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(47832)
Representative proteomes UniProt
(84092)
RP15
(8776)
RP35
(21657)
RP55
(37753)
RP75
(50951)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(47832)
Representative proteomes UniProt
(84092)
RP15
(8776)
RP35
(21657)
RP55
(37753)
RP75
(50951)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(47832)
Representative proteomes UniProt
(84092)
RP15
(8776)
RP35
(21657)
RP55
(37753)
RP75
(50951)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Ponting CP , Schultz J, Bork P , Finn RD
Number in seed: 64
Number in full: 47832
Average length of the domain: 131.60 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 43.41 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.3 21.3
Trusted cut-off 21.3 21.3
Noise cut-off 21.2 21.2
Model length: 140
Family (HMM) version: 28
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UQ_con domain has been found. There are 498 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K8C5 View 3D Structure Click here
A0A0G2KB55 View 3D Structure Click here
A0A0G2KHN8 View 3D Structure Click here
A0A0N7KCM1 View 3D Structure Click here
A0A0P0V6G8 View 3D Structure Click here
A0A0P0V9Q4 View 3D Structure Click here
A0A0P0VP46 View 3D Structure Click here
A0A0P0WI20 View 3D Structure Click here
A0A0P0WX41 View 3D Structure Click here
A0A0P0WZL6 View 3D Structure Click here
A0A0P0XFY8 View 3D Structure Click here
A0A0R0EZF0 View 3D Structure Click here
A0A0R0F7L9 View 3D Structure Click here
A0A0R0FNX1 View 3D Structure Click here
A0A0R0FNX2 View 3D Structure Click here
A0A0R0FNY3 View 3D Structure Click here
A0A0R0FP03 View 3D Structure Click here
A0A0R0G321 View 3D Structure Click here
A0A0R0GQV0 View 3D Structure Click here
A0A0R0H669 View 3D Structure Click here
A0A0R0HF85 View 3D Structure Click here
A0A0R0I7X0 View 3D Structure Click here
A0A0R0JD00 View 3D Structure Click here
A0A0R0JMD5 View 3D Structure Click here
A0A0R0KPF4 View 3D Structure Click here
A0A0R4IUU4 View 3D Structure Click here
A0A0R4IYY2 View 3D Structure Click here
A0A0R4J375 View 3D Structure Click here
A0A0R4J4H5 View 3D Structure Click here
A0A140T8I4 View 3D Structure Click here
A0A143ZY34 View 3D Structure Click here
A0A1B0GUS4 View 3D Structure Click here
A0A1D6E1Y4 View 3D Structure Click here
A0A1D6E1Y7 View 3D Structure Click here
A0A1D6ELE4 View 3D Structure Click here
A0A1D6ENM7 View 3D Structure Click here
A0A1D6FCC1 View 3D Structure Click here
A0A1D6FH82 View 3D Structure Click here
A0A1D6FHD1 View 3D Structure Click here
A0A1D6FJU1 View 3D Structure Click here
A0A1D6FJY8 View 3D Structure Click here
A0A1D6FRP9 View 3D Structure Click here
A0A1D6FSE0 View 3D Structure Click here
A0A1D6G0U5 View 3D Structure Click here
A0A1D6G1D6 View 3D Structure Click here
A0A1D6G1D6 View 3D Structure Click here
A0A1D6G555 View 3D Structure Click here
A0A1D6GJ79 View 3D Structure Click here
A0A1D6GKI5 View 3D Structure Click here
A0A1D6GPX9 View 3D Structure Click here
A0A1D6GV09 View 3D Structure Click here
A0A1D6GYT0 View 3D Structure Click here
A0A1D6HT13 View 3D Structure Click here
A0A1D6HT13 View 3D Structure Click here
A0A1D6HUB6 View 3D Structure Click here
A0A1D6I1H9 View 3D Structure Click here
A0A1D6J174 View 3D Structure Click here
A0A1D6JNR7 View 3D Structure Click here
A0A1D6K0D1 View 3D Structure Click here
A0A1D6K7I4 View 3D Structure Click here
A0A1D6KGW2 View 3D Structure Click here
A0A1D6KUA8 View 3D Structure Click here
A0A1D6KUC5 View 3D Structure Click here
A0A1D6KYI9 View 3D Structure Click here
A0A1D6L7C0 View 3D Structure Click here
A0A1D6LKH6 View 3D Structure Click here
A0A1D6LNL8 View 3D Structure Click here
A0A1D6LQF9 View 3D Structure Click here
A0A1D6LTJ2 View 3D Structure Click here
A0A1D6LTV9 View 3D Structure Click here
A0A1D6MC51 View 3D Structure Click here
A0A1D6MC51 View 3D Structure Click here
A0A1D6MCH9 View 3D Structure Click here
A0A1D6MF01 View 3D Structure Click here
A0A1D6MMD1 View 3D Structure Click here
A0A1D6MQI6 View 3D Structure Click here
A0A1D6MRU8 View 3D Structure Click here
A0A1D6NG29 View 3D Structure Click here
A0A1D6NGW9 View 3D Structure Click here
A0A1D6NLJ7 View 3D Structure Click here
A0A1D6NT78 View 3D Structure Click here
A0A1D6PF47 View 3D Structure Click here
A0A1D6PU21 View 3D Structure Click here
A0A1D6PWM6 View 3D Structure Click here
A0A1D6Q5K0 View 3D Structure Click here
A0A1D6Q757 View 3D Structure Click here
A0A1D8PFF9 View 3D Structure Click here
A0A1D8PKG7 View 3D Structure Click here
A0A1D8PP96 View 3D Structure Click here
A0A1D8PQD4 View 3D Structure Click here
A0A1D8PTY7 View 3D Structure Click here
A0A1D8PU40 View 3D Structure Click here
A0A1T5HUK0 View 3D Structure Click here
A0A2K5ATR7 View 3D Structure Click here
A0A2R8QGJ9 View 3D Structure Click here
A0A2R8QI56 View 3D Structure Click here
A0A2R8QIN6 View 3D Structure Click here
A0A368UI92 View 3D Structure Click here
A0A6I8MX03 View 3D Structure Click here
A0PJN4 View 3D Structure Click here
A1L167 View 3D Structure Click here
A1Z8B5 View 3D Structure Click here
A1ZBR5 View 3D Structure Click here
A2AFH1 View 3D Structure Click here
A2AFH2 View 3D Structure Click here
A2BIR4 View 3D Structure Click here
A4HRN6 View 3D Structure Click here
A4HS64 View 3D Structure Click here
A4HSL5 View 3D Structure Click here
A4HTB1 View 3D Structure Click here
A4HVS0 View 3D Structure Click here
A4HZT8 View 3D Structure Click here
A4I122 View 3D Structure Click here
A4I123 View 3D Structure Click here
A4I7L2 View 3D Structure Click here
A4I7R2 View 3D Structure Click here
A4I9B7 View 3D Structure Click here
A4I9P7 View 3D Structure Click here
A4I9W7 View 3D Structure Click here
A4IB24 View 3D Structure Click here
A4QNV0 View 3D Structure Click here
A4QNX5 View 3D Structure Click here
A9JRT4 View 3D Structure Click here
B0S6A7 View 3D Structure Click here
B1AUC4 View 3D Structure Click here
B2GV55 View 3D Structure Click here
B2RYD0 View 3D Structure Click here
B2RZ96 View 3D Structure Click here
B4FA99 View 3D Structure Click here
B4FC97 View 3D Structure Click here
B4FCG1 View 3D Structure Click here
B4FCQ9 View 3D Structure Click here
B4FD26 View 3D Structure Click here
B4FI48 View 3D Structure Click here
B4FIK1 View 3D Structure Click here
B4FMX0 View 3D Structure Click here
B4FSG6 View 3D Structure Click here
B5DEI4 View 3D Structure Click here
B5DFI8 View 3D Structure Click here
B6SIV2 View 3D Structure Click here
B6SK03 View 3D Structure Click here
B6SPY0 View 3D Structure Click here
B6SZE0 View 3D Structure Click here
B6T659 View 3D Structure Click here
B6TA94 View 3D Structure Click here
B6TAV9 View 3D Structure Click here
B6TEM7 View 3D Structure Click here
B7EAV1 View 3D Structure Click here
C4J9T9 View 3D Structure Click here
C6KSR0 View 3D Structure Click here
C6SV99 View 3D Structure Click here
C6SVL7 View 3D Structure Click here
C6SVP6 View 3D Structure Click here
C6SW33 View 3D Structure Click here
C6SWF0 View 3D Structure Click here
C6SWR4 View 3D Structure Click here
C6SX33 View 3D Structure Click here
C6SXA6 View 3D Structure Click here
C6SXY4 View 3D Structure Click here
C6SZD1 View 3D Structure Click here
C6SZW2 View 3D Structure Click here
C6T129 View 3D Structure Click here
C6T174 View 3D Structure Click here
C6T1V1 View 3D Structure Click here
C6T263 View 3D Structure Click here
C6T2F1 View 3D Structure Click here
C6T394 View 3D Structure Click here
C6T5B4 View 3D Structure Click here
C6TAY6 View 3D Structure Click here
C6TJ43 View 3D Structure Click here
C6TJX5 View 3D Structure Click here
C6TLV8 View 3D Structure Click here
C6TMV6 View 3D Structure Click here
D3ZDK2 View 3D Structure Click here
D3ZFY8 View 3D Structure Click here
D3ZL88 View 3D Structure Click here
D3ZNQ6 View 3D Structure Click here
D3ZUW6 View 3D Structure Click here
D3ZXS8 View 3D Structure Click here
D3ZXV0 View 3D Structure Click here
D3ZYE1 View 3D Structure Click here
D4A453 View 3D Structure Click here
D4ABY4 View 3D Structure Click here
D4ADP2 View 3D Structure Click here
E9AH78 View 3D Structure Click here
F1M158 View 3D Structure Click here
F1M227 View 3D Structure Click here
F1M3L4 View 3D Structure Click here
F1M403 View 3D Structure Click here
F1Q4R2 View 3D Structure Click here
F1QWM3 View 3D Structure Click here
F1R1E9 View 3D Structure Click here
F4HPP7 View 3D Structure Click here
F4I6V2 View 3D Structure Click here
F7F5A1 View 3D Structure Click here
G3V6M7 View 3D Structure Click here
H8W3X5 View 3D Structure Click here
I1J996 View 3D Structure Click here
I1JGK4 View 3D Structure Click here
I1JZY3 View 3D Structure Click here
I1K6H0 View 3D Structure Click here
I1K9A6 View 3D Structure Click here
I1KCQ0 View 3D Structure Click here
I1KHJ7 View 3D Structure Click here
I1KMR9 View 3D Structure Click here
I1KSB4 View 3D Structure Click here
I1KWZ3 View 3D Structure Click here
I1KXR3 View 3D Structure Click here
I1L0R5 View 3D Structure Click here
I1L2W9 View 3D Structure Click here
I1L6I1 View 3D Structure Click here
I1L9H8 View 3D Structure Click here
I1LD22 View 3D Structure Click here
I1LHB7 View 3D Structure Click here
I1LIM2 View 3D Structure Click here
I1LLY9 View 3D Structure Click here
I1LPD6 View 3D Structure Click here
I1LPS4 View 3D Structure Click here
I1LV04 View 3D Structure Click here
I1LV57 View 3D Structure Click here
I1LX80 View 3D Structure Click here
I1M0A8 View 3D Structure Click here
I1M241 View 3D Structure Click here
I1MEJ2 View 3D Structure Click here
I1MGF5 View 3D Structure Click here
I1MKV3 View 3D Structure Click here
I1MML3 View 3D Structure Click here
I1MRQ0 View 3D Structure Click here
I1MTJ4 View 3D Structure Click here
I1MTR4 View 3D Structure Click here
I1N7B5 View 3D Structure Click here
I1NAS2 View 3D Structure Click here
I1NE09 View 3D Structure Click here
I1NHE9 View 3D Structure Click here
K7KIV2 View 3D Structure Click here
K7KX39 View 3D Structure Click here
K7L3J2 View 3D Structure Click here
K7L5R7 View 3D Structure Click here
K7M2C4 View 3D Structure Click here
K7MJQ9 View 3D Structure Click here
K7MJR2 View 3D Structure Click here
K7MQ19 View 3D Structure Click here
K7MTV5 View 3D Structure Click here
K7MY00 View 3D Structure Click here
K7N197 View 3D Structure Click here
K7N2S7 View 3D Structure Click here
K7UCZ6 View 3D Structure Click here
K7USW8 View 3D Structure Click here
K7V9X1 View 3D Structure Click here
K7WD30 View 3D Structure Click here
M0R3Q5 View 3D Structure Click here
M0R4P9 View 3D Structure Click here
M0R6B6 View 3D Structure Click here
O00102 View 3D Structure Click here
O00103 View 3D Structure Click here
O00762 View 3D Structure Click here
O13685 View 3D Structure Click here
O14933 View 3D Structure Click here
O22656 View 3D Structure Click here
O23239 View 3D Structure Click here
O24560 View 3D Structure Click here
O42646 View 3D Structure Click here
O45495 View 3D Structure Click here
O48838 View 3D Structure Click here
O74201 View 3D Structure Click here
O74549 View 3D Structure Click here
O74810 View 3D Structure Click here
O74983 View 3D Structure Click here
O76542 View 3D Structure Click here
O77397 View 3D Structure Click here
O97241 View 3D Structure Click here
P06104 View 3D Structure Click here
P14682 View 3D Structure Click here
P15731 View 3D Structure Click here
P15732 View 3D Structure Click here
P21734 View 3D Structure Click here
P23566 View 3D Structure Click here
P25153 View 3D Structure Click here
P25865 View 3D Structure Click here
P25867 View 3D Structure Click here
P28263 View 3D Structure Click here
P29340 View 3D Structure Click here
P33296 View 3D Structure Click here
P34477 View 3D Structure Click here
P35128 View 3D Structure Click here
P35129 View 3D Structure Click here
P35131 View 3D Structure Click here
P35132 View 3D Structure Click here
P35133 View 3D Structure Click here
P35134 View 3D Structure Click here
P40984 View 3D Structure Click here
P42743 View 3D Structure Click here
P42745 View 3D Structure Click here
P42746 View 3D Structure Click here
P42747 View 3D Structure Click here
P42748 View 3D Structure Click here
P42749 View 3D Structure Click here
P42750 View 3D Structure Click here
P46595 View 3D Structure Click here
P49427 View 3D Structure Click here
P49459 View 3D Structure Click here
P50623 View 3D Structure Click here
P51668 View 3D Structure Click here
P51965 View 3D Structure Click here
P52478 View 3D Structure Click here
P52482 View 3D Structure Click here
P52483 View 3D Structure Click here
P52484 View 3D Structure Click here
P52485 View 3D Structure Click here
P52486 View 3D Structure Click here
P52487 View 3D Structure Click here
P52490 View 3D Structure Click here
P52491 View 3D Structure Click here
P52492 View 3D Structure Click here
P53152 View 3D Structure Click here
P60604 View 3D Structure Click here
P60605 View 3D Structure Click here
P61077 View 3D Structure Click here
P61078 View 3D Structure Click here
P61079 View 3D Structure Click here
P61080 View 3D Structure Click here
P61081 View 3D Structure Click here
P61082 View 3D Structure Click here
P61086 View 3D Structure Click here
P61087 View 3D Structure Click here
P61088 View 3D Structure Click here
P61089 View 3D Structure Click here
P62253 View 3D Structure Click here
P62254 View 3D Structure Click here
P62255 View 3D Structure Click here
P62256 View 3D Structure Click here
P62257 View 3D Structure Click here
P62837 View 3D Structure Click here
P62838 View 3D Structure Click here
P62839 View 3D Structure Click here
P63146 View 3D Structure Click here
P63147 View 3D Structure Click here
P63149 View 3D Structure Click here
P63279 View 3D Structure Click here
P63280 View 3D Structure Click here
P63281 View 3D Structure Click here
P68036 View 3D Structure Click here
P68037 View 3D Structure Click here
P70711 View 3D Structure Click here
P91853 View 3D Structure Click here
Q02159 View 3D Structure Click here
Q08BH7 View 3D Structure Click here
Q0D571 View 3D Structure Click here
Q0DJS7 View 3D Structure Click here
Q0DK90 View 3D Structure Click here
Q0J8W1 View 3D Structure Click here
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