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654  structures 5885  species 0  interactions 13249  sequences 175  architectures

Family: HSP90 (PF00183)

Summary: Hsp90 protein

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Hsp90". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Hsp90 protein Provide feedback

No Pfam abstract.

Literature references

  1. Prodromou C, Roe SM, Piper PW, Pearl LH; , Nat Struct Biol 1997;4:477-482.: A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone. PUBMED:9187656 EPMC:9187656


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001404

Molecular chaperones, or heat shock proteins (Hsps) are ubiquitous proteins that act to maintain proper protein folding within the cell [ PUBMED:11407116 ]. They assist in the folding of nascent polypeptide chains, and are also involved in the re-folding of denatured proteins following proteotoxic stress. As their name implies, the heat shock proteins were first identified as proteins that were up-regulated under conditions of elevated temperature. However, subsequent studies have shown that increased Hsp expression is induced by a variety of cellular stresses, including oxidative stress and inflammation. Five major Hsp families have been determined, and are categorized according to their molecular size (Hsp100, Hsp90, Hsp70, Hsp60, and the small Hsps). Hsps are involved in a variety of cellular processes that are ATP-dependent. These include: prevention of protein aggregation, protein degradation, protein trafficking, and maintenance of signalling proteins in a conformation that permits activation.

Hsp90 chaperones are unique in their ability to regulate a specific subset of cellular signalling proteins that have been implicated in disease processes, including intracellular protein kinases, steroid hormone receptors, and growth factor receptors [ PUBMED:9521088 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(87)
Full
(13249)
Representative proteomes UniProt
(45793)
RP15
(2323)
RP35
(6531)
RP55
(11727)
RP75
(18131)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(87)
Full
(13249)
Representative proteomes UniProt
(45793)
RP15
(2323)
RP35
(6531)
RP55
(11727)
RP75
(18131)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(87)
Full
(13249)
Representative proteomes UniProt
(45793)
RP15
(2323)
RP35
(6531)
RP55
(11727)
RP75
(18131)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD
Number in seed: 87
Number in full: 13249
Average length of the domain: 371.50 aa
Average identity of full alignment: 31 %
Average coverage of the sequence by the domain: 65.10 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.4 24.4
Trusted cut-off 24.4 24.4
Noise cut-off 24.3 24.3
Model length: 518
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HSP90 domain has been found. There are 654 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0W604 View 3D Structure Click here
A0A0P0XPT3 View 3D Structure Click here
A0A0R0FF44 View 3D Structure Click here
A0A0R0FF44 View 3D Structure Click here
A0A0R0FGQ5 View 3D Structure Click here
A0A0R0GHB3 View 3D Structure Click here
A0A0R0HKV1 View 3D Structure Click here
A0A0R0I089 View 3D Structure Click here
A0A0R0I089 View 3D Structure Click here
A0A0R0IG87 View 3D Structure Click here
A0A0R0JDE1 View 3D Structure Click here
A0A0R0JDE1 View 3D Structure Click here
A0A0R0KPW1 View 3D Structure Click here
A0A1D6ES19 View 3D Structure Click here
A0A1D6GWE1 View 3D Structure Click here
A0A1D6I6H5 View 3D Structure Click here
A0A1D6I6T0 View 3D Structure Click here
A0A1D6KID1 View 3D Structure Click here
A0A1D6KID1 View 3D Structure Click here
A0A1D6LFA6 View 3D Structure Click here
A0A1D6LMW9 View 3D Structure Click here
A0A286YAP4 View 3D Structure Click here
A0A2R8RKV0 View 3D Structure Click here
A1Z6L9 View 3D Structure Click here
A4I4C9 View 3D Structure Click here
C0P4Q3 View 3D Structure Click here
C0PDG3 View 3D Structure Click here
C3UZ63 View 3D Structure Click here
D3ZXC7 View 3D Structure Click here
D6C4Z9 View 3D Structure Click here
D6C500 View 3D Structure Click here
E9AHM8 View 3D Structure Click here
E9AHM9 View 3D Structure Click here
E9AHQ7 View 3D Structure Click here
F4JFN3 View 3D Structure Click here
I1J675 View 3D Structure Click here
I1JEL6 View 3D Structure Click here
I1JJL6 View 3D Structure Click here
I1JJQ4 View 3D Structure Click here
I1L314 View 3D Structure Click here
I1M6E1 View 3D Structure Click here
I1MC31 View 3D Structure Click here
I1MC31 View 3D Structure Click here
I1MPI1 View 3D Structure Click here
I1MY38 View 3D Structure Click here
K7MXK0 View 3D Structure Click here
K7V364 View 3D Structure Click here
O03986 View 3D Structure Click here
O57521 View 3D Structure Click here
P02828 View 3D Structure Click here
P02829 View 3D Structure Click here
P07900 View 3D Structure Click here
P07901 View 3D Structure Click here
P08113 View 3D Structure Click here
P08238 View 3D Structure Click here
P0A6Z3 View 3D Structure Click here
P11499 View 3D Structure Click here
P14625 View 3D Structure Click here
P15108 View 3D Structure Click here
P27323 View 3D Structure Click here
P34058 View 3D Structure Click here
P41887 View 3D Structure Click here
P46598 View 3D Structure Click here
P51818 View 3D Structure Click here
P54651 View 3D Structure Click here
P55737 View 3D Structure Click here
P82995 View 3D Structure Click here
P9WMJ7 View 3D Structure Click here
Q07078 View 3D Structure Click here
Q08277 View 3D Structure Click here
Q0IN14 View 3D Structure Click here
Q0J0Z5 View 3D Structure Click here
Q0J4P2 View 3D Structure Click here
Q12931 View 3D Structure Click here
Q14568 View 3D Structure Click here
Q18688 View 3D Structure Click here
Q22235 View 3D Structure Click here
Q2L6Y6 View 3D Structure Click here
Q4CQS6 View 3D Structure Click here
Q4D253 View 3D Structure Click here
Q4DBM6 View 3D Structure Click here
Q4DBM7 View 3D Structure Click here
Q4DKH8 View 3D Structure Click here
Q4DW89 View 3D Structure Click here
Q4E2Q2 View 3D Structure Click here
Q58FF3 View 3D Structure Click here
Q58FF3 View 3D Structure Click here
Q58FF6 View 3D Structure Click here
Q58FF6 View 3D Structure Click here
Q58FF7 View 3D Structure Click here
Q58FF7 View 3D Structure Click here
Q58FF7 View 3D Structure Click here
Q58FF8 View 3D Structure Click here
Q58FF8 View 3D Structure Click here
Q58FG0 View 3D Structure Click here
Q58FG0 View 3D Structure Click here
Q58FG1 View 3D Structure Click here
Q58FG1 View 3D Structure Click here
Q5RG12 View 3D Structure Click here
Q5XHZ0 View 3D Structure Click here
Q5Z9N8 View 3D Structure Click here
Q66HD0 View 3D Structure Click here
Q69QQ6 View 3D Structure Click here
Q6ZCV7 View 3D Structure Click here
Q86L04 View 3D Structure Click here
Q8I0V4 View 3D Structure Click here
Q8IC05 View 3D Structure Click here
Q8IC05 View 3D Structure Click here
Q8III6 View 3D Structure Click here
Q8IL32 View 3D Structure Click here
Q90474 View 3D Structure Click here
Q9CQN1 View 3D Structure Click here
Q9NKX1 View 3D Structure Click here
Q9SIF2 View 3D Structure Click here
Q9STX5 View 3D Structure Click here
Q9VAY2 View 3D Structure Click here