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620  structures 4320  species 0  interactions 27493  sequences 259  architectures

Family: Glyco_hydro_1 (PF00232)

Summary: Glycosyl hydrolase family 1

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Glycoside hydrolase family 1". More...

Glycoside hydrolase family 1 Edit Wikipedia article

Glycosyl hydrolase family 1
PDB 1vff EBI.jpg
Identifiers
SymbolGlyco_hydro_1
PfamPF00232
Pfam clanCL0058
InterProIPR001360
PROSITEPDOC00495
SCOPe1cbg / SUPFAM
OPM superfamily117
OPM protein3gnr
Membranome522

Glycoside hydrolase family 1 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]

Glycoside hydrolase family 1 CAZY GH_1 comprises enzymes with a number of known activities; beta-glucosidase (EC 3.2.1.21); beta-galactosidase (EC 3.2.1.23); 6-phospho-beta-galactosidase (EC 3.2.1.85); 6-phospho-beta-glucosidase (EC 3.2.1.86); lactase-phlorizin hydrolase (EC 3.2.1.62), lactase (EC 3.2.1.108); beta-mannosidase (EC 3.2.1.25); myrosinase (EC 3.2.1.147).

Subfamilies

Human proteins containing this domain

GBA3; KL; KLB; LCT; LCTL;

External links

References

  1. ^ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
  2. ^ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
  3. ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 (Pt 2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
  4. ^ "Home". CAZy.org. Retrieved 2018-03-06.
  5. ^ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
  6. ^ "Glycoside Hydrolase Family 1". CAZypedia.org. Retrieved 2018-03-06.
  7. ^ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes". Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. PMID 29040563.


This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl hydrolase family 1 Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001360

O-Glycosyl hydrolases ( EC ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ PUBMED:7624375 , PUBMED:8535779 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 1 CAZY comprises enzymes with a number of known activities; beta-glucosidase ( EC ); beta-galactosidase ( EC ); 6-phospho-beta-galactosidase ( EC ); 6-phospho-beta-glucosidase ( EC ); lactase-phlorizin hydrolase ( EC ), ( EC ); beta-mannosidase ( EC ); myrosinase ( EC ).

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(11)
Full
(27493)
Representative proteomes UniProt
(85377)
RP15
(2740)
RP35
(12332)
RP55
(24932)
RP75
(38711)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(11)
Full
(27493)
Representative proteomes UniProt
(85377)
RP15
(2740)
RP35
(12332)
RP55
(24932)
RP75
(38711)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(11)
Full
(27493)
Representative proteomes UniProt
(85377)
RP15
(2740)
RP35
(12332)
RP55
(24932)
RP75
(38711)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: glycosyl_hydro1;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 11
Number in full: 27493
Average length of the domain: 351.10 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 89.34 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.6 22.6
Trusted cut-off 22.6 22.6
Noise cut-off 22.5 22.5
Model length: 453
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Colour assignments

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Bacteria Bacteria Other sequences Other sequences
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_hydro_1 domain has been found. There are 620 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JT97 View 3D Structure Click here
A0A0G2JVP8 View 3D Structure Click here
A0A0P0WLF3 View 3D Structure Click here
A0A0R0F6T6 View 3D Structure Click here
A0A0R0FV74 View 3D Structure Click here
A0A0R0FVQ2 View 3D Structure Click here
A0A0R0FXQ4 View 3D Structure Click here
A0A0R0G789 View 3D Structure Click here
A0A0R0G7V6 View 3D Structure Click here
A0A0R0GFB2 View 3D Structure Click here
A0A0R0GVF8 View 3D Structure Click here
A0A0R0GW17 View 3D Structure Click here
A0A0R0GY42 View 3D Structure Click here
A0A0R0H2R3 View 3D Structure Click here
A0A0R0H3T1 View 3D Structure Click here
A0A0R0H4T6 View 3D Structure Click here
A0A0R0HAJ8 View 3D Structure Click here
A0A0R0HB92 View 3D Structure Click here
A0A0R0HGH0 View 3D Structure Click here
A0A0R0HGM1 View 3D Structure Click here
A0A0R0HGM1 View 3D Structure Click here
A0A0R0HQ37 View 3D Structure Click here
A0A0R0HQ37 View 3D Structure Click here
A0A0R0IIZ3 View 3D Structure Click here
A0A0R0IM88 View 3D Structure Click here
A0A0R0IM88 View 3D Structure Click here
A0A0R0IME8 View 3D Structure Click here
A0A0R0J3R1 View 3D Structure Click here
A0A0R0J787 View 3D Structure Click here
A0A0R0J8F6 View 3D Structure Click here
A0A0R0JIT8 View 3D Structure Click here
A0A0R0KJK5 View 3D Structure Click here
A0A0R0KZR2 View 3D Structure Click here
A0A0R0L2G5 View 3D Structure Click here
A0A0R0L2G5 View 3D Structure Click here
A0A0R0L459 View 3D Structure Click here
A0A0R4IX01 View 3D Structure Click here
A0A0R4IX01 View 3D Structure Click here
A0A0R4IX01 View 3D Structure Click here
A0A0R4J4Q8 View 3D Structure Click here
A0A0R4J5E1 View 3D Structure Click here
A0A0R4J610 View 3D Structure Click here
A0A1D6E653 View 3D Structure Click here
A0A1D6E653 View 3D Structure Click here
A0A1D6E654 View 3D Structure Click here
A0A1D6E654 View 3D Structure Click here
A0A1D6E655 View 3D Structure Click here
A0A1D6E8I7 View 3D Structure Click here
A0A1D6E8I7 View 3D Structure Click here
A0A1D6E8I7 View 3D Structure Click here
A0A1D6EEZ0 View 3D Structure Click here
A0A1D6F8B3 View 3D Structure Click here
A0A1D6F8B3 View 3D Structure Click here
A0A1D6FCY4 View 3D Structure Click here
A0A1D6G924 View 3D Structure Click here
A0A1D6GTQ2 View 3D Structure Click here
A0A1D6GTQ2 View 3D Structure Click here
A0A1D6GU99 View 3D Structure Click here
A0A1D6I8D5 View 3D Structure Click here
A0A1D6ILF5 View 3D Structure Click here
A0A1D6IX82 View 3D Structure Click here
A0A1D6J2J3 View 3D Structure Click here
A0A1D6JAB5 View 3D Structure Click here
A0A1D6JAB5 View 3D Structure Click here
A0A1D6JST8 View 3D Structure Click here
A0A1D6L137 View 3D Structure Click here
A0A1D6L143 View 3D Structure Click here
A0A1D6M1S7 View 3D Structure Click here
A0A1D6MUP9 View 3D Structure Click here
A0A1D6MUQ1 View 3D Structure Click here
A0A1D6MY43 View 3D Structure Click here
A0A1D6P1A6 View 3D Structure Click here
A0A1D6P1A6 View 3D Structure Click here
A0A1D6P1A6 View 3D Structure Click here
A0A1D6PHF5 View 3D Structure Click here
A0A1D6PHF5 View 3D Structure Click here
A0A1D6Q1W0 View 3D Structure Click here
A0A286Y8V0 View 3D Structure Click here
A0A368UJ31 View 3D Structure Click here
A0A368UJ31 View 3D Structure Click here
A0A368UK41 View 3D Structure Click here
A3BMZ5 View 3D Structure Click here
A3C053 View 3D Structure Click here
B3H5Q1 View 3D Structure Click here
B4FZJ2 View 3D Structure Click here
B4G004 View 3D Structure Click here
B5AK47 View 3D Structure Click here
B7ECS8 View 3D Structure Click here
B7F7K7 View 3D Structure Click here
B7F8N7 View 3D Structure Click here
B8A1R1 View 3D Structure Click here
B9FHH2 View 3D Structure Click here
D3Z8T6 View 3D Structure Click here
F1Q8B5 View 3D Structure Click here
F1Q8B5 View 3D Structure Click here
F1Q8B5 View 3D Structure Click here
F1Q8B5 View 3D Structure Click here
F1QBK3 View 3D Structure Click here
F1QBK3 View 3D Structure Click here
F1QHY5 View 3D Structure Click here
F1RC43 View 3D Structure Click here
F1RC43 View 3D Structure Click here
F1RC43 View 3D Structure Click here
F8VPT3 View 3D Structure Click here
F8VPT3 View 3D Structure Click here
F8VPT3 View 3D Structure Click here
F8VPT3 View 3D Structure Click here
I1J5Z0 View 3D Structure Click here
I1KEC9 View 3D Structure Click here
I1KJ35 View 3D Structure Click here
I1KKG3 View 3D Structure Click here
I1KMM6 View 3D Structure Click here
I1KMM6 View 3D Structure Click here
I1KZS2 View 3D Structure Click here
I1LJR9 View 3D Structure Click here
I1LJS0 View 3D Structure Click here
I1LJS1 View 3D Structure Click here
I1LJS4 View 3D Structure Click here
I1LQF7 View 3D Structure Click here
I1LQF9 View 3D Structure Click here
I1LQG1 View 3D Structure Click here
I1LQG6 View 3D Structure Click here
I1LVG0 View 3D Structure Click here
I1MBS8 View 3D Structure Click here
K7K217 View 3D Structure Click here
K7L114 View 3D Structure Click here
K7L6T8 View 3D Structure Click here
K7L8B8 View 3D Structure Click here
K7LPH8 View 3D Structure Click here
K7LPI2 View 3D Structure Click here
K7LT75 View 3D Structure Click here
K7LT77 View 3D Structure Click here
K7LUQ3 View 3D Structure Click here
K7LUQ5 View 3D Structure Click here
K7LWD0 View 3D Structure Click here
K7M6U7 View 3D Structure Click here
K7TGE1 View 3D Structure Click here
K7U546 View 3D Structure Click here
K7W2F0 View 3D Structure Click here
O35082 View 3D Structure Click here
O35082 View 3D Structure Click here
O35082 View 3D Structure Click here
O48779 View 3D Structure Click here
O64879 View 3D Structure Click here
O64882 View 3D Structure Click here
O64883 View 3D Structure Click here
O65458 View 3D Structure Click here
O80689 View 3D Structure Click here
O80690 View 3D Structure Click here
O82772 View 3D Structure Click here
P09848 View 3D Structure Click here
P09848 View 3D Structure Click here
P09848 View 3D Structure Click here
P09848 View 3D Structure Click here
P11988 View 3D Structure Click here
P24240 View 3D Structure Click here
P37702 View 3D Structure Click here
P49235 View 3D Structure Click here
Q02401 View 3D Structure Click here
Q02401 View 3D Structure Click here
Q02401 View 3D Structure Click here
Q02401 View 3D Structure Click here
Q0DA21 View 3D Structure Click here
Q0DIT2 View 3D Structure Click here
Q0J0G1 View 3D Structure Click here
Q0J0G2 View 3D Structure Click here
Q0J0N4 View 3D Structure Click here
Q18758 View 3D Structure Click here
Q1M320 View 3D Structure Click here
Q1M320 View 3D Structure Click here
Q2G1A9 View 3D Structure Click here
Q2G2D5 View 3D Structure Click here
Q2QSR8 View 3D Structure Click here
Q339X2 View 3D Structure Click here
Q3E8E5 View 3D Structure Click here
Q3ECS3 View 3D Structure Click here
Q3ECW8 View 3D Structure Click here
Q41761 View 3D Structure Click here
Q46829 View 3D Structure Click here
Q4V3B3 View 3D Structure Click here
Q53NF0 View 3D Structure Click here
Q5JK35 View 3D Structure Click here
Q5N863 View 3D Structure Click here
Q5QMT0 View 3D Structure Click here
Q5Z9Z0 View 3D Structure Click here
Q60DX8 View 3D Structure Click here
Q60DY1 View 3D Structure Click here
Q67XN2 View 3D Structure Click here
Q682B4 View 3D Structure Click here
Q6DGC8 View 3D Structure Click here
Q6L597 View 3D Structure Click here
Q6L597 View 3D Structure Click here
Q6UWM7 View 3D Structure Click here
Q75I93 View 3D Structure Click here
Q75I94 View 3D Structure Click here
Q7EXZ4 View 3D Structure Click here
Q7F9K4 View 3D Structure Click here
Q7XKV2 View 3D Structure Click here
Q7XKV4 View 3D Structure Click here
Q7XKV5 View 3D Structure Click here
Q7XPY5 View 3D Structure Click here
Q7XPY7 View 3D Structure Click here
Q7XSK0 View 3D Structure Click here
Q7XSK1 View 3D Structure Click here
Q7XSK2 View 3D Structure Click here
Q84WV2 View 3D Structure Click here
Q84YK7 View 3D Structure Click here
Q86Z14 View 3D Structure Click here
Q86Z14 View 3D Structure Click here
Q86Z14 View 3D Structure Click here
Q8GRX1 View 3D Structure Click here
Q8GXT2 View 3D Structure Click here
Q8K1F9 View 3D Structure Click here
Q8L6H7 View 3D Structure Click here
Q8L6H7 View 3D Structure Click here
Q8L7J2 View 3D Structure Click here
Q8RXN9 View 3D Structure Click here
Q8RZL1 View 3D Structure Click here
Q8S3J3 View 3D Structure Click here
Q93Y07 View 3D Structure Click here
Q93Y07 View 3D Structure Click here
Q93ZI4 View 3D Structure Click here
Q99N32 View 3D Structure Click here
Q99N32 View 3D Structure Click here
Q99N32 View 3D Structure Click here
Q9C525 View 3D Structure Click here
Q9C5C2 View 3D Structure Click here
Q9C8K1 View 3D Structure Click here
Q9C8Y9 View 3D Structure Click here
Q9FH03 View 3D Structure Click here
Q9FIU7 View 3D Structure Click here
Q9FIW4 View 3D Structure Click here
Q9FLU8 View 3D Structure Click here
Q9FLU9 View 3D Structure Click here
Q9FMD8 View 3D Structure Click here
Q9FZE0 View 3D Structure Click here
Q9H227 View 3D Structure Click here
Q9LIF9 View 3D Structure Click here
Q9LKR7 View 3D Structure Click here
Q9LU02 View 3D Structure Click here
Q9LV33 View 3D Structure Click here
Q9LV34 View 3D Structure Click here
Q9LZJ1 View 3D Structure Click here
Q9M1C9 View 3D Structure Click here
Q9M1D0 View 3D Structure Click here
Q9M1D1 View 3D Structure Click here
Q9SE50 View 3D Structure Click here
Q9SLA0 View 3D Structure Click here
Q9SR37 View 3D Structure Click here
Q9STP4 View 3D Structure Click here
Q9SVS1 View 3D Structure Click here
Q9TZA0 View 3D Structure Click here
Q9UEF7 View 3D Structure Click here
Q9UEF7 View 3D Structure Click here
Q9UEF7 View 3D Structure Click here
Q9VV98 View 3D Structure Click here
Q9Z2Y9 View 3D Structure Click here
Q9Z2Y9 View 3D Structure Click here
Q9Z2Y9 View 3D Structure Click here
Q9ZUI3 View 3D Structure Click here