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398  structures 8837  species 0  interactions 59022  sequences 327  architectures

Family: Aminotran_5 (PF00266)

Summary: Aminotransferase class-V

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Aminotransferase, class V". More...

Aminotransferase, class V Edit Wikipedia article

Aminotransferase class-V
Identifiers
SymbolAminotran_5
PfamPF00266
InterProIPR000192
PROSITEPDOC00514
SCOPe1bjo / SUPFAM
CDDcd00611

Aminotransferase class-V is an evolutionary conserved protein domain. This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.

Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped[1] into subfamilies. This family is called class-V.

Subfamilies

Human proteins containing this domain

AGXT; KYNU; MOCOS; NFS1; PSAT1; SCLY; TLH6;

References

  1. ^ Ouzounis C, Sander C (May 1993). "Homology of the NifS family of proteins to a new class of pyridoxal phosphate-dependent enzymes". FEBS Letters. 322 (2): 159–64. doi:10.1016/0014-5793(93)81559-I. PMID 8482384.
This article incorporates text from the public domain Pfam and InterPro: IPR000192

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Aminotransferase class-V Provide feedback

This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000192

Aminotransferases share certain mechanistic features with other pyridoxal- phosphate dependent enzymes, such as the covalent binding of the pyridoxal- phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [ PUBMED:8482384 ] into subfamilies. This entry represents an aminotransferase class-V domain, which is found in amino transferases and other related, though functionally distinct enzymes, including cysteine desulphurase.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan PLP_aminotran (CL0061), which has the following description:

This superfamily contains a variety of PLP-dependent enzymes.

The clan contains the following 16 members:

Alliinase_C Aminotran_1_2 Aminotran_3 Aminotran_5 Asp_aminotransf Beta_elim_lyase ComK Cys_Met_Meta_PP DegT_DnrJ_EryC1 GDC-P Met_gamma_lyase OKR_DC_1 Pyridoxal_deC SelA SepSecS SHMT

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(34)
Full
(59022)
Representative proteomes UniProt
(247237)
RP15
(8258)
RP35
(27955)
RP55
(57207)
RP75
(94478)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(34)
Full
(59022)
Representative proteomes UniProt
(247237)
RP15
(8258)
RP35
(27955)
RP55
(57207)
RP75
(94478)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(34)
Full
(59022)
Representative proteomes UniProt
(247237)
RP15
(8258)
RP35
(27955)
RP55
(57207)
RP75
(94478)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: aminotran_5;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 34
Number in full: 59022
Average length of the domain: 324.80 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 79.90 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.5 21.5
Trusted cut-off 21.5 21.5
Noise cut-off 21.4 21.4
Model length: 371
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Aminotran_5 domain has been found. There are 398 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0Y7R5 View 3D Structure Click here
A0A0P0Y800 View 3D Structure Click here
A0A1D6KIG3 View 3D Structure Click here
A0A1D6KIH4 View 3D Structure Click here
A0A1D6KII8 View 3D Structure Click here
A0A1D6LQ27 View 3D Structure Click here
A0A1D6LQ27 View 3D Structure Click here
A0A1D6MRA8 View 3D Structure Click here
A0A1D6P5T2 View 3D Structure Click here
A0A1D6P5T2 View 3D Structure Click here
A0A1D6QGN0 View 3D Structure Click here
A0A1D8PCX5 View 3D Structure Click here
A0A1W2Q693 View 3D Structure Click here
A0A2R8QEQ1 View 3D Structure Click here
A0A368UH16 View 3D Structure Click here
A0A368UHM9 View 3D Structure Click here
A2VD33 View 3D Structure Click here
A4I2F1 View 3D Structure Click here
A4I2Q8 View 3D Structure Click here
A4I940 View 3D Structure Click here
A4I940 View 3D Structure Click here
A8WFT4 View 3D Structure Click here
B4FDS2 View 3D Structure Click here
B4FLP7 View 3D Structure Click here
B4FRI1 View 3D Structure Click here
B6T171 View 3D Structure Click here
C0PGB3 View 3D Structure Click here
C6TK73 View 3D Structure Click here
E9AG24 View 3D Structure Click here
E9AHW5 View 3D Structure Click here
E9AHW5 View 3D Structure Click here
F1QY24 View 3D Structure Click here
I1J8D7 View 3D Structure Click here
I1J9H6 View 3D Structure Click here
I1JCA9 View 3D Structure Click here
I1JR16 View 3D Structure Click here
I1KZR4 View 3D Structure Click here
I1KZR4 View 3D Structure Click here
I1LAT4 View 3D Structure Click here
I1LH30 View 3D Structure Click here
I1LI96 View 3D Structure Click here
I1NBM9 View 3D Structure Click here
I1NEU8 View 3D Structure Click here
I1NGP3 View 3D Structure Click here
K7K5U4 View 3D Structure Click here
K7KR58 View 3D Structure Click here
K7KR59 View 3D Structure Click here
K7L6Z8 View 3D Structure Click here
K7LE04 View 3D Structure Click here
K7MIN2 View 3D Structure Click here
K7MRF5 View 3D Structure Click here
K7TRT6 View 3D Structure Click here
O35423 View 3D Structure Click here
O49543 View 3D Structure Click here
O61741 View 3D Structure Click here
O69668 View 3D Structure Click here
O74351 View 3D Structure Click here
O74542 View 3D Structure Click here
O94431 View 3D Structure Click here
P09139 View 3D Structure Click here
P0A6B7 View 3D Structure Click here
P21549 View 3D Structure Click here
P23721 View 3D Structure Click here
P25374 View 3D Structure Click here
P33330 View 3D Structure Click here
P43567 View 3D Structure Click here
P70712 View 3D Structure Click here
P77444 View 3D Structure Click here
P87185 View 3D Structure Click here
P91856 View 3D Structure Click here
P9WQ67 View 3D Structure Click here
P9WQ69 View 3D Structure Click here
P9WQ71 View 3D Structure Click here
P9WQ73 View 3D Structure Click here
Q05979 View 3D Structure Click here
Q0INV6 View 3D Structure Click here
Q0ITX2 View 3D Structure Click here
Q10089 View 3D Structure Click here
Q10349 View 3D Structure Click here
Q14CH1 View 3D Structure Click here
Q16719 View 3D Structure Click here
Q18026 View 3D Structure Click here
Q19434 View 3D Structure Click here
Q1LYQ9 View 3D Structure Click here
Q21657 View 3D Structure Click here
Q2FXK2 View 3D Structure Click here
Q2FXL0 View 3D Structure Click here
Q2FXV4 View 3D Structure Click here
Q2FY35 View 3D Structure Click here
Q2FZY5 View 3D Structure Click here
Q3E6S9 View 3D Structure Click here
Q46925 View 3D Structure Click here
Q4CYC0 View 3D Structure Click here
Q4D0R8 View 3D Structure Click here
Q4DGA0 View 3D Structure Click here
Q4DHB8 View 3D Structure Click here
Q4DHV6 View 3D Structure Click here
Q4DMD6 View 3D Structure Click here
Q4DQ63 View 3D Structure Click here
Q4DQD7 View 3D Structure Click here
Q4DRC1 View 3D Structure Click here
Q4DVR1 View 3D Structure Click here
Q54GN1 View 3D Structure Click here
Q54GT6 View 3D Structure Click here
Q54Q04 View 3D Structure Click here
Q54X04 View 3D Structure Click here
Q559G8 View 3D Structure Click here
Q55CQ6 View 3D Structure Click here
Q56YA5 View 3D Structure Click here
Q58369 View 3D Structure Click here
Q59P52 View 3D Structure Click here
Q59QC4 View 3D Structure Click here
Q5JNT6 View 3D Structure Click here
Q655R6 View 3D Structure Click here
Q655R6 View 3D Structure Click here
Q68FT9 View 3D Structure Click here
Q6ERL4 View 3D Structure Click here
Q6PHK4 View 3D Structure Click here
Q6ZFI6 View 3D Structure Click here
Q803I7 View 3D Structure Click here
Q8IBI5 View 3D Structure Click here
Q8IBT4 View 3D Structure Click here
Q8IBT4 View 3D Structure Click here
Q8IPA0 View 3D Structure Click here
Q8LMR0 View 3D Structure Click here
Q93WX6 View 3D Structure Click here
Q94055 View 3D Structure Click here
Q96255 View 3D Structure Click here
Q96EN8 View 3D Structure Click here
Q96I15 View 3D Structure Click here
Q99K85 View 3D Structure Click here
Q99P39 View 3D Structure Click here
Q9AX15 View 3D Structure Click here
Q9C5X8 View 3D Structure Click here
Q9C5X8 View 3D Structure Click here
Q9CXF0 View 3D Structure Click here
Q9FGL6 View 3D Structure Click here
Q9JLI6 View 3D Structure Click here
Q9LGZ2 View 3D Structure Click here
Q9M1R1 View 3D Structure Click here
Q9N4F1 View 3D Structure Click here
Q9SHP0 View 3D Structure Click here
Q9VAN0 View 3D Structure Click here
Q9VKD3 View 3D Structure Click here
Q9VRA2 View 3D Structure Click here
Q9VRA2 View 3D Structure Click here
Q9W3Z3 View 3D Structure Click here
Q9Y617 View 3D Structure Click here
Q9Y697 View 3D Structure Click here
Q9Z1J3 View 3D Structure Click here