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275  structures 1470  species 0  interactions 62264  sequences 1584  architectures

Family: CH (PF00307)

Summary: Calponin homology (CH) domain

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This is the Wikipedia entry entitled "Calponin homology domain". More...

Calponin homology domain Edit Wikipedia article

Calponin homology (CH) domain
2RR8.pdb.jpg
Solution structure of calponin homology domain of IQGAP1[1]
Identifiers
SymbolCH
PfamPF00307
InterProIPR001715
SMARTCH
PROSITEPDOC00019
SCOPe1aoa / SUPFAM
CDDcd00014

Calponin homology domain (or CH domain) is a family of actin binding domains found in both cytoskeletal proteins and signal transduction proteins.[2] The domain is about 100 amino acids in length and is composed of four alpha helices.[3] It comprises the following groups of actin-binding domains:

A comprehensive review of proteins containing this type of actin-binding domains is given in.[4]

The CH domain is involved in actin binding in some members of the family. However, in calponins there is evidence that the CH domain is not involved in its actin binding activity.[5] Most proteins have two copies of the CH domain, however some proteins such as calponin and the human vav proto-oncogene (P15498) have only a single copy. The structure of an example CH domain has been determined using X-ray crystallography.[6]

Examples

Human genes encoding calponin homology domain-containing proteins include:

References

  1. ^ PDB: 2RR8​; Umemoto R, Nishida N, Ogino S, Shimada I (September 2010). "NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode". J. Biomol. NMR. 48 (1): 59–64. doi:10.1007/s10858-010-9434-8. PMID 20644981.
  2. ^ Saraste M, Castresana J (1995). "Does Vav bind to F-actin through a CH domain?". FEBS Lett. 374 (2): 149–151. doi:10.1016/0014-5793(95)01098-Y. PMID 7589522.
  3. ^ Korenbaum, E.; Rivero, F. (Sep 2002). "Calponin homology domains at a glance". J Cell Sci. 115 (Pt 18): 3543–5. CiteSeerX 10.1.1.608.8653. doi:10.1242/jcs.00003. PMID 12186940.
  4. ^ Hartwig JH (1995). "Actin-binding proteins. 1: Spectrin super family". Protein Prof. 2 (7): 703–800. PMID 7584474.
  5. ^ Gimona M, Mital R (1998). "The single CH domain of calponin is neither sufficient nor necessary for F-actin binding". J. Cell Sci. 111: 1813–1821. PMID 9625744.
  6. ^ Saraste M, Carugo KD, Banuelos S (1997). "Crystal structure of a calponin homology domain". Nat. Struct. Biol. 4 (3): 175–179. doi:10.1038/nsb0397-175. PMID 9164454.
This article incorporates text from the public domain Pfam and InterPro: IPR001715

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Calponin homology (CH) domain Provide feedback

The CH domain is found in both cytoskeletal proteins and signal transduction proteins [1]. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity [4]. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin and P15498 have only a single copy.

Literature references

  1. Castresana J, Saraste M; , FEBS Lett 1995;374:149-151.: Does Vav bind to F-actin through a CH domain? PUBMED:7589522 EPMC:7589522

  2. Carugo KD, Banuelos S, Saraste M; , Nat Struct Biol 1997;4:175-179.: Crystal structure of a calponin homology domain. PUBMED:9164454 EPMC:9164454

  3. Stradal T, Kranewitter W, Winder SJ, Gimona M; , FEBS Lett 1998;431:134-137.: CH domains revisited. PUBMED:9708889 EPMC:9708889

  4. Gimona M, Mital R; , J Cell Sci 1998;111:1813-1821.: The single CH domain of calponin is neither sufficient nor necessary for F-actin binding. PUBMED:9625744 EPMC:9625744


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001715

A number of actin-binding proteins, including spectrin, alpha-actinin and fimbrin, contain a 250 amino acid stretch called the actin binding domain (ABD). The ABD has probably arisen from duplication of a domain which is also found in a single copy in a number of other proteins like calponin or the vav proto-oncogene and has been called calponin homology (CH) domain [ PUBMED:9708889 , PUBMED:9887274 ].

A detailed analysis of The CH domain-containing proteins has shown that they can be divided in three groups [ PUBMED:9708889 ]:

  • The fimbrin family of monomeric actin cross-linking molecules containing two ABDs
  • Dimeric cross-linking proteins (alpha-actinin, beta-spectrin, filamin, etc.) and monomeric F-actin binding proteins (dystrophin, utrophin) each containing one ABD
  • Proteins containing only a single amino terminal CH domain.

Each single ABD, comprising two CH domains, is able to bind one actin monomer in the filament. The N-terminal CH domain has the intrinsic ability to bind actin, albeit with lower affinity than the complete ABD, whereas the C-terminal CH bind actin extremely weakly or not at all. Nevertheless both CH domains are required for a fully functional ABD; the C-terminal CH domain contributing to the overall stability of the complete ABD through inter-domain helix-helix interactions [ PUBMED:9708889 ]. Some of the proteins containing a single CH domain also bind to actin, although this has not been shown to be via the single CH domain alone [ PUBMED:9887274 ]. In addition, the CH domain occurs also in a number of proteins not known to bind actin, a notable example being the vav protooncogene.

The resolution of the 3D structure of various CH domains has shown that the conserved core consist of four major alpha-helices [ PUBMED:9887274 ].

Proteins containing a calponin domain include:

  • Calponin, which is involved in the regulation of contractility and organisation of the actin cytoskeleton in smooth muscle cells [ PUBMED:11839310 ].
  • Beta-spectrin, a major component of a submembrane cytoskeletal network connecting actin filaments to integral plasma membrane proteins [ PUBMED:17121810 ].
  • The actin-cross-linking domain of the fimbrin/plastin family of actin filament bundling or cross-linking proteins [ PUBMED:9302997 ].
  • Utrophin,a close homologue of dystrophin [ PUBMED:9887274 ].
  • Dystrophin, the protein found to be defective in Duchenne muscular dystrophy; this protein contains a tandem repeat of two CH domains [ PUBMED:10801490 ].
  • Actin-binding domain of plectin, a large and widely expressed cytolinker protein [ PUBMED:15128297 ].
  • The N-terminal microtubule-binding domain of microtubule-associated protein eb1 (end-binding protein), a member of a conserved family of proteins that localise to the plus-ends of microtubules [ PUBMED:12857735 ].
  • Ras GTPase-activating-like protein rng2, an IQGAP protein that is essential for the assembly of an actomyosin ring during cytokinesis [ PUBMED:15272162 ].
  • Transgelin, which suppresses androgen receptor transactivation [ PUBMED:17082327 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan CH (CL0188), which has the following description:

The calponin homology (CH) domain is found in a variety of contexts, ranging from proteins involved in signalling pathways to cytoskeletal proteins. They seem to have diverse cellular functions, which are thought to include actin binding, involvement in the MAP kinase signalling pathway, and regulation of GEF activity in Rho family GTPase pathways. Structurally, they are organised into three layers, with two parallel alpha helices in the core being sandwiched between another two helices, one on each side [1].

The clan contains the following 7 members:

CAMSAP_CH CDC24 CH CH_2 DUF5745 IFT81_CH MIP-T3

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(121)
Full
(62264)
Representative proteomes UniProt
(109291)
RP15
(8774)
RP35
(23229)
RP55
(52075)
RP75
(72231)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(121)
Full
(62264)
Representative proteomes UniProt
(109291)
RP15
(8774)
RP35
(23229)
RP55
(52075)
RP75
(72231)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(121)
Full
(62264)
Representative proteomes UniProt
(109291)
RP15
(8774)
RP35
(23229)
RP55
(52075)
RP75
(72231)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: actinin-binding;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 121
Number in full: 62264
Average length of the domain: 107.60 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 11.18 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.0 22.1
Trusted cut-off 26.0 22.1
Noise cut-off 25.9 22.0
Model length: 109
Family (HMM) version: 33
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the CH domain has been found. There are 275 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JXT8 View 3D Structure Click here
A0A0G2JXT8 View 3D Structure Click here
A0A0G2JY25 View 3D Structure Click here
A0A0G2JY25 View 3D Structure Click here
A0A0G2JZB7 View 3D Structure Click here
A0A0G2K014 View 3D Structure Click here
A0A0G2K014 View 3D Structure Click here
A0A0G2K014 View 3D Structure Click here
A0A0G2K014 View 3D Structure Click here
A0A0G2K5D7 View 3D Structure Click here
A0A0G2K677 View 3D Structure Click here
A0A0G2K677 View 3D Structure Click here
A0A0G2K6Q4 View 3D Structure Click here
A0A0G2K6R8 View 3D Structure Click here
A0A0G2K8R3 View 3D Structure Click here
A0A0G2K8W9 View 3D Structure Click here
A0A0G2K8W9 View 3D Structure Click here
A0A0G2KFQ1 View 3D Structure Click here
A0A0G2L1F5 View 3D Structure Click here
A0A0G2L1F5 View 3D Structure Click here
A0A0G2L974 View 3D Structure Click here
A0A0G2QC04 View 3D Structure Click here
A0A0G2QC04 View 3D Structure Click here
A0A0G2QC04 View 3D Structure Click here
A0A0G2QC04 View 3D Structure Click here
A0A0P0WBQ2 View 3D Structure Click here
A0A0R0EWD3 View 3D Structure Click here
A0A0R0F2G7 View 3D Structure Click here
A0A0R0F741 View 3D Structure Click here
A0A0R0J1Q2 View 3D Structure Click here
A0A0R0JZ28 View 3D Structure Click here
A0A0R0K0F1 View 3D Structure Click here
A0A0R0KJ22 View 3D Structure Click here
A0A0R0KNM8 View 3D Structure Click here
A0A0R0LD71 View 3D Structure Click here
A0A0R4I9F0 View 3D Structure Click here
A0A0R4IGU0 View 3D Structure Click here
A0A0R4IJJ4 View 3D Structure Click here
A0A0R4INF7 View 3D Structure Click here
A0A0R4IR49 View 3D Structure Click here
A0A0R4IR49 View 3D Structure Click here
A0A140UHX6 View 3D Structure Click here
A0A140UHX6 View 3D Structure Click here
A0A143ZVZ5 View 3D Structure Click here
A0A1D5NSI4 View 3D Structure Click here
A0A1D5NSJ6 View 3D Structure Click here
A0A1D6F857 View 3D Structure Click here
A0A1D6FTQ2 View 3D Structure Click here
A0A1D6GC98 View 3D Structure Click here
A0A1D6HBU0 View 3D Structure Click here
A0A1D6HBU0 View 3D Structure Click here
A0A1D6HBU0 View 3D Structure Click here
A0A1D6HBU0 View 3D Structure Click here
A0A1D6HIG6 View 3D Structure Click here
A0A1D6HIG6 View 3D Structure Click here
A0A1D6HIG6 View 3D Structure Click here
A0A1D6HIG6 View 3D Structure Click here
A0A1D6ID73 View 3D Structure Click here
A0A1D6IWA3 View 3D Structure Click here
A0A1D6K037 View 3D Structure Click here
A0A1D6MAM0 View 3D Structure Click here
A0A1D6MJQ5 View 3D Structure Click here
A0A1D6MTL3 View 3D Structure Click here
A0A1D6MTL3 View 3D Structure Click here
A0A1D6MTL3 View 3D Structure Click here
A0A1D6MTL3 View 3D Structure Click here
A0A1D6NCS8 View 3D Structure Click here
A0A1D6PCB4 View 3D Structure Click here
A0A1D6PNF3 View 3D Structure Click here
A0A1D6Q9D0 View 3D Structure Click here
A0A1D6Q9D0 View 3D Structure Click here
A0A1D6Q9D0 View 3D Structure Click here
A0A1D6Q9D0 View 3D Structure Click here
A0A1D8PHA7 View 3D Structure Click here
A0A1D8PHP1 View 3D Structure Click here
A0A1D8PPY8 View 3D Structure Click here
A0A1D8PPY8 View 3D Structure Click here
A0A1D8PPY8 View 3D Structure Click here
A0A1D8PPY8 View 3D Structure Click here
A0A1P8B7Z9 View 3D Structure Click here
A0A286YBW2 View 3D Structure Click here
A0A2R8Q1F4 View 3D Structure Click here
A0A2R8Q1V1 View 3D Structure Click here
A0A2R8Q1V1 View 3D Structure Click here
A0A2R8Q515 View 3D Structure Click here
A0A2R8Q558 View 3D Structure Click here
A0A2R8Q6H9 View 3D Structure Click here
A0A2R8Q720 View 3D Structure Click here
A0A2R8Q720 View 3D Structure Click here
A0A2R8Q7Y4 View 3D Structure Click here
A0A2R8QBK4 View 3D Structure Click here
A0A2R8QBL5 View 3D Structure Click here
A0A2R8QBL5 View 3D Structure Click here
A0A2R8QDC7 View 3D Structure Click here
A0A2R8QDC7 View 3D Structure Click here
A0A2R8QH31 View 3D Structure Click here
A0A2R8QH73 View 3D Structure Click here
A0A2R8QKL4 View 3D Structure Click here
A0A2R8QQS8 View 3D Structure Click here
A0A2R8RKM3 View 3D Structure Click here
A0A2R8RLC7 View 3D Structure Click here
A0A2R8RXS1 View 3D Structure Click here
A1Z6P3 View 3D Structure Click here
A1ZBF1 View 3D Structure Click here
A2ASQ4 View 3D Structure Click here
A2BEV4 View 3D Structure Click here
A2CE93 View 3D Structure Click here
A3KNP3 View 3D Structure Click here
A3KNP3 View 3D Structure Click here
A3QJV0 View 3D Structure Click here
A4IDS0 View 3D Structure Click here
A4IG46 View 3D Structure Click here
A4IG46 View 3D Structure Click here
A4UZL3 View 3D Structure Click here
A5PLJ3 View 3D Structure Click here
A7MC00 View 3D Structure Click here
A8MU46 View 3D Structure Click here
B0S585 View 3D Structure Click here
B0UYM8 View 3D Structure Click here
B2GV98 View 3D Structure Click here
B3H6Z8 View 3D Structure Click here
B6TN74 View 3D Structure Click here
B8A1F9 View 3D Structure Click here
B8A4X7 View 3D Structure Click here
B8A668 View 3D Structure Click here
B8JHU4 View 3D Structure Click here
B8JHU4 View 3D Structure Click here
B9EUM5 View 3D Structure Click here
B9FL70 View 3D Structure Click here
B9G8P1 View 3D Structure Click here
C0JPT7 View 3D Structure Click here
C0JPT7 View 3D Structure Click here
D1GJ56 View 3D Structure Click here
D1GJ56 View 3D Structure Click here
D3ZBP4 View 3D Structure Click here
D3ZCS4 View 3D Structure Click here
D3ZCV0 View 3D Structure Click here
D3ZCV0 View 3D Structure Click here
D3ZEN0 View 3D Structure Click here
D3ZGN7 View 3D Structure Click here
D3ZKG5 View 3D Structure Click here
D3ZKG5 View 3D Structure Click here
D3ZQL6 View 3D Structure Click here
D3ZR69 View 3D Structure Click here
D3ZRX9 View 3D Structure Click here
D3ZUC1 View 3D Structure Click here
D3ZUE1 View 3D Structure Click here
D3ZWK2 View 3D Structure Click here
D3ZWK2 View 3D Structure Click here
D3ZWP4 View 3D Structure Click here
D4A1F2 View 3D Structure Click here
D4A456 View 3D Structure Click here
D4A626 View 3D Structure Click here
D4A626 View 3D Structure Click here
D4A8M4 View 3D Structure Click here
D4AB19 View 3D Structure Click here
D4ABA5 View 3D Structure Click here
E0AHA7 View 3D Structure Click here
E0AHA7 View 3D Structure Click here
E7EYZ7 View 3D Structure Click here
E7F6H4 View 3D Structure Click here
E7F836 View 3D Structure Click here
E7F9T0 View 3D Structure Click here
E7FA45 View 3D Structure Click here
E7FBD5 View 3D Structure Click here
E7FDY6 View 3D Structure Click here
E7FEL3 View 3D Structure Click here
E7FG55 View 3D Structure Click here
E9PSW6 View 3D Structure Click here
E9PX29 View 3D Structure Click here
E9PX29 View 3D Structure Click here
E9PYF4 View 3D Structure Click here
E9Q842 View 3D Structure Click here
E9QI62 View 3D Structure Click here
E9QI62 View 3D Structure Click here
E9QIL4 View 3D Structure Click here
F1LR12 View 3D Structure Click here
F1LVX2 View 3D Structure Click here
F1LW74 View 3D Structure Click here
F1M392 View 3D Structure Click here
F1Q515 View 3D Structure Click here
F1QAZ3 View 3D Structure Click here
F1QCE2 View 3D Structure Click here
F1QCE2 View 3D Structure Click here
F1QCE2 View 3D Structure Click here
F1QCE2 View 3D Structure Click here
F1QGL5 View 3D Structure Click here
F1QGL5 View 3D Structure Click here
F1QH17 View 3D Structure Click here
F1QQE5 View 3D Structure Click here
F1QQE5 View 3D Structure Click here
F1QS54 View 3D Structure Click here
F1QUR8 View 3D Structure Click here
F1QWK4 View 3D Structure Click here
F1QXB0 View 3D Structure Click here
F1QXB0 View 3D Structure Click here
F1RA39 View 3D Structure Click here
F1RA97 View 3D Structure Click here
F1RA97 View 3D Structure Click here
F1RBY2 View 3D Structure Click here
F1RE63 View 3D Structure Click here
F4HZF0 View 3D Structure Click here
F4IL57 View 3D Structure Click here
F4J2M6 View 3D Structure Click here
F4JX00 View 3D Structure Click here
F6NN15 View 3D Structure Click here
F8VQ29 View 3D Structure Click here
G3V7Q7 View 3D Structure Click here
G3V857 View 3D Structure Click here
G4SJU0 View 3D Structure Click here
G5ECW3 View 3D Structure Click here
G5EFB5 View 3D Structure Click here
I1J9A7 View 3D Structure Click here
I1JBJ0 View 3D Structure Click here
I1JJT0 View 3D Structure Click here
I1JJT0 View 3D Structure Click here
I1JJT0 View 3D Structure Click here
I1JJT0 View 3D Structure Click here
I1JMA0 View 3D Structure Click here
I1JMA0 View 3D Structure Click here
I1JMA0 View 3D Structure Click here
I1JMA0 View 3D Structure Click here
I1JWW4 View 3D Structure Click here
I1KCR7 View 3D Structure Click here
I1KYP4 View 3D Structure Click here
I1KYY8 View 3D Structure Click here
I1KYY8 View 3D Structure Click here
I1KYY8 View 3D Structure Click here
I1KYY8 View 3D Structure Click here
I1L7S7 View 3D Structure Click here
I1L9D8 View 3D Structure Click here
I1LB71 View 3D Structure Click here
I1M675 View 3D Structure Click here
I1M675 View 3D Structure Click here
I1M675 View 3D Structure Click here
I1M675 View 3D Structure Click here
I1M6D7 View 3D Structure Click here
I1M6K8 View 3D Structure Click here
I1M6K8 View 3D Structure Click here
I1M6K8 View 3D Structure Click here
I1M6K8 View 3D Structure Click here
I1MM58 View 3D Structure Click here
I1MM58 View 3D Structure Click here
I1MM58 View 3D Structure Click here
I1MM58 View 3D Structure Click here
I1MTS4 View 3D Structure Click here
I1NB97 View 3D Structure Click here
K7KBJ8 View 3D Structure Click here
K7KBJ8 View 3D Structure Click here
K7KBJ8 View 3D Structure Click here
K7KBJ8 View 3D Structure Click here
K7KGD1 View 3D Structure Click here
K7L3W3 View 3D Structure Click here
K7L4E7 View 3D Structure Click here
K7LN60 View 3D Structure Click here
M0R7M8 View 3D Structure Click here
M0R8A4 View 3D Structure Click here
O01542 View 3D Structure Click here
O13728 View 3D Structure Click here
O13728 View 3D Structure Click here
O14185 View 3D Structure Click here
O14188 View 3D Structure Click here
O15020 View 3D Structure Click here
O15020 View 3D Structure Click here
O16785 View 3D Structure Click here
O16785 View 3D Structure Click here
O17666 View 3D Structure Click here
O17772 View 3D Structure Click here
O43707 View 3D Structure Click here
O43707 View 3D Structure Click here
O43903 View 3D Structure Click here
O44727 View 3D Structure Click here
O44788 View 3D Structure Click here
O50064 View 3D Structure Click here
O50064 View 3D Structure Click here
O50064 View 3D Structure Click here
O50064 View 3D Structure Click here
O59945 View 3D Structure Click here
O59945 View 3D Structure Click here
O59945 View 3D Structure Click here
O59945 View 3D Structure Click here
O75369 View 3D Structure Click here
O75369 View 3D Structure Click here
O75427 View 3D Structure Click here
O76329 View 3D Structure Click here
O76329 View 3D Structure Click here
O81635 View 3D Structure Click here
O88990 View 3D Structure Click here
O88990 View 3D Structure Click here
O94851 View 3D Structure Click here
O97251 View 3D Structure Click here
P05095 View 3D Structure Click here
P05095 View 3D Structure Click here
P11277 View 3D Structure Click here
P11277 View 3D Structure Click here
P11862 View 3D Structure Click here
P12814 View 3D Structure Click here
P12814 View 3D Structure Click here
P13466 View 3D Structure Click here
P13466 View 3D Structure Click here
P13796 View 3D Structure Click here
P13796 View 3D Structure Click here
P13796 View 3D Structure Click here
P13796 View 3D Structure Click here
P13797 View 3D Structure Click here
P13797 View 3D Structure Click here
P13797 View 3D Structure Click here
P13797 View 3D Structure Click here
P14318 View 3D Structure Click here
P15498 View 3D Structure Click here
P15508 View 3D Structure Click here
P15508 View 3D Structure Click here
P18091 View 3D Structure Click here
P18091 View 3D Structure Click here
P21333 View 3D Structure Click here
P21333 View 3D Structure Click here
P31232 View 3D Structure Click here
P32599 View 3D Structure Click here
P32599 View 3D Structure Click here
P32599 View 3D Structure Click here
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