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30  structures 1079  species 0  interactions 12397  sequences 247  architectures

Family: Glyco_hydro_17 (PF00332)

Summary: Glycosyl hydrolases family 17

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Glycoside hydrolase family 17". More...

Glycoside hydrolase family 17 Edit Wikipedia article

Glycoside hydrolase, family 17
PDB 2cyg EBI.jpg
crystal structure at 1.45- resolution of the major allergen endo-beta-1,3-glucanase of banana as a molecular basis for the latex-fruit syndrome
Identifiers
SymbolGlyco_hydro_17
PfamPF00332
Pfam clanCL0058
InterProIPR000490
PROSITEPDOC00507
SCOPe1ghs / SUPFAM
CAZyGH17

In molecular biology, Glycoside hydrolase family 17 is a family of glycoside hydrolases. It folds into a TIM barrel.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7] y[ _]9 Glycoside hydrolase family 17 CAZY GH_17 comprises enzymes with several known activities; endo-1,3-beta-glucosidase (EC 3.2.1.39); lichenase (EC 3.2.1.73); exo-1,3-glucanase (EC 3.2.1.58). Currently these enzymes have only been found in plants and in fungi.

References

  1. ^ Henrissat B, Callebaut I, Fabrega S, Lehn P, Mornon JP, Davies G (July 1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proceedings of the National Academy of Sciences of the United States of America. 92 (15): 7090–4. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375.
  2. ^ Davies G, Henrissat B (September 1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–9. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
  3. ^ Henrissat B, Bairoch A (June 1996). "Updating the sequence-based classification of glycosyl hydrolases". The Biochemical Journal. 316 ( Pt 2) (Pt 2): 695–6. doi:10.1042/bj3160695. PMC 1217404. PMID 8687420.
  4. ^ "Home". CAZy.org. Retrieved 2018-03-06.
  5. ^ Lombard V, Golaconda Ramulu H, Drula E, Coutinho PM, Henrissat B (January 2014). "The carbohydrate-active enzymes database (CAZy) in 2013". Nucleic Acids Research. 42 (Database issue): D490–5. doi:10.1093/nar/gkt1178. PMC 3965031. PMID 24270786.
  6. ^ "Glycoside Hydrolase Family 17". CAZypedia.org. Retrieved 2018-03-06.
  7. ^ CAZypedia Consortium (December 2018). "Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes" (PDF). Glycobiology. 28 (1): 3–8. doi:10.1093/glycob/cwx089. hdl:21.11116/0000-0003-B7EB-6. PMID 29040563.
This article incorporates text from the public domain Pfam and InterPro: IPR000490

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl hydrolases family 17 Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000490

O-Glycosyl hydrolases ( EC ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ PUBMED:7624375 , PUBMED:8535779 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Glycoside hydrolase family 17 CAZY comprises enzymes with several known activities; endo-1,3-beta-glucosidase ( EC ); lichenase ( EC ); exo-1,3-glucanase ( EC ). Currently these enzymes have only been found in plants and in fungi.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(6)
Full
(12397)
Representative proteomes UniProt
(19630)
RP15
(1273)
RP35
(6248)
RP55
(10087)
RP75
(13718)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(6)
Full
(12397)
Representative proteomes UniProt
(19630)
RP15
(1273)
RP35
(6248)
RP55
(10087)
RP75
(13718)
Alignment:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(6)
Full
(12397)
Representative proteomes UniProt
(19630)
RP15
(1273)
RP35
(6248)
RP55
(10087)
RP75
(13718)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: glycosyl_hydro4;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 6
Number in full: 12397
Average length of the domain: 262.10 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 63.41 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.2 28.2
Trusted cut-off 28.2 28.2
Noise cut-off 28.1 28.1
Model length: 313
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_hydro_17 domain has been found. There are 30 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KNL4 View 3D Structure Click here
A0A0P0VCS5 View 3D Structure Click here
A0A0P0VCU3 View 3D Structure Click here
A0A0P0VCW2 View 3D Structure Click here
A0A0P0VUY0 View 3D Structure Click here
A0A0P0VYH3 View 3D Structure Click here
A0A0P0W076 View 3D Structure Click here
A0A0P0WX98 View 3D Structure Click here
A0A0P0WYH6 View 3D Structure Click here
A0A0P0X7J0 View 3D Structure Click here
A0A0P0XDW1 View 3D Structure Click here
A0A0P0XIQ2 View 3D Structure Click here
A0A0P0XQ41 View 3D Structure Click here
A0A0P0Y3N8 View 3D Structure Click here
A0A0R0EFF0 View 3D Structure Click here
A0A0R0EKK9 View 3D Structure Click here
A0A0R0FC01 View 3D Structure Click here
A0A0R0FPD3 View 3D Structure Click here
A0A0R0FPD3 View 3D Structure Click here
A0A0R0FR52 View 3D Structure Click here
A0A0R0FXW2 View 3D Structure Click here
A0A0R0FY51 View 3D Structure Click here
A0A0R0FZD7 View 3D Structure Click here
A0A0R0G0Q7 View 3D Structure Click here
A0A0R0G0X3 View 3D Structure Click here
A0A0R0G124 View 3D Structure Click here
A0A0R0GI68 View 3D Structure Click here
A0A0R0GPT5 View 3D Structure Click here
A0A0R0GYZ0 View 3D Structure Click here
A0A0R0H127 View 3D Structure Click here
A0A0R0HEZ3 View 3D Structure Click here
A0A0R0ID46 View 3D Structure Click here
A0A0R0ID46 View 3D Structure Click here
A0A0R0J9M6 View 3D Structure Click here
A0A0R0JJJ5 View 3D Structure Click here
A0A0R0JJJ5 View 3D Structure Click here
A0A0R0K0I4 View 3D Structure Click here
A0A0R0KHR2 View 3D Structure Click here
A0A0R0KI96 View 3D Structure Click here
A0A0R0KSQ6 View 3D Structure Click here
A0A0R0KTM8 View 3D Structure Click here
A0A0R0KWC9 View 3D Structure Click here
A0A0R0L1A2 View 3D Structure Click here
A0A0R0L892 View 3D Structure Click here
A0A0R0L9X1 View 3D Structure Click here
A0A1D6DSY2 View 3D Structure Click here
A0A1D6EBJ2 View 3D Structure Click here
A0A1D6EHD6 View 3D Structure Click here
A0A1D6EHD9 View 3D Structure Click here
A0A1D6EXK7 View 3D Structure Click here
A0A1D6EXK7 View 3D Structure Click here
A0A1D6FML0 View 3D Structure Click here
A0A1D6FSM9 View 3D Structure Click here
A0A1D6FSM9 View 3D Structure Click here
A0A1D6G4P8 View 3D Structure Click here
A0A1D6G805 View 3D Structure Click here
A0A1D6GFT3 View 3D Structure Click here
A0A1D6GIR2 View 3D Structure Click here
A0A1D6GKM3 View 3D Structure Click here
A0A1D6GL68 View 3D Structure Click here
A0A1D6I138 View 3D Structure Click here
A0A1D6I966 View 3D Structure Click here
A0A1D6ICM1 View 3D Structure Click here
A0A1D6IE31 View 3D Structure Click here
A0A1D6IE31 View 3D Structure Click here
A0A1D6IE38 View 3D Structure Click here
A0A1D6IE38 View 3D Structure Click here
A0A1D6IE44 View 3D Structure Click here
A0A1D6IE44 View 3D Structure Click here
A0A1D6IHR5 View 3D Structure Click here
A0A1D6JV25 View 3D Structure Click here
A0A1D6JVU3 View 3D Structure Click here
A0A1D6K476 View 3D Structure Click here
A0A1D6KC71 View 3D Structure Click here
A0A1D6KJP8 View 3D Structure Click here
A0A1D6LKH5 View 3D Structure Click here
A0A1D6M7B9 View 3D Structure Click here
A0A1D6N1P0 View 3D Structure Click here
A0A1D6N1P3 View 3D Structure Click here
A0A1D6N1P5 View 3D Structure Click here
A0A1D6N6L8 View 3D Structure Click here
A0A1D6PTZ2 View 3D Structure Click here
A0A1D8PL94 View 3D Structure Click here
A0A1P8B420 View 3D Structure Click here
A0A1X7YF21 View 3D Structure Click here
A0A368UHV6 View 3D Structure Click here
B4F8L6 View 3D Structure Click here
B4F8X5 View 3D Structure Click here
B4FA15 View 3D Structure Click here
B4FB19 View 3D Structure Click here
B4FB31 View 3D Structure Click here
B4FBQ3 View 3D Structure Click here
B4FBY2 View 3D Structure Click here
B6T391 View 3D Structure Click here
B6TIF7 View 3D Structure Click here
B6TNS8 View 3D Structure Click here
B6TW83 View 3D Structure Click here
B6TY63 View 3D Structure Click here
B6UAM9 View 3D Structure Click here
C0HHC0 View 3D Structure Click here
C0P4Z9 View 3D Structure Click here
C0P905 View 3D Structure Click here
C0PD14 View 3D Structure Click here
C0PD77 View 3D Structure Click here
C0PD77 View 3D Structure Click here
C4J480 View 3D Structure Click here
C4JAF6 View 3D Structure Click here
E1AFV5 View 3D Structure Click here
F4I4R0 View 3D Structure Click here
F4IHD3 View 3D Structure Click here
F4IKB3 View 3D Structure Click here
F4IY34 View 3D Structure Click here
F4J030 View 3D Structure Click here
F4J270 View 3D Structure Click here
F4K3D8 View 3D Structure Click here
F4K6W1 View 3D Structure Click here
F4KH28 View 3D Structure Click here
I1J9D6 View 3D Structure Click here
I1JIJ8 View 3D Structure Click here
I1JN95 View 3D Structure Click here
I1JSP4 View 3D Structure Click here
I1JWA3 View 3D Structure Click here
I1K3W5 View 3D Structure Click here
I1K4S3 View 3D Structure Click here
I1K775 View 3D Structure Click here
I1K927 View 3D Structure Click here
I1KA45 View 3D Structure Click here
I1KNE6 View 3D Structure Click here
I1KPW0 View 3D Structure Click here
I1KSB7 View 3D Structure Click here
I1KVF0 View 3D Structure Click here
I1KZ22 View 3D Structure Click here
I1LBX5 View 3D Structure Click here
I1LH71 View 3D Structure Click here
I1LIL4 View 3D Structure Click here
I1LIL5 View 3D Structure Click here
I1LLR7 View 3D Structure Click here
I1LMB8 View 3D Structure Click here
I1LPC9 View 3D Structure Click here
I1LTW2 View 3D Structure Click here
I1LYC0 View 3D Structure Click here
I1LZP0 View 3D Structure Click here
I1M052 View 3D Structure Click here
I1M1G0 View 3D Structure Click here
I1M4C5 View 3D Structure Click here
I1M6N3 View 3D Structure Click here
I1M8D6 View 3D Structure Click here
I1M9P8 View 3D Structure Click here
I1MCF3 View 3D Structure Click here
I1MF29 View 3D Structure Click here
I1ML36 View 3D Structure Click here
I1MMU2 View 3D Structure Click here
I1MS25 View 3D Structure Click here
I1MU75 View 3D Structure Click here
I1MWJ9 View 3D Structure Click here
I1MWK5 View 3D Structure Click here
I1MZE7 View 3D Structure Click here
I1MZV8 View 3D Structure Click here
I1N1Z0 View 3D Structure Click here
I1N8W5 View 3D Structure Click here
K7K1V9 View 3D Structure Click here
K7KIP5 View 3D Structure Click here
K7KNH9 View 3D Structure Click here
K7KRR7 View 3D Structure Click here
K7KV41 View 3D Structure Click here
K7KWD3 View 3D Structure Click here
K7KZD3 View 3D Structure Click here
K7L356 View 3D Structure Click here
K7L4X9 View 3D Structure Click here
K7LBA7 View 3D Structure Click here
K7LBN6 View 3D Structure Click here
K7LNT9 View 3D Structure Click here
K7LNT9 View 3D Structure Click here
K7LQ60 View 3D Structure Click here
K7LTU1 View 3D Structure Click here
K7M6H2 View 3D Structure Click here
K7MAY1 View 3D Structure Click here
K7MBB3 View 3D Structure Click here
K7MBB3 View 3D Structure Click here
K7MJE4 View 3D Structure Click here
K7MVE5 View 3D Structure Click here
K7MY78 View 3D Structure Click here
K7N0T3 View 3D Structure Click here
K7UF69 View 3D Structure Click here
K7VJL4 View 3D Structure Click here
K7VLG8 View 3D Structure Click here
K7VP58 View 3D Structure Click here
O13990 View 3D Structure Click here
O48727 View 3D Structure Click here
O48812 View 3D Structure Click here
O49352 View 3D Structure Click here
O49353 View 3D Structure Click here
O65399 View 3D Structure Click here
P15703 View 3D Structure Click here
P33157 View 3D Structure Click here
P49237 View 3D Structure Click here
P52395 View 3D Structure Click here
P53334 View 3D Structure Click here
Q03773 View 3D Structure Click here
Q04951 View 3D Structure Click here
Q06915 View 3D Structure Click here
Q0D572 View 3D Structure Click here
Q0D5S1 View 3D Structure Click here
Q0DEW3 View 3D Structure Click here
Q0J0Q3 View 3D Structure Click here
Q0JDD4 View 3D Structure Click here
Q0JG30 View 3D Structure Click here
Q0JG51 View 3D Structure Click here
Q10MT1 View 3D Structure Click here
Q10P58 View 3D Structure Click here
Q33AW5 View 3D Structure Click here
Q4PSF2 View 3D Structure Click here
Q53K23 View 3D Structure Click here
Q53MA7 View 3D Structure Click here
Q59XX2 View 3D Structure Click here
Q5AIB2 View 3D Structure Click here
Q5AMT2 View 3D Structure Click here
Q5JMU8 View 3D Structure Click here
Q5JNL0 View 3D Structure Click here
Q5N7B6 View 3D Structure Click here
Q65X69 View 3D Structure Click here
Q69LE4 View 3D Structure Click here
Q69X84 View 3D Structure Click here
Q6ESE5 View 3D Structure Click here
Q6H4Z1 View 3D Structure Click here
Q6L5J3 View 3D Structure Click here
Q6NKW9 View 3D Structure Click here
Q6YVU4 View 3D Structure Click here
Q6YVU7 View 3D Structure Click here
Q6YVW0 View 3D Structure Click here
Q6YXZ6 View 3D Structure Click here
Q6Z4B3 View 3D Structure Click here
Q6Z7A0 View 3D Structure Click here
Q6ZHG1 View 3D Structure Click here
Q75K72 View 3D Structure Click here
Q7F164 View 3D Structure Click here
Q7F1F4 View 3D Structure Click here
Q7F354 View 3D Structure Click here
Q7Y090 View 3D Structure Click here
Q7Y157 View 3D Structure Click here
Q7Y179 View 3D Structure Click here
Q84QM8 View 3D Structure Click here
Q84SP3 View 3D Structure Click here
Q852K4 View 3D Structure Click here
Q8GT15 View 3D Structure Click here
Q8GT15 View 3D Structure Click here
Q8GTK3 View 3D Structure Click here
Q8GYS2 View 3D Structure Click here
Q8H822 View 3D Structure Click here
Q8L837 View 3D Structure Click here
Q8L868 View 3D Structure Click here
Q8S2G6 View 3D Structure Click here
Q8S9Q6 View 3D Structure Click here
Q8S9R1 View 3D Structure Click here
Q8VY12 View 3D Structure Click here
Q8VYE5 View 3D Structure Click here
Q8VZ16 View 3D Structure Click here
Q8VZJ2 View 3D Structure Click here
Q93Z08 View 3D Structure Click here
Q94CD8 View 3D Structure Click here
Q94CR1 View 3D Structure Click here
Q9C7U5 View 3D Structure Click here
Q9CA15 View 3D Structure Click here
Q9CA16 View 3D Structure Click here
Q9FGH4 View 3D Structure Click here
Q9FHX5 View 3D Structure Click here
Q9FJU9 View 3D Structure Click here
Q9FJX7 View 3D Structure Click here
Q9FK49 View 3D Structure Click here
Q9LK11 View 3D Structure Click here
Q9LK41 View 3D Structure Click here
Q9LP27 View 3D Structure Click here
Q9LV98 View 3D Structure Click here
Q9M069 View 3D Structure Click here
Q9M088 View 3D Structure Click here
Q9M2M0 View 3D Structure Click here
Q9M2T6 View 3D Structure Click here
Q9M357 View 3D Structure Click here
Q9SNC1 View 3D Structure Click here
Q9SQR1 View 3D Structure Click here
Q9SRT4 View 3D Structure Click here
Q9ZQG9 View 3D Structure Click here
Q9ZU91 View 3D Structure Click here
Q9ZUP5 View 3D Structure Click here