Summary: Interleukin-1 / 18
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This is the Wikipedia entry entitled "Interleukin". More...
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Interleukin-1 / 18 Provide feedback
This family includes interleukin-1 and interleukin-18.
Internal database links
SCOOP: | FGF |
External database links
HOMSTRAD: | intb |
PRINTS: | PR00264 |
PROSITE: | PDOC00226 |
SCOP: | 1i1b |
This tab holds annotation information from the InterPro database.
InterPro entry IPR000975
This entry represents the Interleukin-1 family, which includes seven ligands with agonist activity (IL1-alpha and IL1-beta, IL-18, IL-33, IL36-alpha, IL36-beta, IL36-gamma), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37) [ PUBMED:24332029 ].
Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis [ PUBMED:2969618 ]. Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [ PUBMED:8702856 ]. The receptors both exist in transmembrane (TM) and soluble forms: the soluble IL-1 receptor is thought to be post-translationally derived from cleavage of the extracellular portion of the membrane receptors. The receptors can both bind all three forms of IL-1: IL-1 alpha, IL-1 beta and the receptor antagonist IL-1RA [ PUBMED:1833184 ].
Gene Ontology
The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.
Cellular component | extracellular space (GO:0005615) |
Molecular function | cytokine activity (GO:0005125) |
Biological process | immune response (GO:0006955) |
inflammatory response (GO:0006954) |
Domain organisation
Below is a listing of the unique domain organisations or architectures in which this domain is found. More...
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Pfam Clan
This family is a member of clan Trefoil (CL0066), which has the following description:
This family corresponds to a large set of related beta-trefoil proteins [1]. The beta-trefoil is formed by six two-stranded hairpins [2]. Three of these form a barrel structure and the other three are in a triangular array that caps the barrel. The arrangement of the secondary structures gives the molecules a pseudo 3-fold axis.
The clan contains the following 23 members:
AbfB Agglutinin Agglutinin_C Botulinum_HA-17 BTD CDtoxinA DUF569 Fascin FGF FRG1 IL1 IL33 Inhibitor_I48 Inhibitor_I66 Ins145_P3_rec Kunitz_legume Lectin_C_term Lipoprotein_11 MIR NTNH_C Ricin_B_lectin RicinB_lectin_2 Toxin_R_bind_CAlignments
We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...
View options
We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.
Seed (13) |
Full (1516) |
Representative proteomes | UniProt (2665) |
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RP15 (72) |
RP35 (322) |
RP55 (1066) |
RP75 (1634) |
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Jalview | |||||||
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PP/heatmap | 1 |
1Cannot generate PP/Heatmap alignments for seeds; no PP data available
Key:
available,
not generated,
— not available.
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.
Seed (13) |
Full (1516) |
Representative proteomes | UniProt (2665) |
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RP15 (72) |
RP35 (322) |
RP55 (1066) |
RP75 (1634) |
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Raw Stockholm | |||||||
Gzipped |
You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.
HMM logo
HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...
Trees
This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.
Note: You can also download the data file for the tree.
Curation and family details
This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.
Curation
Seed source: | Prosite |
Previous IDs: | interleukin-1; |
Type: | Domain |
Sequence Ontology: | SO:0000417 |
Author: |
Finn RD |
Number in seed: | 13 |
Number in full: | 1516 |
Average length of the domain: | 114.80 aa |
Average identity of full alignment: | 25 % |
Average coverage of the sequence by the domain: | 54.62 % |
HMM information
HMM build commands: |
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
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Model details: |
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Model length: | 119 | ||||||||||||
Family (HMM) version: | 21 | ||||||||||||
Download: | download the raw HMM for this family |
Species distribution
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Selections
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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...
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Structures
For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the IL1 domain has been found. There are 125 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.
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