Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
247  structures 3642  species 0  interactions 25077  sequences 455  architectures

Family: Dynamin_N (PF00350)

Summary: Dynamin family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Dynamin". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Dynamin family Provide feedback

No Pfam abstract.

Literature references

  1. Warnock DE, Schmid SL; , Bioessays 1996;18:885-893.: Dynamin GTPase, a force-generating molecular switch. PUBMED:8939066 EPMC:8939066

  2. Obar RA, Collins CA, Hammarback JA, Shpetner HS, Vallee RB; , Nature 1990;347:256-261.: Molecular cloning of the microtubule-associated mechanochemical enzyme dynamin reveals homology with a new family of GTP-binding proteins. PUBMED:2144893 EPMC:2144893


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR022812

Membrane transport between compartments in eukaryotic cells requires proteins that allow the budding and scission of nascent cargo vesicles from one compartment and their targeting and fusion with another. Dynamins are large GTPases that belong to a protein superfamily [ PUBMED:15040446 ] that, in eukaryotic cells, includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins [ PUBMED:2142876 , PUBMED:2112425 , PUBMED:1532158 , PUBMED:2607176 ], and are involved in the scission of a wide range of vesicles and organelles. They play a role in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance.

The minimal distinguishing architectural features that are common to all dynamins and are distinct from other GTPases are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains; the middle domain and the GTPase effector domain (GED), which are involved in oligomerization and regulation of the GTPase activity.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan P-loop_NTPase (CL0023), which has the following description:

AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].

The clan contains the following 243 members:

6PF2K AAA AAA-ATPase_like AAA_10 AAA_11 AAA_12 AAA_13 AAA_14 AAA_15 AAA_16 AAA_17 AAA_18 AAA_19 AAA_2 AAA_21 AAA_22 AAA_23 AAA_24 AAA_25 AAA_26 AAA_27 AAA_28 AAA_29 AAA_3 AAA_30 AAA_31 AAA_32 AAA_33 AAA_34 AAA_35 AAA_5 AAA_6 AAA_7 AAA_8 AAA_9 AAA_PrkA ABC_ATPase ABC_tran ABC_tran_Xtn Adeno_IVa2 Adenylsucc_synt ADK AFG1_ATPase AIG1 APS_kinase Arf ArsA_ATPase ATP-synt_ab ATP_bind_1 ATP_bind_2 ATPase ATPase_2 Bac_DnaA BCA_ABC_TP_C Beta-Casp bpMoxR Cas_Csn2 Cas_St_Csn2 CbiA CBP_BcsQ CDC73_C CENP-M CFTR_R CLP1_P CMS1 CoaE CobA_CobO_BtuR CobU cobW CPT CSM2 CTP_synth_N Cytidylate_kin Cytidylate_kin2 DAP3 DBINO DEAD DEAD_2 DLIC DNA_pack_C DNA_pack_N DNA_pol3_delta DNA_pol3_delta2 DnaB_C dNK DO-GTPase1 DO-GTPase2 DUF1611 DUF1726 DUF2075 DUF2326 DUF2478 DUF257 DUF2791 DUF2813 DUF3584 DUF463 DUF5906 DUF6079 DUF815 DUF853 DUF87 DUF927 Dynamin_N Dynein_heavy Elong_Iki1 ELP6 ERCC3_RAD25_C Exonuc_V_gamma FeoB_N Fer4_NifH Flavi_DEAD FTHFS FtsK_SpoIIIE G-alpha Gal-3-0_sulfotr GBP GBP_C GTP_EFTU Gtr1_RagA Guanylate_kin GvpD HDA2-3 Helicase_C Helicase_C_2 Helicase_C_4 Helicase_RecD Herpes_Helicase Herpes_ori_bp Herpes_TK HSA HydF_dimer HydF_tetramer Hydin_ADK IIGP IPPT IPT iSTAND IstB_IS21 KAP_NTPase KdpD Kinase-PPPase Kinesin KTI12 LAP1C Lon_2 LpxK MCM MeaB MEDS Mg_chelatase Microtub_bd MipZ MMR_HSR1 MMR_HSR1_C MobB MukB Mur_ligase_M MutS_V Myosin_head NACHT NAT_N NB-ARC NOG1 NTPase_1 NTPase_P4 OPA1_C ORC3_N P-loop_TraG ParA Parvo_NS1 PAXNEB PduV-EutP PhoH PIF1 Ploopntkinase1 Ploopntkinase2 Ploopntkinase3 Podovirus_Gp16 Polyoma_lg_T_C Pox_A32 PPK2 PPV_E1_C PRK PSY3 Rad17 Rad51 Ras RecA ResIII RHD3 RhoGAP_pG1_pG2 RHSP RNA12 RNA_helicase Roc RsgA_GTPase RuvB_N SbcCD_C SecA_DEAD Septin Sigma54_activ_2 Sigma54_activat SKI SMC_N SNF2-rel_dom Spore_III_AA Spore_IV_A SRP54 SRPRB SulA Sulfotransfer_1 Sulfotransfer_2 Sulfotransfer_3 Sulfotransfer_4 Sulfotransfer_5 Sulphotransf SWI2_SNF2 T2SSE T4SS-DNA_transf Terminase_1 Terminase_3 Terminase_6N Terminase_GpA Thymidylate_kin TIP49 TK TniB Torsin TraG-D_C tRNA_lig_kinase TrwB_AAD_bind TsaE UvrB UvrD-helicase UvrD_C UvrD_C_2 Viral_helicase1 VirC1 VirE YqeC Zeta_toxin Zot

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(64)
Full
(25077)
Representative proteomes UniProt
(58657)
RP15
(3528)
RP35
(10879)
RP55
(21009)
RP75
(30284)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(64)
Full
(25077)
Representative proteomes UniProt
(58657)
RP15
(3528)
RP35
(10879)
RP55
(21009)
RP75
(30284)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(64)
Full
(25077)
Representative proteomes UniProt
(58657)
RP15
(3528)
RP35
(10879)
RP55
(21009)
RP75
(30284)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: dynamin;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 64
Number in full: 25077
Average length of the domain: 176.90 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 24.88 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 168
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Dynamin_N domain has been found. There are 247 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2L559 View 3D Structure Click here
A0A0N7KTN7 View 3D Structure Click here
A0A0P0V6L3 View 3D Structure Click here
A0A0P0W699 View 3D Structure Click here
A0A0P0W9A2 View 3D Structure Click here
A0A0R0FD34 View 3D Structure Click here
A0A0R0FKB4 View 3D Structure Click here
A0A0R0H0V0 View 3D Structure Click here
A0A0R0IKS3 View 3D Structure Click here
A0A0R4IBZ4 View 3D Structure Click here
A0A0R4IIR1 View 3D Structure Click here
A0A0R4IXR0 View 3D Structure Click here
A0A1D6DU63 View 3D Structure Click here
A0A1D6ECY4 View 3D Structure Click here
A0A1D6ELQ4 View 3D Structure Click here
A0A1D6FJS7 View 3D Structure Click here
A0A1D6G5F4 View 3D Structure Click here
A0A1D6G5W0 View 3D Structure Click here
A0A1D6GC10 View 3D Structure Click here
A0A1D6GU10 View 3D Structure Click here
A0A1D6HJQ5 View 3D Structure Click here
A0A1D6JWT4 View 3D Structure Click here
A0A1D6JWT6 View 3D Structure Click here
A0A1D6KPH4 View 3D Structure Click here
A0A1D6MC12 View 3D Structure Click here
A0A1D6N309 View 3D Structure Click here
A0A1D6NRA8 View 3D Structure Click here
A0A1D8PKC9 View 3D Structure Click here
A0A1D8PN45 View 3D Structure Click here
A0A2R8PX39 View 3D Structure Click here
A0A2R8RYX8 View 3D Structure Click here
A0A368UGV8 View 3D Structure Click here
A0AUR2 View 3D Structure Click here
A1Z9N0 View 3D Structure Click here
A4HY50 View 3D Structure Click here
A4HZS6 View 3D Structure Click here
A4I4S9 View 3D Structure Click here
A4IA07 View 3D Structure Click here
A8WIN6 View 3D Structure Click here
B3DHW7 View 3D Structure Click here
B3LF48 View 3D Structure Click here
B4F8W2 View 3D Structure Click here
B4FPT9 View 3D Structure Click here
B6SKP8 View 3D Structure Click here
C0HFG9 View 3D Structure Click here
C0PEU8 View 3D Structure Click here
C0PHK6 View 3D Structure Click here
D3YWJ0 View 3D Structure Click here
E7EXQ4 View 3D Structure Click here
E7FC95 View 3D Structure Click here
E9QGV7 View 3D Structure Click here
F1LWG8 View 3D Structure Click here
F1M575 View 3D Structure Click here
F1QXF9 View 3D Structure Click here
F1R785 View 3D Structure Click here
F4HPR5 View 3D Structure Click here
F6NHV1 View 3D Structure Click here
F6NSK7 View 3D Structure Click here
F6P001 View 3D Structure Click here
F6P2T1 View 3D Structure Click here
F6P8C7 View 3D Structure Click here
F8W429 View 3D Structure Click here
G5ECC3 View 3D Structure Click here
I1JAE5 View 3D Structure Click here
I1JDI1 View 3D Structure Click here
I1JJC9 View 3D Structure Click here
I1JMI7 View 3D Structure Click here
I1JW11 View 3D Structure Click here
I1K5J8 View 3D Structure Click here
I1K693 View 3D Structure Click here
I1KDU5 View 3D Structure Click here
I1KHV2 View 3D Structure Click here
I1KJE0 View 3D Structure Click here
I1KNI2 View 3D Structure Click here
I1KNS5 View 3D Structure Click here
I1KQC2 View 3D Structure Click here
I1KQX5 View 3D Structure Click here
I1KR58 View 3D Structure Click here
I1KYV5 View 3D Structure Click here
I1KZR0 View 3D Structure Click here
I1KZX5 View 3D Structure Click here
I1LG73 View 3D Structure Click here
I1LVI3 View 3D Structure Click here
I1M2M2 View 3D Structure Click here
I1ME12 View 3D Structure Click here
I1MFL9 View 3D Structure Click here
I1MQT0 View 3D Structure Click here
I1MR19 View 3D Structure Click here
I1N0J5 View 3D Structure Click here
K7KQK4 View 3D Structure Click here
K7L2A6 View 3D Structure Click here
K7L2I2 View 3D Structure Click here
K7LV22 View 3D Structure Click here
K7M173 View 3D Structure Click here
O00429 View 3D Structure Click here
O18412 View 3D Structure Click here
O35303 View 3D Structure Click here
O60313 View 3D Structure Click here
O95140 View 3D Structure Click here
P0DM85 View 3D Structure Click here
P18588 View 3D Structure Click here
P18589 View 3D Structure Click here
P18590 View 3D Structure Click here
P20591 View 3D Structure Click here
P20592 View 3D Structure Click here
P21575 View 3D Structure Click here
P21576 View 3D Structure Click here
P27619 View 3D Structure Click here
P32266 View 3D Structure Click here
P38297 View 3D Structure Click here
P39052 View 3D Structure Click here
P39053 View 3D Structure Click here
P39054 View 3D Structure Click here
P39055 View 3D Structure Click here
P42697 View 3D Structure Click here
P50570 View 3D Structure Click here
P54861 View 3D Structure Click here
P58281 View 3D Structure Click here
P87320 View 3D Structure Click here
P9WJ95 View 3D Structure Click here
P9WJ99 View 3D Structure Click here
Q05193 View 3D Structure Click here
Q08877 View 3D Structure Click here
Q09748 View 3D Structure Click here
Q0DG31 View 3D Structure Click here
Q0DXR0 View 3D Structure Click here
Q0J5L5 View 3D Structure Click here
Q10NS9 View 3D Structure Click here
Q18965 View 3D Structure Click here
Q23424 View 3D Structure Click here
Q2FYJ0 View 3D Structure Click here
Q2FYJ0 View 3D Structure Click here
Q2TA68 View 3D Structure Click here
Q39821 View 3D Structure Click here
Q39828 View 3D Structure Click here
Q3UD61 View 3D Structure Click here
Q4CPW0 View 3D Structure Click here
Q4CYH4 View 3D Structure Click here
Q4DCC9 View 3D Structure Click here
Q4DH62 View 3D Structure Click here
Q4DYK9 View 3D Structure Click here
Q4E5A3 View 3D Structure Click here
Q4E689 View 3D Structure Click here
Q4V8H8 View 3D Structure Click here
Q54MH8 View 3D Structure Click here
Q54ST5 View 3D Structure Click here
Q55AX0 View 3D Structure Click here
Q55F94 View 3D Structure Click here
Q59P94 View 3D Structure Click here
Q5AFB7 View 3D Structure Click here
Q5JJJ5 View 3D Structure Click here
Q5JNJ6 View 3D Structure Click here
Q5RHR9 View 3D Structure Click here
Q5TYP7 View 3D Structure Click here
Q5U3A7 View 3D Structure Click here
Q641Z6 View 3D Structure Click here
Q650Z3 View 3D Structure Click here
Q653F5 View 3D Structure Click here
Q654U5 View 3D Structure Click here
Q66HW2 View 3D Structure Click here
Q68CJ6 View 3D Structure Click here
Q6DKF0 View 3D Structure Click here
Q6ET46 View 3D Structure Click here
Q6NY81 View 3D Structure Click here
Q6P3J7 View 3D Structure Click here
Q7SXN5 View 3D Structure Click here
Q7TQ48 View 3D Structure Click here
Q7XBZ9 View 3D Structure Click here
Q7XR66 View 3D Structure Click here
Q7YU24 View 3D Structure Click here
Q800G5 View 3D Structure Click here
Q800G8 View 3D Structure Click here
Q80U63 View 3D Structure Click here
Q811U4 View 3D Structure Click here
Q84N64 View 3D Structure Click here
Q84XF3 View 3D Structure Click here
Q86TD4 View 3D Structure Click here
Q8BH64 View 3D Structure Click here
Q8BZ98 View 3D Structure Click here
Q8I5M3 View 3D Structure Click here
Q8IB44 View 3D Structure Click here
Q8IHR4 View 3D Structure Click here
Q8IJ32 View 3D Structure Click here
Q8IWA4 View 3D Structure Click here
Q8JH68 View 3D Structure Click here
Q8K1M6 View 3D Structure Click here
Q8LF21 View 3D Structure Click here
Q8LFT2 View 3D Structure Click here
Q8R3Z7 View 3D Structure Click here
Q8R491 View 3D Structure Click here
Q8R4Z9 View 3D Structure Click here
Q8R500 View 3D Structure Click here
Q8S3C9 View 3D Structure Click here
Q8S944 View 3D Structure Click here
Q8T8W3 View 3D Structure Click here
Q8W315 View 3D Structure Click here
Q8WQC9 View 3D Structure Click here
Q94464 View 3D Structure Click here
Q94CF0 View 3D Structure Click here
Q9EQP2 View 3D Structure Click here
Q9FNX5 View 3D Structure Click here
Q9H223 View 3D Structure Click here
Q9H4M9 View 3D Structure Click here
Q9LQ55 View 3D Structure Click here
Q9NLB8 View 3D Structure Click here
Q9NZN3 View 3D Structure Click here
Q9NZN4 View 3D Structure Click here
Q9QXY6 View 3D Structure Click here
Q9SE83 View 3D Structure Click here
Q9U1M9 View 3D Structure Click here
Q9UQ16 View 3D Structure Click here
Q9URZ5 View 3D Structure Click here
Q9USY7 View 3D Structure Click here
Q9VQE0 View 3D Structure Click here
Q9WVK4 View 3D Structure Click here
Q9WVP9 View 3D Structure Click here
Q9ZP55 View 3D Structure Click here
Q9ZP56 View 3D Structure Click here