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115  structures 1364  species 0  interactions 19625  sequences 279  architectures

Family: Pkinase_C (PF00433)

Summary: Protein kinase C terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Protein kinase C". More...

Protein kinase C Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Protein kinase C terminal domain Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR017892

Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [ PUBMED:3291115 ]:

  • Serine/threonine-protein kinases
  • Tyrosine-protein kinases
  • Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)

Protein kinase function is evolutionarily conserved from Escherichia coli to human [ PUBMED:12471243 ]. Protein kinases play a role in a multitude of cellular processes, including division, proliferation, apoptosis, and differentiation [ PUBMED:12368087 ]. Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other proteins. The catalytic subunits of protein kinases are highly conserved, and several structures have been solved [ PUBMED:15078142 ], leading to large screens to develop kinase-specific inhibitors for the treatments of a number of diseases [ PUBMED:15320712 ].

This domain is found in a large variety of protein kinases with different functions and dependencies. Protein kinase C, for example, is a calcium-activated, phospholipid-dependent serine- and threonine-specific enzyme. It is activated by diacylglycerol which, in turn, phosphorylates a range of cellular proteins. This domain is most often found associated with INTERPRO .

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(434)
Full
(19625)
Representative proteomes UniProt
(32353)
RP15
(2274)
RP35
(6589)
RP55
(16017)
RP75
(21700)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(434)
Full
(19625)
Representative proteomes UniProt
(32353)
RP15
(2274)
RP35
(6589)
RP55
(16017)
RP75
(21700)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(434)
Full
(19625)
Representative proteomes UniProt
(32353)
RP15
(2274)
RP35
(6589)
RP55
(16017)
RP75
(21700)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_135 (release 1.0)
Previous IDs: pkinase_C;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD
Number in seed: 434
Number in full: 19625
Average length of the domain: 43.60 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 6.29 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.9 15.0
Trusted cut-off 20.9 16.2
Noise cut-off 20.8 14.9
Model length: 46
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Pkinase_C domain has been found. There are 115 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K366 View 3D Structure Click here
A0A0G2K4A8 View 3D Structure Click here
A0A0G2KG61 View 3D Structure Click here
A0A0R0FHW6 View 3D Structure Click here
A0A0R0HP14 View 3D Structure Click here
A0A0R4ID09 View 3D Structure Click here
A0A0R4IDB7 View 3D Structure Click here
A0A0R4IPY3 View 3D Structure Click here
A0A0R4IY09 View 3D Structure Click here
A0A1D6FFL0 View 3D Structure Click here
A0A1D6FN77 View 3D Structure Click here
A0A1D6FT73 View 3D Structure Click here
A0A1D6IMS9 View 3D Structure Click here
A0A1D6K201 View 3D Structure Click here
A0A1D6KTJ7 View 3D Structure Click here
A0A2R8QBK5 View 3D Structure Click here
A0A2R8QDD3 View 3D Structure Click here
A0A2R8QDF2 View 3D Structure Click here
A0A2R8QFC7 View 3D Structure Click here
A0A2R8QFS2 View 3D Structure Click here
A0A2R8QIY5 View 3D Structure Click here
A0A2R8QJ48 View 3D Structure Click here
A0A2R8RM45 View 3D Structure Click here
A0A2R8RTH3 View 3D Structure Click here
A0A4V0ILM7 View 3D Structure Click here
A1Z7T0 View 3D Structure Click here
A1Z9X0 View 3D Structure Click here
A2BIB3 View 3D Structure Click here
A3KQ53 View 3D Structure Click here
A4GW50 View 3D Structure Click here
A7MBL8 View 3D Structure Click here
B0S4T7 View 3D Structure Click here
B1H1I7 View 3D Structure Click here
B6SWM7 View 3D Structure Click here
B8A467 View 3D Structure Click here
B8JM87 View 3D Structure Click here
C0HGU8 View 3D Structure Click here
C0PHA7 View 3D Structure Click here
C6T7K3 View 3D Structure Click here
D3Z8E0 View 3D Structure Click here
D3ZSB7 View 3D Structure Click here
D4AE24 View 3D Structure Click here
D9IL79 View 3D Structure Click here
E7EXT6 View 3D Structure Click here
E7F164 View 3D Structure Click here
E7F368 View 3D Structure Click here
E7F469 View 3D Structure Click here
E7F4L5 View 3D Structure Click here
E7F7I3 View 3D Structure Click here
E7FE05 View 3D Structure Click here
E9QG10 View 3D Structure Click here
F1LYL8 View 3D Structure Click here
F1M7N7 View 3D Structure Click here
F1M7Y5 View 3D Structure Click here
F1QBK0 View 3D Structure Click here
F1QXD6 View 3D Structure Click here
F1R506 View 3D Structure Click here
F1R730 View 3D Structure Click here
F4I2K0 View 3D Structure Click here
F4I6E4 View 3D Structure Click here
F4KFD4 View 3D Structure Click here
F6NV75 View 3D Structure Click here
G3V9Q4 View 3D Structure Click here
I1JB62 View 3D Structure Click here
I1JP50 View 3D Structure Click here
I1JTZ3 View 3D Structure Click here
I1K8E5 View 3D Structure Click here
I1L6Z1 View 3D Structure Click here
I1LYM3 View 3D Structure Click here
I1M8M5 View 3D Structure Click here
I1N377 View 3D Structure Click here
I1N9S3 View 3D Structure Click here
I1NI89 View 3D Structure Click here
K7LGQ9 View 3D Structure Click here
K7LK50 View 3D Structure Click here
M9PI41 View 3D Structure Click here
O00141 View 3D Structure Click here
O08874 View 3D Structure Click here
O54874 View 3D Structure Click here
O75582 View 3D Structure Click here
O75676 View 3D Structure Click here
O94487 View 3D Structure Click here
P05129 View 3D Structure Click here
P05130 View 3D Structure Click here
P05696 View 3D Structure Click here
P05771 View 3D Structure Click here
P09215 View 3D Structure Click here
P09216 View 3D Structure Click here
P09217 View 3D Structure Click here
P11792 View 3D Structure Click here
P12688 View 3D Structure Click here
P13677 View 3D Structure Click here
P13678 View 3D Structure Click here
P16054 View 3D Structure Click here
P17252 View 3D Structure Click here
P18653 View 3D Structure Click here
P18654 View 3D Structure Click here
P18961 View 3D Structure Click here
P20444 View 3D Structure Click here
P22204 View 3D Structure Click here
P23298 View 3D Structure Click here
P23443 View 3D Structure Click here
P24583 View 3D Structure Click here
P24723 View 3D Structure Click here
P28178 View 3D Structure Click here
P28867 View 3D Structure Click here
P31749 View 3D Structure Click here
P31750 View 3D Structure Click here
P31751 View 3D Structure Click here
P32328 View 3D Structure Click here
P34722 View 3D Structure Click here
P34885 View 3D Structure Click here
P36582 View 3D Structure Click here
P36583 View 3D Structure Click here
P38070 View 3D Structure Click here
P41743 View 3D Structure Click here
P42818 View 3D Structure Click here
P47196 View 3D Structure Click here
P47197 View 3D Structure Click here
P50530 View 3D Structure Click here
P51812 View 3D Structure Click here
P54644 View 3D Structure Click here
P63318 View 3D Structure Click here
P63319 View 3D Structure Click here
P67999 View 3D Structure Click here
P68403 View 3D Structure Click here
P68404 View 3D Structure Click here
P70268 View 3D Structure Click here
P83099 View 3D Structure Click here
Q02111 View 3D Structure Click here
Q02156 View 3D Structure Click here
Q02956 View 3D Structure Click here
Q04759 View 3D Structure Click here
Q05513 View 3D Structure Click here
Q05655 View 3D Structure Click here
Q06226 View 3D Structure Click here
Q09898 View 3D Structure Click here
Q0D3L1 View 3D Structure Click here
Q10364 View 3D Structure Click here
Q10LV1 View 3D Structure Click here
Q15208 View 3D Structure Click here
Q15349 View 3D Structure Click here
Q15418 View 3D Structure Click here
Q16512 View 3D Structure Click here
Q16513 View 3D Structure Click here
Q17941 View 3D Structure Click here
Q18846 View 3D Structure Click here
Q19266 View 3D Structure Click here
Q1PF34 View 3D Structure Click here
Q21734 View 3D Structure Click here
Q2L6W9 View 3D Structure Click here
Q39030 View 3D Structure Click here
Q3UU96 View 3D Structure Click here
Q54IH8 View 3D Structure Click here
Q59QB9 View 3D Structure Click here
Q5AAN6 View 3D Structure Click here
Q5AHG6 View 3D Structure Click here
Q5ANK2 View 3D Structure Click here
Q5RH05 View 3D Structure Click here
Q5SNF8 View 3D Structure Click here
Q5TZ37 View 3D Structure Click here
Q5VT25 View 3D Structure Click here
Q60823 View 3D Structure Click here
Q62074 View 3D Structure Click here
Q63433 View 3D Structure Click here
Q63484 View 3D Structure Click here
Q63531 View 3D Structure Click here
Q64617 View 3D Structure Click here
Q6L535 View 3D Structure Click here
Q6P5Z2 View 3D Structure Click here
Q6PFQ0 View 3D Structure Click here
Q7SY24 View 3D Structure Click here
Q7T2C5 View 3D Structure Click here
Q7TPS0 View 3D Structure Click here
Q7TSE6 View 3D Structure Click here
Q7TSJ6 View 3D Structure Click here
Q7ZTW4 View 3D Structure Click here
Q7ZUC5 View 3D Structure Click here
Q803L5 View 3D Structure Click here
Q80UW5 View 3D Structure Click here
Q8BSK8 View 3D Structure Click here
Q8BWW9 View 3D Structure Click here
Q8C050 View 3D Structure Click here
Q8INB9 View 3D Structure Click here
Q8K045 View 3D Structure Click here
Q8L7S7 View 3D Structure Click here
Q8R4U9 View 3D Structure Click here
Q8R4V0 View 3D Structure Click here
Q8UUX0 View 3D Structure Click here
Q90XF2 View 3D Structure Click here
Q91VJ4 View 3D Structure Click here
Q94533 View 3D Structure Click here
Q96BR1 View 3D Structure Click here
Q9AUZ4 View 3D Structure Click here
Q9ERE3 View 3D Structure Click here
Q9LW66 View 3D Structure Click here
Q9NAH6 View 3D Structure Click here
Q9NRM7 View 3D Structure Click here
Q9P7J8 View 3D Structure Click here
Q9QZS5 View 3D Structure Click here
Q9UBS0 View 3D Structure Click here
Q9UK32 View 3D Structure Click here
Q9V3I5 View 3D Structure Click here
Q9VR61 View 3D Structure Click here
Q9W1B0 View 3D Structure Click here
Q9WTQ0 View 3D Structure Click here
Q9WUA6 View 3D Structure Click here
Q9WUT3 View 3D Structure Click here
Q9WVC6 View 3D Structure Click here
Q9XTG7 View 3D Structure Click here
Q9Y243 View 3D Structure Click here
Q9Y2H1 View 3D Structure Click here
Q9Z1M4 View 3D Structure Click here
Q9Z2B9 View 3D Structure Click here