Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
196  structures 1554  species 0  interactions 49226  sequences 1013  architectures

Family: UCH (PF00443)

Summary: Ubiquitin carboxyl-terminal hydrolase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Ubiquitin carboxyl-terminal hydrolase Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001394

Ubiquitin carboxyl-terminal hydrolases (UCH) ( EC ) [ PUBMED:1647207 ] are thiol proteases that recognise and hydrolyse the peptide bond at the C-terminal glycine of ubiquitin. These enzymes are involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. The deubiquitinsing proteases can be split into 2 size ranges, 20-30kDa ( INTERPRO ) and 100-200kDa [ PUBMED:7845226 ]: the second class consist of large proteins (800 to 2000 residues) that belong to the peptidase family C19, and this group is currently represented by yeast UBP1 [ PUBMED:2050695 ].

UCH thiol proteases contain an N-terminal catalytic domain sometimes followed by C-terminal extensions that mediate protein-protein interactions [ PUBMED:23845989 ]. This entry represents the catalytic domain of UCH proteins of the UBP1 group.

Cysteine peptidases with a chymotrypsin-like fold are included in clan PA, which also includes serine peptidases. Cysteine peptidases that are N-terminal nucleophile hydrolases are included in clan PB. Cysteine peptidases with a tertiary structure similar to that of the serine-type aspartyl dipeptidase are included in clan PC. Cysteine peptidases with an intein-like fold are included in clan PD, which also includes asparagine lyases.

A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families [ PUBMED:11517925 ]. Clans CF, CM, CN, CO, CP and PD contain only one family.

Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N -ethylmaleimide or p -chloromercuribenzoate.

Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a beta-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [ PUBMED:7044372 ].

Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an alpha/beta/alpha sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues [ PUBMED:9891971 ]. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.

Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a beta barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.

Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed beta barrel decorated with helices with the active site at one end of the barrel [ PUBMED:14725770 ]. The active site consists of a His/Cys catalytic dyad.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(54)
Full
(49226)
Representative proteomes UniProt
(88355)
RP15
(9203)
RP35
(21756)
RP55
(40197)
RP75
(53610)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(54)
Full
(49226)
Representative proteomes UniProt
(88355)
RP15
(9203)
RP35
(21756)
RP55
(40197)
RP75
(53610)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(54)
Full
(49226)
Representative proteomes UniProt
(88355)
RP15
(9203)
RP35
(21756)
RP55
(40197)
RP75
(53610)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: UCH-2;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 54
Number in full: 49226
Average length of the domain: 382.80 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 44.27 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.9 23.9
Trusted cut-off 23.9 23.9
Noise cut-off 23.8 23.8
Model length: 278
Family (HMM) version: 31
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UCH domain has been found. There are 196 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JUX4 View 3D Structure Click here
A0A0G2JXC4 View 3D Structure Click here
A0A0G2JYY1 View 3D Structure Click here
A0A0G2JZU8 View 3D Structure Click here
A0A0G2K2C7 View 3D Structure Click here
A0A0G2K2V3 View 3D Structure Click here
A0A0G2K4S7 View 3D Structure Click here
A0A0G2K952 View 3D Structure Click here
A0A0G2KWQ2 View 3D Structure Click here
A0A0G2QC35 View 3D Structure Click here
A0A0N7KQM0 View 3D Structure Click here
A0A0P0V8R4 View 3D Structure Click here
A0A0P0WFP5 View 3D Structure Click here
A0A0P0WT89 View 3D Structure Click here
A0A0P0X2E4 View 3D Structure Click here
A0A0P0XI69 View 3D Structure Click here
A0A0P0XII6 View 3D Structure Click here
A0A0P0XJI7 View 3D Structure Click here
A0A0P0XPE6 View 3D Structure Click here
A0A0P0Y308 View 3D Structure Click here
A0A0P0Y561 View 3D Structure Click here
A0A0P0YDU9 View 3D Structure Click here
A0A0R0EGZ2 View 3D Structure Click here
A0A0R0EQ48 View 3D Structure Click here
A0A0R0GKM7 View 3D Structure Click here
A0A0R0GRJ6 View 3D Structure Click here
A0A0R0GSM7 View 3D Structure Click here
A0A0R0H004 View 3D Structure Click here
A0A0R0HS93 View 3D Structure Click here
A0A0R0IPI1 View 3D Structure Click here
A0A0R0IY29 View 3D Structure Click here
A0A0R0JEG4 View 3D Structure Click here
A0A0R0KS44 View 3D Structure Click here
A0A0R0KZL0 View 3D Structure Click here
A0A0R4IFT8 View 3D Structure Click here
A0A0R4IPU7 View 3D Structure Click here
A0A0R4IQS2 View 3D Structure Click here
A0A140LGM9 View 3D Structure Click here
A0A140LGR1 View 3D Structure Click here
A0A1D5NSA9 View 3D Structure Click here
A0A1D6DW87 View 3D Structure Click here
A0A1D6DXV9 View 3D Structure Click here
A0A1D6E9C7 View 3D Structure Click here
A0A1D6EAT2 View 3D Structure Click here
A0A1D6EGP6 View 3D Structure Click here
A0A1D6ESQ1 View 3D Structure Click here
A0A1D6F3S5 View 3D Structure Click here
A0A1D6F9P9 View 3D Structure Click here
A0A1D6FSU9 View 3D Structure Click here
A0A1D6GTX8 View 3D Structure Click here
A0A1D6H5U8 View 3D Structure Click here
A0A1D6HGK6 View 3D Structure Click here
A0A1D6HSL7 View 3D Structure Click here
A0A1D6HSS3 View 3D Structure Click here
A0A1D6I2F1 View 3D Structure Click here
A0A1D6I638 View 3D Structure Click here
A0A1D6IME8 View 3D Structure Click here
A0A1D6IUI3 View 3D Structure Click here
A0A1D6JPU6 View 3D Structure Click here
A0A1D6JSI9 View 3D Structure Click here
A0A1D6KC62 View 3D Structure Click here
A0A1D6KLG8 View 3D Structure Click here
A0A1D6KLG8 View 3D Structure Click here
A0A1D6LDR0 View 3D Structure Click here
A0A1D6LQJ2 View 3D Structure Click here
A0A1D6MMV5 View 3D Structure Click here
A0A1D6MTS2 View 3D Structure Click here
A0A1D6MVD8 View 3D Structure Click here
A0A1D6NAF8 View 3D Structure Click here
A0A1D6NI32 View 3D Structure Click here
A0A1D6NMU6 View 3D Structure Click here
A0A1D6P656 View 3D Structure Click here
A0A1D6P656 View 3D Structure Click here
A0A1D6PKI7 View 3D Structure Click here
A0A1D6Q1V8 View 3D Structure Click here
A0A1D6Q1V9 View 3D Structure Click here
A0A1D6QL28 View 3D Structure Click here
A0A1D6QPL2 View 3D Structure Click here
A0A1D8PC77 View 3D Structure Click here
A0A1D8PCM4 View 3D Structure Click here
A0A1D8PDT6 View 3D Structure Click here
A0A1D8PFU3 View 3D Structure Click here
A0A1D8PG89 View 3D Structure Click here
A0A1D8PGI9 View 3D Structure Click here
A0A1D8PIM4 View 3D Structure Click here
A0A1D8PIP6 View 3D Structure Click here
A0A1D8PKC4 View 3D Structure Click here
A0A1D8PLU4 View 3D Structure Click here
A0A1D8PP95 View 3D Structure Click here
A0A1D8PT66 View 3D Structure Click here
A0A1P8AN44 View 3D Structure Click here
A0A1P8AVB5 View 3D Structure Click here
A0A1P8BG67 View 3D Structure Click here
A0A1X7YGK7 View 3D Structure Click here
A0A1X7YHN9 View 3D Structure Click here
A0A1X7YHX0 View 3D Structure Click here
A0A2R8Q9M8 View 3D Structure Click here
A0A2R8QB18 View 3D Structure Click here
A0A2R8QQQ6 View 3D Structure Click here
A0A2R8QST4 View 3D Structure Click here
A0A2R8RHG2 View 3D Structure Click here
A0A2R8RHY7 View 3D Structure Click here
A0A2R8RJV9 View 3D Structure Click here
A0A2R8RT31 View 3D Structure Click here
A0A2R8RV99 View 3D Structure Click here
A0A368UG72 View 3D Structure Click here
A0A4V0IKF7 View 3D Structure Click here
A2BGT0 View 3D Structure Click here
A3AF13 View 3D Structure Click here
A3KQ59 View 3D Structure Click here
A4FUN7 View 3D Structure Click here
A4HTX1 View 3D Structure Click here
A4HWL5 View 3D Structure Click here
A4HWX0 View 3D Structure Click here
A4HXI6 View 3D Structure Click here
A4HZ39 View 3D Structure Click here
A4I0Q0 View 3D Structure Click here
A4I2S8 View 3D Structure Click here
A4I4U4 View 3D Structure Click here
A4I5F1 View 3D Structure Click here
A4I7U2 View 3D Structure Click here
A4I8B2 View 3D Structure Click here
A4IAH7 View 3D Structure Click here
A4IB74 View 3D Structure Click here
A4IBF1 View 3D Structure Click here
A5PMR2 View 3D Structure Click here
A5PN09 View 3D Structure Click here
A5PN09 View 3D Structure Click here
A5WWB0 View 3D Structure Click here
A6H8I0 View 3D Structure Click here
A6NCW0 View 3D Structure Click here
A6NCW7 View 3D Structure Click here
A6NNY8 View 3D Structure Click here
A8HAL1 View 3D Structure Click here
A8MUK1 View 3D Structure Click here
B0G199 View 3D Structure Click here
B1AQJ2 View 3D Structure Click here
B1AY13 View 3D Structure Click here
B1AY15 View 3D Structure Click here
B2GUX4 View 3D Structure Click here
B2GUZ1 View 3D Structure Click here
B2GV41 View 3D Structure Click here
B2RQC2 View 3D Structure Click here
B4FI55 View 3D Structure Click here
B4FU72 View 3D Structure Click here
B6TEU9 View 3D Structure Click here
B7ZDA8 View 3D Structure Click here
B8A398 View 3D Structure Click here
C0PCY1 View 3D Structure Click here
C7J0W5 View 3D Structure Click here
C7J965 View 3D Structure Click here
C9J2P7 View 3D Structure Click here
C9JJH3 View 3D Structure Click here
C9JLJ4 View 3D Structure Click here
C9JPN9 View 3D Structure Click here
C9JVI0 View 3D Structure Click here
D3Z8K5 View 3D Structure Click here
D3ZDI9 View 3D Structure Click here
D3ZED6 View 3D Structure Click here
D3ZGB0 View 3D Structure Click here
D3ZJ49 View 3D Structure Click here
D3ZJ96 View 3D Structure Click here
D3ZL95 View 3D Structure Click here
D3ZLQ8 View 3D Structure Click here
D3ZLQ8 View 3D Structure Click here
D3ZN39 View 3D Structure Click here
D3ZNQ4 View 3D Structure Click here
D3ZPG5 View 3D Structure Click here
D3ZTX7 View 3D Structure Click here
D3ZU96 View 3D Structure Click here
D3ZUR6 View 3D Structure Click here
D3ZVQ0 View 3D Structure Click here
D4A251 View 3D Structure Click here
D4A2R6 View 3D Structure Click here
D4A5S1 View 3D Structure Click here
D4ABE5 View 3D Structure Click here
D4ACD3 View 3D Structure Click here
D4AEI6 View 3D Structure Click here
D6R901 View 3D Structure Click here
D6R9N7 View 3D Structure Click here
D6RA61 View 3D Structure Click here
D6RBM5 View 3D Structure Click here
D6RBQ6 View 3D Structure Click here
D6RCP7 View 3D Structure Click here
D6RJB6 View 3D Structure Click here
E7EY58 View 3D Structure Click here
E7EYZ1 View 3D Structure Click here
E7EZD6 View 3D Structure Click here
E7F4C0 View 3D Structure Click here
E7F4N9 View 3D Structure Click here
E7F6T8 View 3D Structure Click here
E7FCR5 View 3D Structure Click here
E7FD00 View 3D Structure Click here
E7FEV5 View 3D Structure Click here
E7FGV9 View 3D Structure Click here
E9AGA8 View 3D Structure Click here
E9AHK7 View 3D Structure Click here
E9Q6Y8 View 3D Structure Click here
E9Q9U0 View 3D Structure Click here
E9QFQ5 View 3D Structure Click here
E9QG68 View 3D Structure Click here
F1LPJ7 View 3D Structure Click here
F1LSM0 View 3D Structure Click here
F1LSW9 View 3D Structure Click here
F1LYZ4 View 3D Structure Click here
F1M413 View 3D Structure Click here
F1M625 View 3D Structure Click here
F1M8S4 View 3D Structure Click here
F1Q6K1 View 3D Structure Click here
F1Q7D2 View 3D Structure Click here
F1QFS9 View 3D Structure Click here
F1QNF4 View 3D Structure Click here
F1QNF4 View 3D Structure Click here
F1QPF4 View 3D Structure Click here
F1QUS9 View 3D Structure Click here
F1QW62 View 3D Structure Click here
F1QY38 View 3D Structure Click here
F1R2P1 View 3D Structure Click here
F1R4B7 View 3D Structure Click here
F1RBA1 View 3D Structure Click here
F1RDC7 View 3D Structure Click here
F4I9U7 View 3D Structure Click here
F4I9U9 View 3D Structure Click here
F4I9V7 View 3D Structure Click here
F4IGQ2 View 3D Structure Click here
F4IGQ3 View 3D Structure Click here
F4JCR1 View 3D Structure Click here
F4JCR3 View 3D Structure Click here
F4JL64 View 3D Structure Click here
F4JL70 View 3D Structure Click here
F4K529 View 3D Structure Click here
F8VPU6 View 3D Structure Click here
F8VPZ3 View 3D Structure Click here
G5E8G2 View 3D Structure Click here
G5E8I7 View 3D Structure Click here
G5EBW2 View 3D Structure Click here
G5ECC7 View 3D Structure Click here
H2KYU7 View 3D Structure Click here
H2L010 View 3D Structure Click here
I1J4V4 View 3D Structure Click here
I1JGZ3 View 3D Structure Click here
I1JIM7 View 3D Structure Click here
I1JU40 View 3D Structure Click here
I1JZT8 View 3D Structure Click here
I1K4J0 View 3D Structure Click here
I1K8J2 View 3D Structure Click here
I1K929 View 3D Structure Click here
I1KE56 View 3D Structure Click here
I1KT09 View 3D Structure Click here
I1KTD3 View 3D Structure Click here
I1KU89 View 3D Structure Click here
I1L5I7 View 3D Structure Click here
I1L9D9 View 3D Structure Click here
I1LBX6 View 3D Structure Click here
I1LNK3 View 3D Structure Click here
I1LSZ2 View 3D Structure Click here
I1LZK9 View 3D Structure Click here
I1LZT3 View 3D Structure Click here
I1M2Q1 View 3D Structure Click here
I1M9B2 View 3D Structure Click here
I1M9E2 View 3D Structure Click here
I1M9Q7 View 3D Structure Click here
I1MAZ7 View 3D Structure Click here
I1MJ12 View 3D Structure Click here
I1MT28 View 3D Structure Click here
I1MTN8 View 3D Structure Click here
I1MU32 View 3D Structure Click here
I1MWI0 View 3D Structure Click here
I1MWZ8 View 3D Structure Click here
I1MY83 View 3D Structure Click here
I1MYR5 View 3D Structure Click here
I1N8N2 View 3D Structure Click here
I1NE39 View 3D Structure Click here
I1NIH9 View 3D Structure Click here
I3IT16 View 3D Structure Click here
K7K1E2 View 3D Structure Click here
K7K6D3 View 3D Structure Click here
K7KG49 View 3D Structure Click here
K7KIQ1 View 3D Structure Click here
K7KJ19 View 3D Structure Click here
K7KR37 View 3D Structure Click here
K7LF25 View 3D Structure Click here
K7LJ00 View 3D Structure Click here
K7LJ01 View 3D Structure Click here
K7LRW5 View 3D Structure Click here
K7LVU7 View 3D Structure Click here
K7M2Y2 View 3D Structure Click here
K7MDV0 View 3D Structure Click here
K7MNB1 View 3D Structure Click here
K7MVZ0 View 3D Structure Click here
K7TY00 View 3D Structure Click here
K7UI42 View 3D Structure Click here
K7VA26 View 3D Structure Click here
M0QWN7 View 3D Structure Click here
M9PD06 View 3D Structure Click here
O00507 View 3D Structure Click here
O01467 View 3D Structure Click here
O22207 View 3D Structure Click here
O24454 View 3D Structure Click here
O44787 View 3D Structure Click here
O60079 View 3D Structure Click here
O60139 View 3D Structure Click here
O74442 View 3D Structure Click here
O75317 View 3D Structure Click here
O75604 View 3D Structure Click here
O88623 View 3D Structure Click here
O94269 View 3D Structure Click here
O94782 View 3D Structure Click here
O94782 View 3D Structure Click here
O94966 View 3D Structure Click here
O96612 View 3D Structure Click here
P0C7H9 View 3D Structure Click here
P0C7I0 View 3D Structure Click here
P15975 View 3D Structure Click here
P25037 View 3D Structure Click here
P32571 View 3D Structure Click here
P34547 View 3D Structure Click here
P35123 View 3D Structure Click here
P35125 View 3D Structure Click here
P36026 View 3D Structure Click here
P38187 View 3D Structure Click here
P38237 View 3D Structure Click here
P39538 View 3D Structure Click here
P39944 View 3D Structure Click here
P39967 View 3D Structure Click here
P40453 View 3D Structure Click here
P40818 View 3D Structure Click here
P43593 View 3D Structure Click here
P45974 View 3D Structure Click here
P50101 View 3D Structure Click here
P50102 View 3D Structure Click here
P51784 View 3D Structure Click here
P52479 View 3D Structure Click here
P53874 View 3D Structure Click here
P54201 View 3D Structure Click here
P54578 View 3D Structure Click here
P56399 View 3D Structure Click here
P57080 View 3D Structure Click here
P62068 View 3D Structure Click here
P62069 View 3D Structure Click here
P70398 View 3D Structure Click here
P91502 View 3D Structure Click here
Q01476 View 3D Structure Click here
Q01477 View 3D Structure Click here
Q02863 View 3D Structure Click here
Q09738 View 3D Structure Click here
Q09879 View 3D Structure Click here
Q09931 View 3D Structure Click here
Q0D3X3 View 3D Structure Click here
Q0DAG6 View 3D Structure Click here
Q0DGV1 View 3D Structure Click here
Q0DUV5 View 3D Structure Click here
Q0DYH3 View 3D Structure Click here
Q0E2F9 View 3D Structure Click here
Q0INA3 View 3D Structure Click here
Q0J0M6 View 3D Structure Click here
Q0J492 View 3D Structure Click here
Q0J4A0 View 3D Structure Click here
Q0JCS2 View 3D Structure Click here
Q0WX57 View 3D Structure Click here
Q11119 View 3D Structure Click here
Q13107 View 3D Structure Click here
Q14694 View 3D Structure Click here
Q17361 View 3D Structure Click here
Q19132 View 3D Structure Click here
Q1MT86 View 3D Structure Click here
Q1MTK1 View 3D Structure Click here
Q1W9P9 View 3D Structure Click here
Q22240 View 3D Structure Click here
Q24574 View 3D Structure Click here
Q2KJ09 View 3D Structure Click here
Q2QZX2 View 3D Structure Click here
Q2R4I5 View 3D Structure Click here
Q33AW7 View 3D Structure Click here
Q3KR59 View 3D Structure Click here
Q3LFD5 View 3D Structure Click here
Q3TIX9 View 3D Structure Click here
Q3UJD6 View 3D Structure Click here
Q3UN04 View 3D Structure Click here
Q3V0C5 View 3D Structure Click here
Q4CL15 View 3D Structure Click here
Q4CRZ3 View 3D Structure Click here
Q4CTT7 View 3D Structure Click here
Q4CTT9 View 3D Structure Click here
Q4CUI7 View 3D Structure Click here
Q4CXY4 View 3D Structure Click here
Q4CYB0 View 3D Structure Click here
Q4D0S8 View 3D Structure Click here
Q4D1W6 View 3D Structure Click here
Q4D313 View 3D Structure Click here
Q4D6N2 View 3D Structure Click here
Q4D6U5 View 3D Structure Click here
Q4DCS7 View 3D Structure Click here
Q4DF80 View 3D Structure Click here
Q4DFS1 View 3D Structure Click here
Q4DG39 View 3D Structure Click here
Q4DMB6 View 3D Structure Click here
Q4DNK8 View 3D Structure Click here
Q4DRN4 View 3D Structure Click here
Q4DS35 View 3D Structure Click here
Q4DTJ5 View 3D Structure Click here
Q4DW10 View 3D Structure Click here
Q4DYG8 View 3D Structure Click here
Q4E0K4 View 3D Structure Click here
Q4E0V5 View 3D Structure Click here
Q4E0W2 View 3D Structure Click here
Q4E259 View 3D Structure Click here
Q4E391 View 3D Structure Click here
Q4E407 View 3D Structure Click here
Q4E680 View 3D Structure Click here
Q4FE55 View 3D Structure Click here
Q4VSI4 View 3D Structure Click here
Q53GS9 View 3D Structure Click here
Q54BB6 View 3D Structure Click here
Q54G37 View 3D Structure Click here
Q54H96 View 3D Structure Click here
Q54PQ7 View 3D Structure Click here
Q54SH6 View 3D Structure Click here
Q54XH4 View 3D Structure Click here
Q556A3 View 3D Structure Click here
Q556A3 View 3D Structure Click here
Q55AP9 View 3D Structure Click here
Q55BC4 View 3D Structure Click here
Q55BI4 View 3D Structure Click here
Q55BP7 View 3D Structure Click here
Q55EJ1 View 3D Structure Click here
Q569C3 View 3D Structure Click here
Q5A675 View 3D Structure Click here
Q5BKP2 View 3D Structure Click here
Q5D006 View 3D Structure Click here
Q5DU02 View 3D Structure Click here
Q5I043 View 3D Structure Click here
Q5JK78 View 3D Structure Click here
Q5U2N2 View 3D Structure Click here
Q5U349 View 3D Structure Click here
Q5VRV7 View 3D Structure Click here
Q61068 View 3D Structure Click here
Q66H62 View 3D Structure Click here
Q67XW5 View 3D Structure Click here
Q69MX3 View 3D Structure Click here
Q6A4J8 View 3D Structure Click here
Q6AYC7 View 3D Structure Click here
Q6IE24 View 3D Structure Click here
Q6J1Y9 View 3D Structure Click here
Q6K8Z3 View 3D Structure Click here
Q6P8X6 View 3D Structure Click here
Q6P9L4 View 3D Structure Click here
Q6QN14 View 3D Structure Click here
Q6R6M4 View 3D Structure Click here
Q6YXC1 View 3D Structure Click here
Q6ZIC7 View 3D Structure Click here
Q6ZJC2 View 3D Structure Click here
Q6ZKX9 View 3D Structure Click here
Q70CQ1 View 3D Structure Click here
Q70CQ3 View 3D Structure Click here
Q70CQ4 View 3D Structure Click here
Q70EK8 View 3D Structure Click here
Q70EK9 View 3D Structure Click here
Q70EL1 View 3D Structure Click here
Q70EL2 View 3D Structure Click here
Q70EL3 View 3D Structure Click here
Q70EL4 View 3D Structure Click here
Q76LT8 View 3D Structure Click here
Q7JKC3 View 3D Structure Click here
Q7JLI8 View 3D Structure Click here
Q7JQI1 View 3D Structure Click here
Q7JW61 View 3D Structure Click here
Q7M764 View 3D Structure Click here
Q7RTZ2 View 3D Structure Click here
Q7ZUM8 View 3D Structure Click here
Q80TQ2 View 3D Structure Click here
Q80U87 View 3D Structure Click here
Q84WC6 View 3D Structure Click here
Q84WU2 View 3D Structure Click here
Q869U4 View 3D Structure Click here
Q86J16 View 3D Structure Click here
Q86KB3 View 3D Structure Click here
Q86KB3 View 3D Structure Click here
Q86T82 View 3D Structure Click here
Q86UV5 View 3D Structure Click here
Q8BJQ2 View 3D Structure Click here
Q8BL06 View 3D Structure Click here
Q8BUM9 View 3D Structure Click here
Q8BW70 View 3D Structure Click here
Q8BWR4 View 3D Structure Click here
Q8BY87 View 3D Structure Click here
Q8C0R0 View 3D Structure Click here
Q8C2S0 View 3D Structure Click here
Q8C6M1 View 3D Structure Click here
Q8C6M1 View 3D Structure Click here
Q8CEG8 View 3D Structure Click here
Q8H148 View 3D Structure Click here
Q8H7M6 View 3D Structure Click here
Q8I077 View 3D Structure Click here
Q8I1U8 View 3D Structure Click here
Q8I1Z5 View 3D Structure Click here
Q8I3A3 View 3D Structure Click here
Q8I3J3 View 3D Structure Click here
Q8I3U1 View 3D Structure Click here
Q8I6Z8 View 3D Structure Click here
Q8ILU9 View 3D Structure Click here
Q8IQ27 View 3D Structure Click here
Q8K387 View 3D Structure Click here
Q8L6Y1 View 3D Structure Click here
Q8LAM0 View 3D Structure Click here
Q8NB14 View 3D Structure Click here
Q8NFA0 View 3D Structure Click here
Q8R5H1 View 3D Structure Click here
Q8R5K2 View 3D Structure Click here
Q8TEY7 View 3D Structure Click here
Q8W4N3 View 3D Structure Click here
Q8WT44 View 3D Structure Click here
Q91W36 View 3D Structure Click here
Q92353 View 3D Structure Click here
Q92995 View 3D Structure Click here
Q93008 View 3D Structure Click here
Q93009 View 3D Structure Click here
Q93875 View 3D Structure Click here
Q93Y01 View 3D Structure Click here
Q949Y0 View 3D Structure Click here
Q96K76 View 3D Structure Click here
Q96RU2 View 3D Structure Click here
Q99K46 View 3D Structure Click here
Q99LG0 View 3D Structure Click here
Q99MX1 View 3D Structure Click here
Q9BKQ6 View 3D Structure Click here
Q9BXU7 View 3D Structure Click here
Q9C585 View 3D Structure Click here
Q9D9M2 View 3D Structure Click here
Q9ES63 View 3D Structure Click here
Q9FHN1 View 3D Structure Click here
Q9FIQ1 View 3D Structure Click here
Q9FKP5 View 3D Structure Click here
Q9FPS0 View 3D Structure Click here
Q9FPS2 View 3D Structure Click here
Q9FPS3 View 3D Structure Click here
Q9FPS4 View 3D Structure Click here
Q9FPS7 View 3D Structure Click here
Q9FPS9 View 3D Structure Click here
Q9FPT1 View 3D Structure Click here
Q9FPT5 View 3D Structure Click here
Q9GRV2 View 3D Structure Click here
Q9H0E7 View 3D Structure Click here
Q9H9J4 View 3D Structure Click here
Q9HBJ7 View 3D Structure Click here
Q9JMA1 View 3D Structure Click here
Q9LEW0 View 3D Structure Click here
Q9MAQ3 View 3D Structure Click here
Q9N5M9 View 3D Structure Click here
Q9NQC7 View 3D Structure Click here
Q9NVE5 View 3D Structure Click here
Q9P275 View 3D Structure Click here
Q9P2H5 View 3D Structure Click here
Q9P3U0 View 3D Structure Click here
Q9P7S5 View 3D Structure Click here
Q9P7V9 View 3D Structure Click here
Q9QZL6 View 3D Structure Click here
Q9R085 View 3D Structure Click here
Q9SB51 View 3D Structure Click here
Q9SCJ9 View 3D Structure Click here
Q9SJA1 View 3D Structure Click here
Q9SSP7 View 3D Structure Click here
Q9SSP9 View 3D Structure Click here
Q9UHP3 View 3D Structure Click here
Q9UK80 View 3D Structure Click here
Q9UMW8 View 3D Structure Click here
Q9UPT9 View 3D Structure Click here
Q9UPU5 View 3D Structure Click here
Q9USM5 View 3D Structure Click here
Q9USR2 View 3D Structure Click here
Q9UTT1 View 3D Structure Click here
Q9UUD6 View 3D Structure Click here
Q9VCT9 View 3D Structure Click here
Q9VDD8 View 3D Structure Click here
Q9VKZ8 View 3D Structure Click here
Q9VRP5 View 3D Structure Click here
Q9VVR1 View 3D Structure Click here
Q9VWP1 View 3D Structure Click here
Q9VYQ8 View 3D Structure Click here
Q9VZU7 View 3D Structure Click here
Q9W0L7 View 3D Structure Click here
Q9W117 View 3D Structure Click here
Q9W462 View 3D Structure Click here
Q9W462 View 3D Structure Click here
Q9W4C3 View 3D Structure Click here
Q9WTV6 View 3D Structure Click here
Q9Y2K6 View 3D Structure Click here
Q9Y2K6 View 3D Structure Click here
Q9Y4E8 View 3D Structure Click here
Q9Y5T5 View 3D Structure Click here
Q9Y6I4 View 3D Structure Click here
Q9ZSB5 View 3D Structure Click here
U4PBM0 View 3D Structure Click here
V6CJY2 View 3D Structure Click here
X1WG21 View 3D Structure Click here