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40  structures 1375  species 0  interactions 10917  sequences 183  architectures

Family: HSF_DNA-bind (PF00447)

Summary: HSF-type DNA-binding

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Heat shock factor". More...

Heat shock factor Edit Wikipedia article

HSF-type DNA-binding
Heat shock factor 3HTS.png
Structure of the dimeric DNA binding domain of the yeast heat shock factor (cyan and green) bound to DNA (brown) based on PDB: 3HTS​.
Identifiers
SymbolHSF_DNA-bind
PfamPF00447
InterProIPR000232
PROSITEPDOC00381
SCOPe1hks / SUPFAM
Vertebrate heat shock transcription factor
Identifiers
SymbolVert_HS_TF
PfamPF06546
InterProIPR010542

In molecular biology, heat shock factors (HSF), are the transcription factors that regulate the expression of the heat shock proteins.[1][2] A typical example is the heat shock factor of Drosophila melanogaster.[3]

Function

Heat shock factors (HSF) are transcriptional activators of heat shock genes.[3] These activators bind specifically to Heat Shock sequence Elements (HSE) throughout the genome[4] whose consensus-sequence is a tandem array of three oppositely oriented "AGAAN" motifs or a degenerate version thereof. Under non-stressed conditions, Drosophila HSF is a nuclear-localized unbound monomer, whereas heat shock activation results in trimerization and binding to the HSE.[5] The Heat Shock sequence Element is highly conserved from yeast to humans.[6]

Heat shock factor 1 (HSF-1) is the major regulator of heat shock protein transcription in eukaryotes. In the absence of cellular stress, HSF-1 is inhibited by association with heat shock proteins and is therefore not active. Cellular stresses, such as increased temperature, can cause proteins in the cell to misfold. Heat shock proteins bind to the misfolded proteins and associate from HSF-1. This allows HSF1 to form trimers and translocate to the cell nucleus and activate transcription.[7] Its function is not only critical to overcome the proteotoxic effects of thermal stress, but also needed for proper animal development and the overall survival of cancer cells.[8][9]

Structure

Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats.[10] Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear in humans.[5] Two sequences flanking the N-terminal zippers fit the consensus of a bi-partite nuclear localization signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus.[10] The DNA-binding component of HSF lies to the N-terminus of the first NLS region, and is referred to as the HSF domain.

Isoforms

Humans express the following heat shock factors:

gene protein
HSF1 heat shock transcription factor 1
HSF2 heat shock transcription factor 2
HSF2BP heat shock transcription factor 2 binding protein
HSF4 heat shock transcription factor 4
HSF5 heat shock transcription factor family member 5
HSFX1 heat shock transcription factor family, X linked 1
HSFX2 heat shock transcription factor family, X linked 2
HSFY1 heat shock transcription factor, Y-linked 1
HSFY2 heat shock transcription factor, Y-linked 2

References

  1. ^ Sorger PK (May 1991). "Heat shock factor and the heat shock response". Cell. 65 (3): 363–6. doi:10.1016/0092-8674(91)90452-5. PMID 2018972.
  2. ^ Morimoto RI (March 1993). "Cells in stress: transcriptional activation of heat shock genes". Science. 259 (5100): 1409–10. Bibcode:1993Sci...259.1409M. doi:10.1126/science.8451637. PMID 8451637.
  3. ^ a b Clos J, Westwood JT, Becker PB, Wilson S, Lambert K, Wu C (November 1990). "Molecular cloning and expression of a hexameric Drosophila heat shock factor subject to negative regulation". Cell. 63 (5): 1085–97. doi:10.1016/0092-8674(90)90511-C. PMID 2257625.
  4. ^ Guertin MJ, Lis JT (September 2010). "Chromatin landscape dictates HSF binding to target DNA elements". PLoS Genet. 6 (9): e1001114. doi:10.1371/journal.pgen.1001114. PMC 2936546. PMID 20844575.
  5. ^ a b Rabindran SK, Giorgi G, Clos J, Wu C (August 1991). "Molecular cloning and expression of a human heat shock factor, HSF1". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 6906–10. Bibcode:1991PNAS...88.6906R. doi:10.1073/pnas.88.16.6906. PMC 52202. PMID 1871105.
  6. ^ Guertin MJ, Petesch SJ, Zobeck KL, Min IM, Lis JT (2010). "Drosophila heat shock system as a general model to investigate transcriptional regulation". Cold Spring Harb. Symp. Quant. Biol. 75: 1–9. doi:10.1101/sqb.2010.75.039. PMC 5967404. PMID 21467139.
  7. ^ Prahlad V, Morimoto RI (February 2009). "Integrating the stress response: lessons for neurodegenerative diseases from C. elegans". Trends Cell Biol. 19 (2): 52–61. doi:10.1016/j.tcb.2008.11.002. PMC 4843516. PMID 19112021.
  8. ^ Salamanca HH, Fuda N, Shi H, Lis JT (August 2011). "An RNA aptamer perturbs heat shock transcription factor activity in Drosophila melanogaster". Nucleic Acids Res. 39 (15): 6729–40. doi:10.1093/nar/gkr206. PMC 3159435. PMID 21576228.
  9. ^ Salamanca HH, Antonyak MA, Cerione RA, Shi H, Lis JT (2014). "Inhibiting heat shock factor 1 in human cancer cells with a potent RNA aptamer". PLoS ONE. 9 (5): e96330. Bibcode:2014PLoSO...996330S. doi:10.1371/journal.pone.0096330. PMC 4011729. PMID 24800749.
  10. ^ a b Schuetz TJ, Gallo GJ, Sheldon L, Tempst P, Kingston RE (August 1991). "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans". Proc. Natl. Acad. Sci. U.S.A. 88 (16): 6911–5. Bibcode:1991PNAS...88.6911S. doi:10.1073/pnas.88.16.6911. PMC 52203. PMID 1871106.
This article incorporates text from the public domain Pfam and InterPro: IPR000232

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

HSF-type DNA-binding Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000232

Heat shock factor (HSF) is a transcriptional activator of heat shock genes [ PUBMED:2257625 , PUBMED:19864465 ]: it binds specifically to heat shock promoter elements, which are palindromic sequences rich with repetitive purine and pyrimidine motifs [ PUBMED:2257625 ]. Under normal conditions, HSF is a homo-trimeric cytoplasmic protein, but heat shock activation results in relocalisation to the nucleus [ PUBMED:1871105 ]. Each HSF monomer contains one C-terminal and three N-terminal leucine zipper repeats [ PUBMED:1871106 ]. Point mutations in these regions result in disruption of cellular localisation, rendering the protein constitutively nuclear [ PUBMED:1871105 ]. Two sequences flanking the N-terminal zippers fit the consensus of a bi- partite nuclear localisation signal (NLS). Interaction between the N- and C-terminal zippers may result in a structure that masks the NLS sequences: following activation of HSF, these may then be unmasked, resulting in relocalisation of the protein to the nucleus [ PUBMED:1871106 ]. The DNA-binding component of HSF lies to the N terminus of the first NLS region, and is referred to as the HSF domain.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan HTH (CL0123), which has the following description:

This family contains a diverse range of mostly DNA-binding domains that contain a helix-turn-helix motif.

The clan contains the following 353 members:

AbiEi_3_N AbiEi_4 ANAPC2 AphA_like AraR_C Arg_repressor ARID ArsR B-block_TFIIIC B5 Bac_DnaA_C Baculo_PEP_N BetR BHD_3 BLACT_WH Bot1p BrkDBD BsuBI_PstI_RE_N C_LFY_FLO CaiF_GrlA CarD_CdnL_TRCF CDC27 Cdc6_C Cdh1_DBD_1 CDT1 CDT1_C CENP-B_N Costars CPSase_L_D3 Cro Crp CSN4_RPN5_eIF3a CSN8_PSD8_EIF3K CtsR Cullin_Nedd8 CUT CUTL CvfB_WH DBD_HTH DDRGK DEP Dimerisation Dimerisation2 DNA_meth_N DpnI_C DprA_WH DsrC DsrD DUF1016_N DUF1133 DUF1153 DUF1323 DUF134 DUF1441 DUF1492 DUF1495 DUF1670 DUF1804 DUF1819 DUF1836 DUF1870 DUF2089 DUF2250 DUF2316 DUF2513 DUF2582 DUF3116 DUF3253 DUF3853 DUF3860 DUF3908 DUF433 DUF4364 DUF4423 DUF4447 DUF480 DUF4817 DUF5635 DUF573 DUF6088 DUF6262 DUF6362 DUF6432 DUF6462 DUF6471 DUF722 DUF739 DUF742 DUF977 E2F_TDP EAP30 eIF-5_eIF-2B ELL ESCRT-II Ets EutK_C Exc F-112 FaeA Fe_dep_repr_C Fe_dep_repress FeoC FokI_C FokI_N Forkhead FtsK_gamma FUR GcrA GerE GntR GP3_package HARE-HTH HemN_C HNF-1_N Homeobox_KN Homeodomain Homez HPD HrcA_DNA-bdg HSF_DNA-bind HTH_1 HTH_10 HTH_11 HTH_12 HTH_13 HTH_15 HTH_16 HTH_17 HTH_18 HTH_19 HTH_20 HTH_21 HTH_22 HTH_23 HTH_24 HTH_25 HTH_26 HTH_27 HTH_28 HTH_29 HTH_3 HTH_30 HTH_31 HTH_32 HTH_33 HTH_34 HTH_35 HTH_36 HTH_37 HTH_38 HTH_39 HTH_40 HTH_41 HTH_42 HTH_43 HTH_45 HTH_46 HTH_47 HTH_48 HTH_49 HTH_5 HTH_50 HTH_51 HTH_52 HTH_53 HTH_54 HTH_55 HTH_56 HTH_57 HTH_58 HTH_59 HTH_6 HTH_7 HTH_8 HTH_9 HTH_ABP1_N HTH_AraC HTH_AsnC-type HTH_CodY HTH_Crp_2 HTH_DeoR HTH_IclR HTH_Mga HTH_micro HTH_OrfB_IS605 HTH_PafC HTH_ParB HTH_psq HTH_SUN2 HTH_Tnp_1 HTH_Tnp_1_2 HTH_Tnp_4 HTH_Tnp_IS1 HTH_Tnp_IS630 HTH_Tnp_ISL3 HTH_Tnp_Mu_1 HTH_Tnp_Mu_2 HTH_Tnp_Tc3_1 HTH_Tnp_Tc3_2 HTH_Tnp_Tc5 HTH_WhiA HxlR IBD IF2_N IRF KicB KilA-N Kin17_mid KORA KorB La LacI LexA_DNA_bind Linker_histone LZ_Tnp_IS481 MADF_DNA_bdg MAGE MARF1_LOTUS MarR MarR_2 MerR MerR-DNA-bind MerR_1 MerR_2 Mga Mnd1 MogR_DNAbind Mor MotA_activ MqsA_antitoxin MRP-L20 MukE Myb_DNA-bind_2 Myb_DNA-bind_3 Myb_DNA-bind_4 Myb_DNA-bind_5 Myb_DNA-bind_6 Myb_DNA-bind_7 Myb_DNA-binding Neugrin NFRKB_winged NOD2_WH NUMOD1 ORC_WH_C OST-HTH P22_Cro PaaX PadR PapB PAX PCI Penicillinase_R Phage_AlpA Phage_antitermQ Phage_CI_repr Phage_CII Phage_NinH Phage_Nu1 Phage_rep_O Phage_rep_org_N Phage_terminase PheRS_DBD1 PheRS_DBD2 PheRS_DBD3 Pou Pox_D5 PqqD PRC2_HTH_1 PUFD PuR_N Put_DNA-bind_N pXO2-72 Raf1_HTH Rap1-DNA-bind Rep_3 RepA_C RepA_N RepC RepL Replic_Relax RFX_DNA_binding Ribosomal_S18 Ribosomal_S19e Ribosomal_S25 Rio2_N RNA_pol_Rpc34 RNA_pol_Rpc82 RNase_H2-Ydr279 ROQ_II RP-C RPA RPA_C RQC Rrf2 RTP RuvB_C S10_plectin SAC3_GANP SANT_DAMP1_like SatD SelB-wing_1 SelB-wing_2 SelB-wing_3 SgrR_N Sigma54_CBD Sigma54_DBD Sigma70_ECF Sigma70_ner Sigma70_r2 Sigma70_r3 Sigma70_r4 Sigma70_r4_2 SinI Ski_Sno SLIDE Slx4 SMC_Nse1 SMC_ScpB SoPB_HTH SpoIIID SRP19 SRP_SPB STN1_2 Sulfolobus_pRN Suv3_N Swi6_N SWIRM Tau95 TBPIP TEA Terminase_5 TetR_N TFA2_Winged_2 TFIIE_alpha TFIIE_beta TFIIF_alpha TFIIF_beta Tn7_Tnp_TnsA_C Tn916-Xis TraI_2_C Trans_reg_C TrfA TrmB tRNA_bind_2 tRNA_bind_3 Trp_repressor UPF0122 UPF0175 Vir_act_alpha_C YdaS_antitoxin YjcQ YokU z-alpha

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(361)
Full
(10917)
Representative proteomes UniProt
(23669)
RP15
(2121)
RP35
(5489)
RP55
(8843)
RP75
(11711)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(361)
Full
(10917)
Representative proteomes UniProt
(23669)
RP15
(2121)
RP35
(5489)
RP55
(8843)
RP75
(11711)
Alignment:
Format:
Order:
Sequence:
Gaps:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(361)
Full
(10917)
Representative proteomes UniProt
(23669)
RP15
(2121)
RP35
(5489)
RP55
(8843)
RP75
(11711)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 361
Number in full: 10917
Average length of the domain: 95.90 aa
Average identity of full alignment: 39 %
Average coverage of the sequence by the domain: 22.12 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.0 22.0
Trusted cut-off 22.0 22.0
Noise cut-off 21.9 21.9
Model length: 98
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HSF_DNA-bind domain has been found. There are 40 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A060D1R4 View 3D Structure Click here
A0A096MK39 View 3D Structure Click here
A0A0R0I4X8 View 3D Structure Click here
A0A0R0IB42 View 3D Structure Click here
A0A1B0GTS1 View 3D Structure Click here
A0A1B0GWH4 View 3D Structure Click here
A0A1D6ERG1 View 3D Structure Click here
A0A1D6FU61 View 3D Structure Click here
A0A1D6FZU3 View 3D Structure Click here
A0A1D6GD30 View 3D Structure Click here
A0A1D6H8P4 View 3D Structure Click here
A0A1D6I5R2 View 3D Structure Click here
A0A1D6I9E7 View 3D Structure Click here
A0A1D6K415 View 3D Structure Click here
A0A1D6KL41 View 3D Structure Click here
A0A1D6L3W5 View 3D Structure Click here
A0A1D6L7L6 View 3D Structure Click here
A0A1D6LC63 View 3D Structure Click here
A0A1D6MA83 View 3D Structure Click here
A0A1D6NI85 View 3D Structure Click here
A0A1D6NJY6 View 3D Structure Click here
A0A1D6PG44 View 3D Structure Click here
A0A1D6QJG3 View 3D Structure Click here
A0A2R8QAT5 View 3D Structure Click here
A0A368UHX6 View 3D Structure Click here
A4QNW9 View 3D Structure Click here
B4FXG7 View 3D Structure Click here
B6SQ49 View 3D Structure Click here
B6SVD5 View 3D Structure Click here
B6SWQ2 View 3D Structure Click here
B6TMF9 View 3D Structure Click here
B7ZXV6 View 3D Structure Click here
B8A239 View 3D Structure Click here
C6T7A7 View 3D Structure Click here
D0VYS2 View 3D Structure Click here
E9QH11 View 3D Structure Click here
F1MAF1 View 3D Structure Click here
F6P697 View 3D Structure Click here
G5EFT5 View 3D Structure Click here
I1J4T4 View 3D Structure Click here
I1J7X9 View 3D Structure Click here
I1JA48 View 3D Structure Click here
I1JAM5 View 3D Structure Click here
I1JIV9 View 3D Structure Click here
I1JNB9 View 3D Structure Click here
I1JPX4 View 3D Structure Click here
I1JTX5 View 3D Structure Click here
I1K3S2 View 3D Structure Click here
I1K431 View 3D Structure Click here
I1K5I6 View 3D Structure Click here
I1KQD5 View 3D Structure Click here
I1KS63 View 3D Structure Click here
I1L3A9 View 3D Structure Click here
I1L4I1 View 3D Structure Click here
I1L7E2 View 3D Structure Click here
I1LFY6 View 3D Structure Click here
I1LGH5 View 3D Structure Click here
I1LHE9 View 3D Structure Click here
I1LY11 View 3D Structure Click here
I1LZF5 View 3D Structure Click here
I1M0B3 View 3D Structure Click here
I1M1P7 View 3D Structure Click here
I1M761 View 3D Structure Click here
I1M939 View 3D Structure Click here
I1MEV9 View 3D Structure Click here
I1MMC1 View 3D Structure Click here
I1MPZ9 View 3D Structure Click here
I1MVX9 View 3D Structure Click here
I1MXN2 View 3D Structure Click here
I1N8Z6 View 3D Structure Click here
I1N9K5 View 3D Structure Click here
I1NDX7 View 3D Structure Click here
I1NGK0 View 3D Structure Click here
I1NGR6 View 3D Structure Click here
K7KFB6 View 3D Structure Click here
K7KP87 View 3D Structure Click here
K7L3H6 View 3D Structure Click here
K7L661 View 3D Structure Click here
K7LH36 View 3D Structure Click here
K7LHS6 View 3D Structure Click here
K7LL72 View 3D Structure Click here
K7MK25 View 3D Structure Click here
K7MNF6 View 3D Structure Click here
K7MZ65 View 3D Structure Click here
K7U5Y9 View 3D Structure Click here
K7V9Y4 View 3D Structure Click here
K7VH39 View 3D Structure Click here
K7W4M8 View 3D Structure Click here
O14283 View 3D Structure Click here
O22230 View 3D Structure Click here
O49402 View 3D Structure Click here
O49402 View 3D Structure Click here
O49403 View 3D Structure Click here
O80982 View 3D Structure Click here
O81821 View 3D Structure Click here
P10961 View 3D Structure Click here
P20134 View 3D Structure Click here
P22813 View 3D Structure Click here
P38532 View 3D Structure Click here
P38533 View 3D Structure Click here
P38889 View 3D Structure Click here
P41151 View 3D Structure Click here
P47175 View 3D Structure Click here
P53050 View 3D Structure Click here
Q00613 View 3D Structure Click here
Q00M68 View 3D Structure Click here
Q00M81 View 3D Structure Click here
Q02953 View 3D Structure Click here
Q03933 View 3D Structure Click here
Q0DBL6 View 3D Structure Click here
Q10KX8 View 3D Structure Click here
Q10PR4 View 3D Structure Click here
Q1PDN3 View 3D Structure Click here
Q338B0 View 3D Structure Click here
Q43457 View 3D Structure Click here
Q4G112 View 3D Structure Click here
Q54UC1 View 3D Structure Click here
Q5A287 View 3D Structure Click here
Q5A4X5 View 3D Structure Click here
Q5AK51 View 3D Structure Click here
Q5AQ33 View 3D Structure Click here
Q5ND04 View 3D Structure Click here
Q5XIQ7 View 3D Structure Click here
Q5Z6A4 View 3D Structure Click here
Q652B0 View 3D Structure Click here
Q657C0 View 3D Structure Click here
Q67TP9 View 3D Structure Click here
Q67U94 View 3D Structure Click here
Q67XK8 View 3D Structure Click here
Q6EUG4 View 3D Structure Click here
Q6F388 View 3D Structure Click here
Q6H6Q7 View 3D Structure Click here
Q6K6S5 View 3D Structure Click here
Q6VBA4 View 3D Structure Click here
Q6VBB2 View 3D Structure Click here
Q6Z9C8 View 3D Structure Click here
Q6Z9R8 View 3D Structure Click here
Q7SZW8 View 3D Structure Click here
Q7XHZ0 View 3D Structure Click here
Q7XRX3 View 3D Structure Click here
Q80Y37 View 3D Structure Click here
Q84MN7 View 3D Structure Click here
Q84T61 View 3D Structure Click here
Q8GYY1 View 3D Structure Click here
Q8H7Y6 View 3D Structure Click here
Q8L7H2 View 3D Structure Click here
Q93VB5 View 3D Structure Click here
Q942D6 View 3D Structure Click here
Q94BZ5 View 3D Structure Click here
Q94J16 View 3D Structure Click here
Q96320 View 3D Structure Click here
Q96LI6 View 3D Structure Click here
Q9C635 View 3D Structure Click here
Q9FK72 View 3D Structure Click here
Q9LQM7 View 3D Structure Click here
Q9LUH8 View 3D Structure Click here
Q9LV52 View 3D Structure Click here
Q9LVW2 View 3D Structure Click here
Q9M1V5 View 3D Structure Click here
Q9R0L1 View 3D Structure Click here
Q9R120 View 3D Structure Click here
Q9S7U5 View 3D Structure Click here
Q9SCW4 View 3D Structure Click here
Q9SCW5 View 3D Structure Click here
Q9SV12 View 3D Structure Click here
Q9T0D3 View 3D Structure Click here
Q9UBD0 View 3D Structure Click here
Q9ULV5 View 3D Structure Click here
Q9W2C1 View 3D Structure Click here