Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
32  structures 2477  species 0  interactions 24713  sequences 360  architectures

Family: Peptidase_S10 (PF00450)

Summary: Serine carboxypeptidase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Serine carboxypeptidase Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001563

This group of serine peptidases belong to MEROPS peptidase family S10 (clan SC). The type example is carboxypeptidase Y from Saccharomyces cerevisiae (Baker's yeast) [ PUBMED:7845208 ].

All known carboxypeptidases are either metallo carboxypeptidases or serine carboxypeptidases ( EC and EC ). The catalytic activity of the serine carboxypeptidases, like that of the trypsin family serine proteases, is provided by a charge relay system involving an aspartic acid residue hydrogen-bonded to a histidine, which is itself hydrogen-bonded to a serine [ PUBMED:2324088 ]. The sequences surrounding the active site serine and histidine residues are highly conserved in all the serine carboxypeptidases.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(50)
Full
(24713)
Representative proteomes UniProt
(44690)
RP15
(3964)
RP35
(12396)
RP55
(20390)
RP75
(27441)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(50)
Full
(24713)
Representative proteomes UniProt
(44690)
RP15
(3964)
RP35
(12396)
RP55
(20390)
RP75
(27441)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(50)
Full
(24713)
Representative proteomes UniProt
(44690)
RP15
(3964)
RP35
(12396)
RP55
(20390)
RP75
(27441)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: serine_carbpept;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD
Number in seed: 50
Number in full: 24713
Average length of the domain: 331.50 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 79.46 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.9 21.9
Trusted cut-off 21.9 21.9
Noise cut-off 21.8 21.8
Model length: 416
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Peptidase_S10 domain has been found. There are 32 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KHD8 View 3D Structure Click here
A0A0N7KM71 View 3D Structure Click here
A0A0N7KT99 View 3D Structure Click here
A0A0P0UZR3 View 3D Structure Click here
A0A0P0VYA8 View 3D Structure Click here
A0A0P0VZ12 View 3D Structure Click here
A0A0P0VZ46 View 3D Structure Click here
A0A0P0VZ77 View 3D Structure Click here
A0A0P0W2K4 View 3D Structure Click here
A0A0P0W2K4 View 3D Structure Click here
A0A0P0WUI9 View 3D Structure Click here
A0A0P0WX88 View 3D Structure Click here
A0A0P0WXW0 View 3D Structure Click here
A0A0P0XMW3 View 3D Structure Click here
A0A0P0XMW9 View 3D Structure Click here
A0A0P0XMW9 View 3D Structure Click here
A0A0P0XNB0 View 3D Structure Click here
A0A0P0XX22 View 3D Structure Click here
A0A0P0Y234 View 3D Structure Click here
A0A0P0Y283 View 3D Structure Click here
A0A0P0Y2H0 View 3D Structure Click here
A0A0P0Y2J3 View 3D Structure Click here
A0A0P0YBR5 View 3D Structure Click here
A0A0P0YBR5 View 3D Structure Click here
A0A0R0E5C1 View 3D Structure Click here
A0A0R0EBE6 View 3D Structure Click here
A0A0R0EH71 View 3D Structure Click here
A0A0R0EHS1 View 3D Structure Click here
A0A0R0F812 View 3D Structure Click here
A0A0R0F812 View 3D Structure Click here
A0A0R0FVK4 View 3D Structure Click here
A0A0R0GRD6 View 3D Structure Click here
A0A0R0GRD6 View 3D Structure Click here
A0A0R0GRD6 View 3D Structure Click here
A0A0R0GUZ3 View 3D Structure Click here
A0A0R0H625 View 3D Structure Click here
A0A0R0HGQ8 View 3D Structure Click here
A0A0R0HPH3 View 3D Structure Click here
A0A0R0HR11 View 3D Structure Click here
A0A0R0HVN0 View 3D Structure Click here
A0A0R0IAW3 View 3D Structure Click here
A0A0R0IF74 View 3D Structure Click here
A0A0R0J7C6 View 3D Structure Click here
A0A0R0JCA1 View 3D Structure Click here
A0A0R0JHG3 View 3D Structure Click here
A0A0R0JSZ7 View 3D Structure Click here
A0A0R0KI66 View 3D Structure Click here
A0A0R0KP39 View 3D Structure Click here
A0A0R0KQK3 View 3D Structure Click here
A0A0R0KXY5 View 3D Structure Click here
A0A0R4ILY1 View 3D Structure Click here
A0A0R4J5A3 View 3D Structure Click here
A0A1D6DU91 View 3D Structure Click here
A0A1D6E5R4 View 3D Structure Click here
A0A1D6E5R4 View 3D Structure Click here
A0A1D6E9P4 View 3D Structure Click here
A0A1D6EC53 View 3D Structure Click here
A0A1D6EC53 View 3D Structure Click here
A0A1D6EL24 View 3D Structure Click here
A0A1D6EMM4 View 3D Structure Click here
A0A1D6EMM5 View 3D Structure Click here
A0A1D6ERI7 View 3D Structure Click here
A0A1D6ERU3 View 3D Structure Click here
A0A1D6ERU3 View 3D Structure Click here
A0A1D6ERU4 View 3D Structure Click here
A0A1D6F2R4 View 3D Structure Click here
A0A1D6F2R4 View 3D Structure Click here
A0A1D6F5R6 View 3D Structure Click here
A0A1D6FI17 View 3D Structure Click here
A0A1D6FI17 View 3D Structure Click here
A0A1D6FZZ8 View 3D Structure Click here
A0A1D6G8V7 View 3D Structure Click here
A0A1D6GTH0 View 3D Structure Click here
A0A1D6GTH7 View 3D Structure Click here
A0A1D6H4G7 View 3D Structure Click here
A0A1D6H7X7 View 3D Structure Click here
A0A1D6H7X8 View 3D Structure Click here
A0A1D6HE50 View 3D Structure Click here
A0A1D6HN58 View 3D Structure Click here
A0A1D6HVT8 View 3D Structure Click here
A0A1D6I612 View 3D Structure Click here
A0A1D6I612 View 3D Structure Click here
A0A1D6I613 View 3D Structure Click here
A0A1D6I613 View 3D Structure Click here
A0A1D6I614 View 3D Structure Click here
A0A1D6I617 View 3D Structure Click here
A0A1D6I617 View 3D Structure Click here
A0A1D6I617 View 3D Structure Click here
A0A1D6I6N5 View 3D Structure Click here
A0A1D6IX23 View 3D Structure Click here
A0A1D6J5H2 View 3D Structure Click here
A0A1D6J5H2 View 3D Structure Click here
A0A1D6J635 View 3D Structure Click here
A0A1D6J7K4 View 3D Structure Click here
A0A1D6K4N6 View 3D Structure Click here
A0A1D6K4N7 View 3D Structure Click here
A0A1D6K4Y8 View 3D Structure Click here
A0A1D6K7R1 View 3D Structure Click here
A0A1D6LWI2 View 3D Structure Click here
A0A1D6M0I7 View 3D Structure Click here
A0A1D6MDV5 View 3D Structure Click here
A0A1D6ML29 View 3D Structure Click here
A0A1D6N7T8 View 3D Structure Click here
A0A1D6NTJ2 View 3D Structure Click here
A0A1D6P7Q0 View 3D Structure Click here
A0A1D6P7Y3 View 3D Structure Click here
A0A1D6P7Y3 View 3D Structure Click here
A0A1D6PNQ4 View 3D Structure Click here
A0A1D6PS11 View 3D Structure Click here
A0A1D6PTL8 View 3D Structure Click here
A0A1D6PZC2 View 3D Structure Click here
A0A1D6PZC2 View 3D Structure Click here
A0A1D8PDM9 View 3D Structure Click here
A0A1D8PN69 View 3D Structure Click here
A0A1D8PRC2 View 3D Structure Click here
A0A2R8PXL7 View 3D Structure Click here
A0A368UI30 View 3D Structure Click here
A4HXS0 View 3D Structure Click here
B4FBF2 View 3D Structure Click here
B4FRC3 View 3D Structure Click here
B4FWQ4 View 3D Structure Click here
B4G126 View 3D Structure Click here
B6SYG2 View 3D Structure Click here
B6TXF8 View 3D Structure Click here
B8A0Q3 View 3D Structure Click here
C0P3N6 View 3D Structure Click here
C0P3N6 View 3D Structure Click here
C0P7P2 View 3D Structure Click here
C0P8L3 View 3D Structure Click here
C0PED9 View 3D Structure Click here
C0PHM0 View 3D Structure Click here
C4JBF7 View 3D Structure Click here
F1QYP6 View 3D Structure Click here
G5EDP0 View 3D Structure Click here
H2KW63 View 3D Structure Click here
I1JGQ5 View 3D Structure Click here
I1JM17 View 3D Structure Click here
I1JN31 View 3D Structure Click here
I1JN35 View 3D Structure Click here
I1JWD2 View 3D Structure Click here
I1JXP6 View 3D Structure Click here
I1KBY4 View 3D Structure Click here
I1KLG0 View 3D Structure Click here
I1KWE7 View 3D Structure Click here
I1KWR6 View 3D Structure Click here
I1L5K6 View 3D Structure Click here
I1L697 View 3D Structure Click here
I1LA88 View 3D Structure Click here
I1LCV9 View 3D Structure Click here
I1LD24 View 3D Structure Click here
I1LIR5 View 3D Structure Click here
I1LL06 View 3D Structure Click here
I1LL09 View 3D Structure Click here
I1LM53 View 3D Structure Click here
I1LNY6 View 3D Structure Click here
I1LPI4 View 3D Structure Click here
I1LPI7 View 3D Structure Click here
I1LRA7 View 3D Structure Click here
I1LTM8 View 3D Structure Click here
I1LXX8 View 3D Structure Click here
I1LXY0 View 3D Structure Click here
I1M0E8 View 3D Structure Click here
I1M1K5 View 3D Structure Click here
I1M294 View 3D Structure Click here
I1M4G0 View 3D Structure Click here
I1M4H1 View 3D Structure Click here
I1M8J3 View 3D Structure Click here
I1MAF1 View 3D Structure Click here
I1MED8 View 3D Structure Click here
I1MGT5 View 3D Structure Click here
I1MNL7 View 3D Structure Click here
I1MRU5 View 3D Structure Click here
I1MT17 View 3D Structure Click here
I1MXR6 View 3D Structure Click here
I1N3Z7 View 3D Structure Click here
I1N4K0 View 3D Structure Click here
I1N4Y5 View 3D Structure Click here
I1N8P9 View 3D Structure Click here
I1N8Q1 View 3D Structure Click here
I1ND84 View 3D Structure Click here
I1ND90 View 3D Structure Click here
I1NHE6 View 3D Structure Click here
K7KKK0 View 3D Structure Click here
K7KM24 View 3D Structure Click here
K7KUN7 View 3D Structure Click here
K7KVS1 View 3D Structure Click here
K7L2B6 View 3D Structure Click here
K7L888 View 3D Structure Click here
K7LIK2 View 3D Structure Click here
K7LQ97 View 3D Structure Click here
K7LX88 View 3D Structure Click here
K7MQY5 View 3D Structure Click here
K7MTJ7 View 3D Structure Click here
K7MY41 View 3D Structure Click here
K7N0R1 View 3D Structure Click here
K7N0R3 View 3D Structure Click here
K7N1G9 View 3D Structure Click here
K7N217 View 3D Structure Click here
K7TPY5 View 3D Structure Click here
K7VCZ3 View 3D Structure Click here
K8ESM2 View 3D Structure Click here
K8ESM2 View 3D Structure Click here
K8ESM2 View 3D Structure Click here
K8ESM2 View 3D Structure Click here
O04084 View 3D Structure Click here
O13849 View 3D Structure Click here
O23364 View 3D Structure Click here
O60123 View 3D Structure Click here
O64810 View 3D Structure Click here
O64811 View 3D Structure Click here
O76725 View 3D Structure Click here
O81009 View 3D Structure Click here
O82229 View 3D Structure Click here
P00729 View 3D Structure Click here
P09620 View 3D Structure Click here
P10619 View 3D Structure Click here
P16675 View 3D Structure Click here
P32825 View 3D Structure Click here
P32826 View 3D Structure Click here
P37890 View 3D Structure Click here
P37891 View 3D Structure Click here
P38109 View 3D Structure Click here
P52712 View 3D Structure Click here
P52715 View 3D Structure Click here
P52716 View 3D Structure Click here
P52717 View 3D Structure Click here
Q09991 View 3D Structure Click here
Q0D401 View 3D Structure Click here
Q0D9A6 View 3D Structure Click here
Q0DRG7 View 3D Structure Click here
Q0ISU2 View 3D Structure Click here
Q0JBL4 View 3D Structure Click here
Q0WPR4 View 3D Structure Click here
Q0WRX3 View 3D Structure Click here
Q10A76 View 3D Structure Click here
Q10DG0 View 3D Structure Click here
Q10DG3 View 3D Structure Click here
Q10K80 View 3D Structure Click here
Q10QL9 View 3D Structure Click here
Q1PF08 View 3D Structure Click here
Q2R3G8 View 3D Structure Click here
Q2R5M2 View 3D Structure Click here
Q2R8W8 View 3D Structure Click here
Q2V465 View 3D Structure Click here
Q33BK5 View 3D Structure Click here
Q4CMQ4 View 3D Structure Click here
Q4CMQ5 View 3D Structure Click here
Q4DTP6 View 3D Structure Click here
Q4DTP7 View 3D Structure Click here
Q4PSY2 View 3D Structure Click here
Q4QR71 View 3D Structure Click here
Q54DY7 View 3D Structure Click here
Q54VW1 View 3D Structure Click here
Q56WF8 View 3D Structure Click here
Q5AFP8 View 3D Structure Click here
Q5QLC0 View 3D Structure Click here
Q5SMV5 View 3D Structure Click here
Q5W6C5 View 3D Structure Click here
Q5W727 View 3D Structure Click here
Q5ZA19 View 3D Structure Click here
Q5ZA26 View 3D Structure Click here
Q5ZCC2 View 3D Structure Click here
Q67Y83 View 3D Structure Click here
Q6AYS3 View 3D Structure Click here
Q6H7I7 View 3D Structure Click here
Q6K4Y0 View 3D Structure Click here
Q6K673 View 3D Structure Click here
Q6YYX5 View 3D Structure Click here
Q6ZH05 View 3D Structure Click here
Q75HY1 View 3D Structure Click here
Q75HY2 View 3D Structure Click here
Q75I01 View 3D Structure Click here
Q75KN5 View 3D Structure Click here
Q7F9I3 View 3D Structure Click here
Q7X7Y5 View 3D Structure Click here
Q7XSG1 View 3D Structure Click here
Q7ZU43 View 3D Structure Click here
Q84W27 View 3D Structure Click here
Q84WF0 View 3D Structure Click here
Q869Q8 View 3D Structure Click here
Q8H780 View 3D Structure Click here
Q8IP31 View 3D Structure Click here
Q8IRI8 View 3D Structure Click here
Q8L7B2 View 3D Structure Click here
Q8L9Y0 View 3D Structure Click here
Q8RUW5 View 3D Structure Click here
Q8RWJ6 View 3D Structure Click here
Q8S8K6 View 3D Structure Click here
Q8S8P0 View 3D Structure Click here
Q8VY01 View 3D Structure Click here
Q8VZU3 View 3D Structure Click here
Q920A5 View 3D Structure Click here
Q920A6 View 3D Structure Click here
Q93Y09 View 3D Structure Click here
Q94269 View 3D Structure Click here
Q94269 View 3D Structure Click here
Q94269 View 3D Structure Click here
Q94269 View 3D Structure Click here
Q949Q7 View 3D Structure Click here
Q9C7D2 View 3D Structure Click here
Q9C7D3 View 3D Structure Click here
Q9C7D4 View 3D Structure Click here
Q9C7D6 View 3D Structure Click here
Q9C7Z9 View 3D Structure Click here
Q9CAU0 View 3D Structure Click here
Q9CAU1 View 3D Structure Click here
Q9CAU2 View 3D Structure Click here
Q9CAU3 View 3D Structure Click here
Q9CAU4 View 3D Structure Click here
Q9D3S9 View 3D Structure Click here
Q9FFB0 View 3D Structure Click here
Q9FFB2 View 3D Structure Click here
Q9FFB2 View 3D Structure Click here
Q9FH05 View 3D Structure Click here
Q9FH06 View 3D Structure Click here
Q9FP87 View 3D Structure Click here
Q9H3G5 View 3D Structure Click here
Q9HB40 View 3D Structure Click here
Q9LEY1 View 3D Structure Click here
Q9LSM9 View 3D Structure Click here
Q9LSV8 View 3D Structure Click here
Q9LXY6 View 3D Structure Click here
Q9M099 View 3D Structure Click here
Q9M9Q6 View 3D Structure Click here
Q9MAR8 View 3D Structure Click here
Q9SFB5 View 3D Structure Click here
Q9SQX6 View 3D Structure Click here
Q9SV02 View 3D Structure Click here
Q9SV04 View 3D Structure Click here
Q9VDT5 View 3D Structure Click here
Q9VJN0 View 3D Structure Click here
Q9W0N8 View 3D Structure Click here
Q9ZQQ0 View 3D Structure Click here
Q9ZUG3 View 3D Structure Click here