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164  structures 7393  species 0  interactions 26068  sequences 175  architectures

Family: Inositol_P (PF00459)

Summary: Inositol monophosphatase family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

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Inositol monophosphatase family Provide feedback

No Pfam abstract.

Literature references

  1. York JD, Ponder JW, Chen ZW, Mathews FS, Majerus PW; , Biochemistry 1994;33:13164-13171.: Crystal structure of inositol polyphosphate 1-phosphatase at 2.3-A resolution. PUBMED:7947723 EPMC:7947723


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000760

It has been shown that several proteins share two sequence motifs [ PUBMED:1660408 ]. Two of these proteins, vertebrate and plant inositol monophosphatase ( EC ), and vertebrate inositol polyphosphate 1-phosphatase ( EC ), are enzymes of the inositol phosphate second messenger signalling pathway, and share similar enzyme activity. Both enzymes exhibit an absolute requirement for metal ions (Mg2 is preferred), and their amino acid sequences contain a number of conserved motifs, which are also shared by several other proteins related to MPTASE (including products of fungal QaX and qutG, bacterial suhB and cysQ, and yeast hal2) [ PUBMED:7761465 ]. The function of the other proteins is not yet clear, but it is suggested that they may act by enhancing the synthesis or degradation of phosphorylated messenger molecules [ PUBMED:1660408 ]. Structural analysis of these proteins has revealed a common core of 155 residues, which includes residues essential for metal binding and catalysis. An interesting property of the enzymes of this family is their sensitivity to Li+. The targets and mechanism of action of Li+ are unknown, but overactive inositol phosphate signalling may account for symptoms of manic depression [ PUBMED:2553271 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Phospoesterase (CL0171), which has the following description:

Members of this clan show metal-dependent / lithium sensitive phosphomonoesterase activity. The clan includes inositol polyphosphate 1 phosphatase and fructose 1,6-bisphosphatase [1].

The clan contains the following 3 members:

FBPase FBPase_glpX Inositol_P

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(44)
Full
(26068)
Representative proteomes UniProt
(100199)
RP15
(3454)
RP35
(11712)
RP55
(25104)
RP75
(41454)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(44)
Full
(26068)
Representative proteomes UniProt
(100199)
RP15
(3454)
RP35
(11712)
RP55
(25104)
RP75
(41454)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(44)
Full
(26068)
Representative proteomes UniProt
(100199)
RP15
(3454)
RP35
(11712)
RP55
(25104)
RP75
(41454)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: inositol_P;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Griffiths-Jones SR
Number in seed: 44
Number in full: 26068
Average length of the domain: 259.40 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 90.93 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.5 20.5
Trusted cut-off 20.5 20.5
Noise cut-off 20.4 20.4
Model length: 272
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Inositol_P domain has been found. There are 164 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0XL79 View 3D Structure Click here
A0A0P0Y8A3 View 3D Structure Click here
A0A0R0G583 View 3D Structure Click here
A0A0R0G610 View 3D Structure Click here
A0A1D6FBS3 View 3D Structure Click here
A0A1D6IF45 View 3D Structure Click here
A0A1D6KWE2 View 3D Structure Click here
A0A1D6QBR8 View 3D Structure Click here
A0A2R8QN59 View 3D Structure Click here
A0A2R8QN59 View 3D Structure Click here
A4HWI6 View 3D Structure Click here
A4HWI6 View 3D Structure Click here
A4HXL7 View 3D Structure Click here
A4I797 View 3D Structure Click here
B6T613 View 3D Structure Click here
C0PES7 View 3D Structure Click here
D4AD37 View 3D Structure Click here
E7F3N0 View 3D Structure Click here
I1JSL1 View 3D Structure Click here
I1KDC3 View 3D Structure Click here
I1KE06 View 3D Structure Click here
I1KNJ4 View 3D Structure Click here
I1KRI3 View 3D Structure Click here
I1L008 View 3D Structure Click here
I1LT10 View 3D Structure Click here
I1M2B3 View 3D Structure Click here
I1MFP3 View 3D Structure Click here
K7KQ02 View 3D Structure Click here
K7KSF4 View 3D Structure Click here
K7L2M5 View 3D Structure Click here
K7LWP0 View 3D Structure Click here
K7M0G4 View 3D Structure Click here
K7M1Q6 View 3D Structure Click here
K7M1Q6 View 3D Structure Click here
K7URV3 View 3D Structure Click here
O14732 View 3D Structure Click here
O49623 View 3D Structure Click here
O53907 View 3D Structure Click here
O55023 View 3D Structure Click here
O94505 View 3D Structure Click here
O95861 View 3D Structure Click here
P0ADG4 View 3D Structure Click here
P0CY20 View 3D Structure Click here
P22255 View 3D Structure Click here
P29218 View 3D Structure Click here
P32179 View 3D Structure Click here
P38710 View 3D Structure Click here
P49441 View 3D Structure Click here
P49442 View 3D Structure Click here
P95189 View 3D Structure Click here
P97697 View 3D Structure Click here
P9WKI9 View 3D Structure Click here
P9WKJ1 View 3D Structure Click here
Q05533 View 3D Structure Click here
Q0D5I5 View 3D Structure Click here
Q0DWN3 View 3D Structure Click here
Q19420 View 3D Structure Click here
Q23493 View 3D Structure Click here
Q2FVV7 View 3D Structure Click here
Q2G2G4 View 3D Structure Click here
Q2QWT4 View 3D Structure Click here
Q2YDR3 View 3D Structure Click here
Q38945 View 3D Structure Click here
Q42546 View 3D Structure Click here
Q4CXF9 View 3D Structure Click here
Q4DAY4 View 3D Structure Click here
Q4DPS5 View 3D Structure Click here
Q503S9 View 3D Structure Click here
Q54U72 View 3D Structure Click here
Q55F34 View 3D Structure Click here
Q57573 View 3D Structure Click here
Q58327 View 3D Structure Click here
Q58327 View 3D Structure Click here
Q59XQ1 View 3D Structure Click here
Q5RJK6 View 3D Structure Click here
Q5ZEQ3 View 3D Structure Click here
Q6DGB2 View 3D Structure Click here
Q6F2U7 View 3D Structure Click here
Q6H6B9 View 3D Structure Click here
Q6NPM8 View 3D Structure Click here
Q6Z413 View 3D Structure Click here
Q6Z4I1 View 3D Structure Click here
Q7KTW5 View 3D Structure Click here
Q80V26 View 3D Structure Click here
Q84VY5 View 3D Structure Click here
Q869K3 View 3D Structure Click here
Q8CIN7 View 3D Structure Click here
Q8GY63 View 3D Structure Click here
Q91UZ5 View 3D Structure Click here
Q94F00 View 3D Structure Click here
Q9M0Y6 View 3D Structure Click here
Q9M8S8 View 3D Structure Click here
Q9NX62 View 3D Structure Click here
Q9VAG9 View 3D Structure Click here
Q9VFP6 View 3D Structure Click here
Q9VP62 View 3D Structure Click here
Q9VUW1 View 3D Structure Click here
Q9VUW2 View 3D Structure Click here
Q9VUW3 View 3D Structure Click here
Q9VUW4 View 3D Structure Click here
Q9VYF2 View 3D Structure Click here
Q9Z0S1 View 3D Structure Click here
Q9Z1N4 View 3D Structure Click here