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568  structures 8653  species 0  interactions 45852  sequences 236  architectures

Family: NTP_transferase (PF00483)

Summary: Nucleotidyl transferase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Nucleotidyl transferase Provide feedback

This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.

Literature references

  1. Jensen SO, Reeves PR; , Biochim Biophys Acta 1998;1382:5-7.: Domain organisation in phosphomannose isomerases (types I and II). PUBMED:9507048 EPMC:9507048


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005835

Nucleotidyl transferases transfer nucleotides from one compound to another. This domain is found in a number of enzymes that transfer nucleotides onto phosphosugars [ PUBMED:9507048 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(35)
Full
(45852)
Representative proteomes UniProt
(208144)
RP15
(6246)
RP35
(22252)
RP55
(45530)
RP75
(76278)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(35)
Full
(45852)
Representative proteomes UniProt
(208144)
RP15
(6246)
RP35
(22252)
RP55
(45530)
RP75
(76278)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(35)
Full
(45852)
Representative proteomes UniProt
(208144)
RP15
(6246)
RP35
(22252)
RP55
(45530)
RP75
(76278)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Bateman A
Previous IDs: ADP_glu_Plase;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 35
Number in full: 45852
Average length of the domain: 239.30 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 66.00 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.2 21.2
Trusted cut-off 21.2 21.2
Noise cut-off 21.1 21.1
Model length: 247
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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The tree shows the occurrence of this domain across different species. More...

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Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NTP_transferase domain has been found. There are 568 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0Y646 View 3D Structure Click here
A0A0R0EJ12 View 3D Structure Click here
A0A0R0F6M9 View 3D Structure Click here
A0A0R0GLW2 View 3D Structure Click here
A0A0R0JH94 View 3D Structure Click here
A0A0R0K2N5 View 3D Structure Click here
A0A1D6FPJ1 View 3D Structure Click here
A0A1D6HP23 View 3D Structure Click here
A0A1D6HWJ4 View 3D Structure Click here
A0A1D6IQZ6 View 3D Structure Click here
A0A1D6J8X7 View 3D Structure Click here
A0A1D6J8X7 View 3D Structure Click here
A0A1D6JRK2 View 3D Structure Click here
A0A1D6L376 View 3D Structure Click here
A0A1D6MDR4 View 3D Structure Click here
A0A1D6NHY1 View 3D Structure Click here
A0A1D6PHU3 View 3D Structure Click here
A0A1D6PZG8 View 3D Structure Click here
A0A368UH27 View 3D Structure Click here
A3QMC8 View 3D Structure Click here
A4I048 View 3D Structure Click here
B1AUN2 View 3D Structure Click here
B4FEP8 View 3D Structure Click here
B4G0L2 View 3D Structure Click here
C4JAC1 View 3D Structure Click here
C6TE56 View 3D Structure Click here
C6TI75 View 3D Structure Click here
C9WSW4 View 3D Structure Click here
D4A746 View 3D Structure Click here
F1RBR0 View 3D Structure Click here
F4I8U2 View 3D Structure Click here
F4IFA4 View 3D Structure Click here
F6NZ60 View 3D Structure Click here
I1JI22 View 3D Structure Click here
I1JJP2 View 3D Structure Click here
I1JRJ1 View 3D Structure Click here
I1JX24 View 3D Structure Click here
I1K764 View 3D Structure Click here
I1KSB2 View 3D Structure Click here
I1LJC2 View 3D Structure Click here
I1LQ25 View 3D Structure Click here
I1N6T7 View 3D Structure Click here
I1NBK6 View 3D Structure Click here
I1NC49 View 3D Structure Click here
K7KGH6 View 3D Structure Click here
K7KHJ1 View 3D Structure Click here
K7KHT8 View 3D Structure Click here
K7KVU9 View 3D Structure Click here
K7LRM0 View 3D Structure Click here
K7MNW9 View 3D Structure Click here
K7MPN6 View 3D Structure Click here
L7N6A5 View 3D Structure Click here
O05576 View 3D Structure Click here
O22287 View 3D Structure Click here
O49733 View 3D Structure Click here
O60064 View 3D Structure Click here
O64760 View 3D Structure Click here
O74484 View 3D Structure Click here
O93827 View 3D Structure Click here
P0A6V1 View 3D Structure Click here
P0AAB6 View 3D Structure Click here
P0AEP3 View 3D Structure Click here
P15280 View 3D Structure Click here
P24174 View 3D Structure Click here
P32501 View 3D Structure Click here
P37744 View 3D Structure Click here
P41940 View 3D Structure Click here
P55228 View 3D Structure Click here
P55229 View 3D Structure Click here
P55230 View 3D Structure Click here
P55231 View 3D Structure Click here
P55234 View 3D Structure Click here
P55241 View 3D Structure Click here
P56287 View 3D Structure Click here
P56288 View 3D Structure Click here
P61887 View 3D Structure Click here
P70541 View 3D Structure Click here
P80361 View 3D Structure Click here
P87163 View 3D Structure Click here
P9WH13 View 3D Structure Click here
P9WN43 View 3D Structure Click here
Q0D7I3 View 3D Structure Click here
Q10Q61 View 3D Structure Click here
Q1G3F7 View 3D Structure Click here
Q1RM52 View 3D Structure Click here
Q2G0S3 View 3D Structure Click here
Q2G1T6 View 3D Structure Click here
Q4CMK4 View 3D Structure Click here
Q4CU94 View 3D Structure Click here
Q4D1S1 View 3D Structure Click here
Q4D8L3 View 3D Structure Click here
Q4DE52 View 3D Structure Click here
Q54FQ8 View 3D Structure Click here
Q54K39 View 3D Structure Click here
Q54RF3 View 3D Structure Click here
Q58501 View 3D Structure Click here
Q58730 View 3D Structure Click here
Q5A6S3 View 3D Structure Click here
Q5AL34 View 3D Structure Click here
Q5XIC1 View 3D Structure Click here
Q5Z6D2 View 3D Structure Click here
Q688T8 View 3D Structure Click here
Q69T99 View 3D Structure Click here
Q6AVT2 View 3D Structure Click here
Q6DBU5 View 3D Structure Click here
Q6GMK8 View 3D Structure Click here
Q6K3F7 View 3D Structure Click here
Q6Z9A3 View 3D Structure Click here
Q7G065 View 3D Structure Click here
Q7JZB4 View 3D Structure Click here
Q7SXP8 View 3D Structure Click here
Q7ZTY5 View 3D Structure Click here
Q84JH5 View 3D Structure Click here
Q86HG0 View 3D Structure Click here
Q8BTZ7 View 3D Structure Click here
Q8H1Q7 View 3D Structure Click here
Q8ILP1 View 3D Structure Click here
Q8SXU3 View 3D Structure Click here
Q922H4 View 3D Structure Click here
Q941P2 View 3D Structure Click here
Q941T9 View 3D Structure Click here
Q947B9 View 3D Structure Click here
Q96IJ6 View 3D Structure Click here
Q9C9P3 View 3D Structure Click here
Q9M2S0 View 3D Structure Click here
Q9N4V3 View 3D Structure Click here
Q9NR50 View 3D Structure Click here
Q9SIK1 View 3D Structure Click here
Q9SRU3 View 3D Structure Click here
Q9W541 View 3D Structure Click here
Q9Y5P6 View 3D Structure Click here