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624  structures 8873  species 0  interactions 48133  sequences 239  architectures

Family: NTP_transferase (PF00483)

Summary: Nucleotidyl transferase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Nucleotidyl transferase Provide feedback

This family includes a wide range of enzymes which transfer nucleotides onto phosphosugars.

Literature references

  1. Jensen SO, Reeves PR; , Biochim Biophys Acta 1998;1382:5-7.: Domain organisation in phosphomannose isomerases (types I and II). PUBMED:9507048 EPMC:9507048


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR005835

Nucleotidyl transferases transfer nucleotides from one compound to another. This domain is found in a number of enzymes that transfer nucleotides onto phosphosugars [ PUBMED:9507048 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(35)
Full
(48133)
Representative proteomes UniProt
(223988)
RP15
(6776)
RP35
(23565)
RP55
(48490)
RP75
(81611)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(35)
Full
(48133)
Representative proteomes UniProt
(223988)
RP15
(6776)
RP35
(23565)
RP55
(48490)
RP75
(81611)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(35)
Full
(48133)
Representative proteomes UniProt
(223988)
RP15
(6776)
RP35
(23565)
RP55
(48490)
RP75
(81611)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Bateman A
Previous IDs: ADP_glu_Plase;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 35
Number in full: 48133
Average length of the domain: 239 aa
Average identity of full alignment: 21 %
Average coverage of the sequence by the domain: 65.76 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.2 21.2
Trusted cut-off 21.2 21.2
Noise cut-off 21.1 21.1
Model length: 247
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Tree controls

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The tree shows the occurrence of this domain across different species. More...

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Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the NTP_transferase domain has been found. There are 624 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044QPX0 View 3D Structure Click here
A0A044SNP9 View 3D Structure Click here
A0A044TPF1 View 3D Structure Click here
A0A077YY15 View 3D Structure Click here
A0A077Z7N6 View 3D Structure Click here
A0A077ZF65 View 3D Structure Click here
A0A0D2DCE4 View 3D Structure Click here
A0A0D2EW46 View 3D Structure Click here
A0A0D2G0A8 View 3D Structure Click here
A0A0H3GPU3 View 3D Structure Click here
A0A0H3GQN6 View 3D Structure Click here
A0A0H3GU98 View 3D Structure Click here
A0A0H3GV99 View 3D Structure Click here
A0A0H3GZJ7 View 3D Structure Click here
A0A0H5SR59 View 3D Structure Click here
A0A0K0DZB5 View 3D Structure Click here
A0A0K0E3A9 View 3D Structure Click here
A0A0K0EBN1 View 3D Structure Click here
A0A0N4U423 View 3D Structure Click here
A0A0N4UID3 View 3D Structure Click here
A0A0N4UM90 View 3D Structure Click here
A0A0P0Y646 View 3D Structure Click here
A0A0R0EJ12 View 3D Structure Click here
A0A0R0F6M9 View 3D Structure Click here
A0A0R0GLW2 View 3D Structure Click here
A0A0R0JH94 View 3D Structure Click here
A0A0R0K2N5 View 3D Structure Click here
A0A175W5R0 View 3D Structure Click here
A0A175WDH5 View 3D Structure Click here
A0A175WJ71 View 3D Structure Click here
A0A1C1CHZ0 View 3D Structure Click here
A0A1C1CWV0 View 3D Structure Click here
A0A1C1CYM8 View 3D Structure Click here
A0A1D6FPJ1 View 3D Structure Click here
A0A1D6HP23 View 3D Structure Click here
A0A1D6HWJ4 View 3D Structure Click here
A0A1D6IQZ6 View 3D Structure Click here
A0A1D6J8X7 View 3D Structure Click here
A0A1D6JRK2 View 3D Structure Click here
A0A1D6L376 View 3D Structure Click here