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210  structures 8985  species 0  interactions 118497  sequences 1401  architectures

Family: Glycos_transf_2 (PF00535)

Summary: Glycosyl transferase family 2

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl transferase family 2 Provide feedback

Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001173

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates ([intenz:2.4.1.-]) and related proteins into distinct sequence based families has been described [ PUBMED:9334165 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

This domain is found in a diverse family of glycosyl transferases that transfer the sugar from UDP-glucose, UDP-N-acetyl-galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids [ PUBMED:27973583 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(133)
Full
(118497)
Representative proteomes UniProt
(561111)
RP15
(15562)
RP35
(56200)
RP55
(120722)
RP75
(205764)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(133)
Full
(118497)
Representative proteomes UniProt
(561111)
RP15
(15562)
RP35
(56200)
RP55
(120722)
RP75
(205764)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(133)
Full
(118497)
Representative proteomes UniProt
(561111)
RP15
(15562)
RP35
(56200)
RP55
(120722)
RP75
(205764)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: MRC-LMB Genome group
Previous IDs: glycosyl_transf_2;
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 133
Number in full: 118497
Average length of the domain: 162.50 aa
Average identity of full alignment: 16 %
Average coverage of the sequence by the domain: 42.33 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.3 23.3
Trusted cut-off 23.3 23.3
Noise cut-off 23.2 23.2
Model length: 170
Family (HMM) version: 29
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glycos_transf_2 domain has been found. There are 210 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096MIV6 View 3D Structure Click here
A0A0G2JU25 View 3D Structure Click here
A0A0G2KK98 View 3D Structure Click here
A0A0P0XGQ9 View 3D Structure Click here
A0A0R0GWU7 View 3D Structure Click here
A0A0R4IGF6 View 3D Structure Click here
A0A0R4IV32 View 3D Structure Click here
A0A1D8PEA2 View 3D Structure Click here
A0A1D8PSA5 View 3D Structure Click here
A0A286Y879 View 3D Structure Click here
A0A286Y8F2 View 3D Structure Click here
A0A286YBK3 View 3D Structure Click here
A0A2R8QCE8 View 3D Structure Click here
A0A2R8QJ77 View 3D Structure Click here
A0A2R8QR07 View 3D Structure Click here
A1A5P1 View 3D Structure Click here
A1L229 View 3D Structure Click here
A4I143 View 3D Structure Click here
A4ICW5 View 3D Structure Click here
B0V0U4 View 3D Structure Click here
B4FS25 View 3D Structure Click here
B4FSA4 View 3D Structure Click here
B8A6C4 View 3D Structure Click here
D3ZQA1 View 3D Structure Click here
D3ZTT8 View 3D Structure Click here
D4A3A9 View 3D Structure Click here
D4A864 View 3D Structure Click here
D4A8N1 View 3D Structure Click here
E5D8G1 View 3D Structure Click here
E7EXK5 View 3D Structure Click here
E7EZL6 View 3D Structure Click here
E7F4H6 View 3D Structure Click here
E7FDA0 View 3D Structure Click here
E9AHM5 View 3D Structure Click here
F1LQN1 View 3D Structure Click here
F1Q6D3 View 3D Structure Click here
F1QYD0 View 3D Structure Click here
F1R0I8 View 3D Structure Click here
F1R3L0 View 3D Structure Click here
F1R7M5 View 3D Structure Click here