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297  structures 8393  species 0  interactions 73219  sequences 569  architectures

Family: Rhodanese (PF00581)

Summary: Rhodanese-like domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Rhodanese". More...

Rhodanese Edit Wikipedia article

Rhodanese-like domain
Rhodanase.png
Identifiers
SymbolRhodanese
PfamPF00581
InterProIPR001763
PROSITEPDOC00322
SCOPe2ora / SUPFAM
OPM superfamily413
OPM protein2mpn
CDDcd00158
Membranome571

Rhodanese, also known as rhodanase, thiosulfate sulfurtransferase, thiosulfate cyanide transsulfurase, and thiosulfate thiotransferase,[1] is a mitochondrial enzyme that detoxifies cyanide (CN−) by converting it to thiocyanate (SCN−).[2]

This reaction takes place in two steps. The diagram on the right shows the crystallographically-determined structure of rhodanese. In the first step, thiosulfate is reduced by the thiol group on cysteine-247 1, to form a persulfide and a sulfite 2. In the second step, the persulfide reacts with cyanide to produce thiocyanate, re-generating the cysteine thiol 1.[3]

Rhodanase2.png

This reaction is important for the treatment of exposure to cyanide, since the thiocyanate formed is around 1 / 200 as toxic.[4]:p. 15938 The use of thiosulfate solution as an antidote for cyanide poisoning is based on the activation of this enzymatic cycle.

Rhodanese shares evolutionary relationship with a large family of proteins, including

  • Cdc25 phosphatase catalytic domain.
  • non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases
  • non-catalytic domains of yeast PTP-type MAPK-phosphatases
  • non-catalytic domains of yeast Ubp4, Ubp5, Ubp7
  • non-catalytic domains of mammalian Ubp-Y
  • Drosophila heat shock protein HSP-67BB
  • several bacterial cold-shock and phage shock proteins
  • plant senescence associated proteins
  • catalytic and non-catalytic domains of rhodanese[5]

Rhodanese has an internal duplication. This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.[6]

Human proteins containing this domain

CDC25A; CDC25B; CDC25C; DUSP; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP6; DUSP7; KAT; MKP7; MOCS3; MPST; TBCK; TSGA14; TST; USP8;

Nomenclature

Although the standard nomenclature rules for enzymes indicate that their names are to end with the letters "-ase", rhodanese was first described in 1933,[7] prior to the 1955 establishment of the Enzyme Commission; as such, the older name had already attained widespread usage.

Thiosulfate sulfurtransferase

thiosulfate sulfurtransferase
Identifiers
EC number2.8.1.1
CAS number9026-04-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a thiosulfate sulfurtransferase (EC 2.8.1.1) is an enzyme that catalyzes the chemical reaction

thiosulfate + cyanide sulfite + thiocyanate

Thus, the two substrates of this enzyme are thiosulfate and cyanide, whereas its two products are sulfite and thiocyanate.

Nomenclature

This enzyme belongs to the family of transferases, specifically the sulfurtransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is thiosulfate:cyanide sulfurtransferase. Other names in common use include thiosulfate cyanide transsulfurase, thiosulfate thiotransferase, rhodanese, and rhodanase.

References

  1. ^ EC 2.8.1.1, at the International Union of Biochemistry and Molecular Biology
  2. ^ Cipollone R, Ascenzi P, Tomao P, Imperi F, Visca P (2008). "Enzymatic detoxification of cyanide: clues from Pseudomonas aeruginosa Rhodanese". Journal of Molecular Microbiology and Biotechnology. 15 (2–3): 199–211. doi:10.1159/000121331. PMID 18685272.
  3. ^ Cipollone R, Ascenzi P, Tomao P, Imperi F, Visca P (2008). "Enzymatic detoxification of cyanide: clues from Pseudomonas aeruginosa Rhodanese". Journal of Molecular Microbiology and Biotechnology. 15 (2–3): 199–211. doi:10.1159/000121331. PMID 18685272.
  4. ^ Jaszczak E, Polkowska Å», Narkowicz S, NamieÅ›nik J (July 2017). "Cyanides in the environment-analysis-problems and challenges". Environmental Science and Pollution Research International. 24 (19): 15929–15948. doi:10.1007/s11356-017-9081-7. PMC 5506515. PMID 28512706.
  5. ^ "Thiosulphate sulfurtransferase, conserved site (IPR001307)". EMBL-EBI. InterPro.
  6. ^ Gliubich F, Gazerro M, Zanotti G, Delbono S, Bombieri G, Berni R (August 1996). "Active site structural features for chemically modified forms of rhodanese". The Journal of Biological Chemistry. 271 (35): 21054–61. doi:10.1074/jbc.271.35.21054. PMID 8702871.
  7. ^ Cipollone R, Ascenzi P, Visca P (February 2007). "Common themes and variations in the rhodanese superfamily". IUBMB Life. 59 (2): 51–9. doi:10.1080/15216540701206859. PMID 17454295.

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Rhodanese-like domain Provide feedback

Rhodanese has an internal duplication. This Pfam represents a single copy of this duplicated domain. The domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases.

Literature references

  1. Gliubich F, Gazerro M, Zanotti G, Delbono S, Bombieri G, Berni R; , J Biol Chem 1996;271:21054-21061.: Active site structural features for chemically modified forms of rhodanese. PUBMED:8702871 EPMC:8702871


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001763

Rhodanese, a sulphurtransferase involved in cyanide detoxification (see INTERPRO ) shares evolutionary relationship with a large family of proteins [ PUBMED:9733650 ], including

  • Cdc25 phosphatase catalytic domain.
  • non-catalytic domains of eukaryotic dual-specificity MAPK-phosphatases.
  • non-catalytic domains of yeast PTP-type MAPK-phosphatases.
  • non-catalytic domains of yeast Ubp4, Ubp5, Ubp7.
  • non-catalytic domains of mammalian Ubp-Y.
  • Drosophila heat shock protein HSP-67BB.
  • several bacterial cold-shock and phage shock proteins.
  • plant senescence associated proteins.
  • catalytic and non-catalytic domains of rhodanese (see INTERPRO ).

Rhodanese has an internal duplication. This domain is found as a single copy in other proteins, including phosphatases and ubiquitin C-terminal hydrolases [ PUBMED:8702871 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Phosphatase (CL0031), which has the following description:

This family includes tyrosine and dual specificity phosphatase enzymes.

The clan contains the following 16 members:

CDKN3 DSPc DSPn DUF442 Init_tRNA_PT LMWPc Myotub-related NleF_casp_inhib PTPlike_phytase PTS_IIB Rhodanese Ssu72 Syja_N Y_phosphatase Y_phosphatase2 Y_phosphatase3

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(141)
Full
(73219)
Representative proteomes UniProt
(285018)
RP15
(9555)
RP35
(32922)
RP55
(70552)
RP75
(118470)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(141)
Full
(73219)
Representative proteomes UniProt
(285018)
RP15
(9555)
RP35
(32922)
RP55
(70552)
RP75
(118470)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(141)
Full
(73219)
Representative proteomes UniProt
(285018)
RP15
(9555)
RP35
(32922)
RP55
(70552)
RP75
(118470)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: MRC-LMB Genome group
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 141
Number in full: 73219
Average length of the domain: 105.30 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 40.91 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.2 22.2
Trusted cut-off 22.2 22.2
Noise cut-off 22.1 22.1
Model length: 107
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Rhodanese domain has been found. There are 297 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K9Q0 View 3D Structure Click here
A0A0G2KNS1 View 3D Structure Click here
A0A0N7KG12 View 3D Structure Click here
A0A0P0VF26 View 3D Structure Click here
A0A0P0X177 View 3D Structure Click here
A0A0R0EY78 View 3D Structure Click here
A0A0R0GHT9 View 3D Structure Click here
A0A0R4I9C9 View 3D Structure Click here
A0A0R4IE73 View 3D Structure Click here
A0A0R4IS50 View 3D Structure Click here
A0A1D6E428 View 3D Structure Click here
A0A1D6EFC1 View 3D Structure Click here
A0A1D6I0S8 View 3D Structure Click here
A0A1D6J4M3 View 3D Structure Click here
A0A1D6JZ58 View 3D Structure Click here
A0A1D6KFY9 View 3D Structure Click here
A0A1D6KFY9 View 3D Structure Click here
A0A1D6LCP2 View 3D Structure Click here
A0A1D6NUB5 View 3D Structure Click here
A0A1D6Q8E9 View 3D Structure Click here
A0A1D6QSK0 View 3D Structure Click here
A0A1D6QSK0 View 3D Structure Click here
A0A1D8PIJ8 View 3D Structure Click here
A0A1D8PIJ8 View 3D Structure Click here
A0A1D8PJ05 View 3D Structure Click here
A0A1D8PL33 View 3D Structure Click here
A0A1D8PTD8 View 3D Structure Click here
A0A2R8QPP3 View 3D Structure Click here
A0A2R8RWI3 View 3D Structure Click here
A2BDX3 View 3D Structure Click here
A3ACF3 View 3D Structure Click here
A4HSL9 View 3D Structure Click here
A4HU67 View 3D Structure Click here
A4HU68 View 3D Structure Click here
A4HU69 View 3D Structure Click here
A4I644 View 3D Structure Click here
A4I895 View 3D Structure Click here
A4I8W3 View 3D Structure Click here
A4IA77 View 3D Structure Click here
A4IB11 View 3D Structure Click here
B4FAT0 View 3D Structure Click here
B4FDW3 View 3D Structure Click here
B6SR15 View 3D Structure Click here
B6SZY5 View 3D Structure Click here
B6TNK6 View 3D Structure Click here
B6TQK1 View 3D Structure Click here
B6U016 View 3D Structure Click here
B8A4H7 View 3D Structure Click here
B8A5N7 View 3D Structure Click here
B9FE35 View 3D Structure Click here
C0PPF5 View 3D Structure Click here
C4J4B7 View 3D Structure Click here
C6SXE2 View 3D Structure Click here
C6T9G3 View 3D Structure Click here
C6TC19 View 3D Structure Click here
C6TEH0 View 3D Structure Click here
D1ME28 View 3D Structure Click here
D3ZBG7 View 3D Structure Click here
D3ZN39 View 3D Structure Click here
D4A3W6 View 3D Structure Click here
D4A8L5 View 3D Structure Click here
D4AAH9 View 3D Structure Click here
D4ADA5 View 3D Structure Click here
D4ADT2 View 3D Structure Click here
E7F1E2 View 3D Structure Click here
E7F1V3 View 3D Structure Click here
E9PY03 View 3D Structure Click here
F1Q9K6 View 3D Structure Click here
F1Q9K6 View 3D Structure Click here
F1QQM8 View 3D Structure Click here
F1QVZ9 View 3D Structure Click here
F1R2Q8 View 3D Structure Click here
F1R5W3 View 3D Structure Click here
F1RDV6 View 3D Structure Click here
F4I933 View 3D Structure Click here
F4IPI4 View 3D Structure Click here
F4J9G2 View 3D Structure Click here
G3V8W9 View 3D Structure Click here
G5ECA0 View 3D Structure Click here
G5EEV0 View 3D Structure Click here
G5EEV0 View 3D Structure Click here
H0UI37 View 3D Structure Click here
H9G340 View 3D Structure Click here
I1J7F5 View 3D Structure Click here
I1J8K5 View 3D Structure Click here
I1JCG1 View 3D Structure Click here
I1JJC5 View 3D Structure Click here
I1JNI8 View 3D Structure Click here
I1JYM5 View 3D Structure Click here
I1K180 View 3D Structure Click here
I1K581 View 3D Structure Click here
I1KAW9 View 3D Structure Click here
I1KC98 View 3D Structure Click here
I1KTY9 View 3D Structure Click here
I1KTY9 View 3D Structure Click here
I1LN25 View 3D Structure Click here
I1LP77 View 3D Structure Click here
I1M6M9 View 3D Structure Click here
I1M753 View 3D Structure Click here
I1MAC6 View 3D Structure Click here
I1MJB3 View 3D Structure Click here
I1MJB3 View 3D Structure Click here
I1MY98 View 3D Structure Click here
I1N964 View 3D Structure Click here
K7KA20 View 3D Structure Click here
K7KD46 View 3D Structure Click here
K7LNM8 View 3D Structure Click here
K7MGZ8 View 3D Structure Click here
L7N674 View 3D Structure Click here
M0R7U2 View 3D Structure Click here
O08446 View 3D Structure Click here
O09112 View 3D Structure Click here
O17730 View 3D Structure Click here
O44510 View 3D Structure Click here
O44552 View 3D Structure Click here
O44628 View 3D Structure Click here
O48529 View 3D Structure Click here
O53414 View 3D Structure Click here
O53921 View 3D Structure Click here
O54838 View 3D Structure Click here
O64530 View 3D Structure Click here
O64530 View 3D Structure Click here
O95396 View 3D Structure Click here
P06652 View 3D Structure Click here
P0A6V5 View 3D Structure Click here
P0AG27 View 3D Structure Click here
P20483 View 3D Structure Click here
P22978 View 3D Structure Click here
P23748 View 3D Structure Click here
P23857 View 3D Structure Click here
P24188 View 3D Structure Click here
P24329 View 3D Structure Click here
P24329 View 3D Structure Click here
P25325 View 3D Structure Click here
P25325 View 3D Structure Click here
P27574 View 3D Structure Click here
P28562 View 3D Structure Click here
P28563 View 3D Structure Click here
P30304 View 3D Structure Click here
P30305 View 3D Structure Click here
P30306 View 3D Structure Click here
P30307 View 3D Structure Click here
P30634 View 3D Structure Click here
P31142 View 3D Structure Click here
P31142 View 3D Structure Click here
P32571 View 3D Structure Click here
P32586 View 3D Structure Click here
P38820 View 3D Structure Click here
P39944 View 3D Structure Click here
P40048 View 3D Structure Click here
P40818 View 3D Structure Click here
P42937 View 3D Structure Click here
P48964 View 3D Structure Click here
P48965 View 3D Structure Click here
P48966 View 3D Structure Click here
P48967 View 3D Structure Click here
P52196 View 3D Structure Click here
P52196 View 3D Structure Click here
P55734 View 3D Structure Click here
P78067 View 3D Structure Click here
P78067 View 3D Structure Click here
P91247 View 3D Structure Click here
P95198 View 3D Structure Click here
P97532 View 3D Structure Click here
P97532 View 3D Structure Click here
P9WHF5 View 3D Structure Click here
P9WHF5 View 3D Structure Click here
P9WHF7 View 3D Structure Click here
P9WHF7 View 3D Structure Click here
P9WHF9 View 3D Structure Click here
P9WHF9 View 3D Structure Click here
P9WMN7 View 3D Structure Click here
Q03019 View 3D Structure Click here
Q05922 View 3D Structure Click here
Q05923 View 3D Structure Click here
Q06597 View 3D Structure Click here
Q08686 View 3D Structure Click here
Q08686 View 3D Structure Click here
Q08742 View 3D Structure Click here
Q0E4S8 View 3D Structure Click here
Q0IM09 View 3D Structure Click here
Q0IM09 View 3D Structure Click here
Q0JGY3 View 3D Structure Click here
Q0WWT7 View 3D Structure Click here
Q10038 View 3D Structure Click here
Q10215 View 3D Structure Click here
Q10A88 View 3D Structure Click here
Q10MY4 View 3D Structure Click here
Q10SX6 View 3D Structure Click here
Q12305 View 3D Structure Click here
Q13115 View 3D Structure Click here
Q13202 View 3D Structure Click here
Q16690 View 3D Structure Click here
Q16762 View 3D Structure Click here
Q16762 View 3D Structure Click here
Q16828 View 3D Structure Click here
Q16829 View 3D Structure Click here
Q1HL35 View 3D Structure Click here
Q1JPN0 View 3D Structure Click here
Q21762 View 3D Structure Click here
Q24JL3 View 3D Structure Click here
Q24JL3 View 3D Structure Click here
Q2FUS7 View 3D Structure Click here
Q2FXH3 View 3D Structure Click here
Q2FY36 View 3D Structure Click here
Q2G1R6 View 3D Structure Click here
Q2G1R7 View 3D Structure Click here
Q2QSI2 View 3D Structure Click here
Q2YDV1 View 3D Structure Click here
Q336V5 View 3D Structure Click here
Q38853 View 3D Structure Click here
Q39129 View 3D Structure Click here
Q3U269 View 3D Structure Click here
Q4CQU5 View 3D Structure Click here
Q4CSC3 View 3D Structure Click here
Q4CY97 View 3D Structure Click here
Q4CYR0 View 3D Structure Click here
Q4DBW0 View 3D Structure Click here
Q4DBW1 View 3D Structure Click here
Q4DBW2 View 3D Structure Click here
Q4DJW1 View 3D Structure Click here
Q4DLX6 View 3D Structure Click here
Q4DLX7 View 3D Structure Click here
Q4DLX8 View 3D Structure Click here
Q4DSD5 View 3D Structure Click here
Q4DV84 View 3D Structure Click here
Q4DV84 View 3D Structure Click here
Q4E276 View 3D Structure Click here
Q4KM37 View 3D Structure Click here
Q54E40 View 3D Structure Click here
Q54E40 View 3D Structure Click here
Q54NS5 View 3D Structure Click here
Q54QM6 View 3D Structure Click here
Q550W5 View 3D Structure Click here
Q556Y8 View 3D Structure Click here
Q55FS0 View 3D Structure Click here
Q55G97 View 3D Structure Click here
Q55GF0 View 3D Structure Click here
Q59WH7 View 3D Structure Click here
Q5M863 View 3D Structure Click here
Q5T7W7 View 3D Structure Click here
Q60359 View 3D Structure Click here
Q62767 View 3D Structure Click here
Q63340 View 3D Structure Click here
Q64346 View 3D Structure Click here
Q64623 View 3D Structure Click here
Q69NF7 View 3D Structure Click here
Q69WA8 View 3D Structure Click here
Q6DBR5 View 3D Structure Click here
Q6GQN0 View 3D Structure Click here
Q6H444 View 3D Structure Click here
Q6H4W2 View 3D Structure Click here
Q6H4W2 View 3D Structure Click here
Q6PCP3 View 3D Structure Click here
Q6ZI49 View 3D Structure Click here
Q7SXV1 View 3D Structure Click here
Q7T2L8 View 3D Structure Click here
Q7TNL7 View 3D Structure Click here
Q80U87 View 3D Structure Click here
Q8AWD2 View 3D Structure Click here
Q8BFV3 View 3D Structure Click here
Q8GY31 View 3D Structure Click here
Q8I5Y1 View 3D Structure Click here
Q8IER0 View 3D Structure Click here
Q8K0F1 View 3D Structure Click here
Q8NFU3 View 3D Structure Click here
Q8RUD6 View 3D Structure Click here
Q8TEA7 View 3D Structure Click here
Q8WZK3 View 3D Structure Click here
Q91Z46 View 3D Structure Click here
Q93WI0 View 3D Structure Click here
Q94A65 View 3D Structure Click here
Q99956 View 3D Structure Click here
Q99J99 View 3D Structure Click here
Q99J99 View 3D Structure Click here
Q99NF3 View 3D Structure Click here
Q9BY84 View 3D Structure Click here
Q9BYV8 View 3D Structure Click here
Q9D0B5 View 3D Structure Click here
Q9DBB1 View 3D Structure Click here
Q9ESS0 View 3D Structure Click here
Q9FKW8 View 3D Structure Click here
Q9NUY8 View 3D Structure Click here
Q9SR92 View 3D Structure Click here
Q9USJ1 View 3D Structure Click here
Q9USJ1 View 3D Structure Click here
Q9VCD9 View 3D Structure Click here
Q9VG33 View 3D Structure Click here
Q9VLJ8 View 3D Structure Click here
Q9VPW9 View 3D Structure Click here
Q9VVW5 View 3D Structure Click here
Q9W4F8 View 3D Structure Click here
Q9XTX2 View 3D Structure Click here
Q9XTX2 View 3D Structure Click here
Q9Y6J8 View 3D Structure Click here
Q9Y6W6 View 3D Structure Click here
Q9ZNW0 View 3D Structure Click here