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683  structures 8765  species 0  interactions 144159  sequences 1242  architectures

Family: Acetyltransf_1 (PF00583)

Summary: Acetyltransferase (GNAT) family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Acetyltransferase". More...

Acetyltransferase Edit Wikipedia article

Chemical structure of an acetyl group bound to the remainder R of a molecule.

Acetyltransferase (or transacetylase) is a type of transferase enzyme that transfers an acetyl group.

Examples include:

See also

External links

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acetyltransferase (GNAT) family Provide feedback

This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.

Literature references

  1. Neuwald AF, Landsman D; , Trends Biochem Sci 1997;22:154-155.: GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein. PUBMED:9175471 EPMC:9175471

  2. Chinenov Y; , Trends Biochem Sci 2002;27:115-117.: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?. PUBMED:11893502 EPMC:11893502


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000182

The N-acetyltransferases (NAT) (EC 2.3.1.-) are enzymes that use acetyl coenzyme A (CoA) to transfer an acetyl group to a substrate, a reaction implicated in various functions from bacterial antibiotic resistance to mammalian circadian rhythm and chromatin remodeling. The Gcn5-related N-acetyltransferases (GNAT) catalyze the transfer of the acetyl from the CoA donor to a primary amine of the acceptor. The GNAT proteins share a domain composed of four conserved sequence motifs A-D [ PUBMED:9175471 , PUBMED:10940244 ]. This GNAT domain is named after yeast GCN5 (from General Control Nonrepressed) and related histone acetyltransferases (HATs) like Hat1 and PCAF. HATs acetylate lysine residues of N-terminal histone tails, resulting in transcription activation. Another category of GNAT, the aminoglycoside N-acetyltransferases, confer antibiotic resistance by catalyzing the acetylation of amino groups in aminoglycoside antibiotics [ PUBMED:12592013 ]. GNAT proteins can also have anabolic and catabolic functions in both prokaryotes and eukaryotes [ PUBMED:9175471 , PUBMED:10940244 , PUBMED:12592013 , PUBMED:12527305 , PUBMED:15581578 ].

The acetyltransferase/GNAT domain forms a structurally conserved fold of 6 to 7 beta strands (B) and 4 helices (H) in the topology B1-H1-H2-B2-B3-B4-H3-B5-H4-B6, followed by a C-terminal strand which may be from the same monomer or contributed by another [ PUBMED:10940244 , PUBMED:15581578 ]. Motifs D (B2-B3), A (B4-H3) and B (B5-H4) are collectively called the HAT core [ PUBMED:10940244 , PUBMED:12527305 , PUBMED:15581578 ], while the N-terminal motif C (B1-H1) is less conserved.

Some proteins known to contain a GNAT domain:

  • Yeast GCN5 and Hat1, which are histone acetyltransferases (EC 2.3.1.48).
  • Human PCAF, a histone acetyltransferase.
  • Mammalian serotonin N-acetyltransferase (SNAT) or arylalkylamine NAT (AANAT), which acetylates serotonin into a circadian neurohormone that may participate in light-dark rhythms, and human mood and behavior.
  • Mammalian glucosamine 6-phosphate N-acetyltransferase (GNA1) (EC 2.3.1.4).
  • Escherichia coli rimI and rimJ, which acetylate the N-terminal alanine of ribosomal proteins S18 and S5, respectively (EC 2.3.1.128).
  • Mycobacterium tuberculosis aminoglycoside 2'-N-acetyltransferase (aac), which acetylates the 2' hydroxyl or amino group of a broad spectrum of aminoglycoside antibiotics.
  • Bacillus subtilis bltD and paiA, which acetylate spermine and spermidine.

This entry represents the entire GNAT domain.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(223)
Full
(144159)
Representative proteomes UniProt
(571409)
RP15
(16098)
RP35
(62995)
RP55
(139556)
RP75
(241499)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(223)
Full
(144159)
Representative proteomes UniProt
(571409)
RP15
(16098)
RP35
(62995)
RP55
(139556)
RP75
(241499)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(223)
Full
(144159)
Representative proteomes UniProt
(571409)
RP15
(16098)
RP35
(62995)
RP55
(139556)
RP75
(241499)
Raw Stockholm Download   Download   Download   Download   Download      
Gzipped Download   Download   Download   Download   Download      

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: MRC-LMB Genome group
Previous IDs: Acetyltransf;
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 223
Number in full: 144159
Average length of the domain: 121.10 aa
Average identity of full alignment: 15 %
Average coverage of the sequence by the domain: 51.42 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.7 20.7
Trusted cut-off 20.7 20.7
Noise cut-off 20.6 20.6
Model length: 117
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Acetyltransf_1 domain has been found. There are 683 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K1A0 View 3D Structure Click here
A0A0K3ASB6 View 3D Structure Click here
A0A0P0W427 View 3D Structure Click here
A0A0P0X853 View 3D Structure Click here
A0A0P0YBJ5 View 3D Structure Click here
A0A0R0GB23 View 3D Structure Click here
A0A0R0I9L1 View 3D Structure Click here
A0A0R0IHP4 View 3D Structure Click here
A0A0R0JI04 View 3D Structure Click here
A0A0R0K0F5 View 3D Structure Click here
A0A0R0KKK3 View 3D Structure Click here
A0A0R0KY63 View 3D Structure Click here
A0A0R0L094 View 3D Structure Click here
A0A0R0L7U9 View 3D Structure Click here
A0A0R0LDP2 View 3D Structure Click here
A0A0R4IHX8 View 3D Structure Click here
A0A0R4IXF6 View 3D Structure Click here
A0A1D5NSF9 View 3D Structure Click here
A0A1D6EPJ1 View 3D Structure Click here
A0A1D6F5W4 View 3D Structure Click here
A0A1D6FB17 View 3D Structure Click here
A0A1D6GQK6 View 3D Structure Click here
A0A1D6H2K8 View 3D Structure Click here
A0A1D6HGL2 View 3D Structure Click here
A0A1D6HLN0 View 3D Structure Click here
A0A1D6HRK6 View 3D Structure Click here
A0A1D6HX05 View 3D Structure Click here
A0A1D6II30 View 3D Structure Click here
A0A1D6IP68 View 3D Structure Click here
A0A1D6IXU5 View 3D Structure Click here
A0A1D6JNW2 View 3D Structure Click here
A0A1D6JRP5 View 3D Structure Click here
A0A1D6KRN8 View 3D Structure Click here
A0A1D6L0I5 View 3D Structure Click here
A0A1D6LDB6 View 3D Structure Click here
A0A1D6LQK4 View 3D Structure Click here
A0A1D6LYK2 View 3D Structure Click here
A0A1D6M0F7 View 3D Structure Click here
A0A1D6M2X0 View 3D Structure Click here
A0A1D6M6P1 View 3D Structure Click here
A0A1D6QIS1 View 3D Structure Click here
A0A1D6QRY9 View 3D Structure Click here
A0A1D8PKD5 View 3D Structure Click here
A0A1D8PLA7 View 3D Structure Click here
A0A1D8PP99 View 3D Structure Click here
A0A1D8PSM5 View 3D Structure Click here
A0A1D8PTE9 View 3D Structure Click here
A0A1D8PU80 View 3D Structure Click here
A0A1P8ATB1 View 3D Structure Click here
A0A1P8B7P8 View 3D Structure Click here
A0A286YBP0 View 3D Structure Click here
A0A2R8QCU5 View 3D Structure Click here
A0A368UJ64 View 3D Structure Click here
A0JPQ5 View 3D Structure Click here
A1ZBI9 View 3D Structure Click here
A2ZVA8 View 3D Structure Click here
A3AJD2 View 3D Structure Click here
A3KPA3 View 3D Structure Click here
A4HVG9 View 3D Structure Click here
A4HWS3 View 3D Structure Click here
A4HY02 View 3D Structure Click here
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A4I436 View 3D Structure Click here
A4I5F7 View 3D Structure Click here
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B1H249 View 3D Structure Click here
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B6SUK9 View 3D Structure Click here
B6T7X0 View 3D Structure Click here
B6TIB6 View 3D Structure Click here
B6UHR7 View 3D Structure Click here
C0H4R5 View 3D Structure Click here
C0PBY4 View 3D Structure Click here
C0PGU3 View 3D Structure Click here
C0PKN8 View 3D Structure Click here
C6KTC5 View 3D Structure Click here
C6SYN6 View 3D Structure Click here
C6SZ70 View 3D Structure Click here
C7G005 View 3D Structure Click here
C7IZ16 View 3D Structure Click here
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D3ZA19 View 3D Structure Click here
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I1JWF0 View 3D Structure Click here
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I1KC74 View 3D Structure Click here
I1KF23 View 3D Structure Click here
I1KGS8 View 3D Structure Click here
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I1L0R1 View 3D Structure Click here
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I1LA26 View 3D Structure Click here
I1LD10 View 3D Structure Click here
I1LFY4 View 3D Structure Click here
I1LH72 View 3D Structure Click here
I1LLM4 View 3D Structure Click here
I1LLN9 View 3D Structure Click here
I1LNP3 View 3D Structure Click here
I1LS13 View 3D Structure Click here
I1LVV8 View 3D Structure Click here
I1M655 View 3D Structure Click here
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I1MZX3 View 3D Structure Click here
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I6XA42 View 3D Structure Click here
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K7M825 View 3D Structure Click here
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O05578 View 3D Structure Click here
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O88816 View 3D Structure Click here
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P07347 View 3D Structure Click here
P0A6C5 View 3D Structure Click here
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P0A951 View 3D Structure Click here
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P61599 View 3D Structure Click here
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P79081 View 3D Structure Click here
P85118 View 3D Structure Click here
P96810 View 3D Structure Click here
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Q02908 View 3D Structure Click here
Q03330 View 3D Structure Click here
Q03503 View 3D Structure Click here
Q04751 View 3D Structure Click here
Q06504 View 3D Structure Click here
Q06592 View 3D Structure Click here
Q08689 View 3D Structure Click here
Q09518 View 3D Structure Click here
Q09927 View 3D Structure Click here
Q0D7C8 View 3D Structure Click here
Q0P4A4 View 3D Structure Click here
Q10081 View 3D Structure Click here
Q10Q85 View 3D Structure Click here
Q10R02 View 3D Structure Click here
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Q19835 View 3D Structure Click here
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Q23651 View 3D Structure Click here
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Q2G016 View 3D Structure Click here
Q2G0C1 View 3D Structure Click here
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Q2R3D8 View 3D Structure Click here
Q337G6 View 3D Structure Click here
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Q3MHC1 View 3D Structure Click here
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Q3UX61 View 3D Structure Click here
Q42381 View 3D Structure Click here
Q4CRN8 View 3D Structure Click here
Q4CUJ9 View 3D Structure Click here
Q4D361 View 3D Structure Click here
Q4D945 View 3D Structure Click here
Q4DGL9 View 3D Structure Click here
Q4DGZ6 View 3D Structure Click here
Q4DJ26 View 3D Structure Click here
Q4DJ26 View 3D Structure Click here
Q4DKU2 View 3D Structure Click here
Q4DM28 View 3D Structure Click here
Q4DM28 View 3D Structure Click here
Q4DPP3 View 3D Structure Click here
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Q4DX16 View 3D Structure Click here
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Q54BP5 View 3D Structure Click here
Q54DV6 View 3D Structure Click here
Q54DW0 View 3D Structure Click here
Q54DW0 View 3D Structure Click here
Q54F18 View 3D Structure Click here
Q54G61 View 3D Structure Click here
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Q54MP9 View 3D Structure Click here
Q54R05 View 3D Structure Click here
Q54W72 View 3D Structure Click here
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Q552L6 View 3D Structure Click here
Q559V1 View 3D Structure Click here
Q55DK2 View 3D Structure Click here
Q55G01 View 3D Structure Click here
Q568K5 View 3D Structure Click here
Q58462 View 3D Structure Click here
Q58536 View 3D Structure Click here
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Q59MT3 View 3D Structure Click here
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Q59VF4 View 3D Structure Click here
Q5AAR6 View 3D Structure Click here
Q5AHF9 View 3D Structure Click here
Q5ALW1 View 3D Structure Click here
Q5AMM9 View 3D Structure Click here
Q5KQI6 View 3D Structure Click here
Q5PR44 View 3D Structure Click here
Q5RIC0 View 3D Structure Click here
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Q60E62 View 3D Structure Click here
Q64666 View 3D Structure Click here
Q67UR2 View 3D Structure Click here
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Q6GQM2 View 3D Structure Click here
Q6H820 View 3D Structure Click here
Q6K836 View 3D Structure Click here
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Q6PGB6 View 3D Structure Click here
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Q6Z1Y6 View 3D Structure Click here
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Q7T174 View 3D Structure Click here
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Q7TP41 View 3D Structure Click here
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Q7XQS0 View 3D Structure Click here
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Q84JF4 View 3D Structure Click here
Q851S9 View 3D Structure Click here
Q86J12 View 3D Structure Click here
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Q86VE3 View 3D Structure Click here
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Q8CES0 View 3D Structure Click here
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Q8IB67 View 3D Structure Click here
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