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127  structures 1257  species 0  interactions 43540  sequences 1974  architectures

Family: RhoGEF (PF00621)

Summary: RhoGEF domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "RhoGEF domain". More...

RhoGEF domain Edit Wikipedia article

DH/PH RhoGEF domain
PDB 1dbh EBI.jpg
Structure of the RhoGEF domain from the human Son of sevenless protein, an example of a DH/PH domain RhoGEF.[1]
Identifiers
SymbolRhoGEF
PfamPF00621
InterProIPR035899 IPR000219, IPR035899
SMARTRhoGEF
SCOPe1dbh / SUPFAM
OPM protein1xd4
CDDcd00160
Dedicator of cytokinesis (DOCK) RhoGEF domain
Identifiers
SymbolRhoGEF
PfamPF06920
InterProIPR010703 IPR026791, IPR010703
SCOPe1wg7 / SUPFAM
CDDcd11684

RhoGEF domain describes two distinct structural domains with guanine nucleotide exchange factor (GEF) activity to regulate small GTPases in the Rho family. Rho small GTPases are inactive when bound to GDP but active when bound to GTP; RhoGEF domains in proteins are able to promote GDP release and GTP binding to activate specific Rho family members, including RhoA, Rac1 and Cdc42.

The largest class of RhoGEFs is composed of proteins containing the "Dbl-homology" (DH) domain, which almost always is found together with a pleckstrin-homology (PH) domain to form a combined DH/PH domain structure.[2][3]

A distinct class of RhoGEFs is those proteins containing the DOCK/CZH/DHR-2 domain. This structure has no sequence similarity with DBL-homology domains.[4]

Human proteins containing DH/PH RhoGEF domain

ABR; AKAP13/ARHGEF13/Lbc; ALS2; ALS2CL; ARHGEF1/p115-RhoGEF; ARHGEF10; ARHGEF10L; ARHGEF11/PDZ-RhoGEF.; ARHGEF12/LARG; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF25; ARHGEF26; ARHGEF28; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF6/alpha-PIX; ARHGEF7/beta-PIX; ARHGEF9; BCR; DNMBP; ECT2; ECT2L; FARP1; FARP2; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6; ITSN1/Intersectin 1; ITSN2/Intersectin 2; KALRN/Kalirin; MCF2; MCF2L; MCF2L2; NET1; NGEF; OBSCN; PLEKHG1; PLEKHG2; PLEKHG3; PLEKHG4; PLEKHG4B; PLEKHG5; PLEKHG6; PREX1; PREX2; RASGRF1; RASGRF2; SOS1; SOS2; SPATA13; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3.

Human proteins containing DOCK/CZH RhoGEF domain

DOCK1/DOCK180; DOCK2; DOCK3/MOCA; DOCK4; DOCK5; DOCK6/ZIR1; DOCK7/ZIR2; DOCK8/ZIR3; DOCK9/Zizimin1; DOCK10/Zizimin2; DOCK11/Zizimin3

See also

References

  1. ^ Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein". Cell. 95 (2): 259–68. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.
  2. ^ Fort P, Blangy A (June 2017). "The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals". Genome Biology and Evolution. 9 (6): 1471–1486. doi:10.1093/gbe/evx100. PMC 5499878. PMID 28541439.
  3. ^ Cerione RA, Zheng Y (April 1996). "The Dbl family of oncogenes". Current Opinion in Cell Biology. 8 (2): 216–22. doi:10.1016/s0955-0674(96)80068-8. PMID 8791419.
  4. ^ Côté JF, Vuori K (December 2002). "Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity". Journal of Cell Science. 115 (Pt 24): 4901–13. doi:10.1242/jcs.00219. PMID 12432077.

Further reading

  • Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA (November 1991). "Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product". Nature. 354 (6351): 311–4. doi:10.1038/354311a0. PMID 1956381.
  • Tan EC, Leung T, Manser E, Lim L (December 1993). "The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins". The Journal of Biological Chemistry. 268 (36): 27291–8. PMID 8262969.
  • Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J (October 1998). "Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein". Cell. 95 (2): 259–68. doi:10.1016/S0092-8674(00)81756-0. PMID 9790532.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

RhoGEF domain Provide feedback

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.

Literature references

  1. Cerione RA, Zheng Y; , Curr Opin Cell Biol 1996;8:216-222.: The Dbl family of oncogenes. PUBMED:8791419 EPMC:8791419

  2. Hart MJ, Eva A, Evans T, Aaronson SA, Cerione RA; , Nature 1991;354:311-314.: Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. PUBMED:1956381 EPMC:1956381

  3. Tan EC, Leung T, Manser E, Lim L; , J Biol Chem 1993;268:27291-27298.: The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. PUBMED:8262969 EPMC:8262969

  4. Soisson SM, Nimnual AS, Uy M, Bar-Sagi D, Kuriyan J; , Cell 1998;95:259-268.: Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. PUBMED:9790532 EPMC:9790532


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000219

The Rho family GTPases Rho, Rac and CDC42 regulate a diverse array of cellular processes. Like all members of the Ras superfamily, the Rho proteins cycle between active GTP-bound and inactive GDP-bound conformational states. Activation of Rho proteins through release of bound GDP and subsequent binding of GTP, is catalysed by guanine nucleotide exchange factors (GEFs) in the Dbl family. The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. In addition, all family members possess a second, shared domain designated the pleckstrin homology (PH) domain ( INTERPRO ). Trio and its homologue UNC-73 are unique within the Dbl family insomuch as they encode two distinct DH/PH domain modules. The PH domain is invariably located immediately C-terminal to the DH domain and this invariant topography suggests a functional interdependence between these two structural modules. Biochemical data have established the role of the conserved DH domain in Rho GTPase interaction and activation, and the role of the tandem PH domain in intracellular targeting and/or regulation of DH domain function. The DH domain of Dbl has been shown to mediate oligomerisation that is mostly homophilic in nature. In addition to the tandem DH/PH domains Dbl family GEFs contain diverse structural motifs like serine/threonine kinase, RBD, PDZ, RGS, IQ, REM, Cdc25, RasGEF, CH, SH2, SH3, EF, spectrin or Ig.

The DH domain is composed of three structurally conserved regions separated by more variable regions. It does not share significant sequence homology with other subtypes of small G-protein GEF motifs such as the Cdc25 domain and the Sec7 domain, which specifically interact with Ras and ARF family small GTPases, respectively, nor with other Rho protein interactive motifs, indicating that the Dbl family proteins are evolutionarily unique. The DH domain is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(160)
Full
(43540)
Representative proteomes UniProt
(75018)
RP15
(6257)
RP35
(16105)
RP55
(37008)
RP75
(50004)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(160)
Full
(43540)
Representative proteomes UniProt
(75018)
RP15
(6257)
RP35
(16105)
RP55
(37008)
RP75
(50004)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(160)
Full
(43540)
Representative proteomes UniProt
(75018)
RP15
(6257)
RP35
(16105)
RP55
(37008)
RP75
(50004)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Alignment kindly provided by SMART
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: SMART
Number in seed: 160
Number in full: 43540
Average length of the domain: 175.80 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 15.91 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.6 27.6
Trusted cut-off 27.6 27.6
Noise cut-off 27.5 27.5
Model length: 183
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the RhoGEF domain has been found. There are 127 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4K6L3 View 3D Structure Click here
A0A0G2JTR4 View 3D Structure Click here
A0A0G2JTU0 View 3D Structure Click here
A0A0G2JVR2 View 3D Structure Click here
A0A0G2JW65 View 3D Structure Click here
A0A0G2JXT9 View 3D Structure Click here
A0A0G2JYL3 View 3D Structure Click here
A0A0G2JZE7 View 3D Structure Click here
A0A0G2K2U9 View 3D Structure Click here
A0A0G2K7L6 View 3D Structure Click here
A0A0G2KA11 View 3D Structure Click here
A0A0G2KC93 View 3D Structure Click here
A0A0G2KF42 View 3D Structure Click here
A0A0G2L933 View 3D Structure Click here
A0A0K3AQN0 View 3D Structure Click here
A0A0R4I9W4 View 3D Structure Click here
A0A0R4IDU6 View 3D Structure Click here
A0A0R4IGI8 View 3D Structure Click here
A0A0R4IK42 View 3D Structure Click here
A0A0R4IKD5 View 3D Structure Click here
A0A0R4ILP5 View 3D Structure Click here
A0A0R4IPD6 View 3D Structure Click here
A0A0R4IQD5 View 3D Structure Click here
A0A0R4IRY4 View 3D Structure Click here
A0A0R4ITX4 View 3D Structure Click here
A0A140LG29 View 3D Structure Click here
A0A140LH23 View 3D Structure Click here
A0A140LIP2 View 3D Structure Click here
A0A1D8PI09 View 3D Structure Click here
A0A1D8PNB5 View 3D Structure Click here
A0A1L1SU27 View 3D Structure Click here
A0A286Y8W8 View 3D Structure Click here
A0A286Y9S9 View 3D Structure Click here
A0A286YAR8 View 3D Structure Click here
A0A2R8Q2V3 View 3D Structure Click here
A0A2R8Q3N3 View 3D Structure Click here
A0A2R8Q515 View 3D Structure Click here
A0A2R8Q628 View 3D Structure Click here
A0A2R8Q802 View 3D Structure Click here
A0A2R8Q8K0 View 3D Structure Click here
A0A2R8QA33 View 3D Structure Click here
A0A2R8QCF3 View 3D Structure Click here
A0A2R8QCY0 View 3D Structure Click here
A0A2R8QD21 View 3D Structure Click here
A0A2R8QFM9 View 3D Structure Click here
A0A2R8QHS4 View 3D Structure Click here
A0A2R8QHV5 View 3D Structure Click here
A0A2R8QKA2 View 3D Structure Click here
A0A2R8QR20 View 3D Structure Click here
A0A2R8QRI5 View 3D Structure Click here
A0A2R8QV90 View 3D Structure Click here
A0A2R8RHL8 View 3D Structure Click here
A0A2R8RHL8 View 3D Structure Click here
A0A2R8RSL7 View 3D Structure Click here
A0A2R8YFR7 View 3D Structure Click here
A0A5F8MPP0 View 3D Structure Click here
A1IGU3 View 3D Structure Click here
A1IGU4 View 3D Structure Click here
A1IGU5 View 3D Structure Click here
A1L390 View 3D Structure Click here
A1ZAN6 View 3D Structure Click here
A1ZAQ3 View 3D Structure Click here
A1ZAQ4 View 3D Structure Click here
A1ZBA1 View 3D Structure Click here
A2AWP8 View 3D Structure Click here
A2CEA7 View 3D Structure Click here
A2RUX1 View 3D Structure Click here
A8DZ19 View 3D Structure Click here
A8E7E7 View 3D Structure Click here
A8HAL3 View 3D Structure Click here
A8MVX0 View 3D Structure Click here
B0BN40 View 3D Structure Click here
B0R089 View 3D Structure Click here
B0R0B4 View 3D Structure Click here
B0S4U0 View 3D Structure Click here
B0S6C8 View 3D Structure Click here
B0UY55 View 3D Structure Click here
B2GUW2 View 3D Structure Click here
B8JI51 View 3D Structure Click here
D3YYY8 View 3D Structure Click here
D3Z8W6 View 3D Structure Click here
D3Z9I3 View 3D Structure Click here
D3ZA21 View 3D Structure Click here
D3ZFK8 View 3D Structure Click here
D3ZKB4 View 3D Structure Click here
D3ZMS5 View 3D Structure Click here
D3ZQ60 View 3D Structure Click here
D3ZS72 View 3D Structure Click here
D3ZUD0 View 3D Structure Click here
D3ZWB4 View 3D Structure Click here
D3ZWV8 View 3D Structure Click here
D3ZYG0 View 3D Structure Click here
D4A1D2 View 3D Structure Click here
D4A3T0 View 3D Structure Click here
D4A646 View 3D Structure Click here
D4ABR1 View 3D Structure Click here
D4AD85 View 3D Structure Click here
D4AE81 View 3D Structure Click here
E7EY47 View 3D Structure Click here
E7EYW1 View 3D Structure Click here
E7F1T2 View 3D Structure Click here
E7F1U2 View 3D Structure Click here
E7F2H9 View 3D Structure Click here
E7F2V3 View 3D Structure Click here
E7F3M3 View 3D Structure Click here
E7F3Z6 View 3D Structure Click here
E7F579 View 3D Structure Click here
E7F7V2 View 3D Structure Click here
E7F836 View 3D Structure Click here
E7F9C1 View 3D Structure Click here
E7FAM0 View 3D Structure Click here
E7FBN7 View 3D Structure Click here
E7FBR4 View 3D Structure Click here
E7FCG7 View 3D Structure Click here
E7FDB4 View 3D Structure Click here
E7FDV8 View 3D Structure Click here
E7FE33 View 3D Structure Click here
E7FF78 View 3D Structure Click here
E9PT59 View 3D Structure Click here
E9Q7D5 View 3D Structure Click here
E9QGS1 View 3D Structure Click here
E9QHS5 View 3D Structure Click here
E9QIC8 View 3D Structure Click here
F1LT94 View 3D Structure Click here
F1LTE6 View 3D Structure Click here
F1LUS8 View 3D Structure Click here
F1LUU6 View 3D Structure Click here
F1LWB1 View 3D Structure Click here
F1LXF1 View 3D Structure Click here
F1LYQ8 View 3D Structure Click here
F1MAI3 View 3D Structure Click here
F1Q4X6 View 3D Structure Click here
F1Q4Y0 View 3D Structure Click here
F1Q841 View 3D Structure Click here
F1QA66 View 3D Structure Click here
F1QCM5 View 3D Structure Click here
F1QIN9 View 3D Structure Click here
F1QUJ5 View 3D Structure Click here
F1R019 View 3D Structure Click here
F1R0Z9 View 3D Structure Click here
F1R1Q2 View 3D Structure Click here
F1R6J2 View 3D Structure Click here
F1RE63 View 3D Structure Click here
F1REH9 View 3D Structure Click here
F6P6M2 View 3D Structure Click here
F8VPU2 View 3D Structure Click here
G3V9A0 View 3D Structure Click here
G5ECK4 View 3D Structure Click here
G5EF62 View 3D Structure Click here
G5EFE1 View 3D Structure Click here
H2KYI7 View 3D Structure Click here
H2L0P5 View 3D Structure Click here
M0R3X3 View 3D Structure Click here
M0R4F8 View 3D Structure Click here
M0R7A6 View 3D Structure Click here
M0RBM9 View 3D Structure Click here
M9PHU0 View 3D Structure Click here
O01847 View 3D Structure Click here
O14827 View 3D Structure Click here
O15013 View 3D Structure Click here
O15068 View 3D Structure Click here
O15085 View 3D Structure Click here
O43307 View 3D Structure Click here
O55043 View 3D Structure Click here
O59679 View 3D Structure Click here
O61528 View 3D Structure Click here
O61528 View 3D Structure Click here
O88387 View 3D Structure Click here
O88842 View 3D Structure Click here
O94887 View 3D Structure Click here
O94989 View 3D Structure Click here
P0C5Y8 View 3D Structure Click here
P0C6P5 View 3D Structure Click here
P10911 View 3D Structure Click here
P11274 View 3D Structure Click here
P11433 View 3D Structure Click here
P15498 View 3D Structure Click here
P26675 View 3D Structure Click here
P27671 View 3D Structure Click here
P27870 View 3D Structure Click here
P28818 View 3D Structure Click here
P40995 View 3D Structure Click here
P51862 View 3D Structure Click here
P52734 View 3D Structure Click here
P52735 View 3D Structure Click here
P53046 View 3D Structure Click here
P54100 View 3D Structure Click here
P70392 View 3D Structure Click here
P91621 View 3D Structure Click here
P97433 View 3D Structure Click here
P98174 View 3D Structure Click here
Q008S8 View 3D Structure Click here
Q02384 View 3D Structure Click here
Q05670 View 3D Structure Click here
Q06412 View 3D Structure Click here
Q07139 View 3D Structure Click here
Q07889 View 3D Structure Click here
Q07890 View 3D Structure Click here
Q09733 View 3D Structure Click here
Q09763 View 3D Structure Click here
Q11100 View 3D Structure Click here
Q12774 View 3D Structure Click here
Q12979 View 3D Structure Click here
Q13009 View 3D Structure Click here
Q13972 View 3D Structure Click here
Q14155 View 3D Structure Click here
Q15052 View 3D Structure Click here
Q15811 View 3D Structure Click here
Q1MT42 View 3D Structure Click here
Q1ZX99 View 3D Structure Click here
Q1ZXH8 View 3D Structure Click here
Q1ZXN6 View 3D Structure Click here
Q21430 View 3D Structure Click here
Q21653 View 3D Structure Click here
Q3KR16 View 3D Structure Click here
Q3LAC4 View 3D Structure Click here
Q3U5C8 View 3D Structure Click here
Q3UPH7 View 3D Structure Click here
Q3UTH8 View 3D Structure Click here
Q45FX5 View 3D Structure Click here
Q498M6 View 3D Structure Click here
Q4VAC9 View 3D Structure Click here
Q54B37 View 3D Structure Click here
Q54BV5 View 3D Structure Click here
Q54BY9 View 3D Structure Click here
Q54BZ2 View 3D Structure Click here
Q54C56 View 3D Structure Click here
Q54C71 View 3D Structure Click here
Q54DW4 View 3D Structure Click here
Q54DW4 View 3D Structure Click here
Q54DW7 View 3D Structure Click here
Q54F64 View 3D Structure Click here
Q54F88 View 3D Structure Click here
Q54G10 View 3D Structure Click here
Q54GP2 View 3D Structure Click here
Q54GY6 View 3D Structure Click here
Q54J11 View 3D Structure Click here
Q54J14 View 3D Structure Click here
Q54MM3 View 3D Structure Click here
Q54ND2 View 3D Structure Click here
Q54NG0 View 3D Structure Click here
Q54P24 View 3D Structure Click here
Q54P81 View 3D Structure Click here
Q54PK2 View 3D Structure Click here
Q54S15 View 3D Structure Click here
Q54SG9 View 3D Structure Click here
Q54SR5 View 3D Structure Click here
Q54T65 View 3D Structure Click here
Q54UJ2 View 3D Structure Click here
Q54VX2 View 3D Structure Click here
Q54XA7 View 3D Structure Click here
Q54XW8 View 3D Structure Click here
Q54Y47 View 3D Structure Click here
Q54YP1 View 3D Structure Click here
Q54YZ6 View 3D Structure Click here
Q550V3 View 3D Structure Click here
Q553D3 View 3D Structure Click here
Q55CR5 View 3D Structure Click here
Q55DL8 View 3D Structure Click here
Q55E26 View 3D Structure Click here
Q55G27 View 3D Structure Click here
Q55G61 View 3D Structure Click here
Q58EX7 View 3D Structure Click here
Q5AH90 View 3D Structure Click here
Q5BKC9 View 3D Structure Click here
Q5DU57 View 3D Structure Click here
Q5FVC2 View 3D Structure Click here
Q5FWH6 View 3D Structure Click here
Q5JSP0 View 3D Structure Click here
Q5RH33 View 3D Structure Click here
Q5RHT9 View 3D Structure Click here
Q5SSL4 View 3D Structure Click here
Q5VV41 View 3D Structure Click here
Q5XXR3 View 3D Structure Click here
Q60610 View 3D Structure Click here
Q60875 View 3D Structure Click here
Q60992 View 3D Structure Click here
Q61210 View 3D Structure Click here
Q62245 View 3D Structure Click here
Q63406 View 3D Structure Click here
Q64096 View 3D Structure Click here
Q66JY6 View 3D Structure Click here
Q66T02 View 3D Structure Click here
Q68FM7 View 3D Structure Click here
Q69ZK0 View 3D Structure Click here
Q69ZL1 View 3D Structure Click here
Q6KAU7 View 3D Structure Click here
Q6P720 View 3D Structure Click here
Q6P9R4 View 3D Structure Click here
Q6PAJ1 View 3D Structure Click here
Q6RFZ7 View 3D Structure Click here
Q6TXD4 View 3D Structure Click here
Q6XZF7 View 3D Structure Click here
Q6ZNL6 View 3D Structure Click here
Q6ZPF3 View 3D Structure Click here
Q6ZR37 View 3D Structure Click here
Q6ZSZ5 View 3D Structure Click here
Q6ZV73 View 3D Structure Click here
Q70Z35 View 3D Structure Click here
Q7K4E0 View 3D Structure Click here
Q7KU89 View 3D Structure Click here
Q7KVD1 View 3D Structure Click here
Q7KVD1 View 3D Structure Click here
Q7TNR9 View 3D Structure Click here
Q7Z628 View 3D Structure Click here
Q7Z6J4 View 3D Structure Click here
Q80U35 View 3D Structure Click here
Q80UZ0 View 3D Structure Click here
Q80VK6 View 3D Structure Click here
Q86HN1 View 3D Structure Click here
Q86K95 View 3D Structure Click here
Q86VW2 View 3D Structure Click here
Q86YR7 View 3D Structure Click here
Q8BLE2 View 3D Structure Click here
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