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98  structures 1512  species 0  interactions 22606  sequences 553  architectures

Family: UBA (PF00627)

Summary: UBA/TS-N domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "UBA protein domain". More...

UBA protein domain Edit Wikipedia article

UBA
PDB 1efu EBI.jpg
elongation factor complex ef-tu/ef-ts from escherichia coli
Identifiers
Symbol UBA
Pfam PF00627
Pfam clan CL0214
InterPro IPR000449
PROSITE PDOC50030
SCOP 1efu
SUPERFAMILY 1efu
CDD cd00194

In molecular biology, the protein domain UBA is short for ubiquitin-associated domains. Ubiquitin is a signal added to an incorrectly folded protein, which allows it to be degraded by the proteasome, and the amino acid constituents can be recycled.

Function

This family of proteins is involved in a variety of additional cell processes, such as nucleotide excision repair (NER), spindle pole body duplication, and cell growth.[1]

Protein degradation via the ubiquitin proteasome system (UPS) allows the cell to selectively negatively regulate intracellular proteins. Protein degradation helps to maintain protein quality control, signalling, and cell cycle progression.[2][3] UBA has been proposed to limit ubiquitin chain elongation and to target polyubiquitinated proteins to the 26S proteasome for degradation.[4] They have been identified in modular proteins involved in protein trafficking, DNA repair, proteasomal degradation, and cell cycle regulation. UBA bind to ubiquitin and aids all the cellular processes involved with ubiquitin; this includes:

Localisation

The ubiquitin-associated (UBA) protein domain is found to be localized in the cytoplasm and nucleus.[4]

Structure

UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues.[5]

Examples

The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle.[6]

Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin.[7]

This domain is similar in sequence to the N-terminal domain of translation elongation factor EF1B (or EF-Ts) from bacteria, mitochondria and chloroplasts.

More information about EF1B (EF-Ts) proteins can be found at Protein of the Month: Elongation Factors .

References

  1. ^ Su V, Lau AF (2009). "Ubiquitin-like and ubiquitin-associated domain proteins: significance in proteasomal degradation.". Cell Mol Life Sci. 66 (17): 2819–33. PMC 2725189Freely accessible. PMID 19468686. doi:10.1007/s00018-009-0048-9. 
  2. ^ Gomez TA, Kolawa N, Gee M, Sweredoski MJ, Deshaies RJ (2011). "Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1.". BMC Biol. 9: 33. PMC 3126750Freely accessible. PMID 21627799. doi:10.1186/1741-7007-9-33. 
  3. ^ Tse MK, Hui SK, Yang Y, Yin ST, Hu HY, Zou B, et al. (2011). "Structural analysis of the UBA domain of X-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association.". PLoS ONE. 6 (12): e28511. PMC 3240630Freely accessible. PMID 22194841. doi:10.1371/journal.pone.0028511. 
  4. ^ a b Li J, Chu H, Zhang Y, Mou T, Wu C, Zhang Q, et al. (2012). "The rice HGW gene encodes a ubiquitin-associated (UBA) domain protein that regulates heading date and grain weight.". PLoS ONE. 7 (3): e34231. PMC 3311617Freely accessible. PMID 22457828. doi:10.1371/journal.pone.0034231. 
  5. ^ Hofmann K, Bucher P (May 1996). "The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway". Trends Biochem. Sci. 21 (5): 172–3. PMID 8871400. doi:10.1016/S0968-0004(96)30015-7. 
  6. ^ Dieckmann T, Withers-Ward ES, Jarosinski MA, Liu CF, Chen IS, Feigon J (December 1998). "Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr". Nat. Struct. Biol. 5 (12): 1042–7. PMID 9846873. doi:10.1038/4220. 
  7. ^ Mueller TD, Feigon J (June 2002). "Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions". J. Mol. Biol. 319 (5): 1243–55. PMID 12079361. doi:10.1016/S0022-2836(02)00302-9. 

This article incorporates text from the public domain Pfam and InterPro IPR000449

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

UBA/TS-N domain Provide feedback

This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. The structure of the UBA domain consists of a compact three helix bundle [1]. This domain is found at the N terminus of EF-TS hence the name TS-N. The structure of EF-TS is known and this domain is implicated in its interaction with EF-TU [2]. The domain has been found in non EF-TS proteins such as alpha-NAC P70670 and MJ0280 Q57728 [1].

Literature references

  1. Dieckmann T, Withers-Ward ES, Jarosinski MA, Liu CF, Chen IS, Feigon J; , Nat Struct Biol 1998;5:1042-1047.: Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. PUBMED:9846873 EPMC:9846873

  2. Makarova KS, Aravind L, Galperin MY, Grishin NV, Tatusov RL, Wolf YI, Koonin EV; , Genome Res 1999;9:608-628.: Comparative genomics of the Archaea (Euryarchaeota): evolution of conserved protein families, the stable core, and the variable shell. PUBMED:10413400 EPMC:10413400

  3. Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R; , Nature 1996;379:511-518.: The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. PUBMED:8596629 EPMC:8596629


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR015940

UBA domains are a commonly occurring sequence motif of approximately 45 amino acid residues that are found in diverse proteins involved in the ubiquitin/proteasome pathway, DNA excision-repair, and cell signalling via protein kinases [ PUBMED:8871400 ]. The human homologue of yeast Rad23A is one example of a nucleotide excision-repair protein that contains both an internal and a C-terminal UBA domain. The solution structure of human Rad23A UBA(2) showed that the domain forms a compact three-helix bundle [ PUBMED:9846873 ]. Comparison of the structures of UBA(1) and UBA(2) reveals that both form very similar folds and have a conserved large hydrophobic surface patch which may be a common protein-interacting surface present in diverse UBA domains. Evidence that ubiquitin binds to UBA domains leads to the prediction that the hydrophobic surface patch of UBA domains interacts with the hydrophobic surface on the five-stranded beta-sheet of ubiquitin [ PUBMED:12079361 ].

This domain is similar in sequence to the N-terminal domain of translation elongation factor EF1B (or EF-Ts) from bacteria, mitochondria and chloroplasts [ PUBMED:8596629 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan UBA (CL0214), which has the following description:

This superfamily includes domains related to the UBA domain. These domains are often involved in ubiquitin binding.

The clan contains the following 21 members:

CRAL_TRIO_N CUE DMA DUF1421 E3_UbLigase_EDD E3_UbLigase_RBR GIP1_N HBS1_N HOIP-UBA HYPK_UBA Regnase_1_C RuvA_C TAP_C UBA UBA_2 UBA_3 UBA_4 UBA_5 UBA_6 Ubiq-assoc WIYLD

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(61)
Full
(22606)
Representative proteomes UniProt
(41468)
RP15
(3555)
RP35
(9590)
RP55
(18351)
RP75
(25059)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(61)
Full
(22606)
Representative proteomes UniProt
(41468)
RP15
(3555)
RP35
(9590)
RP55
(18351)
RP75
(25059)
Alignment:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(61)
Full
(22606)
Representative proteomes UniProt
(41468)
RP15
(3555)
RP35
(9590)
RP55
(18351)
RP75
(25059)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Bateman A
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 61
Number in full: 22606
Average length of the domain: 36.80 aa
Average identity of full alignment: 30 %
Average coverage of the sequence by the domain: 5.51 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.4 22.4
Trusted cut-off 22.4 22.4
Noise cut-off 22.3 22.3
Model length: 37
Family (HMM) version: 33
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the UBA domain has been found. There are 98 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4J1A8 View 3D Structure Click here
A0A0B4KFW5 View 3D Structure Click here
A0A0G2K7M2 View 3D Structure Click here
A0A0G2K7M2 View 3D Structure Click here
A0A0G2L7W9 View 3D Structure Click here
A0A0P0VIT9 View 3D Structure Click here
A0A0P0XI76 View 3D Structure Click here
A0A0R0EML8 View 3D Structure Click here
A0A0R0JMD5 View 3D Structure Click here
A0A0R4J375 View 3D Structure Click here
A0A1D5NT00 View 3D Structure Click here
A0A1D6EPM8 View 3D Structure Click here
A0A1D6EPM8 View 3D Structure Click here
A0A1D6G555 View 3D Structure Click here
A0A1D6I428 View 3D Structure Click here
A0A1D6I428 View 3D Structure Click here
A0A1D6JMS0 View 3D Structure Click here
A0A1D6K7R6 View 3D Structure Click here
A0A1D6KZC9 View 3D Structure Click here
A0A1D6MA76 View 3D Structure Click here
A0A1D6ML71 View 3D Structure Click here
A0A1D6MQK4 View 3D Structure Click here
A0A1D6N9Q8 View 3D Structure Click here
A0A1D6NY66 View 3D Structure Click here
A0A1D6NY66 View 3D Structure Click here
A0A1D8PF53 View 3D Structure Click here
A0A1D8PGE3 View 3D Structure Click here
A0A1D8PGE3 View 3D Structure Click here
A0A1D8PGI9 View 3D Structure Click here
A0A2R8PYT0 View 3D Structure Click here
A0A2R8PYT0 View 3D Structure Click here
A0A2R8QF71 View 3D Structure Click here
A0A2R8QGJ9 View 3D Structure Click here
A0A2R8QKJ2 View 3D Structure Click here
A0JPP0 View 3D Structure Click here
A2BFG9 View 3D Structure Click here
A2CEF7 View 3D Structure Click here
A4I4M0 View 3D Structure Click here
A4I4U4 View 3D Structure Click here
A4I614 View 3D Structure Click here
A4ICT1 View 3D Structure Click here
A9JTG7 View 3D Structure Click here
A9JTG7 View 3D Structure Click here
B1WBT8 View 3D Structure Click here
B4F7X8 View 3D Structure Click here
B6T790 View 3D Structure Click here
B6T790 View 3D Structure Click here
B6TB61 View 3D Structure Click here
B6TB61 View 3D Structure Click here
B6TNT9 View 3D Structure Click here
C0PCY1 View 3D Structure Click here
C0PCY1 View 3D Structure Click here
C0PFA7 View 3D Structure Click here
C6TIN6 View 3D Structure Click here
C6TIN6 View 3D Structure Click here
D3ZDI9 View 3D Structure Click here
D3ZDI9 View 3D Structure Click here
D3ZV15 View 3D Structure Click here
D3ZVQ0 View 3D Structure Click here
D3ZVQ0 View 3D Structure Click here
D3ZXS8 View 3D Structure Click here
D4A3P1 View 3D Structure Click here
D4A6T9 View 3D Structure Click here
D4AA63 View 3D Structure Click here
E7F3W3 View 3D Structure Click here
E7F3W3 View 3D Structure Click here
E7F8Q5 View 3D Structure Click here
E9AHE3 View 3D Structure Click here
E9QBH8 View 3D Structure Click here
E9QEM6 View 3D Structure Click here
F1LQF5 View 3D Structure Click here
F1LV21 View 3D Structure Click here
F1M2K4 View 3D Structure Click here
F1Q5N2 View 3D Structure Click here
F1Q8U2 View 3D Structure Click here
F1QE21 View 3D Structure Click here
F1QFS9 View 3D Structure Click here
F1QFS9 View 3D Structure Click here
F1QHZ1 View 3D Structure Click here
F1QHZ1 View 3D Structure Click here
F4KCN6 View 3D Structure Click here
F6P6X0 View 3D Structure Click here
F7ES73 View 3D Structure Click here
F7ES73 View 3D Structure Click here
F7ES73 View 3D Structure Click here
G5EFF7 View 3D Structure Click here
I1J8D4 View 3D Structure Click here
I1JCA6 View 3D Structure Click here
I1JN41 View 3D Structure Click here
I1JQD8 View 3D Structure Click here
I1K3U6 View 3D Structure Click here
I1KE56 View 3D Structure Click here
I1KE56 View 3D Structure Click here
I1KG42 View 3D Structure Click here
I1KG42 View 3D Structure Click here
I1KS98 View 3D Structure Click here
I1KVT1 View 3D Structure Click here
I1KVT1 View 3D Structure Click here
I1KWA5 View 3D Structure Click here
I1KWV5 View 3D Structure Click here
I1KWV5 View 3D Structure Click here
I1LEX5 View 3D Structure Click here
I1LEX5 View 3D Structure Click here
I1LI99 View 3D Structure Click here
I1LSZ2 View 3D Structure Click here
I1LSZ2 View 3D Structure Click here
I1LWN0 View 3D Structure Click here
I1M603 View 3D Structure Click here
I1M603 View 3D Structure Click here
I1M653 View 3D Structure Click here
I1MMX7 View 3D Structure Click here
I1N4G7 View 3D Structure Click here
I1N5C6 View 3D Structure Click here
I1N5C6 View 3D Structure Click here
I1NFH7 View 3D Structure Click here
I1NFH7 View 3D Structure Click here
I3IRW6 View 3D Structure Click here
K7LAF0 View 3D Structure Click here
K7M8N8 View 3D Structure Click here
K7M8N8 View 3D Structure Click here
K7MGG0 View 3D Structure Click here
K7MGM8 View 3D Structure Click here
K7MQF1 View 3D Structure Click here
K7MZE5 View 3D Structure Click here
K7UR93 View 3D Structure Click here
K7USU9 View 3D Structure Click here
O08678 View 3D Structure Click here
O08679 View 3D Structure Click here
O13773 View 3D Structure Click here
O48696 View 3D Structure Click here
O74345 View 3D Structure Click here
O74803 View 3D Structure Click here
O74803 View 3D Structure Click here
O76387 View 3D Structure Click here
O94685 View 3D Structure Click here
O95835 View 3D Structure Click here
P22681 View 3D Structure Click here
P22682 View 3D Structure Click here
P27448 View 3D Structure Click here
P32628 View 3D Structure Click here
P32628 View 3D Structure Click here
P34216 View 3D Structure Click here
P38237 View 3D Structure Click here
P40087 View 3D Structure Click here
P40956 View 3D Structure Click here
P45974 View 3D Structure Click here
P45974 View 3D Structure Click here
P54201 View 3D Structure Click here
P54201 View 3D Structure Click here
P54725 View 3D Structure Click here
P54725 View 3D Structure Click here
P54726 View 3D Structure Click here
P54726 View 3D Structure Click here
P54727 View 3D Structure Click here
P54727 View 3D Structure Click here
P54728 View 3D Structure Click here
P54728 View 3D Structure Click here
P54729 View 3D Structure Click here
P54729 View 3D Structure Click here
P54729 View 3D Structure Click here
P56399 View 3D Structure Click here
P56399 View 3D Structure Click here
P61086 View 3D Structure Click here
P61087 View 3D Structure Click here
P90879 View 3D Structure Click here
P91502 View 3D Structure Click here
P92958 View 3D Structure Click here
Q03141 View 3D Structure Click here
Q04323 View 3D Structure Click here
Q05512 View 3D Structure Click here
Q0J365 View 3D Structure Click here
Q10169 View 3D Structure Click here
Q10187 View 3D Structure Click here
Q10256 View 3D Structure Click here
Q10S80 View 3D Structure Click here
Q11119 View 3D Structure Click here
Q11119 View 3D Structure Click here
Q12242 View 3D Structure Click here
Q1EBV4 View 3D Structure Click here
Q1L8N2 View 3D Structure Click here
Q1L8N2 View 3D Structure Click here
Q1MT86 View 3D Structure Click here
Q1MT86 View 3D Structure Click here
Q23451 View 3D Structure Click here
Q23451 View 3D Structure Click here
Q38997 View 3D Structure Click here
Q3V3E1 View 3D Structure Click here
Q40742 View 3D Structure Click here
Q40742 View 3D Structure Click here
Q499N6 View 3D Structure Click here
Q4CPK3 View 3D Structure Click here
Q4CWR4 View 3D Structure Click here
Q4CXY4 View 3D Structure Click here
Q4CYX4 View 3D Structure Click here
Q4CYX4 View 3D Structure Click here
Q4D7G6 View 3D Structure Click here
Q4D7G6 View 3D Structure Click here
Q4D870 View 3D Structure Click here
Q4DET5 View 3D Structure Click here
Q4DL42 View 3D Structure Click here
Q4DP13 View 3D Structure Click here
Q4E680 View 3D Structure Click here
Q4KMA2 View 3D Structure Click here
Q4KMA2 View 3D Structure Click here
Q54JV3 View 3D Structure Click here
Q54LV1 View 3D Structure Click here
Q54LV1 View 3D Structure Click here
Q54XG4 View 3D Structure Click here
Q5A5Q4 View 3D Structure Click here
Q5BKP2 View 3D Structure Click here
Q5BKP2 View 3D Structure Click here
Q5VRV7 View 3D Structure Click here
Q5VRV7 View 3D Structure Click here
Q5XIR9 View 3D Structure Click here
Q5XIR9 View 3D Structure Click here
Q5Z6P9 View 3D Structure Click here
Q5Z6P9 View 3D Structure Click here
Q642B3 View 3D Structure Click here
Q66HC1 View 3D Structure Click here
Q6ETL3 View 3D Structure Click here
Q6ETL3 View 3D Structure Click here
Q6H734 View 3D Structure Click here
Q6K653 View 3D Structure Click here
Q6NXA9 View 3D Structure Click here
Q6NYG6 View 3D Structure Click here
Q6ZKC1 View 3D Structure Click here
Q6ZKC1 View 3D Structure Click here
Q7KZI7 View 3D Structure Click here
Q7XCL2 View 3D Structure Click here
Q84L30 View 3D Structure Click here
Q84L30 View 3D Structure Click here
Q84L31 View 3D Structure Click here
Q84L31 View 3D Structure Click here
Q84L32 View 3D Structure Click here
Q84L32 View 3D Structure Click here
Q84L33 View 3D Structure Click here
Q84L33 View 3D Structure Click here
Q852Q0 View 3D Structure Click here
Q852Q1 View 3D Structure Click here
Q8BGG7 View 3D Structure Click here
Q8BP97 View 3D Structure Click here
Q8BYR2 View 3D Structure Click here
Q8CIP4 View 3D Structure Click here
Q8IDD9 View 3D Structure Click here
Q8II45 View 3D Structure Click here
Q8IIM8 View 3D Structure Click here
Q8IJS8 View 3D Structure Click here
Q8IJS8 View 3D Structure Click here
Q8L6Y1 View 3D Structure Click here
Q8L6Y1 View 3D Structure Click here
Q8LB17 View 3D Structure Click here
Q8NBM4 View 3D Structure Click here
Q8R1K1 View 3D Structure Click here
Q8R317 View 3D Structure Click here
Q8RXQ2 View 3D Structure Click here
Q8S1Y5 View 3D Structure Click here
Q8SY33 View 3D Structure Click here
Q8TF42 View 3D Structure Click here
Q8VDI7 View 3D Structure Click here
Q8VDI7 View 3D Structure Click here
Q8VHF0 View 3D Structure Click here
Q8VHJ5 View 3D Structure Click here
Q91W18 View 3D Structure Click here
Q922Y1 View 3D Structure Click here
Q92995 View 3D Structure Click here
Q92995 View 3D Structure Click here
Q96L34 View 3D Structure Click here
Q99NB8 View 3D Structure Click here
Q9BSL1 View 3D Structure Click here
Q9BSL1 View 3D Structure Click here
Q9D4I8 View 3D Structure Click here
Q9FI61 View 3D Structure Click here
Q9FLZ3 View 3D Structure Click here
Q9H347 View 3D Structure Click here
Q9H7E2 View 3D Structure Click here
Q9HCJ0 View 3D Structure Click here
Q9JJP9 View 3D Structure Click here
Q9LET3 View 3D Structure Click here
Q9MAT3 View 3D Structure Click here
Q9NIF3 View 3D Structure Click here
Q9NRR5 View 3D Structure Click here
Q9P0L2 View 3D Structure Click here
Q9QZM0 View 3D Structure Click here
Q9SDB9 View 3D Structure Click here
Q9SII8 View 3D Structure Click here
Q9SII9 View 3D Structure Click here
Q9UHD9 View 3D Structure Click here
Q9UMX0 View 3D Structure Click here
Q9V3W9 View 3D Structure Click here
Q9V3W9 View 3D Structure Click here
Q9VBQ3 View 3D Structure Click here
Q9VBQ3 View 3D Structure Click here
Q9VCD5 View 3D Structure Click here
Q9VCD5 View 3D Structure Click here
Q9VCE9 View 3D Structure Click here
Q9VRF3 View 3D Structure Click here
Q9VSC5 View 3D Structure Click here
Q9VUH8 View 3D Structure Click here
Q9VWD9 View 3D Structure Click here
Q9VWS7 View 3D Structure Click here
Q9VXF9 View 3D Structure Click here
Q9VZU7 View 3D Structure Click here
Q9VZU7 View 3D Structure Click here
Q9Y3P4 View 3D Structure Click here
Q9Y5A7 View 3D Structure Click here
Q9Y5A7 View 3D Structure Click here