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512  structures 4011  species 0  interactions 27105  sequences 909  architectures

Family: Glyco_hydro_18 (PF00704)

Summary: Glycosyl hydrolases family 18

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Glycoside hydrolase family 18". More...

Glycoside hydrolase family 18 Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Glycosyl hydrolases family 18 Provide feedback

No Pfam abstract.

Literature references

  1. Perrakis A, Tews I, Dauter Z, Oppenheim AB, Chet I, Wilson KS, Vorgias CE; , Structure 1994;2:1169-1180.: Crystal structure of a bacterial chitinase at 2.3 A resolution. PUBMED:7704527 EPMC:7704527


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001223

O-Glycosyl hydrolases ( EC ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ PUBMED:7624375 , PUBMED:8535779 ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.

Some members of this family, CAZY , belong to the chitinase class II group which includes chitinase, chitodextrinase and the killer toxin of Kluyveromyces lactis. The chitinases hydrolyse chitin oligosaccharides. The family also includes chitinase-like proteins, which bind but do not cleave chitin [ PUBMED:22550243 ]. In addition, the family also includes various glycoproteins from mammals; cartilage glycoprotein and the oviduct-specific glycoproteins are two examples.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(159)
Full
(27105)
Representative proteomes UniProt
(71776)
RP15
(4168)
RP35
(12501)
RP55
(23319)
RP75
(35106)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(159)
Full
(27105)
Representative proteomes UniProt
(71776)
RP15
(4168)
RP35
(12501)
RP55
(23319)
RP75
(35106)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(159)
Full
(27105)
Representative proteomes UniProt
(71776)
RP15
(4168)
RP35
(12501)
RP55
(23319)
RP75
(35106)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_574 (release 2.1)
Previous IDs: glycosyl_hydro8;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 159
Number in full: 27105
Average length of the domain: 300.80 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 57.25 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 29.6 29.6
Trusted cut-off 29.6 29.6
Noise cut-off 29.5 29.5
Model length: 312
Family (HMM) version: 30
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Glyco_hydro_18 domain has been found. There are 512 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JDS2 View 3D Structure Click here
A0A0K3AUR1 View 3D Structure Click here
A0A0N7KTE2 View 3D Structure Click here
A0A0P0W9B7 View 3D Structure Click here
A0A0P0XHR1 View 3D Structure Click here
A0A0R0EHM4 View 3D Structure Click here
A0A0R0ETF9 View 3D Structure Click here
A0A0R0FAL2 View 3D Structure Click here
A0A0R0GP25 View 3D Structure Click here
A0A0R0IHC8 View 3D Structure Click here
A0A0R0JAV1 View 3D Structure Click here
A0A0R4IEY0 View 3D Structure Click here
A0A0R4IJ02 View 3D Structure Click here
A0A1D6HG33 View 3D Structure Click here
A0A1D6HTN8 View 3D Structure Click here
A0A1D6HTN9 View 3D Structure Click here
A0A1D6HXA8 View 3D Structure Click here
A0A1D6HXA9 View 3D Structure Click here
A0A1D6HXB0 View 3D Structure Click here
A0A1D6KV11 View 3D Structure Click here
A0A1D6KV12 View 3D Structure Click here
A0A1D6LZN2 View 3D Structure Click here
A0A1D6MEM1 View 3D Structure Click here
A0A1D6MW10 View 3D Structure Click here
A0A1D6N6L9 View 3D Structure Click here
A0A1D6N6M0 View 3D Structure Click here
A0A1D6N6M1 View 3D Structure Click here
A0A1D6N6M2 View 3D Structure Click here
A0A1D6PXG5 View 3D Structure Click here
A0A286YA73 View 3D Structure Click here
A0JPQ9 View 3D Structure Click here
A0S5V8 View 3D Structure Click here
A4HWX6 View 3D Structure Click here
B4F8H2 View 3D Structure Click here
B4F9H4 View 3D Structure Click here
B4FBN8 View 3D Structure Click here
B4FR99 View 3D Structure Click here
B4G1T3 View 3D Structure Click here
B7F946 View 3D Structure Click here
C6T8G2 View 3D Structure Click here
D3KFR9 View 3D Structure Click here
D4A2D4 View 3D Structure Click here
D6R8W8 View 3D Structure Click here
F1M559 View 3D Structure Click here
F1RA25 View 3D Structure Click here
F1REF7 View 3D Structure Click here
F4JTY4 View 3D Structure Click here
F4JTY7 View 3D Structure Click here
F4JTY8 View 3D Structure Click here
F4JTY9 View 3D Structure Click here
F4JTZ2 View 3D Structure Click here
G5EBF8 View 3D Structure Click here
I1J5W9 View 3D Structure Click here
I1JEB1 View 3D Structure Click here
I1JKS9 View 3D Structure Click here
I1JRW1 View 3D Structure Click here
I1JRZ3 View 3D Structure Click here
I1KI15 View 3D Structure Click here
I1KXS7 View 3D Structure Click here
I1LDJ0 View 3D Structure Click here
I1LT62 View 3D Structure Click here
I1LZM1 View 3D Structure Click here
I1M4Q6 View 3D Structure Click here
I1M4Q7 View 3D Structure Click here
I1MI18 View 3D Structure Click here
I1MPC4 View 3D Structure Click here
I1MT43 View 3D Structure Click here
I1MTX4 View 3D Structure Click here
I1MWY7 View 3D Structure Click here
I1N156 View 3D Structure Click here
I1N7F0 View 3D Structure Click here
I1NH01 View 3D Structure Click here
I1NH02 View 3D Structure Click here
K7KNE1 View 3D Structure Click here
K7L9T3 View 3D Structure Click here
K7LDE9 View 3D Structure Click here
K7LPS8 View 3D Structure Click here
K7M8Z4 View 3D Structure Click here
K7M9J3 View 3D Structure Click here
K7MCM8 View 3D Structure Click here
K7MRJ1 View 3D Structure Click here
K7MRJ2 View 3D Structure Click here
K7TWD3 View 3D Structure Click here
K7UHN7 View 3D Structure Click here
O16237 View 3D Structure Click here
O22080 View 3D Structure Click here
O35744 View 3D Structure Click here
O49824 View 3D Structure Click here
O49825 View 3D Structure Click here
O49826 View 3D Structure Click here
O49827 View 3D Structure Click here
O49830 View 3D Structure Click here
O81854 View 3D Structure Click here
O81861 View 3D Structure Click here
O81862 View 3D Structure Click here
P19172 View 3D Structure Click here
P29029 View 3D Structure Click here
P36222 View 3D Structure Click here
P39657 View 3D Structure Click here
P40953 View 3D Structure Click here
P40954 View 3D Structure Click here
Q01459 View 3D Structure Click here
Q01460 View 3D Structure Click here
Q06350 View 3D Structure Click here
Q0DJN7 View 3D Structure Click here
Q0JK83 View 3D Structure Click here
Q11174 View 3D Structure Click here
Q12889 View 3D Structure Click here
Q13231 View 3D Structure Click here
Q14V32 View 3D Structure Click here
Q15782 View 3D Structure Click here
Q17834 View 3D Structure Click here
Q17835 View 3D Structure Click here
Q17836 View 3D Structure Click here
Q17837 View 3D Structure Click here
Q17839 View 3D Structure Click here
Q17840 View 3D Structure Click here
Q17841 View 3D Structure Click here
Q18143 View 3D Structure Click here
Q18143 View 3D Structure Click here
Q18143 View 3D Structure Click here
Q18607 View 3D Structure Click here
Q18644 View 3D Structure Click here
Q1PE65 View 3D Structure Click here
Q21857 View 3D Structure Click here
Q21858 View 3D Structure Click here
Q21859 View 3D Structure Click here
Q21861 View 3D Structure Click here
Q21862 View 3D Structure Click here
Q21864 View 3D Structure Click here
Q21866 View 3D Structure Click here
Q22468 View 3D Structure Click here
Q22596 View 3D Structure Click here
Q22597 View 3D Structure Click here
Q22597 View 3D Structure Click here
Q23675 View 3D Structure Click here
Q23997 View 3D Structure Click here
Q2R4T2 View 3D Structure Click here
Q53NL1 View 3D Structure Click here
Q53NL2 View 3D Structure Click here
Q53NL5 View 3D Structure Click here
Q53NL8 View 3D Structure Click here
Q53NL9 View 3D Structure Click here
Q53NM0 View 3D Structure Click here
Q54G42 View 3D Structure Click here
Q54KC0 View 3D Structure Click here
Q54KC1 View 3D Structure Click here
Q54YU9 View 3D Structure Click here
Q55FI9 View 3D Structure Click here
Q5AAH2 View 3D Structure Click here
Q5AM60 View 3D Structure Click here
Q5WMW5 View 3D Structure Click here
Q5WMX0 View 3D Structure Click here
Q61362 View 3D Structure Click here
Q62010 View 3D Structure Click here
Q657I8 View 3D Structure Click here
Q6NZZ8 View 3D Structure Click here
Q6P006 View 3D Structure Click here
Q6RY07 View 3D Structure Click here
Q7GCM7 View 3D Structure Click here
Q7KWW8 View 3D Structure Click here
Q7SYK0 View 3D Structure Click here
Q7XEL9 View 3D Structure Click here
Q7XVZ1 View 3D Structure Click here
Q7ZVF1 View 3D Structure Click here
Q80W26 View 3D Structure Click here
Q86JD3 View 3D Structure Click here
Q8I4R4 View 3D Structure Click here
Q8LHN3 View 3D Structure Click here
Q8MLW8 View 3D Structure Click here
Q8MLZ7 View 3D Structure Click here
Q8MM24 View 3D Structure Click here
Q8R242 View 3D Structure Click here
Q8RU26 View 3D Structure Click here
Q8RZ29 View 3D Structure Click here
Q8T0R7 View 3D Structure Click here
Q8T293 View 3D Structure Click here
Q91XA9 View 3D Structure Click here
Q91Z98 View 3D Structure Click here
Q922Q9 View 3D Structure Click here
Q94298 View 3D Structure Click here
Q965P2 View 3D Structure Click here
Q9AT30 View 3D Structure Click here
Q9BWS9 View 3D Structure Click here
Q9BZP6 View 3D Structure Click here
Q9D7Q1 View 3D Structure Click here
Q9FYR9 View 3D Structure Click here
Q9M159 View 3D Structure Click here
Q9NAN7 View 3D Structure Click here
Q9TZF2 View 3D Structure Click here
Q9V3D4 View 3D Structure Click here
Q9VFR3 View 3D Structure Click here
Q9VLS0 View 3D Structure Click here
Q9VZV2 View 3D Structure Click here
Q9VZV2 View 3D Structure Click here
Q9W092 View 3D Structure Click here
Q9W2M5 View 3D Structure Click here
Q9W2M6 View 3D Structure Click here
Q9W2M7 View 3D Structure Click here
Q9W303 View 3D Structure Click here
Q9W3V1 View 3D Structure Click here
Q9W5U2 View 3D Structure Click here
Q9W5U2 View 3D Structure Click here
Q9W5U2 View 3D Structure Click here
Q9W5U2 View 3D Structure Click here
Q9WTV1 View 3D Structure Click here
Q9XU76 View 3D Structure Click here