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82  structures 336  species 0  interactions 10178  sequences 66  architectures

Family: PMP22_Claudin (PF00822)

Summary: PMP-22/EMP/MP20/Claudin family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

PMP-22/EMP/MP20/Claudin family Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004031

This family of evolutionarily related integral membrane proteins includes PMP22, EMP, claudins and voltage-gated calcium channel gamma subunits, many of which which perform diverse functions at specialised cell-cell contacts [ PUBMED:24665403 ]. Family members from vertebrates and invertebrates are highly divergent.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Transporter (CL0375), which has the following description:

The members of this superfamily are probably all transporter protein domains. All families normally carry four tansmembrane regions, which in many instances associate into hexameric structures. They are frequently involved in gap-junction formation between cells or in forming pores linking the cytosol with the extracellulare space 1,2]. The clan includes members of the TCDB superfamilies 1.A.24 and 1.A.25.

The clan contains the following 13 members:

Amastin Atthog Claudin_2 Claudin_3 Clc-like Connexin Fig1 GSG-1 Innexin L_HMGIC_fpl Pannexin_like PMP22_Claudin SUR7

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(13)
Full
(10178)
Representative proteomes UniProt
(16582)
RP15
(887)
RP35
(3314)
RP55
(9053)
RP75
(11828)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(13)
Full
(10178)
Representative proteomes UniProt
(16582)
RP15
(887)
RP35
(3314)
RP55
(9053)
RP75
(11828)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(13)
Full
(10178)
Representative proteomes UniProt
(16582)
RP15
(887)
RP35
(3314)
RP55
(9053)
RP75
(11828)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1393 (release 2.1)
Previous IDs: PMP22;
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 13
Number in full: 10178
Average length of the domain: 162.50 aa
Average identity of full alignment: 23 %
Average coverage of the sequence by the domain: 72.28 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.7 26.7
Trusted cut-off 26.7 26.7
Noise cut-off 26.6 26.6
Model length: 166
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PMP22_Claudin domain has been found. There are 82 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LHK8 View 3D Structure Click here
A0A0G2K0N4 View 3D Structure Click here
A0A0G2KYS3 View 3D Structure Click here
A0A0G2L7R9 View 3D Structure Click here
A0A0R4IEG7 View 3D Structure Click here
A0A0R4IN71 View 3D Structure Click here
A0A0R4INZ4 View 3D Structure Click here
A0A0R4IRK7 View 3D Structure Click here
A0A2R8PY22 View 3D Structure Click here
A0A2R8Q0P2 View 3D Structure Click here
A0A2R8Q922 View 3D Structure Click here
A0A2R8Q9D1 View 3D Structure Click here
A0A2R8QF91 View 3D Structure Click here
A0A2R8QK68 View 3D Structure Click here
A0A2R8QSC2 View 3D Structure Click here
A4QNU3 View 3D Structure Click here
A6NM45 View 3D Structure Click here
B0V349 View 3D Structure Click here
B2GVC0 View 3D Structure Click here
B4F7F0 View 3D Structure Click here
B8JLG4 View 3D Structure Click here
B8JLV2 View 3D Structure Click here
C9JDP6 View 3D Structure Click here
D3YXJ9 View 3D Structure Click here
D3ZEF2 View 3D Structure Click here
D3ZQB5 View 3D Structure Click here
D3ZQJ0 View 3D Structure Click here
D3ZT28 View 3D Structure Click here
D4A2B4 View 3D Structure Click here
D4A386 View 3D Structure Click here
D4A6L7 View 3D Structure Click here
E7EY10 View 3D Structure Click here
E7EZH3 View 3D Structure Click here
E7FAA5 View 3D Structure Click here
E7FGK7 View 3D Structure Click here
E9QCW1 View 3D Structure Click here
E9QHT9 View 3D Structure Click here
F1QB03 View 3D Structure Click here
F1QE46 View 3D Structure Click here
F1QH81 View 3D Structure Click here
F1QIK8 View 3D Structure Click here
F1QKA9 View 3D Structure Click here
F1QP10 View 3D Structure Click here
F1QVR6 View 3D Structure Click here
F1QWK3 View 3D Structure Click here
F1R5J2 View 3D Structure Click here
F1R6Z2 View 3D Structure Click here
G3V7A9 View 3D Structure Click here
G5E8X0 View 3D Structure Click here
G5ED30 View 3D Structure Click here
O00501 View 3D Structure Click here
O14493 View 3D Structure Click here
O15551 View 3D Structure Click here
O35054 View 3D Structure Click here
O35912 View 3D Structure Click here
O54942 View 3D Structure Click here
O60359 View 3D Structure Click here
O75508 View 3D Structure Click here
O88551 View 3D Structure Click here
O88552 View 3D Structure Click here
O88602 View 3D Structure Click here
O88662 View 3D Structure Click here
O95471 View 3D Structure Click here
O95484 View 3D Structure Click here
O95500 View 3D Structure Click here
O95832 View 3D Structure Click here
P16646 View 3D Structure Click here
P25094 View 3D Structure Click here
P47801 View 3D Structure Click here
P54825 View 3D Structure Click here
P54848 View 3D Structure Click here
P54849 View 3D Structure Click here
P54851 View 3D Structure Click here
P54852 View 3D Structure Click here
P55344 View 3D Structure Click here
P56563 View 3D Structure Click here
P56745 View 3D Structure Click here
P56746 View 3D Structure Click here
P56747 View 3D Structure Click here
P56748 View 3D Structure Click here
P56750 View 3D Structure Click here
P56856 View 3D Structure Click here
P56857 View 3D Structure Click here
P56880 View 3D Structure Click here
P57739 View 3D Structure Click here
P78369 View 3D Structure Click here
Q01453 View 3D Structure Click here
Q0P479 View 3D Structure Click here
Q16617 View 3D Structure Click here
Q1L8R5 View 3D Structure Click here
Q1L960 View 3D Structure Click here
Q1RLQ8 View 3D Structure Click here
Q1RLW4 View 3D Structure Click here
Q45RH2 View 3D Structure Click here
Q45RH3 View 3D Structure Click here
Q497B5 View 3D Structure Click here
Q499Q7 View 3D Structure Click here
Q4V8V3 View 3D Structure Click here
Q561T6 View 3D Structure Click here
Q567D5 View 3D Structure Click here
Q568F1 View 3D Structure Click here
Q5BJQ1 View 3D Structure Click here
Q5BKW4 View 3D Structure Click here
Q5I0E5 View 3D Structure Click here
Q5PPJ3 View 3D Structure Click here
Q5QT56 View 3D Structure Click here
Q5XIT8 View 3D Structure Click here
Q60771 View 3D Structure Click here
Q63400 View 3D Structure Click here
Q66HH2 View 3D Structure Click here
Q6AXT9 View 3D Structure Click here
Q6DBT9 View 3D Structure Click here
Q6DGY5 View 3D Structure Click here
Q6DHL0 View 3D Structure Click here
Q6DHP1 View 3D Structure Click here
Q6NUZ6 View 3D Structure Click here
Q6P0U4 View 3D Structure Click here
Q6P608 View 3D Structure Click here
Q6PFS3 View 3D Structure Click here
Q6PFT6 View 3D Structure Click here
Q71RJ2 View 3D Structure Click here
Q7T2E7 View 3D Structure Click here
Q7T2P4 View 3D Structure Click here
Q80W35 View 3D Structure Click here
Q8BXA6 View 3D Structure Click here
Q8N6F1 View 3D Structure Click here
Q8N7P3 View 3D Structure Click here
Q8NHS1 View 3D Structure Click here
Q8QHA3 View 3D Structure Click here
Q8VHW2 View 3D Structure Click here
Q8VHW4 View 3D Structure Click here
Q8VHW5 View 3D Structure Click here
Q8VHW8 View 3D Structure Click here
Q8VHW9 View 3D Structure Click here
Q8VHX0 View 3D Structure Click here
Q8WXS5 View 3D Structure Click here
Q90XR2 View 3D Structure Click here
Q90XR6 View 3D Structure Click here
Q90XR8 View 3D Structure Click here
Q90XR9 View 3D Structure Click here
Q91Y55 View 3D Structure Click here
Q925N4 View 3D Structure Click here
Q96B33 View 3D Structure Click here
Q96FX8 View 3D Structure Click here
Q99P82 View 3D Structure Click here
Q99PA5 View 3D Structure Click here
Q9D7D7 View 3D Structure Click here
Q9D7U6 View 3D Structure Click here
Q9D9H2 View 3D Structure Click here
Q9ET38 View 3D Structure Click here
Q9JJV4 View 3D Structure Click here
Q9JJV5 View 3D Structure Click here
Q9JK95 View 3D Structure Click here
Q9JKD6 View 3D Structure Click here
Q9QYW5 View 3D Structure Click here
Q9UBN1 View 3D Structure Click here
Q9UF02 View 3D Structure Click here
Q9WVL9 View 3D Structure Click here
Q9Y5I7 View 3D Structure Click here
Q9Y698 View 3D Structure Click here
Q9YH90 View 3D Structure Click here
Q9YH91 View 3D Structure Click here
Q9YH92 View 3D Structure Click here
Q9Z0G9 View 3D Structure Click here
Q9Z0S3 View 3D Structure Click here
Q9Z0S4 View 3D Structure Click here
Q9Z0S5 View 3D Structure Click here
Q9Z0S6 View 3D Structure Click here
Q9Z0S7 View 3D Structure Click here
Q9Z1L1 View 3D Structure Click here
Q9Z260 View 3D Structure Click here
Q9Z261 View 3D Structure Click here
Q9Z262 View 3D Structure Click here
X1WEB1 View 3D Structure Click here
X1WFL1 View 3D Structure Click here