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96  structures 399  species 0  interactions 13029  sequences 69  architectures

Family: PMP22_Claudin (PF00822)

Summary: PMP-22/EMP/MP20/Claudin family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

PMP-22/EMP/MP20/Claudin family Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004031

This family of evolutionarily related integral membrane proteins includes PMP22, EMP, claudins and voltage-gated calcium channel gamma subunits, many of which which perform diverse functions at specialised cell-cell contacts [ PUBMED:24665403 ]. Family members from vertebrates and invertebrates are highly divergent.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Transporter (CL0375), which has the following description:

Members of this superfamily normally carry four transmembrane regions, which in many instances associate into hexameric structures. They are frequently involved in gap-junction formation between cells or in forming pores linking the cytosol with the extracellular space [1,2]. Some of them are transporters proteins, including members of the TCDB superfamilies 1.A.24 and 1.A.25.

The clan contains the following 14 members:

Amastin Atthog Claudin_2 Claudin_3 Clc-like Connexin Fig1 GSG-1 Innexin L_HMGIC_fpl Pannexin_like PMP22_Claudin SUR7 TMEM127

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(13)
Full
(13029)
Representative proteomes UniProt
(23316)
RP15
(1083)
RP35
(4024)
RP55
(9912)
RP75
(13348)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(13)
Full
(13029)
Representative proteomes UniProt
(23316)
RP15
(1083)
RP35
(4024)
RP55
(9912)
RP75
(13348)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(13)
Full
(13029)
Representative proteomes UniProt
(23316)
RP15
(1083)
RP35
(4024)
RP55
(9912)
RP75
(13348)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1393 (release 2.1)
Previous IDs: PMP22;
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 13
Number in full: 13029
Average length of the domain: 163.40 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 72.51 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.7 26.7
Trusted cut-off 26.7 26.7
Noise cut-off 26.6 26.6
Model length: 166
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the PMP22_Claudin domain has been found. There are 96 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LHK8 View 3D Structure Click here
A0A0G2K0N4 View 3D Structure Click here
A0A0G2KYS3 View 3D Structure Click here
A0A0G2L7R9 View 3D Structure Click here
A0A0R4IEG7 View 3D Structure Click here
A0A0R4IN71 View 3D Structure Click here
A0A0R4INZ4 View 3D Structure Click here
A0A0R4IRK7 View 3D Structure Click here
A0A2R8PY22 View 3D Structure Click here
A0A2R8Q0P2 View 3D Structure Click here
A0A2R8Q922 View 3D Structure Click here
A0A2R8Q9D1 View 3D Structure Click here
A0A2R8QF91 View 3D Structure Click here
A0A2R8QK68 View 3D Structure Click here
A0A2R8QSC2 View 3D Structure Click here
A4QNU3 View 3D Structure Click here
A6NM45 View 3D Structure Click here
B0V349 View 3D Structure Click here
B2GVC0 View 3D Structure Click here
B4F7F0 View 3D Structure Click here
B8JLG4 View 3D Structure Click here
B8JLV2 View 3D Structure Click here
C9JDP6 View 3D Structure Click here
D3YXJ9 View 3D Structure Click here
D3ZEF2 View 3D Structure Click here
D3ZQB5 View 3D Structure Click here
D3ZQJ0 View 3D Structure Click here
D3ZT28 View 3D Structure Click here
D4A2B4 View 3D Structure Click here
D4A386 View 3D Structure Click here
D4A6L7 View 3D Structure Click here
E7EY10 View 3D Structure Click here
E7EZH3 View 3D Structure Click here
E7FAA5 View 3D Structure Click here
E7FGK7 View 3D Structure Click here
E9QCW1 View 3D Structure Click here
E9QHT9 View 3D Structure Click here
F1QB03 View 3D Structure Click here
F1QE46 View 3D Structure Click here
F1QH81 View 3D Structure Click here