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116  structures 331  species 0  interactions 4723  sequences 57  architectures

Family: Transglut_C (PF00927)

Summary: Transglutaminase family, C-terminal ig like domain

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Transglutaminase family, C-terminal ig like domain Provide feedback

No Pfam abstract.

Literature references

  1. Yee VC, Pedersen LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC; , Proc Natl Acad Sci USA 1994;91:7296-7300.: Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. PUBMED:7913750 EPMC:7913750


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR008958

Transglutaminases catalyse the post-translational modification of proteins at glutamine residues, with formation of isopeptide bonds. Members of the transglutaminase family usually have three domains: N-terminal ( INTERPRO ), middle ( INTERPRO ) and C-terminal. The middle domain is usually well conserved, but family members can display major differences in their N- and C-terminal domains, although their overall structure is conserved [ PUBMED:10411627 ]. This entry represents the C-terminal domain found in transglutaminases, which consists of an immunoglobulin-like beta-sandwich consisting of seven strands in two sheets with a Greek key topology.

The best known transglutaminase is blood coagulation factor XIII, a plasma tetrameric protein composed of two catalytic A subunits and two non-catalytic B subunits. Factor XIII is responsible for cross-linking fibrin chains, thus stabilising the fibrin clot. Protein-glutamine gamma-glutamyltransferases ( EC ) are calcium-dependent enzymes that catalyse the cross-linking of proteins by promoting the formation of isopeptide bonds between the gamma-carboxyl group of a glutamine in one polypeptide chain and the epsilon-amino group of a lysine in a second polypeptide chain. TGases also catalyse the conjugation of polyamines to proteins [ PUBMED:1683845 , PUBMED:1974250 ].

Proteins containing this domain also include Protein 4.2 (also known as Epb42), which is one of the most abundant protein components of the erythrocyte membrane. The protein shares significant sequence homology with transglutaminases, but lacks the catalytic triad residues required for transglutaminase activity [ PUBMED:15692067 ]. The complete or nearly complete absence of protein 4.2 is associated with an atypical form of hereditary spherocytosis (HS) [ PUBMED:19269200 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan E-set (CL0159), which has the following description:

This clan includes a diverse range of domains that have an Ig-like fold and appear to be distantly related to each other. The clan includes: PKD domains, cadherins and several families of bacterial Ig-like domains as well as viral tail fibre proteins. it also includes several Fibronectin type III domain-containing families.

The clan contains the following 238 members:

A2M A2M_BRD A2M_recep AA9 Adeno_GP19K AlcCBM31 Alpha-amylase_N Alpha_adaptinC2 Alpha_E2_glycop Anth_Ig Arch_flagellin aRib Arylsulfotran_N ASF1_hist_chap ATG19 BACON BACON_2 BatD BIg21 Big_1 Big_10 Big_11 Big_12 Big_13 Big_2 Big_3 Big_3_2 Big_3_3 Big_3_4 Big_3_5 Big_4 Big_5 Big_6 Big_7 Big_8 Big_9 Bile_Hydr_Trans BiPBP_C bMG1 bMG10 bMG3 bMG5 bMG6 BslA BsuPI Cadherin Cadherin-like Cadherin_2 Cadherin_3 Cadherin_4 Cadherin_5 Cadherin_pro CagX Calx-beta Candida_ALS_N CARDB CBM39 CBM_X2 CD45 CelD_N Ceramidse_alk_C CHB_HEX_C CHB_HEX_C_1 ChitinaseA_N ChiW_Ig_like Chlam_OMP6 CHU_C Coatamer_beta_C COP-gamma_platf CopC CshA_repeat Cyc-maltodext_N Cytomega_US3 DsbC DUF11 DUF1410 DUF1425 DUF1929 DUF2271 DUF3244 DUF3327 DUF3416 DUF3458 DUF3501 DUF3823_C DUF3859 DUF4165 DUF4179 DUF4426 DUF4469 DUF4625 DUF4879 DUF4959 DUF4981 DUF4982 DUF4998 DUF5001 DUF5008 DUF5011 DUF5065 DUF5115 DUF525 DUF5643 DUF6383 DUF916 EB_dh ECD EpoR_lig-bind ERAP1_C EstA_Ig_like Expansin_C Filamin FixG_C Flavi_glycop_C FlgD_ig fn3 Fn3-like fn3_2 fn3_4 fn3_5 fn3_6 FN3_7 Fn3_assoc fn3_PAP GBS_Bsp-like Glucodextran_B Glyco_hydro2_C5 Glyco_hydro_2 Gmad2 GMP_PDE_delta GPI-anchored Hanta_G1 He_PIG HECW_N HemeBinding_Shp Hemocyanin_C Herpes_BLLF1 HYR IFNGR1 Ig_GlcNase Ig_mannosidase IL12p40_C Il13Ra_Ig IL17R_fnIII_D1 IL17R_fnIII_D2 IL2RB_N1 IL3Ra_N IL4Ra_N IL6Ra-bind Inhibitor_I42 Inhibitor_I71 InlK_D3 Integrin_alpha2 Interfer-bind Invasin_D3 IRK_C IrmA Iron_transport LEA_2 Lep_receptor_Ig LIFR_N Lipase_bact_N LPMO_10 LRR_adjacent LTD Mannosidase_ig MetallophosC MG1 MG2 MG3 MG4 Mo-co_dimer N_BRCA1_IG Na_K-ATPase NEAT Neocarzinostat Neurexophilin NPCBM_assoc PapD_C PBP-Tp47_c Peptidase_C25_C Phlebo_G2_C PhoD_N PKD PKD_2 PKD_3 PKD_4 PKD_5 PKD_6 Por_Secre_tail Pox_vIL-18BP Psg1 PTP_tm Pur_ac_phosph_N Qn_am_d_aII Qn_am_d_aIII RabGGT_insert Reeler REJ RET_CLD1 RET_CLD3 RET_CLD4 RGI_lyase RHD_dimer Rho_GDI Rib RibLong SCAB-Ig SKICH SLAM SoxZ SprB SusE SVA SWM_repeat T2SS-T3SS_pil_N Tafi-CsgC TarS_C1 TcA_RBD TcfC TIG TIG_2 TIG_plexin TIG_SUH Tissue_fac Top6b_C Transglut_C Transglut_N TRAP_beta TraQ_transposon UL16 Velvet WIF Wzt_C Y_Y_Y YBD ZirS_C Zona_pellucida

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(25)
Full
(4723)
Representative proteomes UniProt
(7626)
RP15
(476)
RP35
(1549)
RP55
(4077)
RP75
(5311)
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PP/heatmap 1 View           

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(25)
Full
(4723)
Representative proteomes UniProt
(7626)
RP15
(476)
RP35
(1549)
RP55
(4077)
RP75
(5311)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(25)
Full
(4723)
Representative proteomes UniProt
(7626)
RP15
(476)
RP35
(1549)
RP55
(4077)
RP75
(5311)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1005 (release 3.0)
Previous IDs: 1005; Transglutamin_C;
Type: Domain
Sequence Ontology: SO:0000417
Author: Finn RD , Bateman A , Griffiths-Jones SR
Number in seed: 25
Number in full: 4723
Average length of the domain: 99.70 aa
Average identity of full alignment: 19 %
Average coverage of the sequence by the domain: 24.08 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.6 26.6
Noise cut-off 26.5 26.5
Model length: 106
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Transglut_C domain has been found. There are 116 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K142 View 3D Structure Click here
A0A0G2K142 View 3D Structure Click here
A0A0R4IGK8 View 3D Structure Click here
A0A0R4IKS1 View 3D Structure Click here
A0A0R4IKS1 View 3D Structure Click here
A0A0R4INB1 View 3D Structure Click here
A0A0R4INB1 View 3D Structure Click here
A0A2R8PX12 View 3D Structure Click here
A0A2R8PX12 View 3D Structure Click here
A0A2R8QKL9 View 3D Structure Click here
A0A2R8QKL9 View 3D Structure Click here
A0A2R8RZS2 View 3D Structure Click here
A2ART8 View 3D Structure Click here
A3KQ87 View 3D Structure Click here
B5DF57 View 3D Structure Click here
B5DF57 View 3D Structure Click here
D4A5U3 View 3D Structure Click here
D4A5U3 View 3D Structure Click here
F1LZP5 View 3D Structure Click here
F1M4T7 View 3D Structure Click here
F1M4T7 View 3D Structure Click here
F1QC84 View 3D Structure Click here
F1QC84 View 3D Structure Click here
F1QHM3 View 3D Structure Click here
F1QHM3 View 3D Structure Click here
F1R1A8 View 3D Structure Click here
F1R1A8 View 3D Structure Click here
F1R1R7 View 3D Structure Click here
F1R1R7 View 3D Structure Click here
O08619 View 3D Structure Click here
O08619 View 3D Structure Click here
O43548 View 3D Structure Click here
O43548 View 3D Structure Click here
O95932 View 3D Structure Click here
O95932 View 3D Structure Click here
P00488 View 3D Structure Click here
P00488 View 3D Structure Click here
P16452 View 3D Structure Click here
P16452 View 3D Structure Click here
P21980 View 3D Structure Click here
P21980 View 3D Structure Click here
P21981 View 3D Structure Click here
P21981 View 3D Structure Click here
P22735 View 3D Structure Click here
P22735 View 3D Structure Click here
P23606 View 3D Structure Click here
P23606 View 3D Structure Click here
P49221 View 3D Structure Click here
P49222 View 3D Structure Click here
P49222 View 3D Structure Click here
Q08188 View 3D Structure Click here
Q08188 View 3D Structure Click here
Q08189 View 3D Structure Click here
Q08189 View 3D Structure Click here
Q8BH61 View 3D Structure Click here
Q8BH61 View 3D Structure Click here
Q8BM11 View 3D Structure Click here
Q8BM11 View 3D Structure Click here
Q8BZH1 View 3D Structure Click here
Q96PF1 View 3D Structure Click here
Q99041 View 3D Structure Click here
Q9D7I9 View 3D Structure Click here
Q9D7I9 View 3D Structure Click here
Q9JLF6 View 3D Structure Click here
Q9JLF6 View 3D Structure Click here
Q9VLU2 View 3D Structure Click here
Q9VLU2 View 3D Structure Click here
Q9WVJ6 View 3D Structure Click here
Q9WVJ6 View 3D Structure Click here
X1WG26 View 3D Structure Click here