Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
78  structures 4900  species 0  interactions 12213  sequences 103  architectures

Family: A_deaminase (PF00962)

Summary: Adenosine deaminase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Adenosine deaminase". More...

Adenosine deaminase Edit Wikipedia article

Adenosine deaminase is an enzyme in the purine metabolism.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Adenosine deaminase Provide feedback

No Pfam abstract.

Literature references

  1. Wilson DK, Rudolph FB, Quiocho FA; , Science 1991;252:1278-1284.: Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. PUBMED:1925539 EPMC:1925539


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001365

Adenosine deaminase ( EC ) catalyzes the hydrolytic deamination of adenosine into inosine and AMP deaminase ( EC ) catalyzes the hydrolytic deamination of AMP into IMP. It has been shown [ PUBMED:1998686 ] that these two enzymes share three regions of sequence similarities; these regions are centred on residues which are proposed to play an important role in the catalytic mechanism of these two enzymes.

This entry represents the main structural domain of adenosine deaminase and AMP deaminase proteins.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan Amidohydrolase (CL0034), which has the following description:

This family includes a large family of metal dependent amidohydrolase enzymes [1].

The clan contains the following 17 members:

A_deaminase Amidohydro_1 Amidohydro_2 Amidohydro_3 AMP_deaminase CpsB_CapC DHOase DUF3604 DUF6282 Peptidase_M19 PHP PHP_C PTE RNase_P_p30 TatD_DNase Urease_alpha UxaC

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(6)
Full
(12213)
Representative proteomes UniProt
(41397)
RP15
(1443)
RP35
(5115)
RP55
(11232)
RP75
(18807)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(6)
Full
(12213)
Representative proteomes UniProt
(41397)
RP15
(1443)
RP35
(5115)
RP55
(11232)
RP75
(18807)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(6)
Full
(12213)
Representative proteomes UniProt
(41397)
RP15
(1443)
RP35
(5115)
RP55
(11232)
RP75
(18807)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Sarah Teichmann
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 6
Number in full: 12213
Average length of the domain: 305 aa
Average identity of full alignment: 24 %
Average coverage of the sequence by the domain: 80.79 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.0 27.0
Trusted cut-off 27.0 27.0
Noise cut-off 26.9 26.9
Model length: 330
Family (HMM) version: 25
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the A_deaminase domain has been found. There are 78 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A044T3L8 View 3D Structure Click here
A0A044U704 View 3D Structure Click here
A0A077Z0G7 View 3D Structure Click here
A0A0D2FEG4 View 3D Structure Click here
A0A0D2GSH1 View 3D Structure Click here
A0A0D2GSH6 View 3D Structure Click here
A0A0H3GP55 View 3D Structure Click here
A0A0H5S1B5 View 3D Structure Click here
A0A0K0E9I6 View 3D Structure Click here
A0A0K0INV4 View 3D Structure Click here
A0A0N4UAS6 View 3D Structure Click here
A0A0R0F6Y7 View 3D Structure Click here
A0A175W2P1 View 3D Structure Click here
A0A175WH05 View 3D Structure Click here
A0A183XV06 View 3D Structure Click here
A0A1C1CMS9 View 3D Structure Click here
A0A1C1CNU5 View 3D Structure Click here
A0A1C1CNW2 View 3D Structure Click here
A0A1D6F3Q6 View 3D Structure Click here
A0A3P7EMB9 View 3D Structure Click here
A0A3Q0KEH2 View 3D Structure Click here
A0A509ALD0 View 3D Structure Click here
A0A5K4EPT1 View 3D Structure Click here
A0LRH8 View 3D Structure Click here
A1S1P1 View 3D Structure Click here
A1T5H1 View 3D Structure Click here
A1UCA4 View 3D Structure Click here
A3QJD9 View 3D Structure Click here
A4VQI5 View 3D Structure Click here
A4XYN8 View 3D Structure Click here
A5G460 View 3D Structure Click here
A5I0I2 View 3D Structure Click here
A5KE01 View 3D Structure Click here
A5N6F5 View 3D Structure Click here
A6T9W8 View 3D Structure Click here
A8H819 View 3D Structure Click here
B1KHA6 View 3D Structure Click here
B1WR40 View 3D Structure Click here
B1ZYW1 View 3D Structure Click here
B2HDU8 View 3D Structure Click here