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243  structures 535  species 0  interactions 9195  sequences 153  architectures

Family: Recep_L_domain (PF01030)

Summary: Receptor L domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Receptor L domain Provide feedback

The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix [1]. This Pfam entry is missing the first 50 amino acid residues of the domain.

Literature references

  1. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW; , Nature 1998;394:395-399.: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. PUBMED:9690478 EPMC:9690478


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000494

The structure for the first three domains of the extracellular portion of IGF-1R (type-1 insulin-like growth-factor receptor) has been solved and consists of two L-domains and a cysteine rich region (L1-Cys-rich-L2). The L-domains each consist of a single-stranded right-handed beta-helix. The Cys-rich region is composed of eight disulphide-bonded modules, seven of which form a rod-shaped domain with modules associated in an unusual manner. The three domains surround a central space of sufficient size to accommodate a ligand molecule [ PUBMED:9690478 ].

This entry represents the L-domain. This domain can also be found in insulin receptor(IR) and epidermal growth-factor receptor (EGFR) family members, and in yeast cell surface GPI proteins PST1 and ECM33 [ PUBMED:15583168 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan LRR (CL0022), which has the following description:

Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. This Pfam entry contains Leucine Rich Repeats not recognised by the Pfam:PF00560 model.

The clan contains the following 17 members:

DUF285 FBXL18_C FNIP LRR_1 LRR_10 LRR_11 LRR_12 LRR_2 LRR_3 LRR_4 LRR_5 LRR_6 LRR_8 LRR_9 LRR_RI_capping Recep_L_domain TTSSLRR

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(50)
Full
(9195)
Representative proteomes UniProt
(16142)
RP15
(1283)
RP35
(2925)
RP55
(7844)
RP75
(10003)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(50)
Full
(9195)
Representative proteomes UniProt
(16142)
RP15
(1283)
RP35
(2925)
RP55
(7844)
RP75
(10003)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(50)
Full
(9195)
Representative proteomes UniProt
(16142)
RP15
(1283)
RP35
(2925)
RP55
(7844)
RP75
(10003)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_244 (release 3.0)
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Finn RD , Bateman A
Number in seed: 50
Number in full: 9195
Average length of the domain: 112.90 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 19.27 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.8 21.8
Trusted cut-off 21.8 21.8
Noise cut-off 21.7 21.7
Model length: 110
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Recep_L_domain domain has been found. There are 243 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0A0MPK4 View 3D Structure Click here
A0A0A0MPK4 View 3D Structure Click here
A0A0M7RDT1 View 3D Structure Click here
A0A0R4IFV9 View 3D Structure Click here
A0A0R4IFV9 View 3D Structure Click here
A0A0R4IGP2 View 3D Structure Click here
A0A0R4IGP2 View 3D Structure Click here
A0A168H459 View 3D Structure Click here
A0A2R8QJK4 View 3D Structure Click here
A0A2R8QJK4 View 3D Structure Click here
A0A2R8S059 View 3D Structure Click here
A0A4V0IKC4 View 3D Structure Click here
A0A4V0IKC4 View 3D Structure Click here
A0A4V0IKJ5 View 3D Structure Click here
A0A4V0IKJ5 View 3D Structure Click here
A0A4V0IKJ5 View 3D Structure Click here
A0A679L8V0 View 3D Structure Click here
A0A679L8V0 View 3D Structure Click here
B0R0Q2 View 3D Structure Click here
B0R0Q2 View 3D Structure Click here
B3CJ41 View 3D Structure Click here
B3CJ41 View 3D Structure Click here
B3CJ45 View 3D Structure Click here
B3CJ45 View 3D Structure Click here
B3GWA5 View 3D Structure Click here
B3GWA5 View 3D Structure Click here
E7FG42 View 3D Structure Click here
E7FG42 View 3D Structure Click here
F1QNX5 View 3D Structure Click here
F1QNX5 View 3D Structure Click here
F1QP50 View 3D Structure Click here
F1QP50 View 3D Structure Click here
F1R5S1 View 3D Structure Click here
F1R5S1 View 3D Structure Click here
F8W3W7 View 3D Structure Click here
F8W3W7 View 3D Structure Click here
G3V6K6 View 3D Structure Click here
G3V6K6 View 3D Structure Click here
G5EDS6 View 3D Structure Click here
G5EDS6 View 3D Structure Click here
G5EED3 View 3D Structure Click here
G5EED3 View 3D Structure Click here
G5EED3 View 3D Structure Click here
H2L0E3 View 3D Structure Click here
H2L0E3 View 3D Structure Click here
H2L0E3 View 3D Structure Click here
H2L0F3 View 3D Structure Click here
H2L0F3 View 3D Structure Click here
M1ZJZ8 View 3D Structure Click here
M1ZJZ8 View 3D Structure Click here
M1ZMJ0 View 3D Structure Click here
O16340 View 3D Structure Click here
O16340 View 3D Structure Click here
O16395 View 3D Structure Click here
O16395 View 3D Structure Click here
O16750 View 3D Structure Click here
O16750 View 3D Structure Click here
O16751 View 3D Structure Click here
O16751 View 3D Structure Click here
O17659 View 3D Structure Click here
O17659 View 3D Structure Click here
O17791 View 3D Structure Click here
O18274 View 3D Structure Click here
O18274 View 3D Structure Click here
O18278 View 3D Structure Click here
O18278 View 3D Structure Click here
O44506 View 3D Structure Click here
O44600 View 3D Structure Click here
O44601 View 3D Structure Click here
O44602 View 3D Structure Click here
O44602 View 3D Structure Click here
O45835 View 3D Structure Click here
O45975 View 3D Structure Click here
O45984 View 3D Structure Click here
O74411 View 3D Structure Click here
P00533 View 3D Structure Click here
P00533 View 3D Structure Click here
P04412 View 3D Structure Click here
P04412 View 3D Structure Click here
P04626 View 3D Structure Click here
P04626 View 3D Structure Click here
P06213 View 3D Structure Click here
P06213 View 3D Structure Click here
P06494 View 3D Structure Click here
P06494 View 3D Structure Click here
P08069 View 3D Structure Click here
P08069 View 3D Structure Click here
P09208 View 3D Structure Click here
P09208 View 3D Structure Click here
P14616 View 3D Structure Click here
P14616 View 3D Structure Click here
P15127 View 3D Structure Click here
P15127 View 3D Structure Click here
P15208 View 3D Structure Click here
P15208 View 3D Structure Click here
P21860 View 3D Structure Click here
P21860 View 3D Structure Click here
P24062 View 3D Structure Click here
P24062 View 3D Structure Click here
P24348 View 3D Structure Click here
P24348 View 3D Structure Click here
P70424 View 3D Structure Click here
P70424 View 3D Structure Click here
P91205 View 3D Structure Click here
Q01279 View 3D Structure Click here
Q01279 View 3D Structure Click here
Q03599 View 3D Structure Click here
Q03599 View 3D Structure Click here
Q15303 View 3D Structure Click here
Q15303 View 3D Structure Click here
Q19110 View 3D Structure Click here
Q19110 View 3D Structure Click here
Q19540 View 3D Structure Click here
Q19893 View 3D Structure Click here
Q1LVG4 View 3D Structure Click here
Q1LVG4 View 3D Structure Click here
Q22200 View 3D Structure Click here
Q22200 View 3D Structure Click here
Q4W5S6 View 3D Structure Click here
Q60751 View 3D Structure Click here
Q60751 View 3D Structure Click here
Q61526 View 3D Structure Click here
Q61526 View 3D Structure Click here
Q61527 View 3D Structure Click here
Q61527 View 3D Structure Click here
Q62799 View 3D Structure Click here
Q62799 View 3D Structure Click here
Q62956 View 3D Structure Click here
Q62956 View 3D Structure Click here
Q64716 View 3D Structure Click here
Q64716 View 3D Structure Click here
Q7YWP0 View 3D Structure Click here
Q94213 View 3D Structure Click here
Q966B5 View 3D Structure Click here
Q966B5 View 3D Structure Click here
Q966B5 View 3D Structure Click here
Q966E0 View 3D Structure Click here
Q968Y9 View 3D Structure Click here
Q968Y9 View 3D Structure Click here
Q9N4N6 View 3D Structure Click here
Q9N4N6 View 3D Structure Click here
Q9N4N7 View 3D Structure Click here
Q9N4N7 View 3D Structure Click here
Q9N4N8 View 3D Structure Click here
Q9N4N8 View 3D Structure Click here
Q9N4N9 View 3D Structure Click here
Q9N4N9 View 3D Structure Click here
Q9N570 View 3D Structure Click here
Q9NA54 View 3D Structure Click here
Q9NA54 View 3D Structure Click here
Q9TXL1 View 3D Structure Click here
Q9TXL4 View 3D Structure Click here
Q9TXL4 View 3D Structure Click here
Q9TXL8 View 3D Structure Click here
Q9TXL8 View 3D Structure Click here
Q9TZG7 View 3D Structure Click here
Q9TZG7 View 3D Structure Click here
Q9TZG7 View 3D Structure Click here
Q9U3D2 View 3D Structure Click here
Q9U3D2 View 3D Structure Click here
Q9U8C5 View 3D Structure Click here
Q9U8C5 View 3D Structure Click here
Q9U8C9 View 3D Structure Click here
Q9U8C9 View 3D Structure Click here
Q9VFE2 View 3D Structure Click here
Q9VFE2 View 3D Structure Click here
Q9VJ04 View 3D Structure Click here
Q9VJ04 View 3D Structure Click here
Q9WTL4 View 3D Structure Click here
Q9WTL4 View 3D Structure Click here
Q9XU16 View 3D Structure Click here
Q9XU16 View 3D Structure Click here
Q9XU16 View 3D Structure Click here
Q9XU44 View 3D Structure Click here
Q9XXF7 View 3D Structure Click here
Q9XXF7 View 3D Structure Click here
Q9XXF7 View 3D Structure Click here
Q9XXF8 View 3D Structure Click here
Q9XXF8 View 3D Structure Click here