Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
33  structures 7803  species 0  interactions 67045  sequences 840  architectures

Family: ABC2_membrane (PF01061)

Summary: ABC-2 type transporter

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "ATP-binding cassette transporter". More...

ATP-binding cassette transporter Edit Wikipedia article

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ABC-2 type transporter Provide feedback

No Pfam abstract.

Literature references

  1. Reizer J, Reizer A, Saier MH Jr; , Protein Sci 1992;1:1326-1332.: A new subfamily of bacterial ABC-type transport systems catalyzing export of drugs and carbohydrates. PUBMED:1303751 EPMC:1303751


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR013525

ABC transporters belong to the ATP-Binding Cassette (ABC) superfamily, which uses the hydrolysis of ATP to energise diverse biological systems. ABC transporters minimally consist of two conserved regions: a highly conserved ATP binding cassette (ABC) and a less conserved transmembrane domain (TMD). These can be found on the same protein or on two different ones. Most ABC transporters function as a dimer and therefore are constituted of four domains, two ABC modules and two TMDs.

ABC transporters are involved in the export or import of a wide variety of substrates ranging from small ions to macromolecules. The major function of ABC import systems is to provide essential nutrients to bacteria. They are found only in prokaryotes and their four constitutive domains are usually encoded by independent polypeptides (two ABC proteins and two TMD proteins). Prokaryotic importers require additional extracytoplasmic binding proteins (one or more per systems) for function. In contrast, export systems are involved in the extrusion of noxious substances, the export of extracellular toxins and the targeting of membrane components. They are found in all living organisms and in general the TMD is fused to the ABC module in a variety of combinations. Some eukaryotic exporters encode the four domains on the same polypeptide chain [ PUBMED:9873074 ].

The ABC module (approximately two hundred amino acid residues) is known to bind and hydrolyse ATP, thereby coupling transport to ATP hydrolysis in a large number of biological processes. The cassette is duplicated in several subfamilies. Its primary sequence is highly conserved, displaying a typical phosphate-binding loop: Walker A, and a magnesium binding site: Walker B. Besides these two regions, three other conserved motifs are present in the ABC cassette: the switch region which contains a histidine loop, postulated to polarise the attaching water molecule for hydrolysis, the signature conserved motif (LSGGQ) specific to the ABC transporter, and the Q-motif (between Walker A and the signature), which interacts with the gamma phosphate through a water bond. The Walker A, Walker B, Q-loop and switch region form the nucleotide binding site [ PUBMED:11421269 , PUBMED:1282354 , PUBMED:9640644 ].

The 3D structure of a monomeric ABC module adopts a stubby L-shape with two distinct arms. ArmI (mainly beta-strand) contains Walker A and Walker B. The important residues for ATP hydrolysis and/or binding are located in the P-loop. The ATP-binding pocket is located at the extremity of armI. The perpendicular armII contains mostly the alpha helical subdomain with the signature motif. It only seems to be required for structural integrity of the ABC module. ArmII is in direct contact with the TMD. The hinge between armI and armII contains both the histidine loop and the Q-loop, making contact with the gamma phosphate of the ATP molecule. ATP hydrolysis leads to a conformational change that could facilitate ADP release. In the dimer the two ABC cassettes contact each other through hydrophobic interactions at the antiparallel beta-sheet of armI by a two-fold axis [ PUBMED:11988180 , PUBMED:11470432 , PUBMED:11402022 , PUBMED:9872322 , PUBMED:11080142 , PUBMED:11532960 ].

The ATP-Binding Cassette (ABC) superfamily forms one of the largest of all protein families with a diversity of physiological functions [ PUBMED:9873074 ]. Several studies have shown that there is a correlation between the functional characterisation and the phylogenetic classification of the ABC cassette [ PUBMED:9873074 , PUBMED:11421270 ]. More than 50 subfamilies have been described based on a phylogenetic and functional classification [ PUBMED:9873074 , PUBMED:11421269 , PUBMED:11421270 ].

A number of bacterial transport systems have been found to contain integral membrane components that have similar sequences [ PUBMED:1303751 ]: these systems fit the characteristics of ATP-binding cassette transporters [ PUBMED:1659649 ]. The proteins form homo- or hetero-oligomeric channels, allowing ATP-mediated transport. Hydropathy analysis of the proteins has revealed the presence of 6 possible transmembrane regions. These proteins belong to family 2 of ABC transporters.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

Loading domain graphics...

Pfam Clan

This family is a member of clan ABC-2 (CL0181), which has the following description:

These families are similar to the ABC-2 transporter subfamily, as described in [1] (Pfam:PF01061). Members of this family are involved in drug transport and resistance. CcmB protein family (Pfam:PF03379) members are also transporters; they are required for haem export into the periplasm [2].

The clan contains the following 17 members:

12TM_1 ABC2_membrane ABC2_membrane_2 ABC2_membrane_3 ABC2_membrane_4 ABC2_membrane_5 ABC2_membrane_6 ABC2_membrane_7 ABC_export ABC_tran_2 CcmB DUF2705 DUF3526 DUF3533 DUF6198 PDR_CDR YitT_membrane

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(214)
Full
(67045)
Representative proteomes UniProt
(183748)
RP15
(8249)
RP35
(30439)
RP55
(58442)
RP75
(91607)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(214)
Full
(67045)
Representative proteomes UniProt
(183748)
RP15
(8249)
RP35
(30439)
RP55
(58442)
RP75
(91607)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(214)
Full
(67045)
Representative proteomes UniProt
(183748)
RP15
(8249)
RP35
(30439)
RP55
(58442)
RP75
(91607)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_865 (release 3.0) & Pfam-B_31 (release 15.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 214
Number in full: 67045
Average length of the domain: 204.80 aa
Average identity of full alignment: 16 %
Average coverage of the sequence by the domain: 40.26 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.9 26.9
Trusted cut-off 26.9 26.9
Noise cut-off 26.8 26.8
Model length: 210
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

Sunburst controls

Hide

Weight segments by...


Change the size of the sunburst

Small
Large

Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

Align selected sequences to HMM

Generate a FASTA-format file

Clear selection

This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

Loading sunburst data...

Tree controls

Hide

The tree shows the occurrence of this domain across different species. More...

Loading...

Please note: for large trees this can take some time. While the tree is loading, you can safely switch away from this tab but if you browse away from the family page entirely, the tree will not be loaded.

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ABC2_membrane domain has been found. There are 33 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0N7KF66 View 3D Structure Click here
A0A0P0V2F0 View 3D Structure Click here
A0A0P0V3M7 View 3D Structure Click here
A0A0P0VIB9 View 3D Structure Click here
A0A0P0VM04 View 3D Structure Click here
A0A0P0XK84 View 3D Structure Click here
A0A0P0XLR2 View 3D Structure Click here
A0A0P0XLR2 View 3D Structure Click here
A0A0P0XN42 View 3D Structure Click here
A0A0P0XZV4 View 3D Structure Click here
A0A0P0Y9Q9 View 3D Structure Click here
A0A0R0EXX2 View 3D Structure Click here
A0A0R0EYV9 View 3D Structure Click here
A0A0R0EYV9 View 3D Structure Click here
A0A0R0FFZ5 View 3D Structure Click here
A0A0R0FFZ5 View 3D Structure Click here
A0A0R0G2G7 View 3D Structure Click here
A0A0R0G2G7 View 3D Structure Click here
A0A0R0GI77 View 3D Structure Click here
A0A0R0GIB2 View 3D Structure Click here
A0A0R0GIC7 View 3D Structure Click here
A0A0R0GS42 View 3D Structure Click here
A0A0R0GT07 View 3D Structure Click here
A0A0R0HMS1 View 3D Structure Click here
A0A0R0HND6 View 3D Structure Click here
A0A0R0HWD6 View 3D Structure Click here
A0A0R0HWD6 View 3D Structure Click here
A0A0R0HZW6 View 3D Structure Click here
A0A0R0IBD0 View 3D Structure Click here
A0A0R0II74 View 3D Structure Click here
A0A0R0IM35 View 3D Structure Click here
A0A0R0J790 View 3D Structure Click here
A0A0R0J790 View 3D Structure Click here
A0A0R0KKS8 View 3D Structure Click here
A0A0R0KKS8 View 3D Structure Click here
A0A0R0KR27 View 3D Structure Click here
A0A0R0KRM0 View 3D Structure Click here
A0A0R0KTA8 View 3D Structure Click here
A0A0R0KU70 View 3D Structure Click here
A0A0R0KU70 View 3D Structure Click here
A0A0R0KYN1 View 3D Structure Click here
A0A0R4IGG8 View 3D Structure Click here
A0A0R4IUY7 View 3D Structure Click here
A0A1D6E8S3 View 3D Structure Click here
A0A1D6E8S3 View 3D Structure Click here
A0A1D6EHD5 View 3D Structure Click here
A0A1D6FDP9 View 3D Structure Click here
A0A1D6FHG0 View 3D Structure Click here
A0A1D6FHG0 View 3D Structure Click here
A0A1D6FJQ5 View 3D Structure Click here
A0A1D6FYY0 View 3D Structure Click here
A0A1D6FYY0 View 3D Structure Click here
A0A1D6FZ34 View 3D Structure Click here
A0A1D6GNT7 View 3D Structure Click here
A0A1D6H7I1 View 3D Structure Click here
A0A1D6HXA3 View 3D Structure Click here
A0A1D6I198 View 3D Structure Click here
A0A1D6I198 View 3D Structure Click here
A0A1D6I1A8 View 3D Structure Click here
A0A1D6I1A8 View 3D Structure Click here
A0A1D6I292 View 3D Structure Click here
A0A1D6I292 View 3D Structure Click here
A0A1D6I6D8 View 3D Structure Click here
A0A1D6IDG0 View 3D Structure Click here
A0A1D6IDG0 View 3D Structure Click here
A0A1D6IT63 View 3D Structure Click here
A0A1D6IT63 View 3D Structure Click here
A0A1D6IZL2 View 3D Structure Click here
A0A1D6JJ47 View 3D Structure Click here
A0A1D6JP08 View 3D Structure Click here
A0A1D6KKY1 View 3D Structure Click here
A0A1D6KKY1 View 3D Structure Click here
A0A1D6KS71 View 3D Structure Click here
A0A1D6LCF3 View 3D Structure Click here
A0A1D6LCR5 View 3D Structure Click here
A0A1D6LCR5 View 3D Structure Click here
A0A1D6LH56 View 3D Structure Click here
A0A1D6LT24 View 3D Structure Click here
A0A1D6LT24 View 3D Structure Click here
A0A1D6M2Z1 View 3D Structure Click here
A0A1D6MJV0 View 3D Structure Click here
A0A1D6MJV0 View 3D Structure Click here
A0A1D6N7N4 View 3D Structure Click here
A0A1D6NDI4 View 3D Structure Click here
A0A1D6NDI4 View 3D Structure Click here
A0A1D6NEI9 View 3D Structure Click here
A0A1D6NLW7 View 3D Structure Click here
A0A1D6NLW7 View 3D Structure Click here
A0A1D6NLW7 View 3D Structure Click here
A0A1D6NLW8 View 3D Structure Click here
A0A1D6NLW8 View 3D Structure Click here
A0A1D6NM40 View 3D Structure Click here
A0A1D6P0U5 View 3D Structure Click here
A0A1D6P1W9 View 3D Structure Click here
A0A1D6P1W9 View 3D Structure Click here
A0A1D6P382 View 3D Structure Click here
A0A1D6PQM7 View 3D Structure Click here
A0A1D6PQM7 View 3D Structure Click here
A0A1D6QJ88 View 3D Structure Click here
A0A1D6QJ88 View 3D Structure Click here
A0A1D8PCM6 View 3D Structure Click here
A0A1D8PCM6 View 3D Structure Click here
A0A1D8PE84 View 3D Structure Click here
A0A1D8PE84 View 3D Structure Click here
A0A1D8PK15 View 3D Structure Click here
A0A1D8PK15 View 3D Structure Click here
A0A1D8PLV0 View 3D Structure Click here
A0A1D8PQ95 View 3D Structure Click here
A0A1D8PQ95 View 3D Structure Click here
A0A1D8PT53 View 3D Structure Click here
A0A368UHL8 View 3D Structure Click here
A0A368UIF2 View 3D Structure Click here
A0A368UIF2 View 3D Structure Click here
A2BFT1 View 3D Structure Click here
A3BXL8 View 3D Structure Click here
A3BXL8 View 3D Structure Click here
A4HSQ0 View 3D Structure Click here
A4HSQ1 View 3D Structure Click here
A4HWI7 View 3D Structure Click here
A4I078 View 3D Structure Click here
A4ID77 View 3D Structure Click here
B3DG12 View 3D Structure Click here
B4FBM3 View 3D Structure Click here
B6SVU3 View 3D Structure Click here
B6SWU8 View 3D Structure Click here
B6U174 View 3D Structure Click here
B8JI18 View 3D Structure Click here
B8JIM9 View 3D Structure Click here
B9FGJ2 View 3D Structure Click here
B9G300 View 3D Structure Click here
B9G300 View 3D Structure Click here
B9GDE5 View 3D Structure Click here
B9GDE5 View 3D Structure Click here
C7J6G6 View 3D Structure Click here
C7J6G6 View 3D Structure Click here
D3ZCM3 View 3D Structure Click here
D4A896 View 3D Structure Click here
E9AGV1 View 3D Structure Click here
F1QIU0 View 3D Structure Click here
F1QJ06 View 3D Structure Click here
F1RDP4 View 3D Structure Click here
G3V642 View 3D Structure Click here
G9I8W9 View 3D Structure Click here
H2L028 View 3D Structure Click here
I1J6T0 View 3D Structure Click here
I1J884 View 3D Structure Click here
I1JFM7 View 3D Structure Click here
I1JFM7 View 3D Structure Click here
I1JNB6 View 3D Structure Click here
I1JP87 View 3D Structure Click here
I1JP87 View 3D Structure Click here
I1JPG2 View 3D Structure Click here
I1JQC2 View 3D Structure Click here
I1JY09 View 3D Structure Click here
I1K1C0 View 3D Structure Click here
I1K1C0 View 3D Structure Click here
I1K8Y7 View 3D Structure Click here
I1K8Y7 View 3D Structure Click here
I1KBK4 View 3D Structure Click here
I1KE00 View 3D Structure Click here
I1KGJ0 View 3D Structure Click here
I1KGJ0 View 3D Structure Click here
I1KH54 View 3D Structure Click here
I1KH54 View 3D Structure Click here
I1KMI3 View 3D Structure Click here
I1KMK2 View 3D Structure Click here
I1KMK2 View 3D Structure Click here
I1KR15 View 3D Structure Click here
I1KR16 View 3D Structure Click here
I1KV23 View 3D Structure Click here
I1KV23 View 3D Structure Click here
I1L3R0 View 3D Structure Click here
I1LCU7 View 3D Structure Click here
I1LD84 View 3D Structure Click here
I1LEM3 View 3D Structure Click here
I1LIF7 View 3D Structure Click here
I1LPA9 View 3D Structure Click here
I1LPB4 View 3D Structure Click here
I1LTM0 View 3D Structure Click here
I1LV53 View 3D Structure Click here
I1LX53 View 3D Structure Click here
I1M0E5 View 3D Structure Click here
I1M323 View 3D Structure Click here
I1M4I0 View 3D Structure Click here
I1M5P5 View 3D Structure Click here
I1M5P5 View 3D Structure Click here
I1M5Q0 View 3D Structure Click here
I1M6E5 View 3D Structure Click here
I1MCJ7 View 3D Structure Click here
I1MCJ7 View 3D Structure Click here
I1MCJ9 View 3D Structure Click here
I1MCJ9 View 3D Structure Click here
I1MCU3 View 3D Structure Click here
I1MCU3 View 3D Structure Click here
I1MLZ6 View 3D Structure Click here
I1MMS1 View 3D Structure Click here
I1MQD4 View 3D Structure Click here
I1MRW9 View 3D Structure Click here
I1MRW9 View 3D Structure Click here
I1MRX0 View 3D Structure Click here
I1MRX0 View 3D Structure Click here
I1MUE5 View 3D Structure Click here
I1MUE5 View 3D Structure Click here
I1N085 View 3D Structure Click here
I1N9W1 View 3D Structure Click here
I1N9W1 View 3D Structure Click here
I1NA26 View 3D Structure Click here
I1NAW9 View 3D Structure Click here
I1NFU5 View 3D Structure Click here
I1NGY9 View 3D Structure Click here
I1NH97 View 3D Structure Click here
I1NHK4 View 3D Structure Click here
I1NJ72 View 3D Structure Click here
K7K1C1 View 3D Structure Click here
K7K817 View 3D Structure Click here
K7KA64 View 3D Structure Click here
K7KBN6 View 3D Structure Click here
K7KIL7 View 3D Structure Click here
K7KIL7 View 3D Structure Click here
K7KR70 View 3D Structure Click here
K7KRE6 View 3D Structure Click here
K7L3G3 View 3D Structure Click here
K7L467 View 3D Structure Click here
K7L546 View 3D Structure Click here
K7L5C4 View 3D Structure Click here
K7L5C6 View 3D Structure Click here
K7LAD3 View 3D Structure Click here
K7LF09 View 3D Structure Click here
K7LXX9 View 3D Structure Click here
K7M2D7 View 3D Structure Click here
K7M3S0 View 3D Structure Click here
K7M3S0 View 3D Structure Click here
K7M3W8 View 3D Structure Click here
K7M6E9 View 3D Structure Click here
K7M6E9 View 3D Structure Click here
K7M810 View 3D Structure Click here
K7M810 View 3D Structure Click here
K7MMY1 View 3D Structure Click here
K7MMY1 View 3D Structure Click here
K7MQ99 View 3D Structure Click here
K7MQ99 View 3D Structure Click here
K7MS83 View 3D Structure Click here
K7MZ72 View 3D Structure Click here
K7MZ72 View 3D Structure Click here
K7N1E9 View 3D Structure Click here
K7N4D0 View 3D Structure Click here
K7N4D0 View 3D Structure Click here
K7TKH5 View 3D Structure Click here
K7TN88 View 3D Structure Click here
K7TN88 View 3D Structure Click here
K7TU41 View 3D Structure Click here
K7UR04 View 3D Structure Click here
K7UR04 View 3D Structure Click here
K7V3P1 View 3D Structure Click here
K7V410 View 3D Structure Click here
K7V744 View 3D Structure Click here
K7V744 View 3D Structure Click here
K7VQP2 View 3D Structure Click here
M9PBX3 View 3D Structure Click here
O16574 View 3D Structure Click here
O33188 View 3D Structure Click here
O65934 View 3D Structure Click here
O80946 View 3D Structure Click here
O81016 View 3D Structure Click here
O81016 View 3D Structure Click here
O86349 View 3D Structure Click here
P0AFN6 View 3D Structure Click here
P10090 View 3D Structure Click here
P12428 View 3D Structure Click here
P25371 View 3D Structure Click here
P32568 View 3D Structure Click here
P32568 View 3D Structure Click here
P33302 View 3D Structure Click here
P33302 View 3D Structure Click here
P40550 View 3D Structure Click here
P40550 View 3D Structure Click here
P41820 View 3D Structure Click here
P41820 View 3D Structure Click here
P45843 View 3D Structure Click here
P45844 View 3D Structure Click here
P51533 View 3D Structure Click here
P51533 View 3D Structure Click here
P53756 View 3D Structure Click here
P53756 View 3D Structure Click here
P58428 View 3D Structure Click here
P72049 View 3D Structure Click here
P78595 View 3D Structure Click here
P78595 View 3D Structure Click here
P90746 View 3D Structure Click here
P9WG21 View 3D Structure Click here
Q02785 View 3D Structure Click here
Q02785 View 3D Structure Click here
Q04182 View 3D Structure Click here
Q04182 View 3D Structure Click here
Q08234 View 3D Structure Click here
Q08234 View 3D Structure Click here
Q08409 View 3D Structure Click here
Q08409 View 3D Structure Click here
Q09466 View 3D Structure Click here
Q0DIJ5 View 3D Structure Click here
Q0DL71 View 3D Structure Click here
Q0E8U2 View 3D Structure Click here
Q0JBJ8 View 3D Structure Click here
Q0JLC5 View 3D Structure Click here
Q0JLC5 View 3D Structure Click here
Q0KI14 View 3D Structure Click here
Q10AA7 View 3D Structure Click here
Q10RJ4 View 3D Structure Click here
Q11180 View 3D Structure Click here
Q19585 View 3D Structure Click here
Q22802 View 3D Structure Click here
Q2G2X5 View 3D Structure Click here
Q2QT07 View 3D Structure Click here
Q2QV81 View 3D Structure Click here
Q2QV81 View 3D Structure Click here
Q3E9B8 View 3D Structure Click here
Q4CX07 View 3D Structure Click here
Q4D506 View 3D Structure Click here
Q4DAY6 View 3D Structure Click here
Q4DFN9 View 3D Structure Click here
Q4DP88 View 3D Structure Click here
Q4DQX1 View 3D Structure Click here
Q4DRB2 View 3D Structure Click here
Q4DUR5 View 3D Structure Click here
Q4DW41 View 3D Structure Click here
Q4DW56 View 3D Structure Click here
Q4KM08 View 3D Structure Click here
Q54CG0 View 3D Structure Click here
Q54CG0 View 3D Structure Click here
Q54HM0 View 3D Structure Click here
Q54HM0 View 3D Structure Click here
Q54T02 View 3D Structure Click here
Q54TV1 View 3D Structure Click here
Q54TV1 View 3D Structure Click here
Q54TV2 View 3D Structure Click here
Q54TV2 View 3D Structure Click here
Q556W2 View 3D Structure Click here
Q556W2 View 3D Structure Click here
Q55DA0 View 3D Structure Click here
Q55DQ2 View 3D Structure Click here
Q55DQ2 View 3D Structure Click here
Q55DR1 View 3D Structure Click here
Q55DR1 View 3D Structure Click here
Q55DW4 View 3D Structure Click here
Q55GB1 View 3D Structure Click here
Q55GB1 View 3D Structure Click here
Q5A0X6 View 3D Structure Click here
Q5ANA3 View 3D Structure Click here
Q5ANA3 View 3D Structure Click here
Q5Z9S8 View 3D Structure Click here
Q5Z9S8 View 3D Structure Click here
Q64343 View 3D Structure Click here
Q656J6 View 3D Structure Click here
Q69Q33 View 3D Structure Click here
Q6EQ60 View 3D Structure Click here
Q6EQ60 View 3D Structure Click here
Q6K376 View 3D Structure Click here
Q6K4D2 View 3D Structure Click here
Q6YW62 View 3D Structure Click here
Q6YW62 View 3D Structure Click here
Q6YYM2 View 3D Structure Click here
Q75HT8 View 3D Structure Click here
Q7EY81 View 3D Structure Click here
Q7FMW4 View 3D Structure Click here
Q7FMW4 View 3D Structure Click here
Q7KU30 View 3D Structure Click here
Q7PC80 View 3D Structure Click here
Q7PC80 View 3D Structure Click here
Q7PC81 View 3D Structure Click here
Q7PC81 View 3D Structure Click here
Q7PC82 View 3D Structure Click here
Q7PC82 View 3D Structure Click here
Q7PC83 View 3D Structure Click here
Q7PC83 View 3D Structure Click here
Q7PC84 View 3D Structure Click here
Q7PC84 View 3D Structure Click here
Q7PC85 View 3D Structure Click here
Q7PC85 View 3D Structure Click here
Q7PC86 View 3D Structure Click here
Q7PC86 View 3D Structure Click here
Q7PC87 View 3D Structure Click here
Q7PC87 View 3D Structure Click here
Q7PC88 View 3D Structure Click here
Q7PC88 View 3D Structure Click here
Q7TMS5 View 3D Structure Click here
Q7XA72 View 3D Structure Click here
Q80W57 View 3D Structure Click here
Q84TH5 View 3D Structure Click here
Q86HQ2 View 3D Structure Click here
Q8GU82 View 3D Structure Click here
Q8GU82 View 3D Structure Click here
Q8GU83 View 3D Structure Click here
Q8GU83 View 3D Structure Click here
Q8GU84 View 3D Structure Click here
Q8GU84 View 3D Structure Click here
Q8GU85 View 3D Structure Click here
Q8GU85 View 3D Structure Click here
Q8GU86 View 3D Structure Click here
Q8GU86 View 3D Structure Click here
Q8GU87 View 3D Structure Click here
Q8GU87 View 3D Structure Click here
Q8GU88 View 3D Structure Click here
Q8GU88 View 3D Structure Click here
Q8GU89 View 3D Structure Click here
Q8GU89 View 3D Structure Click here
Q8GU92 View 3D Structure Click here
Q8GU92 View 3D Structure Click here
Q8GZ52 View 3D Structure Click here
Q8GZ52 View 3D Structure Click here
Q8H8V7 View 3D Structure Click here
Q8ILJ9 View 3D Structure Click here
Q8IPV3 View 3D Structure Click here
Q8LNT5 View 3D Structure Click here
Q8LQX2 View 3D Structure Click here
Q8LQX2 View 3D Structure Click here
Q8MRL3 View 3D Structure Click here
Q8RWI9 View 3D Structure Click here
Q8RXN0 View 3D Structure Click here
Q8S1S3 View 3D Structure Click here
Q8S628 View 3D Structure Click here
Q8S628 View 3D Structure Click here
Q8ST66 View 3D Structure Click here
Q8ST66 View 3D Structure Click here
Q8T673 View 3D Structure Click here
Q8T673 View 3D Structure Click here
Q8T674 View 3D Structure Click here
Q8T675 View 3D Structure Click here
Q8T675 View 3D Structure Click here
Q8T683 View 3D Structure Click here
Q8T683 View 3D Structure Click here
Q8T685 View 3D Structure Click here
Q8T686 View 3D Structure Click here
Q8T689 View 3D Structure Click here
Q8T690 View 3D Structure Click here
Q8T690 View 3D Structure Click here
Q8T9E6 View 3D Structure Click here
Q91WA9 View 3D Structure Click here
Q93YS4 View 3D Structure Click here
Q94A18 View 3D Structure Click here
Q94A18 View 3D Structure Click here
Q99P81 View 3D Structure Click here
Q99PE7 View 3D Structure Click here
Q99PE8 View 3D Structure Click here
Q9ARU4 View 3D Structure Click here
Q9C0Y5 View 3D Structure Click here
Q9C0Y5 View 3D Structure Click here
Q9C6W5 View 3D Structure Click here
Q9C8J8 View 3D Structure Click here
Q9C8K2 View 3D Structure Click here
Q9DBM0 View 3D Structure Click here
Q9FLX5 View 3D Structure Click here
Q9FNB5 View 3D Structure Click here
Q9FT51 View 3D Structure Click here
Q9FTG6 View 3D Structure Click here
Q9H172 View 3D Structure Click here
Q9H221 View 3D Structure Click here
Q9H222 View 3D Structure Click here
Q9LFG8 View 3D Structure Click here
Q9LFH0 View 3D Structure Click here
Q9LFH0 View 3D Structure Click here
Q9LK50 View 3D Structure Click here
Q9M2V5 View 3D Structure Click here
Q9M2V6 View 3D Structure Click here
Q9M2V7 View 3D Structure Click here
Q9M3D6 View 3D Structure Click here
Q9M9E1 View 3D Structure Click here
Q9M9E1 View 3D Structure Click here
Q9MAH4 View 3D Structure Click here
Q9NGP5 View 3D Structure Click here
Q9NGP5 View 3D Structure Click here
Q9SIT6 View 3D Structure Click here
Q9SW08 View 3D Structure Click here
Q9SZR9 View 3D Structure Click here
Q9U2D0 View 3D Structure Click here
Q9UNQ0 View 3D Structure Click here
Q9VAU1 View 3D Structure Click here
Q9VL61 View 3D Structure Click here
Q9VPJ7 View 3D Structure Click here
Q9VQY4 View 3D Structure Click here
Q9VTL3 View 3D Structure Click here
Q9XIE2 View 3D Structure Click here
Q9XIE2 View 3D Structure Click here
Q9ZU35 View 3D Structure Click here
Q9ZUT0 View 3D Structure Click here
Q9ZUT8 View 3D Structure Click here
Q9ZUT8 View 3D Structure Click here
Q9ZUU9 View 3D Structure Click here