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728  structures 884  species 0  interactions 33428  sequences 542  architectures

Family: ANF_receptor (PF01094)

Summary: Receptor family ligand binding region

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Receptor family ligand binding region Provide feedback

This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.

Literature references

  1. Kuryatov A, Laube B, Betz H, Kuhse J; , Neuron 1994;12:1291-1300.: Mutational analysis of the glycine-binding site of the NMDA receptor: structural similarity with bacterial amino acid-binding proteins. PUBMED:8011339 EPMC:8011339


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001828

This describes a ligand binding domain and includes extracellular ligand binding domains of a wide range of receptors, as well as the bacterial amino acid binding proteins of known structure [ PUBMED:8011339 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Periplas_BP (CL0144), which has the following description:

This clan includes proteins involved in chemotaxis, membrane transport of sugars and allocrites, and the LacI family transcriptional regulators. It also includes some antigenic basic membrane lipoproteins.

The clan contains the following 11 members:

ABC_sub_bind ANF_receptor Bmp DUF3798 LppC Peripla_BP_1 Peripla_BP_3 Peripla_BP_4 Peripla_BP_5 Peripla_BP_6 Peripla_BP_7

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(71)
Full
(33428)
Representative proteomes UniProt
(59072)
RP15
(5615)
RP35
(14483)
RP55
(30199)
RP75
(38816)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(71)
Full
(33428)
Representative proteomes UniProt
(59072)
RP15
(5615)
RP35
(14483)
RP55
(30199)
RP75
(38816)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(71)
Full
(33428)
Representative proteomes UniProt
(59072)
RP15
(5615)
RP35
(14483)
RP55
(30199)
RP75
(38816)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A , Finn RD
Number in seed: 71
Number in full: 33428
Average length of the domain: 313.20 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 39.38 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.4 25.4
Trusted cut-off 25.4 25.4
Noise cut-off 25.3 25.3
Model length: 354
Family (HMM) version: 30
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ANF_receptor domain has been found. There are 728 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A078BQP2 View 3D Structure Click here
A0A096MJB2 View 3D Structure Click here
A0A0B4KHJ0 View 3D Structure Click here
A0A0B4LHR4 View 3D Structure Click here
A0A0G2JVH8 View 3D Structure Click here
A0A0G2JVY7 View 3D Structure Click here
A0A0G2JW95 View 3D Structure Click here
A0A0G2JYA5 View 3D Structure Click here
A0A0G2JYG8 View 3D Structure Click here
A0A0G2JZT8 View 3D Structure Click here
A0A0G2K8E2 View 3D Structure Click here
A0A0G2KAL5 View 3D Structure Click here
A0A0G2KGK2 View 3D Structure Click here
A0A0G2KHT7 View 3D Structure Click here
A0A0G2KMV1 View 3D Structure Click here
A0A0G2KZP1 View 3D Structure Click here
A0A0G2L0N1 View 3D Structure Click here
A0A0H2UKH3 View 3D Structure Click here
A0A0P0WTD2 View 3D Structure Click here
A0A0P0WTE6 View 3D Structure Click here
A0A0P0XLY5 View 3D Structure Click here
A0A0P0XNE5 View 3D Structure Click here
A0A0P0XNT9 View 3D Structure Click here
A0A0R0FUT0 View 3D Structure Click here
A0A0R0FUX9 View 3D Structure Click here
A0A0R0GJI9 View 3D Structure Click here
A0A0R0GSR6 View 3D Structure Click here
A0A0R0H0I1 View 3D Structure Click here
A0A0R0H128 View 3D Structure Click here
A0A0R0IAP1 View 3D Structure Click here
A0A0R0JFH4 View 3D Structure Click here
A0A0R0JKV3 View 3D Structure Click here
A0A0R0JKV3 View 3D Structure Click here
A0A0R0JSN9 View 3D Structure Click here
A0A0R0JT57 View 3D Structure Click here
A0A0R4I9L6 View 3D Structure Click here
A0A0R4IB59 View 3D Structure Click here
A0A0R4IC00 View 3D Structure Click here
A0A0R4IDZ4 View 3D Structure Click here
A0A0R4IG83 View 3D Structure Click here
A0A0R4IH68 View 3D Structure Click here
A0A0R4IHA3 View 3D Structure Click here
A0A0R4IJP4 View 3D Structure Click here
A0A0R4ING5 View 3D Structure Click here
A0A0R4IRN2 View 3D Structure Click here
A0A0R4IS27 View 3D Structure Click here
A0A0R4ITC7 View 3D Structure Click here
A0A0R4IU63 View 3D Structure Click here
A0A0R4IV20 View 3D Structure Click here
A0A0R4IW17 View 3D Structure Click here
A0A0R4IXN8 View 3D Structure Click here
A0A0R4IZ73 View 3D Structure Click here
A0A0U1RPR8 View 3D Structure Click here
A0A140T8U3 View 3D Structure Click here
A0A1D6E1R2 View 3D Structure Click here
A0A1D6EQP7 View 3D Structure Click here
A0A1D6EQP9 View 3D Structure Click here
A0A1D6EXB6 View 3D Structure Click here
A0A1D6GTI6 View 3D Structure Click here
A0A1D6GTI9 View 3D Structure Click here
A0A1D6GTJ2 View 3D Structure Click here
A0A1D6GYP5 View 3D Structure Click here
A0A1D6HMT5 View 3D Structure Click here
A0A1D6HMU4 View 3D Structure Click here
A0A1D6HQP8 View 3D Structure Click here
A0A1D6HQP9 View 3D Structure Click here
A0A1D6I4R9 View 3D Structure Click here
A0A1D6I4S0 View 3D Structure Click here
A0A1D6L242 View 3D Structure Click here
A0A1D6QCK5 View 3D Structure Click here
A0A1W2Q6G1 View 3D Structure Click here
A0A286Y9Q6 View 3D Structure Click here
A0A286YAM5 View 3D Structure Click here
A0A286YAY2 View 3D Structure Click here
A0A2R8PY76 View 3D Structure Click here
A0A2R8Q6M2 View 3D Structure Click here
A0A2R8Q7K7 View 3D Structure Click here
A0A2R8Q8U2 View 3D Structure Click here
A0A2R8QBG2 View 3D Structure Click here
A0A2R8QBI9 View 3D Structure Click here
A0A2R8QBI9 View 3D Structure Click here
A0A2R8QDR4 View 3D Structure Click here
A0A2R8QF68 View 3D Structure Click here
A0A2R8QHT6 View 3D Structure Click here
A0A2R8QKX3 View 3D Structure Click here
A0A2R8QLP2 View 3D Structure Click here
A0A2R8RK86 View 3D Structure Click here
A0A2R8RR22 View 3D Structure Click here
A0A2R8RR57 View 3D Structure Click here
A0A2R8RSJ1 View 3D Structure Click here
A0A2R9YJL7 View 3D Structure Click here
A0A338P6T0 View 3D Structure Click here
A0A3B2W3J6 View 3D Structure Click here
A0A3B2W422 View 3D Structure Click here
A0A3B2W4A7 View 3D Structure Click here
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A0A3B2WB67 View 3D Structure Click here
A0A3B2WBA1 View 3D Structure Click here
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A0A3B2WCY4 View 3D Structure Click here
A0A3Q4EG79 View 3D Structure Click here
A0A3Q4EIC8 View 3D Structure Click here
A0A3Q4L333 View 3D Structure Click here
A0T301 View 3D Structure Click here
A1IMB8 View 3D Structure Click here
A2AIR5 View 3D Structure Click here
A2BE32 View 3D Structure Click here
A2BFQ0 View 3D Structure Click here
A2BH14 View 3D Structure Click here
A2CG69 View 3D Structure Click here
A3KPM6 View 3D Structure Click here
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A3KQH6 View 3D Structure Click here
A3KQI0 View 3D Structure Click here
A3QJX9 View 3D Structure Click here
A3QJY1 View 3D Structure Click here
A4HY85 View 3D Structure Click here
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B0R142 View 3D Structure Click here
B0S550 View 3D Structure Click here
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B1AS29 View 3D Structure Click here
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D4A685 View 3D Structure Click here
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D4A754 View 3D Structure Click here
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D4AB78 View 3D Structure Click here
D4ADJ0 View 3D Structure Click here
E7EAU8 View 3D Structure Click here
E7F101 View 3D Structure Click here
E7F111 View 3D Structure Click here
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E7FH00 View 3D Structure Click here
E7FH62 View 3D Structure Click here
E9PUT5 View 3D Structure Click here
E9PVI0 View 3D Structure Click here
E9PW21 View 3D Structure Click here
E9PW61 View 3D Structure Click here
E9PWD5 View 3D Structure Click here
E9PWW0 View 3D Structure Click here
E9PXI5 View 3D Structure Click here
E9PXJ8 View 3D Structure Click here
E9PY92 View 3D Structure Click here
E9PYF5 View 3D Structure Click here
E9PYL5 View 3D Structure Click here
E9PYS0 View 3D Structure Click here
E9PZ56 View 3D Structure Click here
E9PZA6 View 3D Structure Click here
E9PZJ7 View 3D Structure Click here
E9PZK8 View 3D Structure Click here
E9PZS9 View 3D Structure Click here
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E9PZX4 View 3D Structure Click here
E9Q067 View 3D Structure Click here
E9Q0E7 View 3D Structure Click here
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E9Q0K5 View 3D Structure Click here
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E9Q1C1 View 3D Structure Click here
E9Q1L0 View 3D Structure Click here
E9Q281 View 3D Structure Click here
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E9QGN5 View 3D Structure Click here
F1LPZ0 View 3D Structure Click here
F1LQ12 View 3D Structure Click here
F1LVC2 View 3D Structure Click here
F1LVL1 View 3D Structure Click here
F1LVS7 View 3D Structure Click here
F1LW11 View 3D Structure Click here
F1LZR6 View 3D Structure Click here
F1M1G9 View 3D Structure Click here
F1M1H4 View 3D Structure Click here
F1M1S0 View 3D Structure Click here
F1M924 View 3D Structure Click here
F1MAJ6 View 3D Structure Click here
F1MAL4 View 3D Structure Click here
F1MAT0 View 3D Structure Click here
F1QA08 View 3D Structure Click here
F1QAJ3 View 3D Structure Click here
F1QD68 View 3D Structure Click here
F1QDE5 View 3D Structure Click here
F1QGT7 View 3D Structure Click here
F1QGV1 View 3D Structure Click here
F1QHN9 View 3D Structure Click here
F1QPB6 View 3D Structure Click here
F1QS61 View 3D Structure Click here
F1QS78 View 3D Structure Click here
F1QSU5 View 3D Structure Click here
F1R4B8 View 3D Structure Click here
F1R7V4 View 3D Structure Click here
F1R7V4 View 3D Structure Click here
F1RA84 View 3D Structure Click here
F1RDS4 View 3D Structure Click here
F1RDY7 View 3D Structure Click here
F1RER0 View 3D Structure Click here
F6P3F9 View 3D Structure Click here
F6P6I2 View 3D Structure Click here
F6W043 View 3D Structure Click here
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G3UW56 View 3D Structure Click here
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G3V911 View 3D Structure Click here
G3X931 View 3D Structure Click here
G3XA45 View 3D Structure Click here
G5E8G4 View 3D Structure Click here
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G5EEE9 View 3D Structure Click here
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G5EFQ0 View 3D Structure Click here
G5EG10 View 3D Structure Click here
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H2L002 View 3D Structure Click here
H2L0Q3 View 3D Structure Click here
H3BJ88 View 3D Structure Click here
H3BK29 View 3D Structure Click here
H3BK37 View 3D Structure Click here
I1J8B7 View 3D Structure Click here
I1JST3 View 3D Structure Click here
I1K7B0 View 3D Structure Click here
I1KDN7 View 3D Structure Click here
I1KFC6 View 3D Structure Click here
I1KMD9 View 3D Structure Click here
I1L4P7 View 3D Structure Click here
I1LU56 View 3D Structure Click here
I1LU57 View 3D Structure Click here
I1M440 View 3D Structure Click here
I1M634 View 3D Structure Click here
I1MMT0 View 3D Structure Click here
I3ISH1 View 3D Structure Click here
I3NI77 View 3D Structure Click here
K7L2U8 View 3D Structure Click here
K7LEX1 View 3D Structure Click here
K7LNQ4 View 3D Structure Click here
K7LTZ4 View 3D Structure Click here
K7M0A1 View 3D Structure Click here
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K7M291 View 3D Structure Click here
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K7MFG6 View 3D Structure Click here
K7MNP8 View 3D Structure Click here
K7N5U4 View 3D Structure Click here
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K7N621 View 3D Structure Click here
K7N674 View 3D Structure Click here
K7N686 View 3D Structure Click here
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K7N702 View 3D Structure Click here
K7N705 View 3D Structure Click here
K7N709 View 3D Structure Click here
K7N712 View 3D Structure Click here
K7N741 View 3D Structure Click here
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K7N788 View 3D Structure Click here
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K7UT49 View 3D Structure Click here
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L7N203 View 3D Structure Click here
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L7N269 View 3D Structure Click here
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L7N472 View 3D Structure Click here
M0R454 View 3D Structure Click here
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M0RC83 View 3D Structure Click here
M0RCC4 View 3D Structure Click here
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N1NVB7 View 3D Structure Click here
O00222 View 3D Structure Click here
O01623 View 3D Structure Click here
O04660 View 3D Structure Click here
O15303 View 3D Structure Click here
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O35268 View 3D Structure Click here
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O43424 View 3D Structure Click here
O62026 View 3D Structure Click here
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O70410 View 3D Structure Click here
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P16066 View 3D Structure Click here
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P91550 View 3D Structure Click here
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Q00959 View 3D Structure Click here
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