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17  structures 8404  species 0  interactions 36771  sequences 228  architectures

Family: Band_7 (PF01145)

Summary: SPFH domain / Band 7 family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

SPFH domain / Band 7 family Provide feedback

This family has been called SPFH [1] Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals.

Literature references

  1. Tavernarakis N, Driscoll M, Kyrpides NC; , Trends Biochem Sci 1999;24:425-427.: The SPFH domain: implicated in regulating targeted protein turnover in stomatins and other membrane-associated proteins. PUBMED:10542406 EPMC:10542406

  2. Green JB, Young JP;, BMC Evol Biol. 2008;8:44.: Slipins: ancient origin, duplication and diversification of the stomatin protein family. PUBMED:18267007 EPMC:18267007


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001107

The band-7 protein family comprises a diverse set of membrane-bound proteins characterised by the presence of a conserved domain, the band-7 domain, also known as SPFH or PHB domain [ PUBMED:10542406 ]. The exact function of the band-7 domain is not known, but examples from animal and bacterial stomatin-type proteins demonstrate binding to lipids and the ability to assemble into membrane-bound oligomers that form putative scaffolds [ PUBMED:24782879 ]. A variety of proteins belong to this family. These include the prohibitins, cytoplasmic anti-proliferative proteins and stomatin, an erythrocyte membrane protein. Bacterial HflC protein also belongs to this family.

Note: Band 4.1 and Band 7 proteins refer to human erythrocyte membrane proteins separated by SDS polyacrylamide gels and stained with coomassie blue [ PUBMED:4326772 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan SPFH (CL0433), which has the following description:

This superfamily includes the SPFH family as well as the shoulder domain from the Major Vault Protein [1].

The clan contains the following 3 members:

Band_7 Band_7_1 MVP_shoulder

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(71)
Full
(36771)
Representative proteomes UniProt
(137912)
RP15
(5862)
RP35
(17203)
RP55
(34726)
RP75
(56203)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(71)
Full
(36771)
Representative proteomes UniProt
(137912)
RP15
(5862)
RP35
(17203)
RP55
(34726)
RP75
(56203)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(71)
Full
(36771)
Representative proteomes UniProt
(137912)
RP15
(5862)
RP35
(17203)
RP55
(34726)
RP75
(56203)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Bateman A
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A , Finn RD
Number in seed: 71
Number in full: 36771
Average length of the domain: 184.50 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 52.94 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.1 23.1
Trusted cut-off 23.1 23.1
Noise cut-off 23.0 23.0
Model length: 180
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Band_7 domain has been found. There are 17 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096MJY2 View 3D Structure Click here
A0A0P0W4M8 View 3D Structure Click here
A0A0P0XC31 View 3D Structure Click here
A0A0P0XVF1 View 3D Structure Click here
A0A0R0JJ08 View 3D Structure Click here
A0A0R4IEC2 View 3D Structure Click here
A0A0R4IGK4 View 3D Structure Click here
A0A0R4IYU4 View 3D Structure Click here
A0A1D6E6Y1 View 3D Structure Click here
A0A1D6EAY6 View 3D Structure Click here
A0A1D6GPC6 View 3D Structure Click here
A0A1D6K048 View 3D Structure Click here
A0A1D6K5S9 View 3D Structure Click here
A0A1D6ME97 View 3D Structure Click here
A0A1D6PVW8 View 3D Structure Click here
A0A1D6Q0Q2 View 3D Structure Click here
A0A1D8PIA6 View 3D Structure Click here
A0A1D8PJT2 View 3D Structure Click here
A0A1D8PTU3 View 3D Structure Click here
A0A2R8RXQ8 View 3D Structure Click here
A3QK16 View 3D Structure Click here
A3QMC6 View 3D Structure Click here
A4FVJ0 View 3D Structure Click here
A4HSM6 View 3D Structure Click here
A4HX59 View 3D Structure Click here
A4HYE6 View 3D Structure Click here
A4HYE7 View 3D Structure Click here
A4IAQ8 View 3D Structure Click here
A5PLE0 View 3D Structure Click here
A8DYI6 View 3D Structure Click here
B1WBY7 View 3D Structure Click here
B4FMS7 View 3D Structure Click here
B5DEH2 View 3D Structure Click here
B6TTQ8 View 3D Structure Click here
C0P654 View 3D Structure Click here
C4J530 View 3D Structure Click here
C6TAY3 View 3D Structure Click here
C6TJ60 View 3D Structure Click here
C6TLI9 View 3D Structure Click here
C6TMQ6 View 3D Structure Click here
C6TN05 View 3D Structure Click here
C6TNR1 View 3D Structure Click here
D3ZFH6 View 3D Structure Click here
D4A7E9 View 3D Structure Click here
F1Q9K0 View 3D Structure Click here
F1R5A4 View 3D Structure Click here
F1R9C6 View 3D Structure Click here
H2FLJ1 View 3D Structure Click here
I1J5K8 View 3D Structure Click here
I1JBP9 View 3D Structure Click here
I1JBQ0 View 3D Structure Click here
I1JBQ3 View 3D Structure Click here
I1JW13 View 3D Structure Click here
I1JYF7 View 3D Structure Click here
I1KFR0 View 3D Structure Click here
I1KMD0 View 3D Structure Click here
I1KW20 View 3D Structure Click here
I1L3L1 View 3D Structure Click here
I1L437 View 3D Structure Click here
I1LP54 View 3D Structure Click here
I1LUJ6 View 3D Structure Click here
I1LWI3 View 3D Structure Click here
I1N627 View 3D Structure Click here
K7M2L3 View 3D Structure Click here
K7N0Z0 View 3D Structure Click here
O04331 View 3D Structure Click here
O05769 View 3D Structure Click here
O08917 View 3D Structure Click here
O15706 View 3D Structure Click here
O35129 View 3D Structure Click here
O49460 View 3D Structure Click here
O60121 View 3D Structure Click here
O61491 View 3D Structure Click here
O61492 View 3D Structure Click here
O75477 View 3D Structure Click here
O75955 View 3D Structure Click here
O77376 View 3D Structure Click here
O94550 View 3D Structure Click here
O94905 View 3D Structure Click here
P0AA53 View 3D Structure Click here
P0ABC3 View 3D Structure Click here
P0ABC7 View 3D Structure Click here
P24156 View 3D Structure Click here
P27105 View 3D Structure Click here
P35232 View 3D Structure Click here
P40961 View 3D Structure Click here
P50085 View 3D Structure Click here
P50093 View 3D Structure Click here
P54116 View 3D Structure Click here
P67778 View 3D Structure Click here
P67779 View 3D Structure Click here
P77306 View 3D Structure Click here
P9WPR9 View 3D Structure Click here
Q0JCL7 View 3D Structure Click here
Q10AT9 View 3D Structure Click here
Q14254 View 3D Structure Click here
Q19200 View 3D Structure Click here
Q19958 View 3D Structure Click here
Q20657 View 3D Structure Click here
Q21190 View 3D Structure Click here
Q22165 View 3D Structure Click here
Q27433 View 3D Structure Click here
Q4CPV3 View 3D Structure Click here
Q4CQK8 View 3D Structure Click here
Q4D3E4 View 3D Structure Click here
Q4D3F3 View 3D Structure Click here
Q4D7U7 View 3D Structure Click here
Q4D8I7 View 3D Structure Click here
Q4DCI5 View 3D Structure Click here
Q4DEQ3 View 3D Structure Click here
Q4DUF7 View 3D Structure Click here
Q4DW86 View 3D Structure Click here
Q4FZT0 View 3D Structure Click here
Q4V3D6 View 3D Structure Click here
Q501E6 View 3D Structure Click here
Q54F95 View 3D Structure Click here
Q54GI9 View 3D Structure Click here
Q54K65 View 3D Structure Click here
Q54PD5 View 3D Structure Click here
Q54Q31 View 3D Structure Click here
Q54WZ2 View 3D Structure Click here
Q54WZ3 View 3D Structure Click here
Q54X13 View 3D Structure Click here
Q55CR1 View 3D Structure Click here
Q58237 View 3D Structure Click here
Q58EG2 View 3D Structure Click here
Q59SS4 View 3D Structure Click here
Q5AND0 View 3D Structure Click here
Q5VNU2 View 3D Structure Click here
Q5XI04 View 3D Structure Click here
Q5XIH7 View 3D Structure Click here
Q60634 View 3D Structure Click here
Q6EP40 View 3D Structure Click here
Q6K550 View 3D Structure Click here
Q6L4S3 View 3D Structure Click here
Q6PC13 View 3D Structure Click here
Q6PE84 View 3D Structure Click here
Q6PFT0 View 3D Structure Click here
Q6TH07 View 3D Structure Click here
Q6ZIV7 View 3D Structure Click here
Q7EYR6 View 3D Structure Click here
Q7EZD2 View 3D Structure Click here
Q7KPQ9 View 3D Structure Click here
Q7T1D8 View 3D Structure Click here
Q7YZV6 View 3D Structure Click here
Q7ZZ76 View 3D Structure Click here
Q86IY7 View 3D Structure Click here
Q8BFZ9 View 3D Structure Click here
Q8CI66 View 3D Structure Click here
Q8H918 View 3D Structure Click here
Q8IBC3 View 3D Structure Click here
Q8IJP8 View 3D Structure Click here
Q8K4G9 View 3D Structure Click here
Q8LNW4 View 3D Structure Click here
Q8LNW6 View 3D Structure Click here
Q8S1F0 View 3D Structure Click here
Q8S1F1 View 3D Structure Click here
Q8T4B6 View 3D Structure Click here
Q8TAV4 View 3D Structure Click here
Q91X05 View 3D Structure Click here
Q91X78 View 3D Structure Click here
Q93VP9 View 3D Structure Click here
Q98TZ8 View 3D Structure Click here
Q99623 View 3D Structure Click here
Q99JB2 View 3D Structure Click here
Q9AV57 View 3D Structure Click here
Q9BKU4 View 3D Structure Click here
Q9CAR7 View 3D Structure Click here
Q9FFH5 View 3D Structure Click here
Q9FHM7 View 3D Structure Click here
Q9FM19 View 3D Structure Click here
Q9LK25 View 3D Structure Click here
Q9LV90 View 3D Structure Click here
Q9LVW0 View 3D Structure Click here
Q9LY99 View 3D Structure Click here
Q9LY99 View 3D Structure Click here
Q9M583 View 3D Structure Click here
Q9M585 View 3D Structure Click here
Q9M588 View 3D Structure Click here
Q9M589 View 3D Structure Click here
Q9NP85 View 3D Structure Click here
Q9P7H3 View 3D Structure Click here
Q9SIL6 View 3D Structure Click here
Q9SRH6 View 3D Structure Click here
Q9UBI4 View 3D Structure Click here
Q9UJZ1 View 3D Structure Click here
Q9VGD7 View 3D Structure Click here
Q9VGD9 View 3D Structure Click here
Q9VWL0 View 3D Structure Click here
Q9VZA4 View 3D Structure Click here
Q9W1F7 View 3D Structure Click here
Q9XWC6 View 3D Structure Click here
Q9Z1E1 View 3D Structure Click here
Q9Z2S9 View 3D Structure Click here
Q9ZNT7 View 3D Structure Click here
Q9ZQ87 View 3D Structure Click here