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135  structures 1453  species 0  interactions 7631  sequences 101  architectures

Family: GDA1_CD39 (PF01150)

Summary: GDA1/CD39 (nucleoside phosphatase) family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

GDA1/CD39 (nucleoside phosphatase) family Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000407

A number of nucleoside diphosphate and triphosphate hydrolases as well as some yet uncharacterised proteins have been found to belong to the same family [ PUBMED:8579614 , PUBMED:8703025 ]. The uncharacterised proteins all seem to be membrane-bound.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Actin_ATPase (CL0108), which has the following description:

The actin-like ATPase domain forms an alpha/beta canonical fold. The domain can be subdivided into 1A, 1B, 2A and 2B subdomains. Subdomains 1A and 1B share the same RNAseH-like fold (a five-stranded beta-sheet decorated by a number of alpha-helices). Domains 1A and 2A are conserved in all members of this superfamily, whereas domain 1B and 2B have a variable structure and are even missing from some homologues [1]. Within the actin-like ATPase domain the ATP-binding site is highly conserved. The phosphate part of the ATP is bound in a cleft between subdomains 1A and 2A, whereas the adenosine moiety is bound to residues from domains 2A and 2B[1].

The clan contains the following 34 members:

Acetate_kinase Actin Actin_micro ALP_N AnmK BcrAD_BadFG Carbam_trans_N DDR DUF1464 DUF2229 EutA FGGY_C FGGY_N FtsA Fumble GDA1_CD39 Glucokinase Hexokinase_1 Hexokinase_2 HGD-D HSP70 Hydant_A_N Hydantoinase_A HypF_C MreB_Mbl MutL Pan_kinase PilM_2 Ppx-GppA RACo_C_ter ROK StbA T2SSL TsaD

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(7)
Full
(7631)
Representative proteomes UniProt
(13349)
RP15
(1252)
RP35
(3301)
RP55
(6155)
RP75
(8283)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(7)
Full
(7631)
Representative proteomes UniProt
(13349)
RP15
(1252)
RP35
(3301)
RP55
(6155)
RP75
(8283)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(7)
Full
(7631)
Representative proteomes UniProt
(13349)
RP15
(1252)
RP35
(3301)
RP55
(6155)
RP75
(8283)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: GDA1_CD39_NTPase;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A
Number in seed: 7
Number in full: 7631
Average length of the domain: 355.80 aa
Average identity of full alignment: 25 %
Average coverage of the sequence by the domain: 75.81 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.9 24.9
Trusted cut-off 25.1 24.9
Noise cut-off 24.8 24.8
Model length: 423
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the GDA1_CD39 domain has been found. There are 135 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JX61 View 3D Structure Click here
A0A0G2K5S7 View 3D Structure Click here
A0A0N7KSD1 View 3D Structure Click here
A0A0P0XT28 View 3D Structure Click here
A0A0P0XYD2 View 3D Structure Click here
A0A0P0Y1M2 View 3D Structure Click here
A0A0P0Y6B3 View 3D Structure Click here
A0A0R0E8H5 View 3D Structure Click here
A0A0R0EHU8 View 3D Structure Click here
A0A0R0EHU8 View 3D Structure Click here
A0A0R0GPJ1 View 3D Structure Click here
A0A0R0JQQ4 View 3D Structure Click here
A0A1D6F4J8 View 3D Structure Click here
A0A1D6F5G3 View 3D Structure Click here
A0A1D6GLN1 View 3D Structure Click here
A0A1D6H4J9 View 3D Structure Click here
A0A1D6H4J9 View 3D Structure Click here
A0A1D6H855 View 3D Structure Click here
A0A1D6IMK8 View 3D Structure Click here
A0A1D6IRH6 View 3D Structure Click here
A0A1D6IRH6 View 3D Structure Click here
A0A1D6K1Q0 View 3D Structure Click here
A0A1D6KP05 View 3D Structure Click here
A0A1D6LWS3 View 3D Structure Click here
A0A1D6M660 View 3D Structure Click here
A0A1D6MRK7 View 3D Structure Click here
A0A1D6NEG9 View 3D Structure Click here
A0A1D6PRL0 View 3D Structure Click here
A0A1D6Q307 View 3D Structure Click here
A0A2R8RYZ8 View 3D Structure Click here
A0A368UGT8 View 3D Structure Click here
A0A368UK88 View 3D Structure Click here
A4HUC4 View 3D Structure Click here
A4HWA0 View 3D Structure Click here
B4FTQ8 View 3D Structure Click here
B4FWF1 View 3D Structure Click here
D3ZNB5 View 3D Structure Click here
D4A617 View 3D Structure Click here
E7F8A7 View 3D Structure Click here
E7FG27 View 3D Structure Click here
F1QCU4 View 3D Structure Click here
F1QG13 View 3D Structure Click here
F1R4L9 View 3D Structure Click here
F1RDI7 View 3D Structure Click here
F4JSH1 View 3D Structure Click here
I1J5Q8 View 3D Structure Click here
I1J886 View 3D Structure Click here
I1JD34 View 3D Structure Click here
I1JE47 View 3D Structure Click here
I1ML44 View 3D Structure Click here
I1ML51 View 3D Structure Click here
I1MMS3 View 3D Structure Click here
K7LNS0 View 3D Structure Click here
K7MFT0 View 3D Structure Click here
K7MHH1 View 3D Structure Click here
K7MHH1 View 3D Structure Click here
K7MKN9 View 3D Structure Click here
K7MXR7 View 3D Structure Click here
K7U2Z2 View 3D Structure Click here
M9PBV2 View 3D Structure Click here
O35795 View 3D Structure Click here
O55026 View 3D Structure Click here
O75354 View 3D Structure Click here
O75355 View 3D Structure Click here
O75356 View 3D Structure Click here
O80612 View 3D Structure Click here
P32621 View 3D Structure Click here
P40009 View 3D Structure Click here
P49961 View 3D Structure Click here
P55772 View 3D Structure Click here
P97687 View 3D Structure Click here
Q0IUZ4 View 3D Structure Click here
Q10KM6 View 3D Structure Click here
Q18411 View 3D Structure Click here
Q21815 View 3D Structure Click here
Q2QYE1 View 3D Structure Click here
Q3TCT4 View 3D Structure Click here
Q3U0P5 View 3D Structure Click here
Q4CLN0 View 3D Structure Click here
Q4CUR3 View 3D Structure Click here
Q4D4Q0 View 3D Structure Click here
Q53KM3 View 3D Structure Click here
Q5A1A4 View 3D Structure Click here
Q5DRK1 View 3D Structure Click here
Q5MY95 View 3D Structure Click here
Q6DH30 View 3D Structure Click here
Q6NQA8 View 3D Structure Click here
Q6P6S9 View 3D Structure Click here
Q6Z4P2 View 3D Structure Click here
Q6Z543 View 3D Structure Click here
Q6ZM69 View 3D Structure Click here
Q8BFW6 View 3D Structure Click here
Q8H1D8 View 3D Structure Click here
Q8H7L6 View 3D Structure Click here
Q8IE96 View 3D Structure Click here
Q8ILE7 View 3D Structure Click here
Q8ILE7 View 3D Structure Click here
Q8K0L2 View 3D Structure Click here
Q8TGH6 View 3D Structure Click here
Q9DBT4 View 3D Structure Click here
Q9ER31 View 3D Structure Click here
Q9NQZ7 View 3D Structure Click here
Q9SPM5 View 3D Structure Click here
Q9SQG2 View 3D Structure Click here
Q9USP2 View 3D Structure Click here
Q9UT35 View 3D Structure Click here
Q9WUZ9 View 3D Structure Click here
Q9XI62 View 3D Structure Click here
Q9XU84 View 3D Structure Click here
Q9Y227 View 3D Structure Click here
Q9Y5L3 View 3D Structure Click here