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2  structures 1422  species 0  interactions 8081  sequences 86  architectures

Family: ELO (PF01151)

Summary: GNS1/SUR4 family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

GNS1/SUR4 family Provide feedback

Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis [1]. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 (P40319) affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [2].

Literature references

  1. Oh CS, Toke DA, Mandala S, Martin CE; , J Biol Chem 1997;272:17376-17384.: ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation. PUBMED:9211877 EPMC:9211877

  2. Garcia-Arranz M, Maldonado AM, Mazon MJ, Portillo F; , J Biol Chem 1994;269:18076-18082.: Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation. PUBMED:8027068 EPMC:8027068


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002076

This group of eukaryotic integral membrane proteins are evolutionary related, but exact function has not yet clearly been established. The proteins have from 290 to 435 amino acid residues. Structurally, they seem to be formed of three sections: a N-terminal region with two transmembrane domains, a central hydrophilic loop and a C-terminal region that contains from one to three transmembrane domains. Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis [ PUBMED:8027068 ]. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 ( SWISSPROT ) affects plasma membrane H+-ATPase activity, and may act on a glucose-signalling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1 [ PUBMED:7768822 ].

The ELO family consist of eukaryotic integral membrane proteins involved in fatty acid elongation. This family consist of:

  • Mammalian proteins ELOVL1 to ELOVL4 [ PUBMED:10791983 ]. These proteins all seem to be involved in the synthesis of very long chain fatty acids.
  • Yeast ELO1, ELO2 and ELO3 [ PUBMED:9211877 ]. They seem to be components of membrane-bound fatty acid elongation systems.
  • Caenorhabditis elegans hypothetical protein C40H1.4.
  • Caenorhabditis elegans hypothetical protein D2024.3.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(140)
Full
(8081)
Representative proteomes UniProt
(16292)
RP15
(2200)
RP35
(4242)
RP55
(6897)
RP75
(8897)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(140)
Full
(8081)
Representative proteomes UniProt
(16292)
RP15
(2200)
RP35
(4242)
RP55
(6897)
RP75
(8897)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(140)
Full
(8081)
Representative proteomes UniProt
(16292)
RP15
(2200)
RP35
(4242)
RP55
(6897)
RP75
(8897)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prosite
Previous IDs: GNS1_SUR4;
Type: Family
Sequence Ontology: SO:0100021
Author: Finn RD , Bateman A , Kerrison ND
Number in seed: 140
Number in full: 8081
Average length of the domain: 225.60 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 77.10 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 21.1 21.1
Trusted cut-off 21.1 21.1
Noise cut-off 21.0 21.0
Model length: 250
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the ELO domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4KF65 View 3D Structure Click here
A0A0R0K8T2 View 3D Structure Click here
A0A0R4IG54 View 3D Structure Click here
A0A0R4IT00 View 3D Structure Click here
A0A1D6ERJ0 View 3D Structure Click here
A0A1D6H4G8 View 3D Structure Click here
A0A1D6L0Y4 View 3D Structure Click here
A0A1D6MV48 View 3D Structure Click here
A0A1D8PGU2 View 3D Structure Click here
A1L3X0 View 3D Structure Click here
A1ZBD2 View 3D Structure Click here
A3KP14 View 3D Structure Click here
A4HSN8 View 3D Structure Click here
A4HW06 View 3D Structure Click here
A4HW07 View 3D Structure Click here
A4HW08 View 3D Structure Click here
A4HW09 View 3D Structure Click here
A4HW10 View 3D Structure Click here
A4HW12 View 3D Structure Click here
A4HW13 View 3D Structure Click here
A4HW14 View 3D Structure Click here
A4HW15 View 3D Structure Click here
A4HW16 View 3D Structure Click here
A4HW17 View 3D Structure Click here
A4HW18 View 3D Structure Click here
A4I7T3 View 3D Structure Click here
A8JNR0 View 3D Structure Click here
A9C3R2 View 3D Structure Click here
B8JJK4 View 3D Structure Click here
B8JK95 View 3D Structure Click here
C0H545 View 3D Structure Click here
C6KSQ7 View 3D Structure Click here
C7FZW5 View 3D Structure Click here
D3ZPX9 View 3D Structure Click here
D4A612 View 3D Structure Click here
D4ACH5 View 3D Structure Click here
D4ADY9 View 3D Structure Click here
E7FFN9 View 3D Structure Click here
E9AGL0 View 3D Structure Click here
E9AGL2 View 3D Structure Click here
F1QG35 View 3D Structure Click here
F3Y5R4 View 3D Structure Click here
G5EEE5 View 3D Structure Click here
I1JCT0 View 3D Structure Click here
I1KUK9 View 3D Structure Click here
I1LHM3 View 3D Structure Click here
I1MNI5 View 3D Structure Click here
O35949 View 3D Structure Click here
P25358 View 3D Structure Click here
P39540 View 3D Structure Click here
P40319 View 3D Structure Click here
P49191 View 3D Structure Click here
Q03574 View 3D Structure Click here
Q20300 View 3D Structure Click here
Q20303 View 3D Structure Click here
Q20904 View 3D Structure Click here
Q2QLN2 View 3D Structure Click here
Q4D321 View 3D Structure Click here
Q4D5J7 View 3D Structure Click here
Q4DHY1 View 3D Structure Click here
Q4DHY2 View 3D Structure Click here
Q4DHY3 View 3D Structure Click here
Q4DUK4 View 3D Structure Click here
Q4DUK5 View 3D Structure Click here
Q4DUK6 View 3D Structure Click here
Q4DUK7 View 3D Structure Click here
Q4DX62 View 3D Structure Click here
Q4V3H4 View 3D Structure Click here
Q53RC1 View 3D Structure Click here
Q54CJ4 View 3D Structure Click here
Q54TC9 View 3D Structure Click here
Q555E8 View 3D Structure Click here
Q555E8 View 3D Structure Click here
Q55BY4 View 3D Structure Click here
Q55BY4 View 3D Structure Click here
Q59PF0 View 3D Structure Click here
Q5AN96 View 3D Structure Click here
Q5JZZ4 View 3D Structure Click here
Q5U2Z8 View 3D Structure Click here
Q5XJ87 View 3D Structure Click here
Q6NN18 View 3D Structure Click here
Q6P978 View 3D Structure Click here
Q6PBM2 View 3D Structure Click here
Q6PC64 View 3D Structure Click here
Q7KWQ5 View 3D Structure Click here
Q7LKX0 View 3D Structure Click here
Q86JM5 View 3D Structure Click here
Q8AX86 View 3D Structure Click here
Q8BHI7 View 3D Structure Click here
Q8I251 View 3D Structure Click here
Q8IMY2 View 3D Structure Click here
Q8SXD1 View 3D Structure Click here
Q920L5 View 3D Structure Click here
Q920L6 View 3D Structure Click here
Q920L7 View 3D Structure Click here
Q95T98 View 3D Structure Click here
Q9BW60 View 3D Structure Click here
Q9D2Y9 View 3D Structure Click here
Q9EQC4 View 3D Structure Click here
Q9GZR5 View 3D Structure Click here
Q9H5J4 View 3D Structure Click here
Q9HB03 View 3D Structure Click here
Q9JLJ4 View 3D Structure Click here
Q9JLJ5 View 3D Structure Click here
Q9NAC6 View 3D Structure Click here
Q9NXB9 View 3D Structure Click here
Q9NYP7 View 3D Structure Click here
Q9S804 View 3D Structure Click here
Q9SQU9 View 3D Structure Click here
Q9SQV0 View 3D Structure Click here
Q9SYY4 View 3D Structure Click here
Q9UTF7 View 3D Structure Click here
Q9VCT3 View 3D Structure Click here
Q9VCY5 View 3D Structure Click here
Q9VCY6 View 3D Structure Click here
Q9VCY7 View 3D Structure Click here
Q9VCZ0 View 3D Structure Click here
Q9VH55 View 3D Structure Click here
Q9VH57 View 3D Structure Click here
Q9VH58 View 3D Structure Click here
Q9VH59 View 3D Structure Click here
Q9VHX7 View 3D Structure Click here
Q9VV87 View 3D Structure Click here
Q9XVQ9 View 3D Structure Click here

trRosetta Structure

The structural model below was generated by the Baker group with the trRosetta software using the Pfam UniProt multiple sequence alignment.

The InterPro website shows the contact map for the Pfam SEED alignment. Hovering or clicking on a contact position will highlight its connection to other residues in the alignment, as well as on the 3D structure.

Improved protein structure prediction using predicted inter-residue orientations. Jianyi Yang, Ivan Anishchenko, Hahnbeom Park, Zhenling Peng, Sergey Ovchinnikov, David Baker Proceedings of the National Academy of Sciences Jan 2020, 117 (3) 1496-1503; DOI: 10.1073/pnas.1914677117;