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13  structures 1441  species 0  interactions 25572  sequences 1027  architectures

Family: FYVE (PF01363)

Summary: FYVE zinc finger

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "FYVE domain". More...

FYVE domain Edit Wikipedia article

FYVE zinc finger
1joc.png
Early endosome antigen 1 (EEA1) dimer with lipids.[1]
Identifiers
SymbolFYVE
PfamPF01363
InterProIPR000306
PROSITEPDOC50178
SCOPe1vfy / SUPFAM
OPM superfamily59
OPM protein1vfy
CDDcd00065

In molecular biology the FYVE zinc finger domain is named after the four cysteine-rich proteins: Fab 1 (yeast orthologue of PIKfyve), YOTB, Vac 1 (vesicle transport protein), and EEA1, in which it has been found. FYVE domains bind Phosphatidylinositol 3-phosphate,[2] in a way dependent on its metal ion coordination and basic amino acids. The FYVE domain inserts into cell membranes in a pH-dependent manner.[3] The FYVE domain has been connected to vacuolar protein sorting and endosome function.[4]

Structure

The FYVE domain is composed of two small beta hairpins (or zinc knuckles) followed by an alpha helix.[5] The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions and is characterized by having basic amino acids around the cysteines. Many members of this family also include two histidines in a sequence motif:

R+HHC+XCG, where + represents a charged residue and X any residue

The FYVE finger is structurally similar to the RING domain and the PHD finger.

Examples

The following is a list of human proteins containing this domain:

References

  1. ^ Dumas JJ, Merithew E, Sudharshan E, et al. (November 2001). "Multivalent endosome targeting by homodimeric EEA1". Mol. Cell. 8 (5): 947–58. doi:10.1016/S1097-2765(01)00385-9. PMID 11741531.
  2. ^ Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R (July 1998). "FYVE fingers bind PtdIns(3)P". Nature. 394 (6692): 432–3. doi:10.1038/28767. PMID 9697764.
  3. ^ He J, Vora M, Haney RM, et al. (September 2009). "Membrane insertion of the FYVE domain is modulated by pH". Proteins. 76 (4): 852–60. doi:10.1002/prot.22392. PMC 2909462. PMID 19296456.
  4. ^ Leevers SJ, Vanhaesebroeck B, Waterfield MD (April 1999). "Signalling through phosphoinositide 3-kinases: the lipids take centre stage". Curr. Opin. Cell Biol. 11 (2): 219–25. doi:10.1016/S0955-0674(99)80029-5. PMID 10209156.
  5. ^ Misra S, Hurley JH (May 1999). "Crystal structure of a phosphatidylinositol 3-phosphate-specific membrane-targeting motif, the FYVE domain of Vps27p". Cell. 97 (5): 657–66. doi:10.1016/S0092-8674(00)80776-X. PMID 10367894.

Further reading

  • Stenmark H, Aasland R, Toh BH, D'Arrigo A (September 1996). "Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger". J. Biol. Chem. 271 (39): 24048–54. doi:10.1074/jbc.271.39.24048. PMID 8798641.
  • Stenmark H, Aasland R (December 1999). "FYVE-finger proteins--effectors of an inositol lipid". J. Cell Sci. 112 (Pt 23): 4175–83. PMID 10564636.

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

FYVE zinc finger Provide feedback

The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.

Literature references

  1. Stenmark H, Aasland R, Toh BH, D'Arrigo A; , J Biol Chem 1996;271:24048-24054.: Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. PUBMED:8798641 EPMC:8798641

  2. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; , Nature 1998;394:432-433.: FYVE fingers bind PtdIns(3)P. PUBMED:9697764 EPMC:9697764

  3. Stenmark H, Aasland R; , J Cell Sci 1999;112:4175-4183.: FYVE-finger proteins - effectors of an inositol lipid. PUBMED:10564636 EPMC:10564636


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000306

Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [ PUBMED:10529348 , PUBMED:15963892 , PUBMED:15718139 , PUBMED:17210253 , PUBMED:12665246 ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few [ PUBMED:11179890 ]. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target.

The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two zinc ions [ PUBMED:8798641 ]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE-type domains are divided into two known classes: FYVE domains that specifically bind to phosphatidylinositol 3-phosphate in lipid bilayers and FYVE-related domains of undetermined function [ PUBMED:15576038 ]. Those that bind to phosphatidylinositol 3-phosphate are often found in proteins targeted to lipid membranes that are involved in regulating membrane traffic [ PUBMED:11456498 , PUBMED:11739631 , PUBMED:11509568 ]. Most FYVE domains target proteins to endosomes by binding specifically to phosphatidylinositol-3-phosphate at the membrane surface. By contrast, the CARP2 FYVE-like domain is not optimized to bind to phosphoinositides or insert into lipid bilayers. FYVE domains are distinguished from other zinc fingers by three signature sequences: an N-terminal WxxD motif, a basic R(R/K)HHCR patch, and a C-terminal RVC motif.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan zf-FYVE-PHD (CL0390), which has the following description:

Superfamily contains a number of zinc-fingers, of the FYVE/PHD type, which are found in several groups of proteins including myelin-associated oligodendrocytic basic proteins (MOBP) Rabphilins, melanophilins, exophilins and myosin-VIIA and Rab-interacting protein families.

The clan contains the following 13 members:

ADD_ATRX ADD_DNMT3 FYVE FYVE_2 PHD PHD_2 PHD_4 PHD_Oberon RAG2_PHD zf-HC5HC2H zf-HC5HC2H_2 zf-PHD-like zf-piccolo

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(129)
Full
(25572)
Representative proteomes UniProt
(45507)
RP15
(4026)
RP35
(10679)
RP55
(21272)
RP75
(28332)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(129)
Full
(25572)
Representative proteomes UniProt
(45507)
RP15
(4026)
RP35
(10679)
RP55
(21272)
RP75
(28332)
Alignment:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(129)
Full
(25572)
Representative proteomes UniProt
(45507)
RP15
(4026)
RP35
(10679)
RP55
(21272)
RP75
(28332)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_655 (release 3.0)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Armstrong J
Number in seed: 129
Number in full: 25572
Average length of the domain: 70.50 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 7.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.8 27.8
Trusted cut-off 27.8 27.8
Noise cut-off 27.7 27.7
Model length: 69
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Selections

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the FYVE domain has been found. There are 13 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LHR8 View 3D Structure Click here
A0A0G2K051 View 3D Structure Click here
A0A0G2K2U9 View 3D Structure Click here
A0A0G2K3L8 View 3D Structure Click here
A0A0G2K7L6 View 3D Structure Click here
A0A0G2K8S4 View 3D Structure Click here
A0A0N7KL66 View 3D Structure Click here
A0A0P0VD31 View 3D Structure Click here
A0A0P0VD89 View 3D Structure Click here
A0A0P0W185 View 3D Structure Click here
A0A0P0WDY2 View 3D Structure Click here
A0A0P0WH96 View 3D Structure Click here
A0A0R0F852 View 3D Structure Click here
A0A0R0F9B9 View 3D Structure Click here
A0A0R0FRM1 View 3D Structure Click here
A0A0R0FUP7 View 3D Structure Click here
A0A0R0GIK8 View 3D Structure Click here
A0A0R0HRH0 View 3D Structure Click here
A0A0R0IEG5 View 3D Structure Click here
A0A0R0IP82 View 3D Structure Click here
A0A0R0IUD7 View 3D Structure Click here
A0A0R0JB68 View 3D Structure Click here
A0A0R0K2N8 View 3D Structure Click here
A0A0R0KPM3 View 3D Structure Click here
A0A0R4IFR5 View 3D Structure Click here
A0A0R4IIH4 View 3D Structure Click here
A0A0R4IK06 View 3D Structure Click here
A0A0R4ILP5 View 3D Structure Click here
A0A0R4IQI6 View 3D Structure Click here
A0A0R4IQI6 View 3D Structure Click here
A0A1D6E1T8 View 3D Structure Click here
A0A1D6E4Z3 View 3D Structure Click here
A0A1D6F0H9 View 3D Structure Click here
A0A1D6G2V2 View 3D Structure Click here
A0A1D6G3Z7 View 3D Structure Click here
A0A1D6G474 View 3D Structure Click here
A0A1D6HBS3 View 3D Structure Click here
A0A1D6HG44 View 3D Structure Click here
A0A1D6IJP4 View 3D Structure Click here
A0A1D6K593 View 3D Structure Click here
A0A1D6LI48 View 3D Structure Click here
A0A1D6MBL1 View 3D Structure Click here
A0A1D6N107 View 3D Structure Click here
A0A1D6P215 View 3D Structure Click here
A0A1D6PZP9 View 3D Structure Click here
A0A1D6Q734 View 3D Structure Click here
A0A1D8PGH2 View 3D Structure Click here
A0A1D8PGH4 View 3D Structure Click here
A0A1D8PJA2 View 3D Structure Click here
A0A1D8PU28 View 3D Structure Click here
A0A1I9LLL5 View 3D Structure Click here
A0A1I9LTP1 View 3D Structure Click here
A0A1P8BCA2 View 3D Structure Click here
A0A2R8QAJ5 View 3D Structure Click here
A0A2R8QHS4 View 3D Structure Click here
A0A2R8RTA5 View 3D Structure Click here
A0JMD2 View 3D Structure Click here
A2A8R0 View 3D Structure Click here
A4HRT8 View 3D Structure Click here
A4HV55 View 3D Structure Click here
A4HWP5 View 3D Structure Click here
A4HXT6 View 3D Structure Click here
A4HYB5 View 3D Structure Click here
A4I255 View 3D Structure Click here
A4I276 View 3D Structure Click here
A4I276 View 3D Structure Click here
A4I2I8 View 3D Structure Click here
A4I4X6 View 3D Structure Click here
A4I5L1 View 3D Structure Click here
A4IBW6 View 3D Structure Click here
A4ICF0 View 3D Structure Click here
A5PMI2 View 3D Structure Click here
B0G126 View 3D Structure Click here
B1WBV4 View 3D Structure Click here
B4FKR4 View 3D Structure Click here
B6TVQ4 View 3D Structure Click here
B8A6I2 View 3D Structure Click here
C0PFN1 View 3D Structure Click here
C0PG82 View 3D Structure Click here
D3Z9D2 View 3D Structure Click here
D3Z9I3 View 3D Structure Click here
D3ZDC7 View 3D Structure Click here
D3ZL11 View 3D Structure Click here
D3ZSW9 View 3D Structure Click here
D3ZTZ1 View 3D Structure Click here
D3ZVP7 View 3D Structure Click here
D3ZW40 View 3D Structure Click here
D3ZYT8 View 3D Structure Click here
D4A1J6 View 3D Structure Click here
D4A3T4 View 3D Structure Click here
D4A3T4 View 3D Structure Click here
D4A8G9 View 3D Structure Click here
D4ADF6 View 3D Structure Click here
E7EYW1 View 3D Structure Click here
E7F242 View 3D Structure Click here
E7F242 View 3D Structure Click here
E7F6D8 View 3D Structure Click here
E7F843 View 3D Structure Click here
E7FE23 View 3D Structure Click here
E9AHF7 View 3D Structure Click here
E9Q4P1 View 3D Structure Click here
E9QCS7 View 3D Structure Click here
F1LR42 View 3D Structure Click here
F1LTE6 View 3D Structure Click here
F1QS51 View 3D Structure Click here
F1QVN6 View 3D Structure Click here
F1QYJ2 View 3D Structure Click here
F4I287 View 3D Structure Click here
F4JVE8 View 3D Structure Click here
F4K0X5 View 3D Structure Click here
F4K148 View 3D Structure Click here
F6NK88 View 3D Structure Click here
G5ED68 View 3D Structure Click here
G5ED80 View 3D Structure Click here
G5ED98 View 3D Structure Click here
H2KZI9 View 3D Structure Click here
I1JDG4 View 3D Structure Click here
I1JIY3 View 3D Structure Click here
I1K7I5 View 3D Structure Click here
I1KHJ0 View 3D Structure Click here
I1KXU8 View 3D Structure Click here
I1L7H4 View 3D Structure Click here
I1LDI2 View 3D Structure Click here
I1LYB0 View 3D Structure Click here
I1LYC3 View 3D Structure Click here
I1M1P3 View 3D Structure Click here
I1MEW4 View 3D Structure Click here
I1MS22 View 3D Structure Click here
I1MS36 View 3D Structure Click here
I1MY45 View 3D Structure Click here
I1N146 View 3D Structure Click here
I1N357 View 3D Structure Click here
I1NH07 View 3D Structure Click here
K7LRG1 View 3D Structure Click here
K7LZ47 View 3D Structure Click here
K7MPW4 View 3D Structure Click here
K7UEA9 View 3D Structure Click here
M0R6Q4 View 3D Structure Click here
O13786 View 3D Structure Click here
O13786 View 3D Structure Click here
O13821 View 3D Structure Click here
O14964 View 3D Structure Click here
O45398 View 3D Structure Click here
O59722 View 3D Structure Click here
O76902 View 3D Structure Click here
O88387 View 3D Structure Click here
O88842 View 3D Structure Click here
O95405 View 3D Structure Click here
O96838 View 3D Structure Click here
P32609 View 3D Structure Click here
P34657 View 3D Structure Click here
P34756 View 3D Structure Click here
P40343 View 3D Structure Click here
P52734 View 3D Structure Click here
P53191 View 3D Structure Click here
P98174 View 3D Structure Click here
Q06651 View 3D Structure Click here
Q0D4M1 View 3D Structure Click here
Q0DIJ3 View 3D Structure Click here
Q0DYL0 View 3D Structure Click here
Q0WUR5 View 3D Structure Click here
Q13615 View 3D Structure Click here
Q15075 View 3D Structure Click here
Q17796 View 3D Structure Click here
Q18964 View 3D Structure Click here
Q19088 View 3D Structure Click here
Q21938 View 3D Structure Click here
Q22712 View 3D Structure Click here
Q3TB82 View 3D Structure Click here
Q3TXX3 View 3D Structure Click here
Q499R6 View 3D Structure Click here
Q4CMH1 View 3D Structure Click here
Q4CMR3 View 3D Structure Click here
Q4CRP1 View 3D Structure Click here
Q4CWK8 View 3D Structure Click here
Q4CYI4 View 3D Structure Click here
Q4D056 View 3D Structure Click here
Q4D2Q1 View 3D Structure Click here
Q4D7S1 View 3D Structure Click here
Q4DA82 View 3D Structure Click here
Q4DAQ8 View 3D Structure Click here
Q4DCS2 View 3D Structure Click here
Q4DF11 View 3D Structure Click here
Q4DGK7 View 3D Structure Click here
Q4DIX5 View 3D Structure Click here
Q4DKB1 View 3D Structure Click here
Q4DL90 View 3D Structure Click here
Q4DM49 View 3D Structure Click here
Q4DNY7 View 3D Structure Click here
Q4DSM2 View 3D Structure Click here
Q4DTA0 View 3D Structure Click here
Q4DUA9 View 3D Structure Click here
Q4DVN5 View 3D Structure Click here
Q4DW17 View 3D Structure Click here
Q4DZD2 View 3D Structure Click here
Q4E0I3 View 3D Structure Click here
Q4E0L1 View 3D Structure Click here
Q4E0N2 View 3D Structure Click here
Q4E0Z5 View 3D Structure Click here
Q4E264 View 3D Structure Click here
Q4E4W3 View 3D Structure Click here
Q4E5H5 View 3D Structure Click here
Q4VBV0 View 3D Structure Click here
Q54CH1 View 3D Structure Click here
Q54DW7 View 3D Structure Click here
Q54IL5 View 3D Structure Click here
Q54LD5 View 3D Structure Click here
Q54M34 View 3D Structure Click here
Q54QI3 View 3D Structure Click here
Q54SR5 View 3D Structure Click here
Q54TC3 View 3D Structure Click here
Q54UU9 View 3D Structure Click here
Q54VB5 View 3D Structure Click here
Q54YP1 View 3D Structure Click here
Q55EB9 View 3D Structure Click here
Q55FL4 View 3D Structure Click here
Q59UQ8 View 3D Structure Click here
Q59UQ8 View 3D Structure Click here
Q5ABD9 View 3D Structure Click here
Q5DU37 View 3D Structure Click here
Q5JSP0 View 3D Structure Click here
Q5N8I7 View 3D Structure Click here
Q5PQT2 View 3D Structure Click here
Q5RH33 View 3D Structure Click here
Q5T4F4 View 3D Structure Click here
Q5YLY5 View 3D Structure Click here
Q5Z9E4 View 3D Structure Click here
Q68DK2 View 3D Structure Click here
Q68FU1 View 3D Structure Click here
Q69ZL1 View 3D Structure Click here
Q6EUF2 View 3D Structure Click here
Q6NPS1 View 3D Structure Click here
Q6P7B7 View 3D Structure Click here
Q6TLF1 View 3D Structure Click here
Q6Z4J7 View 3D Structure Click here
Q6ZL20 View 3D Structure Click here
Q6ZNL6 View 3D Structure Click here
Q6ZPK7 View 3D Structure Click here
Q6ZV73 View 3D Structure Click here
Q75JF7 View 3D Structure Click here
Q7K9H6 View 3D Structure Click here
Q7PLP5 View 3D Structure Click here
Q7T3F6 View 3D Structure Click here
Q7X6I6 View 3D Structure Click here
Q7XTM0 View 3D Structure Click here
Q7YU03 View 3D Structure Click here
Q7Z3T8 View 3D Structure Click here
Q7Z6J4 View 3D Structure Click here
Q7ZUV1 View 3D Structure Click here
Q80U44 View 3D Structure Click here
Q80UZ0 View 3D Structure Click here
Q80Y56 View 3D Structure Click here
Q810B6 View 3D Structure Click here
Q810J8 View 3D Structure Click here
Q810J8 View 3D Structure Click here
Q84WW7 View 3D Structure Click here
Q86HN1 View 3D Structure Click here
Q8BIJ7 View 3D Structure Click here
Q8BL66 View 3D Structure Click here
Q8BUB4 View 3D Structure Click here
Q8BY35 View 3D Structure Click here
Q8IEL2 View 3D Structure Click here
Q8IKN0 View 3D Structure Click here
Q8IWB7 View 3D Structure Click here
Q8K296 View 3D Structure Click here
Q8MLR7 View 3D Structure Click here
Q8R4C2 View 3D Structure Click here
Q8VCM3 View 3D Structure Click here
Q8VDC1 View 3D Structure Click here
Q8WXA3 View 3D Structure Click here
Q91WB4 View 3D Structure Click here
Q91XS1 View 3D Structure Click here
Q91ZT5 View 3D Structure Click here
Q947D2 View 3D Structure Click here
Q960X8 View 3D Structure Click here
Q96K21 View 3D Structure Click here
Q96M96 View 3D Structure Click here
Q96P53 View 3D Structure Click here
Q96S99 View 3D Structure Click here
Q96T51 View 3D Structure Click here
Q99LI8 View 3D Structure Click here
Q9ASS2 View 3D Structure Click here
Q9BQ24 View 3D Structure Click here
Q9BQS8 View 3D Structure Click here
Q9DAZ9 View 3D Structure Click here
Q9H1K0 View 3D Structure Click here
Q9H8W4 View 3D Structure Click here
Q9HBF4 View 3D Structure Click here
Q9HBF4 View 3D Structure Click here
Q9HCC9 View 3D Structure Click here
Q9HGN5 View 3D Structure Click here
Q9JJ50 View 3D Structure Click here
Q9LUM0 View 3D Structure Click here
Q9LXL1 View 3D Structure Click here
Q9NYA4 View 3D Structure Click here
Q9P2R3 View 3D Structure Click here
Q9SRZ7 View 3D Structure Click here
Q9TZD0 View 3D Structure Click here
Q9VB70 View 3D Structure Click here
Q9VGP1 View 3D Structure Click here
Q9VKW1 View 3D Structure Click here
Q9VLS5 View 3D Structure Click here
Q9W2M0 View 3D Structure Click here
Q9Y2I7 View 3D Structure Click here
Q9Y7M3 View 3D Structure Click here
Q9Z1T6 View 3D Structure Click here
W6SBE5 View 3D Structure Click here
X1WDS7 View 3D Structure Click here
X5LX76 View 3D Structure Click here