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4  structures 164  species 0  interactions 16402  sequences 630  architectures

Family: B_lectin (PF01453)

Summary: D-mannose binding lectin

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

D-mannose binding lectin Provide feedback

These proteins include mannose-specific lectins from [1] as well as bacteriocins from bacteria [2].

Literature references

  1. Wright CS, Hester G; , Structure 1996;4:1339-1352.: The 2.0 A structure of a cross-linked complex between snowdrop lectin and a branched mannopentaose: evidence for two unique binding modes. PUBMED:8939757 EPMC:8939757

  2. Parret AH, Schoofs G, Proost P, De Mot R; , J Bacteriol 2003;185:897-908.: Plant lectin-like bacteriocin from a rhizosphere-colonizing Pseudomonas isolate. PUBMED:12533465 EPMC:12533465


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR001480

A bulb lectin super-family (Amaryllidaceae, Orchidaceae and Aliaceae) contains a ~115-residue-long domain whose overall three dimensional fold is very similar to that of [ PUBMED:9132060 , PUBMED:7664110 , PUBMED:11522393 ]:

  • Dictyostelium discoideum comitin, an actin binding protein
  • Curculigo latifolia curculin, a sweet tasting and taste-modifying protein

This domain generally binds mannose, but in at least one protein, curculin, it is apparently devoid of mannose-binding activity.

Each bulb-type lectin domain consists of three sequential beta-sheet subdomains (I, II, III) that are inter-related by pseudo three-fold symmetry. The three subdomains are flat four-stranded, antiparallel beta-sheets. Together they form a 12-stranded beta-barrel in which the barrel axis coincides with the pseudo 3-fold axis.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Beta_propeller (CL0186), which has the following description:

This large clan contains proteins that contain beta propellers. These are composed of between 6 and 8 repeats. The individual repeats are composed of a four stranded sheet. The clan includes families such as WD40 Pfam:PF00400 where the individual repeats are modeled. The clan also includes families where the entire propeller is modeled such as Pfam:PF02239 usually because the individual repeats are not discernible. These proteins carry out a very wide diversity of functions including catalysis.

The clan contains the following 88 members:

ANAPC4_WD40 APMAP_N Arylesterase Arylsulfotran_2 Arylsulfotrans B_lectin BBS2_Mid Beta_propel Coatomer_WDAD CPSF_A CyRPA Cytochrom_D1 Dpp_8_9_N DPPIV_N DPPIV_rep DUF1513 DUF1668 DUF2415 DUF3748 DUF4221 DUF4933 DUF4934 DUF5046 DUF5050 DUF5122 DUF5128 DUF5711 DUF839 eIF2A FG-GAP FG-GAP_2 FG-GAP_3 Frtz Ge1_WD40 Glu_cyclase_2 Gmad1 GSDH Hyd_WA IKI3 Itfg2 Kelch_1 Kelch_2 Kelch_3 Kelch_4 Kelch_5 Kelch_6 Lactonase Ldl_recept_b LGFP Lgl_C LVIVD Me-amine-dh_H MgpC MRJP Nbas_N Neisseria_PilC NHL nos_propeller nos_propeller_2 Nucleoporin_N Nup160 PALB2_WD40 PD40 Pectate_lyase22 Peptidase_S9_N PHTB1_N Phytase-like PQQ PQQ_2 PQQ_3 RAG2 RCC1 RCC1_2 Reg_prop SBBP SBP56 SdiA-regulated SGL Str_synth TcdB_toxin_midN Tectonin TolB_like VID27 WD40 WD40_2 WD40_3 WD40_4 WD40_like

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(168)
Full
(16402)
Representative proteomes UniProt
(23647)
RP15
(947)
RP35
(8641)
RP55
(13496)
RP75
(17986)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(168)
Full
(16402)
Representative proteomes UniProt
(23647)
RP15
(947)
RP35
(8641)
RP55
(13496)
RP75
(17986)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(168)
Full
(16402)
Representative proteomes UniProt
(23647)
RP15
(947)
RP35
(8641)
RP55
(13496)
RP75
(17986)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Prodom_2511 (release 99.1)
Previous IDs: Agglutinin; MMBL2; MMBL; Agglutinin;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Griffiths-Jones SR , Studholme DJ , El-Gebali S
Number in seed: 168
Number in full: 16402
Average length of the domain: 100.90 aa
Average identity of full alignment: 34 %
Average coverage of the sequence by the domain: 14.38 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 32.4 32.4
Trusted cut-off 32.4 32.4
Noise cut-off 32.3 32.3
Model length: 106
Family (HMM) version: 26
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the B_lectin domain has been found. There are 4 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A096T7Z1 View 3D Structure Click here
A0A0N7KDE3 View 3D Structure Click here
A0A0N7KHG5 View 3D Structure Click here
A0A0N7KJS0 View 3D Structure Click here
A0A0N7KLL1 View 3D Structure Click here
A0A0N7KM95 View 3D Structure Click here
A0A0N7KPD3 View 3D Structure Click here
A0A0N7KR84 View 3D Structure Click here
A0A0P0UZX5 View 3D Structure Click here
A0A0P0UZZ8 View 3D Structure Click here
A0A0P0V6A7 View 3D Structure Click here
A0A0P0V6E9 View 3D Structure Click here
A0A0P0V6F2 View 3D Structure Click here
A0A0P0V905 View 3D Structure Click here
A0A0P0VBE8 View 3D Structure Click here
A0A0P0W6K3 View 3D Structure Click here
A0A0P0W6Q5 View 3D Structure Click here
A0A0P0W7R2 View 3D Structure Click here
A0A0P0W9H2 View 3D Structure Click here
A0A0P0WAE2 View 3D Structure Click here
A0A0P0WAJ2 View 3D Structure Click here
A0A0P0WAN9 View 3D Structure Click here
A0A0P0WF41 View 3D Structure Click here
A0A0P0WF66 View 3D Structure Click here
A0A0P0WF71 View 3D Structure Click here
A0A0P0WF77 View 3D Structure Click here
A0A0P0WF87 View 3D Structure Click here
A0A0P0WF90 View 3D Structure Click here
A0A0P0WF95 View 3D Structure Click here
A0A0P0WFH6 View 3D Structure Click here
A0A0P0WFW5 View 3D Structure Click here
A0A0P0WG14 View 3D Structure Click here
A0A0P0WIA4 View 3D Structure Click here
A0A0P0WSZ1 View 3D Structure Click here
A0A0P0WYP8 View 3D Structure Click here
A0A0P0WZ81 View 3D Structure Click here
A0A0P0X7Q1 View 3D Structure Click here
A0A0P0XDL5 View 3D Structure Click here
A0A0P0XDV7 View 3D Structure Click here
A0A0P0XIT7 View 3D Structure Click here
A0A0P0XPZ9 View 3D Structure Click here
A0A0P0XQ04 View 3D Structure Click here
A0A0P0XQ09 View 3D Structure Click here
A0A0P0XQ32 View 3D Structure Click here
A0A0P0XQ91 View 3D Structure Click here
A0A0P0XQJ7 View 3D Structure Click here
A0A0P0XQY3 View 3D Structure Click here
A0A0P0XRC1 View 3D Structure Click here
A0A0P0XRC3 View 3D Structure Click here
A0A0P0XYU6 View 3D Structure Click here
A0A0P0Y0I8 View 3D Structure Click here
A0A0P0Y6H8 View 3D Structure Click here
A0A0P0Y700 View 3D Structure Click here
A0A0P0Y7N1 View 3D Structure Click here
A0A0R0E332 View 3D Structure Click here
A0A0R0EGU1 View 3D Structure Click here
A0A0R0EVN8 View 3D Structure Click here
A0A0R0FWY9 View 3D Structure Click here
A0A0R0FXR9 View 3D Structure Click here
A0A0R0G5X7 View 3D Structure Click here
A0A0R0GCB6 View 3D Structure Click here
A0A0R0GPJ5 View 3D Structure Click here
A0A0R0GTK5 View 3D Structure Click here
A0A0R0GZH6 View 3D Structure Click here
A0A0R0H043 View 3D Structure Click here
A0A0R0H4D6 View 3D Structure Click here
A0A0R0H5Y2 View 3D Structure Click here
A0A0R0H7D4 View 3D Structure Click here
A0A0R0H8A8 View 3D Structure Click here
A0A0R0H9S2 View 3D Structure Click here
A0A0R0HBP3 View 3D Structure Click here
A0A0R0HDU4 View 3D Structure Click here
A0A0R0HI02 View 3D Structure Click here
A0A0R0HK22 View 3D Structure Click here
A0A0R0HUZ3 View 3D Structure Click here
A0A0R0IC73 View 3D Structure Click here
A0A0R0IN76 View 3D Structure Click here
A0A0R0IRG6 View 3D Structure Click here
A0A0R0IUS2 View 3D Structure Click here
A0A0R0J0N7 View 3D Structure Click here
A0A0R0J1M0 View 3D Structure Click here
A0A0R0J260 View 3D Structure Click here
A0A0R0J2N0 View 3D Structure Click here
A0A0R0JLC9 View 3D Structure Click here
A0A0R0JLM5 View 3D Structure Click here
A0A0R0JLQ4 View 3D Structure Click here
A0A0R0JM62 View 3D Structure Click here
A0A0R0JNK4 View 3D Structure Click here
A0A0R0JT19 View 3D Structure Click here
A0A0R0JTU4 View 3D Structure Click here
A0A0R0JVL9 View 3D Structure Click here
A0A0R0K3P7 View 3D Structure Click here
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A0A0R0KD14 View 3D Structure Click here
A0A0R0KH31 View 3D Structure Click here
A0A0R0KJ29 View 3D Structure Click here
A0A0R0KJL9 View 3D Structure Click here
A0A0R0LKJ9 View 3D Structure Click here
A0A1D6DXF1 View 3D Structure Click here
A0A1D6DXH6 View 3D Structure Click here
A0A1D6DXH8 View 3D Structure Click here
A0A1D6DXH9 View 3D Structure Click here
A0A1D6DXI3 View 3D Structure Click here
A0A1D6DXI7 View 3D Structure Click here
A0A1D6DXM7 View 3D Structure Click here
A0A1D6EB48 View 3D Structure Click here
A0A1D6EUL5 View 3D Structure Click here
A0A1D6EWT3 View 3D Structure Click here
A0A1D6F8W0 View 3D Structure Click here
A0A1D6FGJ5 View 3D Structure Click here
A0A1D6FSS9 View 3D Structure Click here
A0A1D6G136 View 3D Structure Click here
A0A1D6G137 View 3D Structure Click here
A0A1D6G7A2 View 3D Structure Click here
A0A1D6G922 View 3D Structure Click here
A0A1D6GA09 View 3D Structure Click here
A0A1D6GN29 View 3D Structure Click here
A0A1D6H6B5 View 3D Structure Click here
A0A1D6H9Q0 View 3D Structure Click here
A0A1D6HLB4 View 3D Structure Click here
A0A1D6HLB7 View 3D Structure Click here
A0A1D6HWK7 View 3D Structure Click here
A0A1D6I5R1 View 3D Structure Click here
A0A1D6IAX9 View 3D Structure Click here
A0A1D6IBG7 View 3D Structure Click here
A0A1D6IEI2 View 3D Structure Click here
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A0A1D6ITQ0 View 3D Structure Click here
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A0A1D6J4K7 View 3D Structure Click here
A0A1D6J6V1 View 3D Structure Click here
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A0A1D6J6V6 View 3D Structure Click here
A0A1D6J6V7 View 3D Structure Click here
A0A1D6JF77 View 3D Structure Click here
A0A1D6JF78 View 3D Structure Click here
A0A1D6JTK4 View 3D Structure Click here
A0A1D6KCZ0 View 3D Structure Click here
A0A1D6KH09 View 3D Structure Click here
A0A1D6KIH3 View 3D Structure Click here
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A0A1D6KL97 View 3D Structure Click here
A0A1D6KNU3 View 3D Structure Click here
A0A1D6KQI3 View 3D Structure Click here
A0A1D6LBB2 View 3D Structure Click here
A0A1D6LHG9 View 3D Structure Click here
A0A1D6LJU2 View 3D Structure Click here
A0A1D6M0L4 View 3D Structure Click here
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A0A1D6ML66 View 3D Structure Click here
A0A1D6N9S3 View 3D Structure Click here
A0A1D6N9S7 View 3D Structure Click here
A0A1D6NG97 View 3D Structure Click here
A0A1D6P2B1 View 3D Structure Click here
A0A1D6P4R6 View 3D Structure Click here
A0A1D6P507 View 3D Structure Click here
A0A1D6Q5J8 View 3D Structure Click here
A0A368UHR2 View 3D Structure Click here
A2ZWE1 View 3D Structure Click here
B4FB05 View 3D Structure Click here
B9FEC3 View 3D Structure Click here
C0P3V1 View 3D Structure Click here
C0P6F5 View 3D Structure Click here
C6ZRU8 View 3D Structure Click here
C7IX09 View 3D Structure Click here
I1J9S8 View 3D Structure Click here
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I1JK11 View 3D Structure Click here
I1JK13 View 3D Structure Click here
I1JMA2 View 3D Structure Click here
I1JPX6 View 3D Structure Click here
I1JUC5 View 3D Structure Click here
I1KE60 View 3D Structure Click here
I1KE67 View 3D Structure Click here
I1KE68 View 3D Structure Click here
I1KE70 View 3D Structure Click here
I1KE73 View 3D Structure Click here
I1KE88 View 3D Structure Click here
I1KE90 View 3D Structure Click here
I1KEA9 View 3D Structure Click here
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I1KIJ6 View 3D Structure Click here
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I1KZ76 View 3D Structure Click here
I1KZ77 View 3D Structure Click here
I1KZA4 View 3D Structure Click here
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I1LSY4 View 3D Structure Click here
I1M2E5 View 3D Structure Click here
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I1M2E9 View 3D Structure Click here
I1M2F0 View 3D Structure Click here
I1M307 View 3D Structure Click here
I1M3F1 View 3D Structure Click here
I1M5U0 View 3D Structure Click here
I1ME78 View 3D Structure Click here
I1MI78 View 3D Structure Click here
I1MIG9 View 3D Structure Click here
I1MKV1 View 3D Structure Click here
I1MNZ4 View 3D Structure Click here
I1MWS6 View 3D Structure Click here
I1N359 View 3D Structure Click here
K7K3A2 View 3D Structure Click here
K7K6Z0 View 3D Structure Click here
K7K9A9 View 3D Structure Click here
K7KBW2 View 3D Structure Click here
K7KBW3 View 3D Structure Click here
K7KD19 View 3D Structure Click here
K7KDF6 View 3D Structure Click here
K7KI11 View 3D Structure Click here
K7KT18 View 3D Structure Click here
K7KTI3 View 3D Structure Click here
K7KXC8 View 3D Structure Click here
K7KXD3 View 3D Structure Click here
K7KXE1 View 3D Structure Click here
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K7KXF2 View 3D Structure Click here
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K7KXI2 View 3D Structure Click here
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K7L050 View 3D Structure Click here
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K7L698 View 3D Structure Click here
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K7L8G9 View 3D Structure Click here
K7LAS7 View 3D Structure Click here
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K7LCV5 View 3D Structure Click here
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K7LU18 View 3D Structure Click here
K7LUS0 View 3D Structure Click here
K7LUV3 View 3D Structure Click here
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K7LUW1 View 3D Structure Click here
K7LUW9 View 3D Structure Click here
K7LUY2 View 3D Structure Click here
K7LVZ3 View 3D Structure Click here
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K7LVZ6 View 3D Structure Click here
K7M046 View 3D Structure Click here
K7M1R3 View 3D Structure Click here
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K7M1R6 View 3D Structure Click here
K7M2E9 View 3D Structure Click here
K7M2F0 View 3D Structure Click here
K7M2F6 View 3D Structure Click here
K7M2T9 View 3D Structure Click here
K7M8T0 View 3D Structure Click here
K7MCT9 View 3D Structure Click here
K7MCU0 View 3D Structure Click here
K7MCU5 View 3D Structure Click here
K7MDU4 View 3D Structure Click here
K7MDZ6 View 3D Structure Click here
K7MG77 View 3D Structure Click here
K7MHK9 View 3D Structure Click here
K7MLQ7 View 3D Structure Click here
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K7MYD3 View 3D Structure Click here
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K7N421 View 3D Structure Click here
K7TKD2 View 3D Structure Click here
K7U294 View 3D Structure Click here
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K7UC64 View 3D Structure Click here
K7UIF8 View 3D Structure Click here
K7UZN2 View 3D Structure Click here
K7VD35 View 3D Structure Click here
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O64477 View 3D Structure Click here
O64770 View 3D Structure Click here
O64771 View 3D Structure Click here
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O65238 View 3D Structure Click here
O81832 View 3D Structure Click here
O81833 View 3D Structure Click here
O81905 View 3D Structure Click here
O81906 View 3D Structure Click here
P0DH87 View 3D Structure Click here
P17801 View 3D Structure Click here
P93756 View 3D Structure Click here
Q0DC23 View 3D Structure Click here
Q0IUV4 View 3D Structure Click here
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Q0JD95 View 3D Structure Click here
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Q7XI25 View 3D Structure Click here
Q7XMH0 View 3D Structure Click here
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Q7XQT8 View 3D Structure Click here
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Q7XUM4 View 3D Structure Click here
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Q851M7 View 3D Structure Click here
Q8GY81 View 3D Structure Click here
Q8H821 View 3D Structure Click here
Q8LMB0 View 3D Structure Click here
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Q9SCT7 View 3D Structure Click here
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