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67  structures 2426  species 1  interaction 9745  sequences 145  architectures

Family: Glyco_transf_8 (PF01501)

Summary: Glycosyl transferase family 8

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Glycosyl transferase family 8 Provide feedback

This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase P27128 lipopolysaccharide glucosyltransferase 1 P27129 and glycogenin glucosyltransferase P46976.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002495

The biosynthesis of disaccharides, oligosaccharides and polysaccharides involves the action of hundreds of different glycosyltransferases. These enzymes catalyse the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. A classification of glycosyltransferases using nucleotide diphospho-sugar, nucleotide monophospho-sugar and sugar phosphates (EC) and related proteins into distinct sequence based families has been described [PUBMED:9334165]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site. The same three-dimensional fold is expected to occur within each of the families. Because 3-D structures are better conserved than sequences, several of the families defined on the basis of sequence similarities may have similar 3-D structures and therefore form 'clans'.

Glycosyltransferase family 8 CAZY comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase (EC), lipopolysaccharide glucosyltransferase 1 (EC), glycogenin glucosyltransferase (EC), inositol 1-alpha-galactosyltransferase (EC). These enzymes have a distant similarity to family GT_24.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

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