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8  structures 1479  species 0  interactions 22163  sequences 377  architectures

Family: DHHC (PF01529)

Summary: DHHC palmitoyltransferase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "DHHC domain". More...

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

DHHC palmitoyltransferase Provide feedback

This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases [1]. Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyze this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterized by the presence of a 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein [2]. Some proteins containing a DHHC domain include Drosophila DNZ1 protein [4] Mouse Abl-philin 2 (Aph2) protein [5] Mammalian ZDHHC9 [6] Yeast ankyrin repeat-containing protein AKR1 [7] Yeast Erf2 protein [8] and Arabidopsis thaliana tip growth defective 1 [9].

Literature references

  1. Fukata M, Fukata Y, Adesnik H, Nicoll RA, Bredt DS;, Neuron. 2004;44:987-996.: Identification of PSD-95 palmitoylating enzymes. PUBMED:15603741 EPMC:15603741

  2. Ohno Y, Kashio A, Ogata R, Ishitomi A, Yamazaki Y, Kihara A;, Mol Biol Cell. 2012;23:4543-4551.: Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. PUBMED:23034182 EPMC:23034182

  3. Gonzalez Montoro A, Chumpen Ramirez S, Valdez Taubas J;, J Biol Chem. 2015;290:22448-22459.: The canonical DHHC motif is not absolutely required for the activity of the yeast S-acyltransferases Swf1 and Pfa4. PUBMED:26224664 EPMC:26224664

  4. Mesilaty-Gross S, Reich A, Motro B, Wides R; , Gene 1999;231:173-186.: The drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. PUBMED:10231582 EPMC:10231582

  5. Li B, Cong F, Tan CP, Wang SX, Goff SP;, J Biol Chem. 2002;277:28870-28876.: Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity. PUBMED:12021275 EPMC:12021275

  6. Swarthout JT, Lobo S, Farh L, Croke MR, Greentree WK, Deschenes RJ, Linder ME;, J Biol Chem. 2005;280:31141-31148.: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. PUBMED:16000296 EPMC:16000296

  7. Roth AF, Feng Y, Chen L, Davis NG;, J Cell Biol. 2002;159:23-28.: The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. PUBMED:12370247 EPMC:12370247

  8. Bartels DJ, Mitchell DA, Dong X, Deschenes RJ; , Mol Cell Biol 1999;19:6775-6787.: Erf2, a Novel Gene Product That Affects the Localization and Palmitoylation of Ras2 in Saccharomyces cerevisiae. PUBMED:10490616 EPMC:10490616

  9. Hemsley PA, Kemp AC, Grierson CS;, Plant Cell. 2005;17:2554-2563.: The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis. PUBMED:16100337 EPMC:16100337


This tab holds annotation information from the InterPro database.

InterPro entry IPR001594

This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases [ PUBMED:15603741 ].

Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyse this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterised by the presence of 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein [ PUBMED:23034182 , PUBMED:26224664 ].

Some of the proteins containing a DHHC domain are listed below:

  • Drosophila DNZ1 protein [ PUBMED:10231582 ]
  • Mouse Abl-philin 2 (Aph2) protein. Interacts with c-Abl. May play a role in apoptosis [ PUBMED:12021275 ]
  • Mammalian ZDHHC9, an integral membrane protein [ PUBMED:16000296 ]
  • Yeast ankyrin repeat-containing protein AKR1 [ PUBMED:12370247 ]
  • Yeast Erf2 protein. This protein localizes to the endoplasmic reticulum and seems to be important for Ras function [ PUBMED:10490616 ]
  • Arabidopsis thaliana tip growth defective 1 [ PUBMED:16100337 ]

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(73)
Full
(22163)
Representative proteomes UniProt
(43172)
RP15
(4345)
RP35
(10278)
RP55
(18300)
RP75
(24419)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(73)
Full
(22163)
Representative proteomes UniProt
(43172)
RP15
(4345)
RP35
(10278)
RP55
(18300)
RP75
(24419)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(73)
Full
(22163)
Representative proteomes UniProt
(43172)
RP15
(4345)
RP35
(10278)
RP55
(18300)
RP75
(24419)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_945 (release 4.0)
Previous IDs: zf-DHHC;
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 73
Number in full: 22163
Average length of the domain: 129.00 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 29.75 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 28.7 28.7
Trusted cut-off 28.7 28.7
Noise cut-off 28.6 28.6
Model length: 134
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DHHC domain has been found. There are 8 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4LF16 View 3D Structure Click here
A0A0G2K7F3 View 3D Structure Click here
A0A0P0WG92 View 3D Structure Click here
A0A0P0X5F3 View 3D Structure Click here
A0A0P0XAP5 View 3D Structure Click here
A0A0P0XQE0 View 3D Structure Click here
A0A0P0XYE1 View 3D Structure Click here
A0A0P0Y6S7 View 3D Structure Click here
A0A0R0H1Q3 View 3D Structure Click here
A0A0R0KAE9 View 3D Structure Click here
A0A0R0KFP7 View 3D Structure Click here
A0A0R0LAP6 View 3D Structure Click here
A0A0R4IDP3 View 3D Structure Click here
A0A0R4IF99 View 3D Structure Click here
A0A0R4IQZ2 View 3D Structure Click here
A0A143ZYC1 View 3D Structure Click here
A0A146M427 View 3D Structure Click here
A0A1D6DTM1 View 3D Structure Click here
A0A1D6E1R7 View 3D Structure Click here
A0A1D6ESV8 View 3D Structure Click here
A0A1D6EVG3 View 3D Structure Click here
A0A1D6F082 View 3D Structure Click here
A0A1D6F699 View 3D Structure Click here
A0A1D6F6K6 View 3D Structure Click here
A0A1D6GTY6 View 3D Structure Click here
A0A1D6HIK5 View 3D Structure Click here
A0A1D6HPN8 View 3D Structure Click here
A0A1D6HZE2 View 3D Structure Click here
A0A1D6IIP9 View 3D Structure Click here
A0A1D6JRI5 View 3D Structure Click here
A0A1D6JY39 View 3D Structure Click here
A0A1D6KCL4 View 3D Structure Click here
A0A1D6LQU7 View 3D Structure Click here
A0A1D6M5S9 View 3D Structure Click here
A0A1D6MQX8 View 3D Structure Click here
A0A1D6N2M8 View 3D Structure Click here
A0A1D6N6B2 View 3D Structure Click here
A0A1D6N7D3 View 3D Structure Click here
A0A1D6NQE5 View 3D Structure Click here
A0A1D6P3W0 View 3D Structure Click here
A0A1D6PDK3 View 3D Structure Click here
A0A2R8PVY4 View 3D Structure Click here
A0A4D6K4L3 View 3D Structure Click here
A0A4V0IK78 View 3D Structure Click here
A0JPF8 View 3D Structure Click here
A0JPI5 View 3D Structure Click here
A0PK84 View 3D Structure Click here
A1ZAR2 View 3D Structure Click here
A2CEX1 View 3D Structure Click here
A2VEY9 View 3D Structure Click here
A4HS47 View 3D Structure Click here
A4HTY5 View 3D Structure Click here
A4HV16 View 3D Structure Click here
A4HV17 View 3D Structure Click here
A4HVJ3 View 3D Structure Click here
A4HVU9 View 3D Structure Click here
A4HZD7 View 3D Structure Click here
A4I0K1 View 3D Structure Click here
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A4I0K3 View 3D Structure Click here
A4I1S8 View 3D Structure Click here
A4I395 View 3D Structure Click here
A4I3R5 View 3D Structure Click here
A4I5E8 View 3D Structure Click here
A4I8P0 View 3D Structure Click here
A4IAK1 View 3D Structure Click here
A4IBG8 View 3D Structure Click here
A5WVX9 View 3D Structure Click here
B0S5D5 View 3D Structure Click here
B1H1H3 View 3D Structure Click here
B3DN87 View 3D Structure Click here
B4FA66 View 3D Structure Click here
B4FAG9 View 3D Structure Click here
B4FNS6 View 3D Structure Click here
B4FNW9 View 3D Structure Click here
B4FZ17 View 3D Structure Click here
B4G173 View 3D Structure Click here
B6TXZ3 View 3D Structure Click here
B8A086 View 3D Structure Click here
B8A4F0 View 3D Structure Click here
C0PBY3 View 3D Structure Click here
C0PDP7 View 3D Structure Click here
C0PEM0 View 3D Structure Click here
C6KSU5 View 3D Structure Click here
C7J4J0 View 3D Structure Click here
E7EZI4 View 3D Structure Click here
E7F021 View 3D Structure Click here
E7F4Z4 View 3D Structure Click here
E7F587 View 3D Structure Click here
E7F6D7 View 3D Structure Click here
E7FBS9 View 3D Structure Click here
E7FH11 View 3D Structure Click here
E9AH03 View 3D Structure Click here
E9AH93 View 3D Structure Click here
E9PT74 View 3D Structure Click here
E9PTT0 View 3D Structure Click here
E9PU37 View 3D Structure Click here
E9QCD3 View 3D Structure Click here
F1M6X9 View 3D Structure Click here
F1Q7H8 View 3D Structure Click here
F1QAM1 View 3D Structure Click here
F1QGD2 View 3D Structure Click here
F1QHM7 View 3D Structure Click here
F1QHU6 View 3D Structure Click here
F1QX91 View 3D Structure Click here
F1QXD3 View 3D Structure Click here
F1R013 View 3D Structure Click here
F1RE57 View 3D Structure Click here
G5EFD8 View 3D Structure Click here
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I1J5V1 View 3D Structure Click here
I1J6X1 View 3D Structure Click here
I1JCY3 View 3D Structure Click here
I1JDC7 View 3D Structure Click here
I1JE91 View 3D Structure Click here
I1JKN0 View 3D Structure Click here
I1JMX8 View 3D Structure Click here
I1JRH4 View 3D Structure Click here
I1JS28 View 3D Structure Click here
I1JSS8 View 3D Structure Click here
I1K6Q7 View 3D Structure Click here
I1K7A4 View 3D Structure Click here
I1KL80 View 3D Structure Click here
I1KME9 View 3D Structure Click here
I1KP46 View 3D Structure Click here
I1KQU7 View 3D Structure Click here
I1L6V6 View 3D Structure Click here
I1LAT9 View 3D Structure Click here
I1LCY2 View 3D Structure Click here
I1LDE4 View 3D Structure Click here
I1LI78 View 3D Structure Click here
I1LIM9 View 3D Structure Click here
I1LPE3 View 3D Structure Click here
I1MLE0 View 3D Structure Click here
I1MNM5 View 3D Structure Click here
I1MP44 View 3D Structure Click here
I1MU18 View 3D Structure Click here
I1N7X5 View 3D Structure Click here
I1N8L1 View 3D Structure Click here
I1NC37 View 3D Structure Click here
I1NDL5 View 3D Structure Click here
I1NH41 View 3D Structure Click here
I1NHH9 View 3D Structure Click here
K7K277 View 3D Structure Click here
K7KEJ5 View 3D Structure Click here
K7KVI2 View 3D Structure Click here
K7LGK1 View 3D Structure Click here
K7MTZ1 View 3D Structure Click here
K7MY14 View 3D Structure Click here
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O14345 View 3D Structure Click here
O60069 View 3D Structure Click here
O62144 View 3D Structure Click here
O74384 View 3D Structure Click here
O80685 View 3D Structure Click here
O96238 View 3D Structure Click here
O97224 View 3D Structure Click here
P0C7U3 View 3D Structure Click here
P39010 View 3D Structure Click here
P42836 View 3D Structure Click here
P59267 View 3D Structure Click here
P59268 View 3D Structure Click here
Q03289 View 3D Structure Click here
Q04629 View 3D Structure Click here
Q06551 View 3D Structure Click here
Q09701 View 3D Structure Click here
Q0DHW0 View 3D Structure Click here
Q0IGS7 View 3D Structure Click here
Q0IS80 View 3D Structure Click here
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Q0JB17 View 3D Structure Click here
Q0JNM0 View 3D Structure Click here
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Q10L01 View 3D Structure Click here
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Q10Q54 View 3D Structure Click here
Q12006 View 3D Structure Click here
Q12013 View 3D Structure Click here
Q14AK4 View 3D Structure Click here
Q21161 View 3D Structure Click here
Q21981 View 3D Structure Click here
Q2QQX2 View 3D Structure Click here
Q2QUH9 View 3D Structure Click here
Q2R367 View 3D Structure Click here
Q2TGI4 View 3D Structure Click here
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Q339R3 View 3D Structure Click here
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Q3EC11 View 3D Structure Click here
Q4CM12 View 3D Structure Click here
Q4CMV2 View 3D Structure Click here
Q4CPR1 View 3D Structure Click here
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Q4CW76 View 3D Structure Click here
Q4CXZ9 View 3D Structure Click here
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Q4CZ37 View 3D Structure Click here
Q4D028 View 3D Structure Click here
Q4D288 View 3D Structure Click here
Q4D665 View 3D Structure Click here
Q4D9X4 View 3D Structure Click here
Q4DB68 View 3D Structure Click here
Q4DHC0 View 3D Structure Click here
Q4DHT8 View 3D Structure Click here
Q4DKJ0 View 3D Structure Click here
Q4DKV1 View 3D Structure Click here
Q4DKV2 View 3D Structure Click here
Q4DL47 View 3D Structure Click here
Q4DLF9 View 3D Structure Click here
Q4DMD4 View 3D Structure Click here
Q4DR62 View 3D Structure Click here
Q4DS59 View 3D Structure Click here
Q4DWZ4 View 3D Structure Click here
Q4E0P4 View 3D Structure Click here
Q4E1U0 View 3D Structure Click here
Q4E2K4 View 3D Structure Click here
Q4E3Q1 View 3D Structure Click here
Q500Z2 View 3D Structure Click here
Q52T38 View 3D Structure Click here
Q54B34 View 3D Structure Click here
Q54JY9 View 3D Structure Click here
Q54PF0 View 3D Structure Click here
Q54RL6 View 3D Structure Click here
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Q54X19 View 3D Structure Click here
Q54YH2 View 3D Structure Click here
Q550R7 View 3D Structure Click here
Q552M6 View 3D Structure Click here
Q554E7 View 3D Structure Click here
Q555N7 View 3D Structure Click here
Q557H5 View 3D Structure Click here
Q59NR8 View 3D Structure Click here
Q59QL0 View 3D Structure Click here
Q5A861 View 3D Structure Click here
Q5ADN9 View 3D Structure Click here
Q5AGV7 View 3D Structure Click here
Q5AL27 View 3D Structure Click here
Q5BLG4 View 3D Structure Click here
Q5FC64 View 3D Structure Click here
Q5FVR1 View 3D Structure Click here
Q5JK16 View 3D Structure Click here
Q5M757 View 3D Structure Click here
Q5N959 View 3D Structure Click here
Q5N9N4 View 3D Structure Click here
Q5PNZ1 View 3D Structure Click here
Q5W0Z9 View 3D Structure Click here
Q5Y5T1 View 3D Structure Click here
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Q5Y5T3 View 3D Structure Click here
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Q65XG2 View 3D Structure Click here
Q67WP3 View 3D Structure Click here
Q69UA2 View 3D Structure Click here
Q6DGF5 View 3D Structure Click here
Q6DHI1 View 3D Structure Click here
Q6DR03 View 3D Structure Click here
Q6H885 View 3D Structure Click here
Q6IR37 View 3D Structure Click here
Q6K9R3 View 3D Structure Click here
Q6P3H1 View 3D Structure Click here
Q6UX98 View 3D Structure Click here
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Q6ZJ22 View 3D Structure Click here
Q75HK0 View 3D Structure Click here
Q76IC6 View 3D Structure Click here
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Q7XA86 View 3D Structure Click here
Q7XP60 View 3D Structure Click here
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Q80TN5 View 3D Structure Click here
Q810M4 View 3D Structure Click here
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Q86A83 View 3D Structure Click here
Q8BGJ0 View 3D Structure Click here
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Q8IBV4 View 3D Structure Click here
Q8IE90 View 3D Structure Click here
Q8IEA0 View 3D Structure Click here
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Q8N966 View 3D Structure Click here
Q8R0N9 View 3D Structure Click here
Q8R173 View 3D Structure Click here
Q8T2Q0 View 3D Structure Click here
Q8VC90 View 3D Structure Click here
Q8VDZ4 View 3D Structure Click here
Q8VYP5 View 3D Structure Click here
Q8VYS8 View 3D Structure Click here
Q8WTX9 View 3D Structure Click here
Q8WVZ1 View 3D Structure Click here
Q91WU6 View 3D Structure Click here
Q923G5 View 3D Structure Click here
Q93828 View 3D Structure Click here
Q93VV0 View 3D Structure Click here
Q94C49 View 3D Structure Click here
Q95X59 View 3D Structure Click here
Q969W1 View 3D Structure Click here
Q96GR4 View 3D Structure Click here
Q96MV8 View 3D Structure Click here
Q9C0B5 View 3D Structure Click here
Q9C0W9 View 3D Structure Click here
Q9C533 View 3D Structure Click here
Q9CPV7 View 3D Structure Click here
Q9CWU2 View 3D Structure Click here
Q9D270 View 3D Structure Click here
Q9D6H5 View 3D Structure Click here
Q9ESG8 View 3D Structure Click here
Q9FLM3 View 3D Structure Click here
Q9H6R6 View 3D Structure Click here
Q9H8X9 View 3D Structure Click here
Q9I7L7 View 3D Structure Click here
Q9JKR5 View 3D Structure Click here
Q9LIE4 View 3D Structure Click here
Q9LIH7 View 3D Structure Click here
Q9M115 View 3D Structure Click here
Q9M1K5 View 3D Structure Click here
Q9M306 View 3D Structure Click here
Q9N5D8 View 3D Structure Click here
Q9NPG8 View 3D Structure Click here
Q9NUE0 View 3D Structure Click here
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Q9NYG2 View 3D Structure Click here
Q9SB58 View 3D Structure Click here
Q9TYQ6 View 3D Structure Click here
Q9U2K0 View 3D Structure Click here
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Q9UIJ5 View 3D Structure Click here
Q9ULC8 View 3D Structure Click here
Q9VB73 View 3D Structure Click here
Q9VBM4 View 3D Structure Click here
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Q9VKN8 View 3D Structure Click here
Q9VPM2 View 3D Structure Click here
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Q9VSV3 View 3D Structure Click here
Q9VUW9 View 3D Structure Click here
Q9W251 View 3D Structure Click here
Q9XWD7 View 3D Structure Click here
Q9Y397 View 3D Structure Click here
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