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17  structures 8252  species 0  interactions 32540  sequences 265  architectures

Family: Cation_efflux (PF01545)

Summary: Cation efflux family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Cation efflux family Provide feedback

Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.

Literature references

  1. Xiong A, Jayaswal RK; , J Bacteriol 1998;180:4024-4029.: Molecular characterization of a chromosomal determinant conferring resistance to zinc and cobalt ions in Staphylococcus aureus. PUBMED:9696746 EPMC:9696746

  2. Kunito T, Kusano T, Oyaizu H, Senoo K, Kanazawa S, Matsumoto S; , Biosci Biotechnol Biochem 1996;60:699-704.: Cloning and sequence analysis of czc genes in Alcaligenes sp. strain CT14. PUBMED:8829543 EPMC:8829543


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002524

Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are considered to be efflux pumps that remove these ions from cells [ PUBMED:9696746 , PUBMED:8829543 ], however others are implicated in ion uptake [ PUBMED:1508175 ]. The family has six predicted transmembrane domains. Members of the family are variable in length because of variably sized inserts, often containing low-complexity sequence.

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(59)
Full
(32540)
Representative proteomes UniProt
(113282)
RP15
(4564)
RP35
(14913)
RP55
(30335)
RP75
(48964)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(59)
Full
(32540)
Representative proteomes UniProt
(113282)
RP15
(4564)
RP35
(14913)
RP55
(30335)
RP75
(48964)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(59)
Full
(32540)
Representative proteomes UniProt
(113282)
RP15
(4564)
RP35
(14913)
RP55
(30335)
RP75
(48964)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_232 (release 4.0)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A
Number in seed: 59
Number in full: 32540
Average length of the domain: 203.10 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 55.38 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.6 26.6
Noise cut-off 26.5 26.5
Model length: 199
Family (HMM) version: 23
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Cation_efflux domain has been found. There are 17 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0W8Q3 View 3D Structure Click here
A0A0R0EWT8 View 3D Structure Click here
A0A0R0F7R2 View 3D Structure Click here
A0A0R0FK13 View 3D Structure Click here
A0A0R0GDG8 View 3D Structure Click here
A0A0R0IJU7 View 3D Structure Click here
A0A0R0IUI9 View 3D Structure Click here
A0A0R0J4F5 View 3D Structure Click here
A0A0R0L0L4 View 3D Structure Click here
A0A0R4IEQ2 View 3D Structure Click here
A0A0R4IFM6 View 3D Structure Click here
A0A1D6EDE4 View 3D Structure Click here
A0A1D6FV33 View 3D Structure Click here
A0A1D6HLS4 View 3D Structure Click here
A0A1D6HLS4 View 3D Structure Click here
A0A1D6J541 View 3D Structure Click here
A0A1D6K2U5 View 3D Structure Click here
A0A1D6KPI7 View 3D Structure Click here
A0A1D6MM34 View 3D Structure Click here
A0A1D6N7L6 View 3D Structure Click here
A0A1D8PDG5 View 3D Structure Click here
A0A1D8PGL8 View 3D Structure Click here
A0A1D8PT85 View 3D Structure Click here
A1Z935 View 3D Structure Click here
A4HYG8 View 3D Structure Click here
A4HYG8 View 3D Structure Click here
A4I2S7 View 3D Structure Click here
A4I745 View 3D Structure Click here
A4I802 View 3D Structure Click here
A5PMX1 View 3D Structure Click here
B2RZA8 View 3D Structure Click here
B4FB51 View 3D Structure Click here
C0HFX1 View 3D Structure Click here
C0HGV8 View 3D Structure Click here
C6TAH5 View 3D Structure Click here
D3ZJB7 View 3D Structure Click here
D3ZWW5 View 3D Structure Click here
D3ZY54 View 3D Structure Click here
E7FCR4 View 3D Structure Click here
F1QFA1 View 3D Structure Click here
F1QZA0 View 3D Structure Click here
H2KZN1 View 3D Structure Click here
I1JDS7 View 3D Structure Click here
I1JNL3 View 3D Structure Click here
I1KHN9 View 3D Structure Click here
I1KTX5 View 3D Structure Click here
I1L2E9 View 3D Structure Click here
I1L2V9 View 3D Structure Click here
I1L7X1 View 3D Structure Click here
I1LJX9 View 3D Structure Click here
I1LQK9 View 3D Structure Click here
I1MJD0 View 3D Structure Click here
I1N523 View 3D Structure Click here
I1N992 View 3D Structure Click here
K7K8J1 View 3D Structure Click here
K7KF36 View 3D Structure Click here
K7M4F9 View 3D Structure Click here
K7M897 View 3D Structure Click here
O13918 View 3D Structure Click here
O14329 View 3D Structure Click here
O14863 View 3D Structure Click here
O35149 View 3D Structure Click here
O45923 View 3D Structure Click here
O55174 View 3D Structure Click here
O59758 View 3D Structure Click here
O80632 View 3D Structure Click here
P0CE46 View 3D Structure Click here
P20107 View 3D Structure Click here
P32798 View 3D Structure Click here
P69380 View 3D Structure Click here
P75757 View 3D Structure Click here
P96876 View 3D Structure Click here
P97441 View 3D Structure Click here
P9WGF5 View 3D Structure Click here
Q03218 View 3D Structure Click here
Q03455 View 3D Structure Click here
Q08970 View 3D Structure Click here
Q0DHJ5 View 3D Structure Click here
Q0WU02 View 3D Structure Click here
Q10LJ2 View 3D Structure Click here
Q10PP8 View 3D Structure Click here
Q20272 View 3D Structure Click here
Q20864 View 3D Structure Click here
Q21304 View 3D Structure Click here
Q22541 View 3D Structure Click here
Q2FVK7 View 3D Structure Click here
Q2FWA9 View 3D Structure Click here
Q2G1I9 View 3D Structure Click here
Q2HJ10 View 3D Structure Click here
Q3UVU3 View 3D Structure Click here
Q3V5H6 View 3D Structure Click here
Q3V5J4 View 3D Structure Click here
Q45EL5 View 3D Structure Click here
Q4CYC7 View 3D Structure Click here
Q4D0I2 View 3D Structure Click here
Q4D6N1 View 3D Structure Click here
Q4DAP4 View 3D Structure Click here
Q4DF88 View 3D Structure Click here
Q4DHZ0 View 3D Structure Click here
Q4DK06 View 3D Structure Click here
Q4E390 View 3D Structure Click here
Q54F34 View 3D Structure Click here
Q54N31 View 3D Structure Click here
Q54QU8 View 3D Structure Click here
Q54T06 View 3D Structure Click here
Q55E98 View 3D Structure Click here
Q57891 View 3D Structure Click here
Q5A0W4 View 3D Structure Click here
Q5BJM8 View 3D Structure Click here
Q5IRJ6 View 3D Structure Click here
Q5NA18 View 3D Structure Click here
Q5PQZ3 View 3D Structure Click here
Q5ZR77 View 3D Structure Click here
Q60738 View 3D Structure Click here
Q62720 View 3D Structure Click here
Q62941 View 3D Structure Click here
Q688R1 View 3D Structure Click here
Q6DBM8 View 3D Structure Click here
Q6DG36 View 3D Structure Click here
Q6ICY4 View 3D Structure Click here
Q6K961 View 3D Structure Click here
Q6NXT4 View 3D Structure Click here
Q6P0D1 View 3D Structure Click here
Q6P3M0 View 3D Structure Click here
Q6PFS0 View 3D Structure Click here
Q6PML9 View 3D Structure Click here
Q6QIX3 View 3D Structure Click here
Q6XR72 View 3D Structure Click here
Q6Z7K5 View 3D Structure Click here
Q8BGG0 View 3D Structure Click here
Q8BJM5 View 3D Structure Click here
Q8H1G3 View 3D Structure Click here
Q8H329 View 3D Structure Click here
Q8IBU1 View 3D Structure Click here
Q8IWU4 View 3D Structure Click here
Q8L725 View 3D Structure Click here
Q8NEW0 View 3D Structure Click here
Q8R4H9 View 3D Structure Click here
Q8T0G1 View 3D Structure Click here
Q8TAD4 View 3D Structure Click here
Q8WQB6 View 3D Structure Click here
Q95QW4 View 3D Structure Click here
Q99726 View 3D Structure Click here
Q9BRI3 View 3D Structure Click here
Q9HGQ3 View 3D Structure Click here
Q9JKN1 View 3D Structure Click here
Q9LDU0 View 3D Structure Click here
Q9LXS1 View 3D Structure Click here
Q9M271 View 3D Structure Click here
Q9M2P2 View 3D Structure Click here
Q9SAJ7 View 3D Structure Click here
Q9SI03 View 3D Structure Click here
Q9V471 View 3D Structure Click here
Q9VGS1 View 3D Structure Click here
Q9VKA3 View 3D Structure Click here
Q9VPE3 View 3D Structure Click here
Q9Y6M5 View 3D Structure Click here
Q9ZT63 View 3D Structure Click here