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49  structures 8700  species 0  interactions 26828  sequences 248  architectures

Family: DnaJ_C (PF01556)

Summary: DnaJ C terminal domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Chaperone DnaJ". More...

Chaperone DnaJ Edit Wikipedia article

DnaJ domain
PBB Protein DNAJB1 image.jpg
PDB rendering based on 1hdj.
Identifiers
SymbolDnaJ
PfamPF00226
InterProIPR001623
PROSITEPDOC00553
SCOPe1xbl / SUPFAM
CDDcd06257
Membranome177
DnaJ central domain
Identifiers
SymbolDnaJ_CXXCXGXG
PfamPF00684
Pfam clanCL0518
InterProIPR001305
PROSITEPDOC00553
SCOPe1exk / SUPFAM
DnaJ C terminal domain
PDB 1nlt EBI.jpg
the crystal structure of hsp40 ydj1
Identifiers
SymbolDnaJ_C
PfamPF01556
InterProIPR002939
PROSITEPDOC00553
SCOPe1exk / SUPFAM

In molecular biology, chaperone DnaJ, also known as Hsp40 (heat shock protein 40 kD), is a molecular chaperone protein. It is expressed in a wide variety of organisms from bacteria to humans.[1][2]

Function

Molecular chaperones are a diverse family of proteins that function to protect proteins from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolyzing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. Dimeric GrpE is the co-chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000-fold.[3] DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate-bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle.

This family of proteins contain a 70 amino acid consensus sequence known as the J domain. The J domain of DnaJ interacts with Hsp70 heat shock proteins.[4] DnaJ heat-shock proteins play a role in regulating the ATPase activity of Hsp70 heat-shock proteins.[5][6]

Besides stimulating the ATPase activity of DnaK through its J-domain, DnaJ also associates with unfolded polypeptide chains and prevents their aggregation.[7] Thus, DnaK and DnaJ may bind to one and the same polypeptide chain to form a ternary complex. The formation of a ternary complex may result in cis-interaction of the J-domain of DnaJ with the ATPase domain of DnaK. An unfolded polypeptide may enter the chaperone cycle by associating first either with ATP-liganded DnaK or with DnaJ. DnaK interacts with both the backbone and side chains of a peptide substrate; it thus shows binding polarity and admits only L-peptide segments. In contrast, DnaJ has been shown to bind both L- and D-peptides and is assumed to interact only with the side chains of the substrate.

Domain architecture

Proteins in this family consist of three domains. The N-terminal domain is the J domain (described above). The central domain is a cysteine-rich region, which contains four repeats of the motif CXXCXGXG where X is any amino acid. The isolated cysteine rich domain folds in zinc dependent fashion. Each set of two repeats binds one unit of zinc. Although this domain has been implicated in substrate binding, no evidence of specific interaction between the isolated DNAJ cysteine rich domain and various hydrophobic peptides has been found. This domain has disulphide isomerase activity.[8] The function of the C-terminal is chaperone and dimerization.

Proteins containing a DnaJ domain

References

  1. ^ Qiu XB, Shao YM, Miao S, Wang L (November 2006). "The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones". Cellular and Molecular Life Sciences. 63 (22): 2560–70. doi:10.1007/s00018-006-6192-6. PMID 16952052.
  2. ^ Caplan AJ, Cyr DM, Douglas MG (June 1993). "Eukaryotic homologues of Escherichia coli dnaJ: a diverse protein family that functions with hsp70 stress proteins". Molecular Biology of the Cell. 4 (6): 555–63. doi:10.1091/mbc.4.6.555. PMC 300962. PMID 8374166.
  3. ^ Douglas MG, Cyr DM, Langer T (1994). "DnaJ-like proteins: molecular chaperones and specific regulators of Hsp70". Trends Biochem. Sci. 19 (4): 176–181. doi:10.1016/0968-0004(94)90281-x. PMID 8016869.
  4. ^ Hennessy F, Nicoll WS, Zimmermann R, Cheetham ME, Blatch GL (July 2005). "Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions". Protein Science. 14 (7): 1697–709. doi:10.1110/ps.051406805. PMC 2253343. PMID 15987899.
  5. ^ Fan CY, Lee S, Cyr DM (2003). "Mechanisms for regulation of Hsp70 function by Hsp40". Cell stress & chaperones. 8 (4): 309–16. doi:10.1379/1466-1268(2003)008<0309:MFROHF>2.0.CO;2. PMC 514902. PMID 15115283.
  6. ^ Ohtsuka K, Hata M (2000). "Molecular chaperone function of mammalian Hsp70 and Hsp40--a review". International Journal of Hyperthermia. 16 (3): 231–45. doi:10.1080/026567300285259. PMID 10830586.
  7. ^ Christen P, Han W (2004). "cis-Effect of DnaJ on DnaK in ternary complexes with chimeric DnaK/DnaJ-binding peptides". FEBS Lett. 563 (1): 146–150. doi:10.1016/S0014-5793(04)00290-X. PMID 15063739.
  8. ^ Martinez-Yamout, M.; Legge, G. B.; Zhang, O.; Wright, P. E.; Dyson, H. J. (2000). "Solution Structure of the Cysteine-rich Domain of the Escherichia coli Chaperone Protein DnaJ☆☆☆". Journal of Molecular Biology. 300 (4): 805–818. doi:10.1006/jmbi.2000.3923. PMID 10891270.
This article incorporates text from the public domain Pfam and InterPro: IPR002939
This article incorporates text from the public domain Pfam and InterPro: IPR001623
This article incorporates text from the public domain Pfam and InterPro: IPR001305

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

DnaJ C terminal domain Provide feedback

This family consists of the C terminal region of the DnaJ protein. It is always found associated with PF00226 and PF00684. DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and CTDII, both incorporated in this family are necessary for maintaining the J-domains in their specific relative positions [2]. Structural analysis of PDB:1nlt shows that PF00684 is nested within this DnaJ C-terminal region [3].

Literature references

  1. Kelley WL; , Trends Biochem Sci 1998;23:222-227.: The J-domain family and the recruitment of chaperone power. PUBMED:9644977 EPMC:9644977

  2. Silva JC, Borges JC, Cyr DM, Ramos CH, Torriani IL;, BMC Struct Biol. 2011;11:40.: Central domain deletions affect the SAXS solution structure and function of yeast Hsp40 proteins Sis1 and Ydj1. PUBMED:22011374 EPMC:22011374

  3. Li J, Qian X, Sha B;, Structure. 2003;11:1475-1483.: The crystal structure of the yeast Hsp40 Ydj1 complexed with its peptide substrate. PUBMED:14656432 EPMC:14656432


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002939

Molecular chaperones are a diverse family of proteins that function to protect proteins in the intracellular milieu from irreversible aggregation during synthesis and in times of cellular stress. The bacterial molecular chaperone DnaK is an enzyme that couples cycles of ATP binding, hydrolysis, and ADP release by an N-terminal ATP-hydrolizing domain to cycles of sequestration and release of unfolded proteins by a C-terminal substrate binding domain. Dimeric GrpE is the co-chaperone for DnaK, and acts as a nucleotide exchange factor, stimulating the rate of ADP release 5000-fold [ PUBMED:8016869 ]. DnaK is itself a weak ATPase; ATP hydrolysis by DnaK is stimulated by its interaction with another co-chaperone, DnaJ. Thus the co-chaperones DnaJ and GrpE are capable of tightly regulating the nucleotide-bound and substrate-bound state of DnaK in ways that are necessary for the normal housekeeping functions and stress-related functions of the DnaK molecular chaperone cycle.

Besides stimulating the ATPase activity of DnaK through its J-domain, DnaJ also associates with unfolded polypeptide chains and prevents their aggregation [ PUBMED:15063739 ]. Thus, DnaK and DnaJ may bind to one and the same polypeptide chain to form a ternary complex. The formation of a ternary complex may result in cis-interaction of the J-domain of DnaJ with the ATPase domain of DnaK. An unfolded polypeptide may enter the chaperone cycle by associating first either with ATP-liganded DnaK or with DnaJ. DnaK interacts with both the backbone and side chains of a peptide substrate; it thus shows binding polarity and admits only L-peptide segments. In contrast, DnaJ has been shown to bind both L- and D-peptides and is assumed to interact only with the side chains of the substrate.

This domain consists of the C-terminal region of the DnaJ protein. The function of this domain is unknown. It is found associated with INTERPRO and INTERPRO . DnaJ is a chaperone associated with the Hsp70 heat-shock system involved in protein folding and renaturation after stress. The two C-terminal domains CTDI and this, CTDII, are necessary for maintaining the J-domains in their specific relative positions [ PUBMED:22011374 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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  Seed
(961)
Full
(26828)
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(92009)
RP15
(4390)
RP35
(13131)
RP55
(24593)
RP75
(37983)
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  Seed
(961)
Full
(26828)
Representative proteomes UniProt
(92009)
RP15
(4390)
RP35
(13131)
RP55
(24593)
RP75
(37983)
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  Seed
(961)
Full
(26828)
Representative proteomes UniProt
(92009)
RP15
(4390)
RP35
(13131)
RP55
(24593)
RP75
(37983)
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You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_342 (release 4.0)
Previous IDs: DnaJ_C; CTDII;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bashton M , Bateman A
Number in seed: 961
Number in full: 26828
Average length of the domain: 193.00 aa
Average identity of full alignment: 29 %
Average coverage of the sequence by the domain: 50.87 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 26.6 26.6
Trusted cut-off 26.6 26.6
Noise cut-off 26.5 26.5
Model length: 149
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
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Viroids Viroids Unclassified sequence Unclassified sequence

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DnaJ_C domain has been found. There are 49 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2K5E4 View 3D Structure Click here
A0A0G2K9H9 View 3D Structure Click here
A0A0P0WMP4 View 3D Structure Click here
A0A0P0X6T4 View 3D Structure Click here
A0A0P0XF23 View 3D Structure Click here
A0A0P0YD84 View 3D Structure Click here
A0A0R0E480 View 3D Structure Click here
A0A0R0EKC2 View 3D Structure Click here
A0A0R0G2S7 View 3D Structure Click here
A0A0R0ILH6 View 3D Structure Click here
A0A0R0IQC6 View 3D Structure Click here
A0A0R0IQU3 View 3D Structure Click here
A0A0R0JKE9 View 3D Structure Click here
A0A0R4IYH3 View 3D Structure Click here
A0A143ZY16 View 3D Structure Click here
A0A1D6EHR1 View 3D Structure Click here
A0A1D6ENR7 View 3D Structure Click here
A0A1D6ETZ2 View 3D Structure Click here
A0A1D6EXT3 View 3D Structure Click here
A0A1D6EZH8 View 3D Structure Click here
A0A1D6FI63 View 3D Structure Click here
A0A1D6FI63 View 3D Structure Click here
A0A1D6GG02 View 3D Structure Click here
A0A1D6GLE1 View 3D Structure Click here
A0A1D6HNM7 View 3D Structure Click here
A0A1D6ITZ5 View 3D Structure Click here
A0A1D6J0S9 View 3D Structure Click here
A0A1D6JD84 View 3D Structure Click here
A0A1D6JTM6 View 3D Structure Click here
A0A1D6KIF8 View 3D Structure Click here
A0A1D6LES6 View 3D Structure Click here
A0A1D6LZ70 View 3D Structure Click here
A0A1D6MA54 View 3D Structure Click here
A0A1D6MES0 View 3D Structure Click here
A0A1D6N5S3 View 3D Structure Click here
A0A1D6NS04 View 3D Structure Click here
A0A1D6NY26 View 3D Structure Click here
A0A1D6P7P5 View 3D Structure Click here
A0A1D6P7P5 View 3D Structure Click here
A0A1D6PM15 View 3D Structure Click here
A0A1D6PWA4 View 3D Structure Click here
A0A1D6QBV5 View 3D Structure Click here
A0A1D6QTZ2 View 3D Structure Click here
A0A1D8PNQ8 View 3D Structure Click here
A0A1D8PPM1 View 3D Structure Click here
A0A1D8PSQ3 View 3D Structure Click here
A0A368UI97 View 3D Structure Click here
A0A368UIB8 View 3D Structure Click here
A4HS91 View 3D Structure Click here
A4HYQ6 View 3D Structure Click here
A4HZ48 View 3D Structure Click here
A4I1F2 View 3D Structure Click here
A4I341 View 3D Structure Click here
A4I815 View 3D Structure Click here
A4I8F5 View 3D Structure Click here
A4IBI6 View 3D Structure Click here
A4IC84 View 3D Structure Click here
A5WUU0 View 3D Structure Click here
A5WVI9 View 3D Structure Click here
A7MCD0 View 3D Structure Click here
B0S5B7 View 3D Structure Click here
B4F810 View 3D Structure Click here
B4FDJ5 View 3D Structure Click here
B4FJC3 View 3D Structure Click here
B4FT54 View 3D Structure Click here
B4FTR0 View 3D Structure Click here
B4FVD3 View 3D Structure Click here
B6SZU1 View 3D Structure Click here
B8A1D6 View 3D Structure Click here
B8JM56 View 3D Structure Click here
B9FHF3 View 3D Structure Click here
C0P6C7 View 3D Structure Click here
C0P7S8 View 3D Structure Click here
C0PA53 View 3D Structure Click here
C6KTC7 View 3D Structure Click here
C6T8E0 View 3D Structure Click here
C6TLB6 View 3D Structure Click here
D3ZUU5 View 3D Structure Click here
E7FDL8 View 3D Structure Click here
E9AGM4 View 3D Structure Click here
E9AGY8 View 3D Structure Click here
F1QTK7 View 3D Structure Click here
F1R1Q6 View 3D Structure Click here
F4JY55 View 3D Structure Click here
I1J5I9 View 3D Structure Click here
I1J7F3 View 3D Structure Click here
I1JBH4 View 3D Structure Click here
I1JBS7 View 3D Structure Click here
I1JLE2 View 3D Structure Click here
I1JMV0 View 3D Structure Click here
I1JQQ6 View 3D Structure Click here
I1K906 View 3D Structure Click here
I1KCP0 View 3D Structure Click here
I1KEY3 View 3D Structure Click here
I1KJ68 View 3D Structure Click here
I1KJN4 View 3D Structure Click here
I1KKF4 View 3D Structure Click here
I1KUM7 View 3D Structure Click here
I1KXP3 View 3D Structure Click here
I1KZS5 View 3D Structure Click here
I1LNJ9 View 3D Structure Click here
I1LU10 View 3D Structure Click here
I1LVF4 View 3D Structure Click here
I1M1Z6 View 3D Structure Click here
I1M1Z8 View 3D Structure Click here
I1MAX7 View 3D Structure Click here
I1MCE6 View 3D Structure Click here
I1MEM7 View 3D Structure Click here
I1MEN0 View 3D Structure Click here
I1MJL8 View 3D Structure Click here
I1MYR0 View 3D Structure Click here
I1N198 View 3D Structure Click here
I1N2X9 View 3D Structure Click here
I1NBB0 View 3D Structure Click here
K7K9W1 View 3D Structure Click here
K7KM69 View 3D Structure Click here
K7KQW8 View 3D Structure Click here
K7KRV5 View 3D Structure Click here
K7L6V6 View 3D Structure Click here
K7LFX5 View 3D Structure Click here
K7LFX5 View 3D Structure Click here
K7M3Y8 View 3D Structure Click here
K7M9M0 View 3D Structure Click here
K7THS8 View 3D Structure Click here
K7UU30 View 3D Structure Click here
K7VXU7 View 3D Structure Click here
O04087 View 3D Structure Click here
O16303 View 3D Structure Click here
O35824 View 3D Structure Click here
O45502 View 3D Structure Click here
O49457 View 3D Structure Click here
O60884 View 3D Structure Click here
O74752 View 3D Structure Click here
O75953 View 3D Structure Click here
O89114 View 3D Structure Click here
O94625 View 3D Structure Click here
O94657 View 3D Structure Click here
O96123 View 3D Structure Click here
O96212 View 3D Structure Click here
P08622 View 3D Structure Click here
P0DO01 View 3D Structure Click here
P0DO02 View 3D Structure Click here
P0DO03 View 3D Structure Click here
P25294 View 3D Structure Click here
P25303 View 3D Structure Click here
P25491 View 3D Structure Click here
P25685 View 3D Structure Click here
P31689 View 3D Structure Click here
P35191 View 3D Structure Click here
P36659 View 3D Structure Click here
P39102 View 3D Structure Click here
P42825 View 3D Structure Click here
P53940 View 3D Structure Click here
P59910 View 3D Structure Click here
P63036 View 3D Structure Click here
P63037 View 3D Structure Click here
P87239 View 3D Structure Click here
P9WNV7 View 3D Structure Click here
P9WNV9 View 3D Structure Click here
Q058J9 View 3D Structure Click here
Q09912 View 3D Structure Click here
Q0DYZ8 View 3D Structure Click here
Q0JB88 View 3D Structure Click here
Q0WN54 View 3D Structure Click here
Q0WRX5 View 3D Structure Click here
Q20774 View 3D Structure Click here
Q24133 View 3D Structure Click here
Q27237 View 3D Structure Click here
Q2FXZ3 View 3D Structure Click here
Q2QX63 View 3D Structure Click here
Q38813 View 3D Structure Click here
Q4CXG2 View 3D Structure Click here
Q4D4G9 View 3D Structure Click here
Q4D7B1 View 3D Structure Click here
Q4D820 View 3D Structure Click here
Q4D832 View 3D Structure Click here
Q4D930 View 3D Structure Click here
Q4DD34 View 3D Structure Click here
Q4DGH5 View 3D Structure Click here
Q4DKC8 View 3D Structure Click here
Q4DLU9 View 3D Structure Click here
Q4DS17 View 3D Structure Click here
Q4DTD8 View 3D Structure Click here
Q4DTY2 View 3D Structure Click here
Q4DV92 View 3D Structure Click here
Q4DVP6 View 3D Structure Click here
Q4DYH7 View 3D Structure Click here
Q4E1D7 View 3D Structure Click here
Q4QR73 View 3D Structure Click here
Q54ED3 View 3D Structure Click here
Q54KN8 View 3D Structure Click here
Q54MY7 View 3D Structure Click here
Q54SQ0 View 3D Structure Click here
Q54VQ1 View 3D Structure Click here
Q54XR6 View 3D Structure Click here
Q59V92 View 3D Structure Click here
Q5A355 View 3D Structure Click here
Q5A4Z2 View 3D Structure Click here
Q5N8X4 View 3D Structure Click here
Q5VRK6 View 3D Structure Click here
Q5XIP0 View 3D Structure Click here
Q5YKV6 View 3D Structure Click here
Q688X8 View 3D Structure Click here
Q6DEF3 View 3D Structure Click here
Q6F3B0 View 3D Structure Click here
Q6K850 View 3D Structure Click here
Q6NYZ0 View 3D Structure Click here
Q6TUG0 View 3D Structure Click here
Q6Z6Z5 View 3D Structure Click here
Q7ZUP5 View 3D Structure Click here
Q7ZUW0 View 3D Structure Click here
Q80Y75 View 3D Structure Click here
Q84PD0 View 3D Structure Click here
Q84SD3 View 3D Structure Click here
Q8GWW8 View 3D Structure Click here
Q8I2E1 View 3D Structure Click here
Q8I489 View 3D Structure Click here
Q8IL88 View 3D Structure Click here
Q8MPX3 View 3D Structure Click here
Q8SZX1 View 3D Structure Click here
Q8TA83 View 3D Structure Click here
Q8WW22 View 3D Structure Click here
Q940V1 View 3D Structure Click here
Q94AW8 View 3D Structure Click here
Q96EY1 View 3D Structure Click here
Q99KV1 View 3D Structure Click here
Q99M87 View 3D Structure Click here
Q9D832 View 3D Structure Click here
Q9FTT4 View 3D Structure Click here
Q9JMC3 View 3D Structure Click here
Q9LZK5 View 3D Structure Click here
Q9M034 View 3D Structure Click here
Q9QYJ0 View 3D Structure Click here
Q9QYJ3 View 3D Structure Click here
Q9SIL3 View 3D Structure Click here
Q9SIL4 View 3D Structure Click here
Q9SJZ7 View 3D Structure Click here
Q9SR91 View 3D Structure Click here
Q9SU57 View 3D Structure Click here
Q9SWB5 View 3D Structure Click here
Q9SY77 View 3D Structure Click here
Q9U0J2 View 3D Structure Click here
Q9UBS4 View 3D Structure Click here
Q9UDY4 View 3D Structure Click here
Q9VFV9 View 3D Structure Click here
Q9VPQ2 View 3D Structure Click here
Q9VPY9 View 3D Structure Click here
Q9W083 View 3D Structure Click here
Q9W2U5 View 3D Structure Click here
Q9XFD9 View 3D Structure Click here
Q9XIF5 View 3D Structure Click here