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19  structures 7231  species 0  interactions 30896  sequences 543  architectures

Family: Patatin (PF01734)

Summary: Patatin-like phospholipase

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Patatin-like phospholipase". More...

Patatin-like phospholipase Edit Wikipedia article

1oxw opm.png
Patatin
Identifiers
SymbolPatatin
PfamPF01734
InterProIPR002641
PROSITEPDOC00951
SCOPe1oxw / SUPFAM
OPM superfamily126
OPM protein1oxw
Membranome297

Family of patatin-like phospholipases consists of various patatin glycoproteins from the total soluble protein from potato tubers,[1] and also some proteins found in vertebrates. Patatin is a storage protein but it also has the enzymatic activity of phospholipase, catalysing the cleavage of fatty acids from membrane lipids.[1]

Subfamilies

Human proteins containing this domain

PNPLA1; PNPLA2; PNPLA3; PNPLA4; PNPLA5; PNPLA6; PNPLA7; PNPLA8;

References

  1. ^ a b Mignery GA, Pikaard CS, Park WD (1988). "Molecular characterization of the patatin multigene family of potato". Gene. 62 (1): 27–44. doi:10.1016/0378-1119(88)90577-X. PMID 3371664.
This article incorporates text from the public domain Pfam and InterPro: IPR002641

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Patatin-like phospholipase Provide feedback

This family consists of various patatin glycoproteins from plants. The patatin protein accounts for up to 40% of the total soluble protein in potato tubers [2]. Patatin is a storage protein but it also has the enzymatic activity of lipid acyl hydrolase, catalysing the cleavage of fatty acids from membrane lipids [2]. Members of this family have been found also in vertebrates.

Literature references

  1. Banfalvi Z, Kostyal Z, Barta E; , Mol Gen Genet 1994;245:517-522.: Solanum brevidens possesses a non-sucrose-inducible patatin gene. PUBMED:7808402 EPMC:7808402

  2. Mignery GA, Pikaard CS, Park WD; , Gene 1988;62:27-44.: Molecular characterization of the patatin multigene family of potato. PUBMED:3371664 EPMC:3371664


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002641

The patatin glycoprotein is a nonspecific lipid acyl hydrolase that is found in high concentrations in mature potato tubers. Patatin is reported to play a role in plant signaling, to cleave fatty acids from membrane lipids, and to act as defense against plant parasites. Proteins encoding a patatin-like phospholipase (PNPLA) domain are ubiquitously distributed across all life forms, including eukaryotes and prokaryotes, and are observed to participate in a miscellany of biological roles, including sepsis induction, host colonization, triglyceride metabolism, and membrane trafficking. PNPLA domain containing proteins display lipase and transacylase properties and appear to have major roles in lipid and energy homeostasis [ PUBMED:16799181 , PUBMED:19029121 , PUBMED:20188050 ].

The ~180-amino acid PNPLA domain harbors the evolutionarily conserved consensus serine lipase motif Gly-X-Ser-X-Gly.cIt displays an alpha/beta class protein fold with approximately three layers, basically alpha/beta/alpha in content, in which a central six-stranded beta-sheet is sandwiched essentially between alpha-helices front and back. The central beta-sheet contains five parallel strands and an antiparallel strand at the edge of the sheet. The PNPLA domain has a Ser-Asp catalytic dyad. The catalytic Ser resides in a sharp nucleophile elbow turn loop which follows a beta-strand (beta5) of the central beta-sheet and precedes a helix (helix C) [ PUBMED:12779324 , PUBMED:25248161 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Patatin (CL0323), which has the following description:

This superfamily of enzymes contains a Ser/Asp catalytic dyad. Members of this superfamily are all serine acylhydrolase enzymes.

The clan contains the following 4 members:

Acyl_transf_1 Patatin PLA2_B SAT

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

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We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(108)
Full
(30896)
Representative proteomes UniProt
(107963)
RP15
(4399)
RP35
(14046)
RP55
(28447)
RP75
(47027)
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PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(108)
Full
(30896)
Representative proteomes UniProt
(107963)
RP15
(4399)
RP35
(14046)
RP55
(28447)
RP75
(47027)
Alignment:
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We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(108)
Full
(30896)
Representative proteomes UniProt
(107963)
RP15
(4399)
RP35
(14046)
RP55
(28447)
RP75
(47027)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_2206 (release 4.1)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A , Dlakic M
Number in seed: 108
Number in full: 30896
Average length of the domain: 186.50 aa
Average identity of full alignment: 18 %
Average coverage of the sequence by the domain: 33.99 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 27.7 27.7
Trusted cut-off 27.7 27.7
Noise cut-off 27.6 27.6
Model length: 204
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Patatin domain has been found. There are 19 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0X6Z4 View 3D Structure Click here
A0A0P0XFP9 View 3D Structure Click here
A0A0P0XPE4 View 3D Structure Click here
A0A0P0YBC3 View 3D Structure Click here
A0A0R0EMJ8 View 3D Structure Click here
A0A0R0ENK9 View 3D Structure Click here
A0A0R0G028 View 3D Structure Click here
A0A0R0J9U8 View 3D Structure Click here
A0A0R0KJU3 View 3D Structure Click here
A0A0R4IUV2 View 3D Structure Click here
A0A1D6ERI5 View 3D Structure Click here
A0A1D6EXA8 View 3D Structure Click here
A0A1D6F7H5 View 3D Structure Click here
A0A1D6F7L4 View 3D Structure Click here
A0A1D6F7L5 View 3D Structure Click here
A0A1D6F7L8 View 3D Structure Click here
A0A1D6IDC9 View 3D Structure Click here
A0A1D6JWQ9 View 3D Structure Click here
A0A1D6K2Y9 View 3D Structure Click here
A0A1D6K4Z0 View 3D Structure Click here
A0A1D6KLD2 View 3D Structure Click here
A0A1D6KLD6 View 3D Structure Click here
A0A1D6KLD7 View 3D Structure Click here
A0A1D6KX88 View 3D Structure Click here
A0A1D6KX89 View 3D Structure Click here
A0A1D6MWD7 View 3D Structure Click here
A0A1D6N0Q3 View 3D Structure Click here
A0A1D6QKX3 View 3D Structure Click here
A0A1D8PIX8 View 3D Structure Click here
A0A1X7YGE5 View 3D Structure Click here
A0A2R8RYP7 View 3D Structure Click here
A0A5K1K9G0 View 3D Structure Click here
A2AJ88 View 3D Structure Click here
A4I5P3 View 3D Structure Click here
A4IAC8 View 3D Structure Click here
A8E596 View 3D Structure Click here
B0G109 View 3D Structure Click here
B0S7I0 View 3D Structure Click here
B4F8G3 View 3D Structure Click here
B4FNC5 View 3D Structure Click here
B4FRJ2 View 3D Structure Click here
B9GDN2 View 3D Structure Click here
C0HDU5 View 3D Structure Click here
C0P833 View 3D Structure Click here
D3Z9J9 View 3D Structure Click here
D3ZRC4 View 3D Structure Click here
D3ZXU1 View 3D Structure Click here
D4A227 View 3D Structure Click here
D4A3G9 View 3D Structure Click here
E1JI03 View 3D Structure Click here
E7F4S2 View 3D Structure Click here
E7FGN6 View 3D Structure Click here
F1R844 View 3D Structure Click here
F1RE62 View 3D Structure Click here
F4HX15 View 3D Structure Click here
F4MGD9 View 3D Structure Click here
G5EF58 View 3D Structure Click here
G5EGD6 View 3D Structure Click here
I1JFA4 View 3D Structure Click here
I1JN82 View 3D Structure Click here
I1JTH8 View 3D Structure Click here
I1K7Y0 View 3D Structure Click here
I1KJJ2 View 3D Structure Click here
I1KJJ3 View 3D Structure Click here
I1KNB6 View 3D Structure Click here
I1L0D2 View 3D Structure Click here
I1L840 View 3D Structure Click here
I1LD15 View 3D Structure Click here
I1LHF4 View 3D Structure Click here
I1M8K2 View 3D Structure Click here
I1M8K4 View 3D Structure Click here
I1M8K5 View 3D Structure Click here
I1MDQ4 View 3D Structure Click here
I1MR71 View 3D Structure Click here
I1MXQ7 View 3D Structure Click here
I1MXQ8 View 3D Structure Click here
I1N8V2 View 3D Structure Click here
I6YB49 View 3D Structure Click here
K7K9F9 View 3D Structure Click here
K7L7H6 View 3D Structure Click here
K7LIJ4 View 3D Structure Click here
K7MNQ8 View 3D Structure Click here
K7MNQ9 View 3D Structure Click here
K7V4Q1 View 3D Structure Click here
L0TB61 View 3D Structure Click here
M0R715 View 3D Structure Click here
O05884 View 3D Structure Click here
O06342 View 3D Structure Click here
O14115 View 3D Structure Click here
O23179 View 3D Structure Click here
O23180 View 3D Structure Click here
O23181 View 3D Structure Click here
O48723 View 3D Structure Click here
O53410 View 3D Structure Click here
O60733 View 3D Structure Click here
O69695 View 3D Structure Click here
O80959 View 3D Structure Click here
O96176 View 3D Structure Click here
P0AFR0 View 3D Structure Click here
P0C548 View 3D Structure Click here
P36165 View 3D Structure Click here
P39407 View 3D Structure Click here
P40308 View 3D Structure Click here
P41247 View 3D Structure Click here
P97570 View 3D Structure Click here
P97819 View 3D Structure Click here
P9WIY7 View 3D Structure Click here
P9WIY9 View 3D Structure Click here
Q02331 View 3D Structure Click here
Q04958 View 3D Structure Click here
Q0IS87 View 3D Structure Click here
Q0JJ39 View 3D Structure Click here
Q11186 View 3D Structure Click here
Q12043 View 3D Structure Click here
Q18948 View 3D Structure Click here
Q20500 View 3D Structure Click here
Q21534 View 3D Structure Click here
Q2R189 View 3D Structure Click here
Q32LZ8 View 3D Structure Click here
Q3TRM4 View 3D Structure Click here
Q3V1D5 View 3D Structure Click here
Q4CSM4 View 3D Structure Click here
Q4CY16 View 3D Structure Click here
Q4CYT0 View 3D Structure Click here
Q4D0N1 View 3D Structure Click here
Q4DJX0 View 3D Structure Click here
Q54CM2 View 3D Structure Click here
Q54CR1 View 3D Structure Click here
Q54DE7 View 3D Structure Click here
Q54DN7 View 3D Structure Click here
Q54GD5 View 3D Structure Click here
Q54HM9 View 3D Structure Click here
Q54IM6 View 3D Structure Click here
Q54JJ8 View 3D Structure Click here
Q54QX5 View 3D Structure Click here
Q54QX6 View 3D Structure Click here
Q54QX7 View 3D Structure Click here
Q54XY1 View 3D Structure Click here
Q55G69 View 3D Structure Click here
Q5A368 View 3D Structure Click here
Q5AM72 View 3D Structure Click here
Q5BK26 View 3D Structure Click here
Q6ASS6 View 3D Structure Click here
Q6NPP7 View 3D Structure Click here
Q6ZG42 View 3D Structure Click here
Q6ZG46 View 3D Structure Click here
Q6ZJD3 View 3D Structure Click here
Q6ZV29 View 3D Structure Click here
Q7KUD4 View 3D Structure Click here
Q7XZH2 View 3D Structure Click here
Q7Z6Z6 View 3D Structure Click here
Q84QY3 View 3D Structure Click here
Q8BJ56 View 3D Structure Click here
Q8H133 View 3D Structure Click here
Q8I2R7 View 3D Structure Click here
Q8IY17 View 3D Structure Click here
Q8K1N1 View 3D Structure Click here
Q8MXR3 View 3D Structure Click here
Q8N8W4 View 3D Structure Click here
Q8S0E1 View 3D Structure Click here
Q91WW7 View 3D Structure Click here
Q93ZQ3 View 3D Structure Click here
Q95YD2 View 3D Structure Click here
Q96AD5 View 3D Structure Click here
Q9FIY1 View 3D Structure Click here
Q9LZA6 View 3D Structure Click here
Q9M1I6 View 3D Structure Click here
Q9N5L3 View 3D Structure Click here
Q9N5Z7 View 3D Structure Click here
Q9NP80 View 3D Structure Click here
Q9NST1 View 3D Structure Click here
Q9SV43 View 3D Structure Click here
Q9TYS0 View 3D Structure Click here
Q9U969 View 3D Structure Click here
Q9USJ4 View 3D Structure Click here
Q9VXY8 View 3D Structure Click here
Q9Y7P3 View 3D Structure Click here
Q9Y827 View 3D Structure Click here