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73  structures 5848  species 0  interactions 20731  sequences 255  architectures

Family: DLH (PF01738)

Summary: Dienelactone hydrolase family

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Dienelactone hydrolase family Provide feedback

No Pfam abstract.

Literature references

  1. Pathak D, Ollis D; , J Mol Biol 1990;214:497-525.: Refined structure of dienelactone hydrolase at 1.8 A. PUBMED:2380986 EPMC:2380986


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002925

Dienelactone hydrolases play a crucial role in chlorocatechol degradation via the modified ortho cleavage pathway. Enzymes induced in 4-fluorobenzoate-utilizing bacteria have been classified into three groups on the basis of their specificity towards cis- and trans-dienelactone [ PUBMED:7684040 ]. Some proteins contain repeated small fragments of this domain (for example rat kan-1 protein).

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(11)
Full
(20731)
Representative proteomes UniProt
(78822)
RP15
(2481)
RP35
(8944)
RP55
(19067)
RP75
(33050)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(11)
Full
(20731)
Representative proteomes UniProt
(78822)
RP15
(2481)
RP35
(8944)
RP55
(19067)
RP75
(33050)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(11)
Full
(20731)
Representative proteomes UniProt
(78822)
RP15
(2481)
RP35
(8944)
RP55
(19067)
RP75
(33050)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_757 (release 4.2)
Previous IDs: none
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A
Number in seed: 11
Number in full: 20731
Average length of the domain: 199.00 aa
Average identity of full alignment: 17 %
Average coverage of the sequence by the domain: 73.65 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.0 20.0
Trusted cut-off 20.0 20.0
Noise cut-off 19.9 19.9
Model length: 217
Family (HMM) version: 20
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DLH domain has been found. There are 73 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0B4KF25 View 3D Structure Click here
A0A0P0WLZ6 View 3D Structure Click here
A0A0P0WMJ3 View 3D Structure Click here
A0A0P0XDC1 View 3D Structure Click here
A0A0P0Y160 View 3D Structure Click here
A0A0R0FGW2 View 3D Structure Click here
A0A0R0FIF5 View 3D Structure Click here
A0A0R0FIM6 View 3D Structure Click here
A0A0R0FIM6 View 3D Structure Click here
A0A0R0JIQ1 View 3D Structure Click here
A0A0R0KP61 View 3D Structure Click here
A0A0R4J5G6 View 3D Structure Click here
A0A1D6FQM1 View 3D Structure Click here
A0A1D6FQM6 View 3D Structure Click here
A0A1D6FQM8 View 3D Structure Click here
A0A1D6NNV9 View 3D Structure Click here
A0A1D8PLD7 View 3D Structure Click here
A0A1P8AZN3 View 3D Structure Click here
A4ICB3 View 3D Structure Click here
A7MBU9 View 3D Structure Click here
B4FPA0 View 3D Structure Click here
B4FTK9 View 3D Structure Click here
B4FV80 View 3D Structure Click here
B4FY74 View 3D Structure Click here
D3ZL12 View 3D Structure Click here
F4HYC8 View 3D Structure Click here
I1KFF8 View 3D Structure Click here
I1KFZ9 View 3D Structure Click here
I1KN74 View 3D Structure Click here
I1KN75 View 3D Structure Click here
I1KN78 View 3D Structure Click here
I1LU38 View 3D Structure Click here
I1M160 View 3D Structure Click here
I6XF92 View 3D Structure Click here
K7K181 View 3D Structure Click here
K7L3U5 View 3D Structure Click here
K7LF43 View 3D Structure Click here
K7LTY5 View 3D Structure Click here
K7M2X6 View 3D Structure Click here
K7M2X6 View 3D Structure Click here
O14359 View 3D Structure Click here
O17263 View 3D Structure Click here
O86353 View 3D Structure Click here
P39721 View 3D Structure Click here
P56262 View 3D Structure Click here
P9WHK1 View 3D Structure Click here
Q07505 View 3D Structure Click here
Q09571 View 3D Structure Click here
Q0ITC0 View 3D Structure Click here
Q0J722 View 3D Structure Click here
Q0J728 View 3D Structure Click here
Q18925 View 3D Structure Click here
Q18926 View 3D Structure Click here
Q18927 View 3D Structure Click here
Q3TUU5 View 3D Structure Click here
Q53Q89 View 3D Structure Click here
Q54MZ9 View 3D Structure Click here
Q5AI87 View 3D Structure Click here
Q5AMN4 View 3D Structure Click here
Q5JUR7 View 3D Structure Click here
Q688M8 View 3D Structure Click here
Q688M9 View 3D Structure Click here
Q6ATZ0 View 3D Structure Click here
Q7DFU6 View 3D Structure Click here
Q7TP52 View 3D Structure Click here
Q8LQS5 View 3D Structure Click here
Q8R1G2 View 3D Structure Click here
Q94JY3 View 3D Structure Click here
Q96DG6 View 3D Structure Click here
Q9FVR4 View 3D Structure Click here
Q9LUG8 View 3D Structure Click here
Q9P7U1 View 3D Structure Click here
Q9ZT66 View 3D Structure Click here