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0  structures 6479  species 0  interactions 28774  sequences 178  architectures

Family: Acyl_transf_3 (PF01757)

Summary: Acyltransferase family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Acyltransferase family Provide feedback

This family includes a range of acyltransferase enzymes. This domain is found in many as yet uncharacterised C. elegans proteins and it is approximately 300 amino acids long.

Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002656

This entry contains a range of acyltransferase enzymes as well as yet uncharacterised proteins from Caenorhabditis elegans. It also includes the protein OatA. The pathogenic bacteria, Staphylococcus aureus, is able to cause persistent infections due to its ability to resist the immune defence system. Lysozyme, a cell wall-lytic enzyme, is one of the first defence compounds induced in serum and tissues after the onset of infection.

S. aureus has complete resistance to lysozyme action by O-acetylating its peptidoglycan (PG) by O-acetyltransferase (OatA) [ PUBMED:16861647 , PUBMED:17676995 ]. Staphylococcus bacteria are one of the only bacterial genera that are resistant to lysozyme and tend to colonise the skin and mucosa of humans and animals [ PUBMED:15661003 ]. OatA is an integral membrane protein. This entry also includes NolL proteins. NolL-dependent acetylation is specific for the fucosyl penta-N-acetylglucosamine species. In addition, the NolL protein caused elevated production of lipo-chitin oligosaccharides (LCOs). The NolL protein obtained from Rhizobium loti (Mesorhizobium loti) functions as an acetyl transferase [ PUBMED:10755312 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan Acyl_transf_3 (CL0316), which has the following description:

This superfamily includes a wide variety of integral membrane acyltransferase enzymes that often acylate sugars.

The clan contains the following 7 members:

Acyl_transf_3 Cas1_AcylT DUF418 DUF5009 HGSNAT_cat OpgC_C TraX

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(99)
Full
(28774)
Representative proteomes UniProt
(124811)
RP15
(3389)
RP35
(12594)
RP55
(28420)
RP75
(51320)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(99)
Full
(28774)
Representative proteomes UniProt
(124811)
RP15
(3389)
RP35
(12594)
RP55
(28420)
RP75
(51320)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(99)
Full
(28774)
Representative proteomes UniProt
(124811)
RP15
(3389)
RP35
(12594)
RP55
(28420)
RP75
(51320)
Raw Stockholm Download   Download   Download   Download   Download   Download    
Gzipped Download   Download   Download   Download   Download   Download    

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_708 (release 4.2)
Previous IDs: DUF33;
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A
Number in seed: 99
Number in full: 28774
Average length of the domain: 333.60 aa
Average identity of full alignment: 14 %
Average coverage of the sequence by the domain: 73.99 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 31.0 31.0
Trusted cut-off 31.0 31.0
Noise cut-off 30.9 30.9
Model length: 340
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A061ACQ0 View 3D Structure Click here
A0A0K3ASR6 View 3D Structure Click here
A0A0K3AXT9 View 3D Structure Click here
A0A164D3K0 View 3D Structure Click here
A1Z6Q3 View 3D Structure Click here
A3QMB6 View 3D Structure Click here
A3QMD2 View 3D Structure Click here
A3QMD3 View 3D Structure Click here
A4V4W2 View 3D Structure Click here
A8JUS7 View 3D Structure Click here
B6EU57 View 3D Structure Click here
D3ZAI4 View 3D Structure Click here
F1QGA0 View 3D Structure Click here
F7VJS4 View 3D Structure Click here
G5EBI1 View 3D Structure Click here
G5EC12 View 3D Structure Click here
G5EEY0 View 3D Structure Click here
G5EFU4 View 3D Structure Click here
G5EGR2 View 3D Structure Click here
K8FDX6 View 3D Structure Click here
O02306 View 3D Structure Click here
O02307 View 3D Structure Click here
O06625 View 3D Structure Click here
O16269 View 3D Structure Click here
O16467 View 3D Structure Click here
O16531 View 3D Structure Click here
O16602 View 3D Structure Click here
O17749 View 3D Structure Click here
O17792 View 3D Structure Click here
O18127 View 3D Structure Click here
O18139 View 3D Structure Click here
O18139 View 3D Structure Click here
O33362 View 3D Structure Click here
O44402 View 3D Structure Click here
O44404 View 3D Structure Click here
O45282 View 3D Structure Click here
O45283 View 3D Structure Click here
O45374 View 3D Structure Click here
O45470 View 3D Structure Click here
O45506 View 3D Structure Click here
O45508 View 3D Structure Click here
O45589 View 3D Structure Click here
O45590 View 3D Structure Click here
O45617 View 3D Structure Click here
O45884 View 3D Structure Click here
O53633 View 3D Structure Click here
O62164 View 3D Structure Click here
O62230 View 3D Structure Click here
P37669 View 3D Structure Click here
P75920 View 3D Structure Click here
P75955 View 3D Structure Click here
P91310 View 3D Structure Click here
P96410 View 3D Structure Click here
Q09225 View 3D Structure Click here
Q11064 View 3D Structure Click here
Q17701 View 3D Structure Click here
Q19239 View 3D Structure Click here
Q21687 View 3D Structure Click here
Q21688 View 3D Structure Click here
Q21689 View 3D Structure Click here
Q2FV54 View 3D Structure Click here
Q2FZL0 View 3D Structure Click here
Q2FZS9 View 3D Structure Click here
Q5F4V4 View 3D Structure Click here
Q7JY04 View 3D Structure Click here
Q7KS40 View 3D Structure Click here
Q7YTP8 View 3D Structure Click here
Q86L41 View 3D Structure Click here
Q86MF6 View 3D Structure Click here
Q8BML2 View 3D Structure Click here
Q8IG66 View 3D Structure Click here
Q8IR42 View 3D Structure Click here
Q94056 View 3D Structure Click here
Q9RQP6 View 3D Structure Click here
Q9U1V4 View 3D Structure Click here
Q9UAQ8 View 3D Structure Click here
Q9UAT2 View 3D Structure Click here
Q9VCK7 View 3D Structure Click here
Q9VCK8 View 3D Structure Click here
Q9VCK9 View 3D Structure Click here
Q9VDC5 View 3D Structure Click here
Q9VF31 View 3D Structure Click here
Q9VPZ4 View 3D Structure Click here
Q9VWG4 View 3D Structure Click here
Q9VWG5 View 3D Structure Click here
Q9VWG6 View 3D Structure Click here
Q9VX29 View 3D Structure Click here
Q9VYG5 View 3D Structure Click here
Q9VZA7 View 3D Structure Click here
Q9W322 View 3D Structure Click here
Q9XVG0 View 3D Structure Click here
Q9XVW0 View 3D Structure Click here
Q9XVW1 View 3D Structure Click here