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123  structures 2586  species 0  interactions 19366  sequences 422  architectures

Family: Lipase_3 (PF01764)

Summary: Lipase (class 3)

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Triglyceride lipase". More...

Triglyceride lipase Edit Wikipedia article

Lipase (class 3)
PDB 3tgl EBI.jpg
Structure of Triacyl-glycerol acylhydrolase.
Identifiers
SymbolLipase_3
PfamPF01764
InterProIPR002921
PROSITEPDOC00110
SCOPe3tgl / SUPFAM
OPM superfamily127
OPM protein3tgl
CDDcd00519

Triglyceride lipases are lipases that hydrolyse ester linkages of triglycerides.[1] These lipases are widely distributed in animals, plants and prokaryotes. This family was also called class 3 lipases as they are only distantly related to other lipase families.

Human proteins containing this domain

DAGLA; DAGLB; LOC221955;

References

  1. ^ Chapus C, Rovery M, Sarda L, Verger R (1988). "Minireview on pancreatic lipase and colipase". Biochimie. 70 (9): 1223–1234. doi:10.1016/0300-9084(88)90188-5. PMID 3147715.
This article incorporates text from the public domain Pfam and InterPro: IPR002921

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Lipase (class 3) Provide feedback

No Pfam abstract.

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002921

This entry represents a domain with an alpha/beta hydrolase fold found in feruloyl esterase A [ PUBMED:15081808 ]. It is similar to that found in fungal lipases [ PUBMED:7656005 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(47)
Full
(19366)
Representative proteomes UniProt
(43203)
RP15
(4026)
RP35
(10490)
RP55
(16222)
RP75
(21841)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(47)
Full
(19366)
Representative proteomes UniProt
(43203)
RP15
(4026)
RP35
(10490)
RP55
(16222)
RP75
(21841)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(47)
Full
(19366)
Representative proteomes UniProt
(43203)
RP15
(4026)
RP35
(10490)
RP55
(16222)
RP75
(21841)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_893 (release 4.2)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A
Number in seed: 47
Number in full: 19366
Average length of the domain: 139.60 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 26.79 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 20.9 20.9
Trusted cut-off 20.9 20.9
Noise cut-off 20.8 20.8
Model length: 142
Family (HMM) version: 27
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Lipase_3 domain has been found. There are 123 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0V7I2 View 3D Structure Click here
A0A0P0VBK1 View 3D Structure Click here
A0A0P0VBR4 View 3D Structure Click here
A0A0P0VM05 View 3D Structure Click here
A0A0P0W2G6 View 3D Structure Click here
A0A0P0WCB7 View 3D Structure Click here
A0A0P0WI13 View 3D Structure Click here
A0A0P0WL87 View 3D Structure Click here
A0A0P0WLY0 View 3D Structure Click here
A0A0P0X9X0 View 3D Structure Click here
A0A0P0XXD6 View 3D Structure Click here
A0A0P0Y0L8 View 3D Structure Click here
A0A0P0Y2C1 View 3D Structure Click here
A0A0P0YC44 View 3D Structure Click here
A0A0P0YCI2 View 3D Structure Click here
A0A0R0F2G9 View 3D Structure Click here
A0A0R0FEC7 View 3D Structure Click here
A0A0R0FFT1 View 3D Structure Click here
A0A0R0FMW4 View 3D Structure Click here
A0A0R0GT63 View 3D Structure Click here
A0A0R0GX50 View 3D Structure Click here
A0A0R0HCN9 View 3D Structure Click here
A0A0R0I183 View 3D Structure Click here
A0A0R0I3K9 View 3D Structure Click here
A0A0R0IB80 View 3D Structure Click here
A0A0R0ISW8 View 3D Structure Click here
A0A0R0J7P2 View 3D Structure Click here
A0A0R0K4K3 View 3D Structure Click here
A0A0R0KJN8 View 3D Structure Click here
A0A0R0LB34 View 3D Structure Click here
A0A0R0LBK7 View 3D Structure Click here
A0A0R0LCE1 View 3D Structure Click here
A0A0R0LER5 View 3D Structure Click here
A0A1D6EH29 View 3D Structure Click here
A0A1D6ELR7 View 3D Structure Click here
A0A1D6ELU3 View 3D Structure Click here
A0A1D6FAS4 View 3D Structure Click here
A0A1D6FHM9 View 3D Structure Click here
A0A1D6FKV7 View 3D Structure Click here
A0A1D6FU87 View 3D Structure Click here
A0A1D6GDT4 View 3D Structure Click here
A0A1D6GTZ7 View 3D Structure Click here
A0A1D6HM53 View 3D Structure Click here
A0A1D6HR97 View 3D Structure Click here
A0A1D6IBJ3 View 3D Structure Click here
A0A1D6INI6 View 3D Structure Click here
A0A1D6J908 View 3D Structure Click here
A0A1D6JA02 View 3D Structure Click here
A0A1D6K3R9 View 3D Structure Click here
A0A1D6KGA2 View 3D Structure Click here
A0A1D6KVL0 View 3D Structure Click here
A0A1D6LF94 View 3D Structure Click here
A0A1D6LHD0 View 3D Structure Click here
A0A1D6LHN7 View 3D Structure Click here
A0A1D6LHN8 View 3D Structure Click here
A0A1D6LLE4 View 3D Structure Click here
A0A1D6LWY1 View 3D Structure Click here
A0A1D6LXU5 View 3D Structure Click here
A0A1D6MDI0 View 3D Structure Click here
A0A1D6MDI1 View 3D Structure Click here
A0A1D6MIA3 View 3D Structure Click here
A0A1D6MXD8 View 3D Structure Click here
A0A1D6N1Z5 View 3D Structure Click here
A0A1D6N4E2 View 3D Structure Click here
A0A1D6NE81 View 3D Structure Click here
A0A1D6NHH3 View 3D Structure Click here
A0A1D6NHH4 View 3D Structure Click here
A0A1D6NJJ7 View 3D Structure Click here
A0A1D6NSE2 View 3D Structure Click here
A0A1D6NUQ2 View 3D Structure Click here
A0A1D6PYR3 View 3D Structure Click here
A0A1D6QMC3 View 3D Structure Click here
A0A1D6QN08 View 3D Structure Click here
A0A1D8PLB8 View 3D Structure Click here
A0A1D8PPI4 View 3D Structure Click here
A0A1I6CM73 View 3D Structure Click here
A0A1P8AU29 View 3D Structure Click here
A0A1P8AVY3 View 3D Structure Click here
A0A1P8B3W4 View 3D Structure Click here
A0A1P8B415 View 3D Structure Click here
A0A1P8BAJ1 View 3D Structure Click here
A0A2R8Q244 View 3D Structure Click here
A0A2R8QE21 View 3D Structure Click here
A0A368UGY1 View 3D Structure Click here
A0A368UIZ6 View 3D Structure Click here
A2ZW16 View 3D Structure Click here
A4HVF6 View 3D Structure Click here
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B7Z150 View 3D Structure Click here
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C0P3P0 View 3D Structure Click here
C0P5I4 View 3D Structure Click here
C0PF26 View 3D Structure Click here
C0PGK2 View 3D Structure Click here
C0PMQ4 View 3D Structure Click here
C2BR92 View 3D Structure Click here
C6TNI2 View 3D Structure Click here
C7IXA7 View 3D Structure Click here
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F4HXL0 View 3D Structure Click here
F4I568 View 3D Structure Click here
F4IN30 View 3D Structure Click here
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F4K280 View 3D Structure Click here
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H2KY93 View 3D Structure Click here
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I1MV59 View 3D Structure Click here
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K7KP82 View 3D Structure Click here
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K7L476 View 3D Structure Click here
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K7LF52 View 3D Structure Click here
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K7MM55 View 3D Structure Click here
K7MM57 View 3D Structure Click here
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K7US33 View 3D Structure Click here
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K7VGB3 View 3D Structure Click here
K7VML7 View 3D Structure Click here
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O01584 View 3D Structure Click here
O13934 View 3D Structure Click here
O16189 View 3D Structure Click here
O23522 View 3D Structure Click here
O45953 View 3D Structure Click here
O49523 View 3D Structure Click here
O61218 View 3D Structure Click here
O76409 View 3D Structure Click here
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O82274 View 3D Structure Click here
P0C1S9 View 3D Structure Click here
P25641 View 3D Structure Click here
P47145 View 3D Structure Click here
Q0D6G7 View 3D Structure Click here
Q0IMQ4 View 3D Structure Click here
Q0JC68 View 3D Structure Click here
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Q19891 View 3D Structure Click here
Q20478 View 3D Structure Click here
Q21428 View 3D Structure Click here
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Q2R077 View 3D Structure Click here
Q2RAM0 View 3D Structure Click here
Q336K8 View 3D Structure Click here
Q3EBR6 View 3D Structure Click here
Q4CQ28 View 3D Structure Click here
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Q4CRU3 View 3D Structure Click here
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Q4CYC3 View 3D Structure Click here
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Q4DDS3 View 3D Structure Click here
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Q4DKK8 View 3D Structure Click here
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Q4E307 View 3D Structure Click here
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Q4F883 View 3D Structure Click here
Q4R165 View 3D Structure Click here
Q53MI7 View 3D Structure Click here
Q53P41 View 3D Structure Click here
Q54B77 View 3D Structure Click here
Q54EQ6 View 3D Structure Click here
Q54ET1 View 3D Structure Click here
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Q54TM1 View 3D Structure Click here
Q54YL1 View 3D Structure Click here
Q555H0 View 3D Structure Click here
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Q557A1 View 3D Structure Click here
Q55D81 View 3D Structure Click here
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Q5NBU0 View 3D Structure Click here
Q5YLM1 View 3D Structure Click here
Q651A9 View 3D Structure Click here
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Q67UK0 View 3D Structure Click here
Q680C0 View 3D Structure Click here
Q69TX0 View 3D Structure Click here
Q6DBI3 View 3D Structure Click here
Q6F357 View 3D Structure Click here
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Q6H415 View 3D Structure Click here
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Q6K832 View 3D Structure Click here
Q6KA57 View 3D Structure Click here
Q6WQJ1 View 3D Structure Click here
Q6Z307 View 3D Structure Click here
Q6ZDM3 View 3D Structure Click here
Q7FAL5 View 3D Structure Click here
Q7Y220 View 3D Structure Click here
Q7YX60 View 3D Structure Click here
Q7YX61 View 3D Structure Click here
Q850Z2 View 3D Structure Click here
Q86HM5 View 3D Structure Click here
Q8GW37 View 3D Structure Click here
Q8ILJ3 View 3D Structure Click here
Q8L570 View 3D Structure Click here
Q8MYE7 View 3D Structure Click here
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Q8RZ40 View 3D Structure Click here
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Q8W495 View 3D Structure Click here
Q91WC9 View 3D Structure Click here
Q940L4 View 3D Structure Click here
Q941F1 View 3D Structure Click here
Q948R1 View 3D Structure Click here
Q94AB1 View 3D Structure Click here
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Q9FIP0 View 3D Structure Click here
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Q9LNC2 View 3D Structure Click here
Q9MA46 View 3D Structure Click here
Q9N591 View 3D Structure Click here
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Q9SU71 View 3D Structure Click here
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