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41  structures 1307  species 0  interactions 7287  sequences 211  architectures

Family: DIL (PF01843)

Summary: DIL domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

DIL domain Provide feedback

The DIL domain has no known function.

Literature references

  1. Ponting CP; , Trends Biochem Sci 1995;20:265-266.: AF-6/cno: neither a kinesin nor a myosin, but a bit of both. PUBMED:7667878 EPMC:7667878


This tab holds annotation information from the InterPro database.

InterPro entry IPR002710

The myosin superfamily consists of at least 15 distinct classes of presumed actin-based molecular motors. All members of the superfamily share a similar motor domain and a tail portion which is diagnostic of the class [ PUBMED:11212352 ].

Class V myosins are actin-based molecular motors that function in relatively long-range movements of many intracellular cargoes including organelles, membrane vesicles, and mRNA [ PUBMED:10931864 ]. These motors are ubiquitously found in all eukaryotes. Class V myosins are characterised by the presence of a conserved globular domain at the C terminus of the tail portion: the dilute domain [ PUBMED:7667878 ]. Myosin V moves via attachment of its amino terminal head (motor) domain to actin cables; its carboxyl terminal dilute domain anchors it to cargoes via attachments to organelle-specific receptors [ PUBMED:10931864 , PUBMED:15684027 ].

The dilute domain is also found in the afadin family. Afadins are nectin and actin filament-binding proteins that connect nectin to the actin cytoskeleton [ PUBMED:12456712 ]. The dilute domain of afadin appears to be responsible for actin stress fibre formation [ PUBMED:25712270 ].

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(187)
Full
(7287)
Representative proteomes UniProt
(11689)
RP15
(882)
RP35
(2854)
RP55
(5896)
RP75
(8139)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(187)
Full
(7287)
Representative proteomes UniProt
(11689)
RP15
(882)
RP35
(2854)
RP55
(5896)
RP75
(8139)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(187)
Full
(7287)
Representative proteomes UniProt
(11689)
RP15
(882)
RP35
(2854)
RP55
(5896)
RP75
(8139)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: [1]
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Bateman A
Number in seed: 187
Number in full: 7287
Average length of the domain: 104.40 aa
Average identity of full alignment: 32 %
Average coverage of the sequence by the domain: 7.60 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 24.0 24.0
Trusted cut-off 24.0 24.0
Noise cut-off 23.9 23.9
Model length: 105
Family (HMM) version: 21
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the DIL domain has been found. There are 41 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0V4I7 View 3D Structure Click here
A0A0P0VQ91 View 3D Structure Click here
A0A0P0VRB1 View 3D Structure Click here
A0A0P0W1J8 View 3D Structure Click here
A0A0R0E5G3 View 3D Structure Click here
A0A0R4IFD5 View 3D Structure Click here
A0A0R4IPW9 View 3D Structure Click here
A0A1D6FXQ9 View 3D Structure Click here
A0A1D6G388 View 3D Structure Click here
A0A1D6GHG7 View 3D Structure Click here
A0A1D6GR63 View 3D Structure Click here
A0A1D6HPF7 View 3D Structure Click here
A0A1D6HXR0 View 3D Structure Click here
A0A1D6LCG3 View 3D Structure Click here
A0A1D6MB89 View 3D Structure Click here
A0A1D6NKQ5 View 3D Structure Click here
A0A1D8PDE5 View 3D Structure Click here
A1Z6Z8 View 3D Structure Click here
A7UA95 View 3D Structure Click here
B0G181 View 3D Structure Click here
B5DF05 View 3D Structure Click here
D4A1Z8 View 3D Structure Click here
E7F4R0 View 3D Structure Click here
E7F6P4 View 3D Structure Click here
E7FB39 View 3D Structure Click here
E7FCI5 View 3D Structure Click here
E9Q1F5 View 3D Structure Click here
F1M111 View 3D Structure Click here
F4HWY6 View 3D Structure Click here
F4HXP9 View 3D Structure Click here
F4I460 View 3D Structure Click here
F4I5Q6 View 3D Structure Click here
F4IRU3 View 3D Structure Click here
F4IUG9 View 3D Structure Click here
F4IVR7 View 3D Structure Click here
F4JM19 View 3D Structure Click here
F4K5I9 View 3D Structure Click here
F4K5J1 View 3D Structure Click here
F8W4K6 View 3D Structure Click here
G8JY81 View 3D Structure Click here
I1JRQ8 View 3D Structure Click here
I1JU19 View 3D Structure Click here
I1KTU1 View 3D Structure Click here
I1LY26 View 3D Structure Click here
I1LYR2 View 3D Structure Click here
I1MJG6 View 3D Structure Click here
I1MSD7 View 3D Structure Click here
I1N9X9 View 3D Structure Click here
I1NIS2 View 3D Structure Click here
K7KFL5 View 3D Structure Click here
K7KTA5 View 3D Structure Click here
K7LGK9 View 3D Structure Click here
K7LHD6 View 3D Structure Click here
K7LJT2 View 3D Structure Click here
K7M5Y2 View 3D Structure Click here
K7U9N8 View 3D Structure Click here
K7W4X8 View 3D Structure Click here
O13585 View 3D Structure Click here
O35889 View 3D Structure Click here
O74805 View 3D Structure Click here
O94477 View 3D Structure Click here
P19524 View 3D Structure Click here
P21271 View 3D Structure Click here
P32492 View 3D Structure Click here
P54696 View 3D Structure Click here
P54697 View 3D Structure Click here
P55196 View 3D Structure Click here
P70569 View 3D Structure Click here
Q0DGE1 View 3D Structure Click here
Q0DNL1 View 3D Structure Click here
Q0IXV8 View 3D Structure Click here
Q0IYC2 View 3D Structure Click here
Q0WPU1 View 3D Structure Click here
Q39160 View 3D Structure Click here
Q3U0S6 View 3D Structure Click here
Q54CQ9 View 3D Structure Click here
Q55BH2 View 3D Structure Click here
Q5AKW2 View 3D Structure Click here
Q5U651 View 3D Structure Click here
Q67VX5 View 3D Structure Click here
Q69Z89 View 3D Structure Click here
Q86IC6 View 3D Structure Click here
Q86NJ4 View 3D Structure Click here
Q96JH8 View 3D Structure Click here
Q99104 View 3D Structure Click here
Q9LKB9 View 3D Structure Click here
Q9NQX4 View 3D Structure Click here
Q9QYF3 View 3D Structure Click here
Q9QZQ1 View 3D Structure Click here
Q9ULV0 View 3D Structure Click here
Q9UTB0 View 3D Structure Click here
Q9VN82 View 3D Structure Click here
Q9Y4I1 View 3D Structure Click here
R4GER0 View 3D Structure Click here