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95  structures 5308  species 0  interactions 7882  sequences 53  architectures

Family: SurE (PF01975)

Summary: Survival protein SurE

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This is the Wikipedia entry entitled "SurE, survival protein E". More...

SurE, survival protein E Edit Wikipedia article

PDB 1j9k EBI.jpg
Crystal structure of SurE protein from T.maritima in complex with tungstate.
Symbol SurE
Pfam PF01975
InterPro IPR002828
SCOP 1j9l

In molecular biology, the protein domain surE refers to survival protein E. It was originally found that cells that did not contain this protein, could not survive in the stationary phase, at above normal temperatures, and in high-salt media. Hence the name, survival protein E.[1] It is a metal ion-dependent phosphatase that is found in bacteria, and eukaryotes. It is an important stress response protein.[2] This domain is found in acid phosphatases (EC), 5'-nucleotidases (EC), 3'-nucleotidases (EC) and exopolyphosphatases (EC).

Interaction with pcm gene

The gene, surE, is part of a bicistronic operon found upstream of the pcm gene. When mutated, their phenotypes, or physical characteristics, are very similar and indicate that both gene products are important for survival under stressful conditions.[3]


The C-terminal domain is important mainly for maintaining the oligomeric state of the protein, SurE. The N-terminal domain is thought to be part of the functional domain.[3] Since the SurE is a phosphatase enzyme it removes a phosphate group from a substance, affecting that substance's role in signal transduction.[4]


This protein consists of two protein domain. One is a large, globular N-terminal domain and the other is a smaller C-terminal domain.

N-terminal domain

The N-terminal domain contains a three-layer alpha/beta/alpha sandwich that is homologous with the Rossmann fold (CATH class of which the major feature is a long beta sheet that is composed of nine mostly parallel beta strands.[4] SurEstructural domain has a similar topology to the N-terminal protein domain of the glutaminase/asparaginase family.[5]

C-terminal domain

The C-terminal domain, has 3 beta strands and two protrusions; one of which is a C-terminal alpha helix, and the second is a beta hairpin.[3]


  1. ^ Li C, Ichikawa JK, Ravetto JJ, Kuo HC, Fu JC, Clarke S (1994). "A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome.". J Bacteriol. 176 (19): 6015–22. PMC 196819Freely accessible. PMID 7928962. 
  2. ^ Iwasaki W, Miki K (2007). "Crystal structure of the stationary phase survival protein SurE with metal ion and AMP.". J Mol Biol. 371 (1): 123–36. PMID 17561111. doi:10.1016/j.jmb.2007.05.007. 
  3. ^ a b c Zhang RG, Skarina T, Katz JE, Beasley S, Khachatryan A, Vyas S, et al. (2001). "Structure of Thermotoga maritima stationary phase survival protein SurE: a novel acid phosphatase.". Structure. 9 (11): 1095–106. PMC 2792002Freely accessible. PMID 11709173. doi:10.1016/s0969-2126(01)00675-x. 
  4. ^ a b Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, et al. (2001). "Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family.". Nat Struct Biol. 8 (9): 789–94. PMID 11524683. doi:10.1038/nsb0901-789. 
  5. ^ Mura C, Katz JE, Clarke SG, Eisenberg D (March 2003). "Structure and function of an archaeal homolog of survival protein E (SurEalpha): an acid phosphatase with purine nucleotide specificity". J. Mol. Biol. 326 (5): 1559–75. PMID 12595266. doi:10.1016/S0022-2836(03)00056-1. 

This article incorporates text from the public domain Pfam and InterPro IPR002828

This page is based on a Wikipedia article. The text is available under the Creative Commons Attribution/Share-Alike License.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Survival protein SurE Provide feedback

E. coli cells with the surE gene disrupted are found to survive poorly in stationary phase [1]. It is suggested that SurE may be involved in stress response. Yeast also contains a member of the family P38254. P30887 can complement a mutation in acid phosphatase, suggesting that members of this family could be phosphatases.

Literature references

  1. Li C, Ichikawa JK, Ravetto JJ, Kuo HC, Fu JC, Clarke S; , J Bacteriol 1994;176:6015-6022.: A new gene involved in stationary-phase survival located at 59 minutes on the Escherichia coli chromosome PUBMED:7928962 EPMC:7928962

  2. Treton BY, Le Dall MT, Gaillardin CM; , Curr Genet 1992;22:345-355.: Complementation of Saccharomyces cerevisiae acid phosphatase mutation by a genomic sequence from the yeast Yarrowia lipolytica identifies a new phosphatase. PUBMED:1423722 EPMC:1423722

Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR002828

This entry represents a SurE-like structural domain with a 3-layer alpha/bete/alpha topology that bears some topological similarity to the N-terminal domain of the glutaminase/asparaginase family. This domain is found in the stationary phase survival protein SurE, a metal ion-dependent phosphatase found in eubacteria, archaea and eukaryotes. In Escherichia coli, SurE also has activity as a nucleotidase and exopolyphosphatase, and may be involved in the stress response [ PUBMED:17561111 ]. E. coli cells with mutations in the surE gene survive poorly in stationary phase [ PUBMED:11709173 ]. The structure of SurE homologues have been determined from Thermotoga maritima [ PUBMED:11524683 ] and the archaea Pyrobaculum aerophilum [ PUBMED:12595266 ]. The T. maritima SurE homologue has phosphatase activity that is inhibited by vanadate or tungstate, both of which bind adjacent to the divalent metal ion.

Gene Ontology

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Domain organisation

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Seed source: Enright A
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Enright A , Ouzounis C , Bateman A
Number in seed: 646
Number in full: 7882
Average length of the domain: 192.40 aa
Average identity of full alignment: 33 %
Average coverage of the sequence by the domain: 63.36 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 61295632 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.1 22.1
Trusted cut-off 22.2 22.4
Noise cut-off 21.6 21.5
Model length: 195
Family (HMM) version: 20
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Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence


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For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the SurE domain has been found. There are 95 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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