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58  structures 141  species 0  interactions 9544  sequences 104  architectures

Family: AUX_IAA (PF02309)

Summary: AUX/IAA family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

AUX/IAA family Provide feedback

Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin. Some members of this family are longer and contain an N terminal DNA binding domain, such as O64965. The function of this region is uncertain.

Literature references

  1. Hardtke CS, Berleth T; , EMBO J 1998;17:1405-1411.: The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development. PUBMED:9482737 EPMC:9482737


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR033389

Transcription of the AUX/IAA family of genes is rapidly induced by the plant hormone auxin [ PUBMED:7658471 ]. Some members of this family are longer and contain an N-terminal DNA binding domain, such as SWISSPROT . This entry represents the C-terminal region of the AUX/IAA proteins. The function of this region is uncertain.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(98)
Full
(9544)
Representative proteomes UniProt
(14582)
RP15
(746)
RP35
(4748)
RP55
(7716)
RP75
(10536)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(98)
Full
(9544)
Representative proteomes UniProt
(14582)
RP15
(746)
RP35
(4748)
RP55
(7716)
RP75
(10536)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(98)
Full
(9544)
Representative proteomes UniProt
(14582)
RP15
(746)
RP35
(4748)
RP55
(7716)
RP75
(10536)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_801 (release 5.2)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bateman A , Mian N
Number in seed: 98
Number in full: 9544
Average length of the domain: 149.50 aa
Average identity of full alignment: 28 %
Average coverage of the sequence by the domain: 36.62 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 22.7 22.7
Trusted cut-off 22.7 22.7
Noise cut-off 22.6 22.6
Model length: 240
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
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Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the AUX_IAA domain has been found. There are 58 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0R0EE57 View 3D Structure Click here
A0A0R0ENE0 View 3D Structure Click here
A0A0R0G8P7 View 3D Structure Click here
A0A0R0GVW1 View 3D Structure Click here
A0A0R0HUZ9 View 3D Structure Click here
A0A0R0HY07 View 3D Structure Click here
A0A0R0IPS7 View 3D Structure Click here
A0A0R0L673 View 3D Structure Click here
A0A1D6DTV9 View 3D Structure Click here
A0A1D6DUQ4 View 3D Structure Click here
A0A1D6E906 View 3D Structure Click here
A0A1D6E9Y6 View 3D Structure Click here
A0A1D6E9Y6 View 3D Structure Click here
A0A1D6EH13 View 3D Structure Click here
A0A1D6F1D0 View 3D Structure Click here
A0A1D6FAV3 View 3D Structure Click here
A0A1D6FF66 View 3D Structure Click here
A0A1D6FQU1 View 3D Structure Click here
A0A1D6G1J9 View 3D Structure Click here
A0A1D6GG94 View 3D Structure Click here
A0A1D6GSR8 View 3D Structure Click here
A0A1D6GVG1 View 3D Structure Click here
A0A1D6H0D1 View 3D Structure Click here
A0A1D6H6I5 View 3D Structure Click here
A0A1D6HAQ3 View 3D Structure Click here
A0A1D6HAQ3 View 3D Structure Click here
A0A1D6HNP4 View 3D Structure Click here
A0A1D6IX97 View 3D Structure Click here
A0A1D6JH51 View 3D Structure Click here
A0A1D6JHR5 View 3D Structure Click here
A0A1D6KFH8 View 3D Structure Click here
A0A1D6KG94 View 3D Structure Click here
A0A1D6KJC5 View 3D Structure Click here
A0A1D6L0F3 View 3D Structure Click here
A0A1D6L7W5 View 3D Structure Click here
A0A1D6LPM9 View 3D Structure Click here
A0A1D6LZR0 View 3D Structure Click here
A0A1D6M103 View 3D Structure Click here
A0A1D6M3P7 View 3D Structure Click here
A0A1D6M482 View 3D Structure Click here
A0A1D6M4R3 View 3D Structure Click here
A0A1D6MAK0 View 3D Structure Click here
A0A1D6MC87 View 3D Structure Click here
A0A1D6MEU8 View 3D Structure Click here
A0A1D6MR96 View 3D Structure Click here
A0A1D6MTV6 View 3D Structure Click here
A0A1D6MVX1 View 3D Structure Click here
A0A1D6N2G9 View 3D Structure Click here
A0A1D6N2G9 View 3D Structure Click here
A0A1D6NFV5 View 3D Structure Click here
A0A1D6NML1 View 3D Structure Click here
A0A1D6NRL0 View 3D Structure Click here
A0A1D6PBR5 View 3D Structure Click here
A0A1D6PSN1 View 3D Structure Click here
A0A1D6PTP1 View 3D Structure Click here
A0A1D6Q3A3 View 3D Structure Click here
A0A1D6Q3A3 View 3D Structure Click here
A0A1D6QCA7 View 3D Structure Click here
A0A1D6QKZ2 View 3D Structure Click here
A0A1D6QKZ2 View 3D Structure Click here
A0A1D6QSK8 View 3D Structure Click here
A0A1X7YHJ4 View 3D Structure Click here
A0A368UHB3 View 3D Structure Click here
A2ZRY8 View 3D Structure Click here
A3B9A0 View 3D Structure Click here
B4F9B9 View 3D Structure Click here
B4FD48 View 3D Structure Click here
B4FF21 View 3D Structure Click here
B4FPE1 View 3D Structure Click here
B4FZ89 View 3D Structure Click here
B4G221 View 3D Structure Click here
B6SJA9 View 3D Structure Click here
B6SLY6 View 3D Structure Click here
B6TJZ2 View 3D Structure Click here
B6UDD0 View 3D Structure Click here
B6UDD0 View 3D Structure Click here
B7ZXU5 View 3D Structure Click here
B8A0C3 View 3D Structure Click here
B8A178 View 3D Structure Click here
B8A2Y3 View 3D Structure Click here
C0HHC6 View 3D Structure Click here
C0HHC6 View 3D Structure Click here
C0PH36 View 3D Structure Click here
C0PMW3 View 3D Structure Click here
C6TA77 View 3D Structure Click here
C6TDX6 View 3D Structure Click here
C6TEQ8 View 3D Structure Click here
C6TFS6 View 3D Structure Click here
C6TFS6 View 3D Structure Click here
C6TIB0 View 3D Structure Click here
C6TKK4 View 3D Structure Click here
C6TKM2 View 3D Structure Click here
D2DGW4 View 3D Structure Click here
D9HNV4 View 3D Structure Click here
I1J4B0 View 3D Structure Click here
I1J4W6 View 3D Structure Click here
I1JBA2 View 3D Structure Click here
I1JF48 View 3D Structure Click here
I1JF49 View 3D Structure Click here
I1JH42 View 3D Structure Click here
I1JHQ8 View 3D Structure Click here
I1JIZ7 View 3D Structure Click here
I1JM14 View 3D Structure Click here
I1JM14 View 3D Structure Click here
I1JNZ0 View 3D Structure Click here
I1JNZ1 View 3D Structure Click here
I1JQX8 View 3D Structure Click here
I1JRN2 View 3D Structure Click here
I1JUC1 View 3D Structure Click here
I1JUC1 View 3D Structure Click here
I1JXQ2 View 3D Structure Click here
I1K651 View 3D Structure Click here
I1K6T1 View 3D Structure Click here
I1K8U1 View 3D Structure Click here
I1K9K9 View 3D Structure Click here
I1KBY0 View 3D Structure Click here
I1KGI1 View 3D Structure Click here
I1KH60 View 3D Structure Click here
I1KJW6 View 3D Structure Click here
I1KK13 View 3D Structure Click here
I1KK13 View 3D Structure Click here
I1KNS1 View 3D Structure Click here
I1KNS1 View 3D Structure Click here
I1KP28 View 3D Structure Click here
I1KRX2 View 3D Structure Click here
I1KX40 View 3D Structure Click here
I1L1T2 View 3D Structure Click here
I1L4K7 View 3D Structure Click here
I1L4V9 View 3D Structure Click here
I1LES9 View 3D Structure Click here
I1LM27 View 3D Structure Click here
I1LT90 View 3D Structure Click here
I1LY86 View 3D Structure Click here
I1LYD6 View 3D Structure Click here
I1LZQ2 View 3D Structure Click here
I1LZQ2 View 3D Structure Click here
I1M1J4 View 3D Structure Click here
I1M5G0 View 3D Structure Click here
I1M5I6 View 3D Structure Click here
I1M5N4 View 3D Structure Click here
I1MB30 View 3D Structure Click here
I1MBP7 View 3D Structure Click here
I1MC56 View 3D Structure Click here
I1MCK6 View 3D Structure Click here
I1MCL2 View 3D Structure Click here
I1MCV5 View 3D Structure Click here
I1MJS6 View 3D Structure Click here
I1MS06 View 3D Structure Click here
I1MS55 View 3D Structure Click here
I1MY19 View 3D Structure Click here
I1MZK6 View 3D Structure Click here
I1N2J8 View 3D Structure Click here
I1N9L9 View 3D Structure Click here
I1N9M2 View 3D Structure Click here
I1NBJ0 View 3D Structure Click here
I1NC99 View 3D Structure Click here
I1NFP6 View 3D Structure Click here
I1NIA4 View 3D Structure Click here
I1NIQ7 View 3D Structure Click here
K7K2W3 View 3D Structure Click here
K7K310 View 3D Structure Click here
K7K310 View 3D Structure Click here
K7K5Q4 View 3D Structure Click here
K7K8B6 View 3D Structure Click here
K7KFJ3 View 3D Structure Click here
K7KH37 View 3D Structure Click here
K7KH37 View 3D Structure Click here
K7KZ35 View 3D Structure Click here
K7KZU2 View 3D Structure Click here
K7L1H8 View 3D Structure Click here
K7L1H8 View 3D Structure Click here
K7L4N0 View 3D Structure Click here
K7L4R6 View 3D Structure Click here
K7LGN6 View 3D Structure Click here
K7LH61 View 3D Structure Click here
K7LJA8 View 3D Structure Click here
K7M3W3 View 3D Structure Click here
K7MAG3 View 3D Structure Click here
K7MC63 View 3D Structure Click here
K7MET6 View 3D Structure Click here
K7MET6 View 3D Structure Click here
K7TJD3 View 3D Structure Click here
K7TU37 View 3D Structure Click here
K7TVT3 View 3D Structure Click here
K7TX47 View 3D Structure Click here
K7U104 View 3D Structure Click here
K7U5R7 View 3D Structure Click here
K7V6I2 View 3D Structure Click here
O24407 View 3D Structure Click here
O24408 View 3D Structure Click here
O24409 View 3D Structure Click here
O24410 View 3D Structure Click here
P0C127 View 3D Structure Click here
P0C128 View 3D Structure Click here
P0C129 View 3D Structure Click here
P0C130 View 3D Structure Click here
P0C131 View 3D Structure Click here
P0C132 View 3D Structure Click here
P0C133 View 3D Structure Click here
P13088 View 3D Structure Click here
P13089 View 3D Structure Click here
P33077 View 3D Structure Click here
P33078 View 3D Structure Click here
P49677 View 3D Structure Click here
P49678 View 3D Structure Click here
P93022 View 3D Structure Click here
P93024 View 3D Structure Click here
P93830 View 3D Structure Click here
Q0D9R7 View 3D Structure Click here
Q0DWF2 View 3D Structure Click here
Q0J951 View 3D Structure Click here
Q0J9G7 View 3D Structure Click here
Q0JCZ4 View 3D Structure Click here
Q0JCZ4 View 3D Structure Click here
Q0JKG7 View 3D Structure Click here
Q10D34 View 3D Structure Click here
Q2QM84 View 3D Structure Click here
Q2QQX6 View 3D Structure Click here
Q2R3F5 View 3D Structure Click here
Q38822 View 3D Structure Click here
Q38824 View 3D Structure Click here
Q38825 View 3D Structure Click here
Q38826 View 3D Structure Click here
Q38827 View 3D Structure Click here
Q38828 View 3D Structure Click here
Q38829 View 3D Structure Click here
Q38830 View 3D Structure Click here
Q38831 View 3D Structure Click here
Q38832 View 3D Structure Click here
Q5JK20 View 3D Structure Click here
Q5JK20 View 3D Structure Click here
Q5NB25 View 3D Structure Click here
Q5NB85 View 3D Structure Click here
Q5VRD1 View 3D Structure Click here
Q5VRD1 View 3D Structure Click here
Q5VRR0 View 3D Structure Click here
Q5W670 View 3D Structure Click here
Q5Z749 View 3D Structure Click here
Q652A1 View 3D Structure Click here
Q652A1 View 3D Structure Click here
Q653U3 View 3D Structure Click here
Q69TU6 View 3D Structure Click here
Q69VE0 View 3D Structure Click here
Q6AT10 View 3D Structure Click here
Q6AT33 View 3D Structure Click here
Q6H543 View 3D Structure Click here
Q6H6V4 View 3D Structure Click here
Q6K846 View 3D Structure Click here
Q6YVY0 View 3D Structure Click here
Q6YZW0 View 3D Structure Click here
Q6Z2W3 View 3D Structure Click here
Q6Z5M0 View 3D Structure Click here
Q6ZL57 View 3D Structure Click here
Q75GB1 View 3D Structure Click here
Q75GK0 View 3D Structure Click here
Q75GK1 View 3D Structure Click here
Q7Y1H8 View 3D Structure Click here
Q7Y1H8 View 3D Structure Click here
Q8H174 View 3D Structure Click here
Q8L7G0 View 3D Structure Click here
Q8LAL2 View 3D Structure Click here
Q8LQ74 View 3D Structure Click here
Q8RYC6 View 3D Structure Click here
Q8RYC8 View 3D Structure Click here
Q8S983 View 3D Structure Click here
Q93WC4 View 3D Structure Click here
Q93WC4 View 3D Structure Click here
Q94JM3 View 3D Structure Click here
Q9C5W9 View 3D Structure Click here
Q9C5W9 View 3D Structure Click here
Q9C5X0 View 3D Structure Click here
Q9C7I9 View 3D Structure Click here
Q9C8N7 View 3D Structure Click here
Q9C8N7 View 3D Structure Click here
Q9C8N9 View 3D Structure Click here
Q9C966 View 3D Structure Click here
Q9FGV1 View 3D Structure Click here
Q9FKM7 View 3D Structure Click here
Q9FX25 View 3D Structure Click here
Q9LG86 View 3D Structure Click here
Q9LQE3 View 3D Structure Click here
Q9LQE8 View 3D Structure Click here
Q9M1R4 View 3D Structure Click here
Q9XED8 View 3D Structure Click here
Q9XFM0 View 3D Structure Click here
Q9XFM0 View 3D Structure Click here
Q9XID4 View 3D Structure Click here
Q9XID4 View 3D Structure Click here
Q9ZPY6 View 3D Structure Click here
Q9ZPY6 View 3D Structure Click here
Q9ZSY8 View 3D Structure Click here
Q9ZTX8 View 3D Structure Click here