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3  structures 4964  species 0  interactions 22687  sequences 248  architectures

Family: Zip (PF02535)

Summary: ZIP Zinc transporter

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

ZIP Zinc transporter Provide feedback

The ZIP family consists of zinc transport proteins and many putative metal transporters. The main contribution to this family is from the Arabidopsis thaliana ZIP protein family these proteins are responsible for zinc uptake in the plant [1]. Also found within this family are C. elegans proteins of unknown function which are annotated as being similar to human growth arrest inducible gene product, although this protein in not found within this family.

Literature references

  1. Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D; , Proc Natl Acad Sci U S A 1998;95:7220-7224.: Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. PUBMED:9618566 EPMC:9618566


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR003689

These ZIP zinc transporter proteins define a family of metal ion transporters that are found in plants, protozoa, fungi, invertebrates, and vertebrates, making it now possible to address questions of metal ion accumulation and homeostasis in diverse organisms [ PUBMED:9618566 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan DMT (CL0184), which has the following description:

This clan contains a variety of transporters which have 4, 5, 9 or 10 membrane spanning helices. Many of the 10 membrane spanning transporters appear to be a duplication of the 5 spanning unit [1]. Many of these families contain a characteristic glycine rich motif close to the C-terminus.

The clan contains the following 22 members:

CRCB CRT-like CSG2 DMT_6 DMT_YdcZ DUF5989 EamA EmrE Mg_trans_NIPA Multi_Drug_Res Nuc_sug_transp PUNUT RhaT SLC35F Sugar_transport TMEM144 TMEM234 TPT UAA UPF0060 Ureide_permease Zip

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(37)
Full
(22687)
Representative proteomes UniProt
(57680)
RP15
(4167)
RP35
(10784)
RP55
(19390)
RP75
(27602)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(37)
Full
(22687)
Representative proteomes UniProt
(57680)
RP15
(4167)
RP35
(10784)
RP55
(19390)
RP75
(27602)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(37)
Full
(22687)
Representative proteomes UniProt
(57680)
RP15
(4167)
RP35
(10784)
RP55
(19390)
RP75
(27602)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1189 (release 5.4) & Pfam-B_1903 (Release 7.5)
Previous IDs: none
Type: Family
Sequence Ontology: SO:0100021
Author: Bashton M , Bateman A
Number in seed: 37
Number in full: 22687
Average length of the domain: 238.40 aa
Average identity of full alignment: 16 %
Average coverage of the sequence by the domain: 70.74 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 35.1 35.1
Trusted cut-off 35.1 35.1
Noise cut-off 35.0 35.0
Model length: 333
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the Zip domain has been found. There are 3 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2KQY6 View 3D Structure Click here
A0A0R0JK26 View 3D Structure Click here
A0A0R4IDS1 View 3D Structure Click here
A0A0R4IDS1 View 3D Structure Click here
A0A1D6DZT6 View 3D Structure Click here
A0A1D6GG62 View 3D Structure Click here
A0A1D6GK97 View 3D Structure Click here
A0A1D6GKM0 View 3D Structure Click here
A0A1D6K5L1 View 3D Structure Click here
A0A1D6KL71 View 3D Structure Click here
A0A1D6LSQ8 View 3D Structure Click here
A0A1D6M6B9 View 3D Structure Click here
A0A1D6N096 View 3D Structure Click here
A0A1D6PTR4 View 3D Structure Click here
A0A1D6QRD8 View 3D Structure Click here
A0A1D8PGH6 View 3D Structure Click here
A0A1D8PGN5 View 3D Structure Click here
A0A1D8PMR6 View 3D Structure Click here
A0A2R8Q6G1 View 3D Structure Click here
A0A2R8Q8K9 View 3D Structure Click here
A0A2R8QBR5 View 3D Structure Click here
A0A2R8QMN5 View 3D Structure Click here
A0JPN2 View 3D Structure Click here
A1Z6P0 View 3D Structure Click here
A1Z6P0 View 3D Structure Click here
A3BI11 View 3D Structure Click here
A4I3R9 View 3D Structure Click here
A4I7B1 View 3D Structure Click here
A4I9G1 View 3D Structure Click here
A4IJ72 View 3D Structure Click here
B3DKI6 View 3D Structure Click here
B4FAU1 View 3D Structure Click here
B5DEF5 View 3D Structure Click here
B6SZI8 View 3D Structure Click here
B6U8Z3 View 3D Structure Click here
C0HIK6 View 3D Structure Click here
C6KST8 View 3D Structure Click here
C6TJF2 View 3D Structure Click here
D3ZIN1 View 3D Structure Click here
D3ZSF7 View 3D Structure Click here
D3ZZM0 View 3D Structure Click here
D4A517 View 3D Structure Click here
D4A517 View 3D Structure Click here
D4A8R5 View 3D Structure Click here
E7EXQ5 View 3D Structure Click here
E7EXQ5 View 3D Structure Click here
F1QKB6 View 3D Structure Click here
F8W5D4 View 3D Structure Click here
G3X943 View 3D Structure Click here
I1JEM8 View 3D Structure Click here
I1K3B7 View 3D Structure Click here
I1KMA5 View 3D Structure Click here
I1KRP8 View 3D Structure Click here
I1KTX1 View 3D Structure Click here
I1KYI4 View 3D Structure Click here
I1L6X2 View 3D Structure Click here
I1LLN6 View 3D Structure Click here
I1M4Y5 View 3D Structure Click here
I1M515 View 3D Structure Click here
I1MBD7 View 3D Structure Click here
I1MDA4 View 3D Structure Click here
I1MDD2 View 3D Structure Click here
I1MDD3 View 3D Structure Click here
I1MJD5 View 3D Structure Click here
I1MZX4 View 3D Structure Click here
I1MZX4 View 3D Structure Click here
I1N0B5 View 3D Structure Click here
I1N3B8 View 3D Structure Click here
K7KI73 View 3D Structure Click here
K7KI73 View 3D Structure Click here
K7LPJ7 View 3D Structure Click here
K7LT87 View 3D Structure Click here
K7LYA5 View 3D Structure Click here
K7M5W1 View 3D Structure Click here
K7MNG4 View 3D Structure Click here
K7U2V8 View 3D Structure Click here
K7UAS7 View 3D Structure Click here
K7VHM7 View 3D Structure Click here
O04089 View 3D Structure Click here
O23039 View 3D Structure Click here
O62192 View 3D Structure Click here
O64738 View 3D Structure Click here
O81123 View 3D Structure Click here
O81850 View 3D Structure Click here
O82643 View 3D Structure Click here
O94402 View 3D Structure Click here
O94639 View 3D Structure Click here
P0A8H3 View 3D Structure Click here
P32804 View 3D Structure Click here
P34240 View 3D Structure Click here
P40544 View 3D Structure Click here
P40544 View 3D Structure Click here
P59889 View 3D Structure Click here
P91348 View 3D Structure Click here
P91354 View 3D Structure Click here
Q09957 View 3D Structure Click here
Q0DHE3 View 3D Structure Click here
Q12067 View 3D Structure Click here
Q12436 View 3D Structure Click here
Q13433 View 3D Structure Click here
Q13433 View 3D Structure Click here
Q15043 View 3D Structure Click here
Q17996 View 3D Structure Click here
Q17996 View 3D Structure Click here
Q19913 View 3D Structure Click here
Q22395 View 3D Structure Click here
Q2M1K6 View 3D Structure Click here
Q31125 View 3D Structure Click here
Q38856 View 3D Structure Click here
Q38856 View 3D Structure Click here
Q3KR82 View 3D Structure Click here
Q3KR82 View 3D Structure Click here
Q4CK87 View 3D Structure Click here
Q4CN32 View 3D Structure Click here
Q4CN33 View 3D Structure Click here
Q4CVF3 View 3D Structure Click here
Q4CVF4 View 3D Structure Click here
Q4CVF5 View 3D Structure Click here
Q4CVF6 View 3D Structure Click here
Q4CZ59 View 3D Structure Click here
Q4CZ60 View 3D Structure Click here
Q4DE41 View 3D Structure Click here
Q4V887 View 3D Structure Click here
Q504Y0 View 3D Structure Click here
Q54LY6 View 3D Structure Click here
Q54MB9 View 3D Structure Click here
Q54T89 View 3D Structure Click here
Q556U8 View 3D Structure Click here
Q55EA1 View 3D Structure Click here
Q55EA1 View 3D Structure Click here
Q55FL1 View 3D Structure Click here
Q58442 View 3D Structure Click here
Q5A7N9 View 3D Structure Click here
Q5A7N9 View 3D Structure Click here
Q5BL29 View 3D Structure Click here
Q5BL29 View 3D Structure Click here
Q5FVQ0 View 3D Structure Click here
Q5FWH7 View 3D Structure Click here
Q5U1X7 View 3D Structure Click here
Q5W6X5 View 3D Structure Click here
Q5Z653 View 3D Structure Click here
Q6BEU0 View 3D Structure Click here
Q6H7N1 View 3D Structure Click here
Q6L8F7 View 3D Structure Click here
Q6L8F9 View 3D Structure Click here
Q6L8G0 View 3D Structure Click here
Q6L8G1 View 3D Structure Click here
Q6MGB4 View 3D Structure Click here
Q6MX47 View 3D Structure Click here
Q6P5F6 View 3D Structure Click here
Q6P5F6 View 3D Structure Click here
Q6P5W5 View 3D Structure Click here
Q6P6S2 View 3D Structure Click here
Q6PEH9 View 3D Structure Click here
Q6YSC5 View 3D Structure Click here
Q6ZJ91 View 3D Structure Click here
Q6ZMH5 View 3D Structure Click here
Q75HB1 View 3D Structure Click here
Q75JD1 View 3D Structure Click here
Q75N73 View 3D Structure Click here
Q78IQ7 View 3D Structure Click here
Q7JZR2 View 3D Structure Click here
Q7XLD4 View 3D Structure Click here
Q852F6 View 3D Structure Click here
Q8AW42 View 3D Structure Click here
Q8BFU1 View 3D Structure Click here
Q8BFU1 View 3D Structure Click here
Q8BWY7 View 3D Structure Click here
Q8BZH0 View 3D Structure Click here
Q8BZH0 View 3D Structure Click here
Q8C145 View 3D Structure Click here
Q8IJI1 View 3D Structure Click here
Q8LE59 View 3D Structure Click here
Q8N1S5 View 3D Structure Click here
Q8S3W4 View 3D Structure Click here
Q8SWW2 View 3D Structure Click here
Q8W245 View 3D Structure Click here
Q8W246 View 3D Structure Click here
Q91W10 View 3D Structure Click here
Q92504 View 3D Structure Click here
Q940Q3 View 3D Structure Click here
Q941P4 View 3D Structure Click here
Q94DG6 View 3D Structure Click here
Q94EG9 View 3D Structure Click here
Q94EG9 View 3D Structure Click here
Q96H72 View 3D Structure Click here
Q96H72 View 3D Structure Click here
Q99K24 View 3D Structure Click here
Q9BRY0 View 3D Structure Click here
Q9C0K1 View 3D Structure Click here
Q9C9Z1 View 3D Structure Click here
Q9D856 View 3D Structure Click here
Q9FIS2 View 3D Structure Click here
Q9LTH9 View 3D Structure Click here
Q9M647 View 3D Structure Click here
Q9NP94 View 3D Structure Click here
Q9NUM3 View 3D Structure Click here
Q9NUM3 View 3D Structure Click here
Q9NY26 View 3D Structure Click here
Q9PUB8 View 3D Structure Click here
Q9QZ03 View 3D Structure Click here
Q9SLG3 View 3D Structure Click here
Q9ULF5 View 3D Structure Click here
Q9UT11 View 3D Structure Click here
Q9V3A4 View 3D Structure Click here
Q9V4C6 View 3D Structure Click here
Q9V4C6 View 3D Structure Click here
Q9VAF0 View 3D Structure Click here
Q9VEX1 View 3D Structure Click here
Q9VFA2 View 3D Structure Click here
Q9VSL7 View 3D Structure Click here
Q9VSL7 View 3D Structure Click here
Q9XTQ7 View 3D Structure Click here
Q9XUC4 View 3D Structure Click here
Q9XVJ5 View 3D Structure Click here
Q9XVR4 View 3D Structure Click here
Q9XWH3 View 3D Structure Click here
U4PS08 View 3D Structure Click here