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47  structures 1439  species 0  interactions 10178  sequences 152  architectures

Family: MA3 (PF02847)

Summary: MA3 domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

MA3 domain Provide feedback

Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains [1].

Literature references

  1. Ponting CP; , Trends Biochem Sci 2000;25:423-426.: Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. PUBMED:10973054 EPMC:10973054


External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR003891

This entry represents the MI domain (after MA-3 and eIF4G), it is a protein-protein interaction module of ~130 amino acids [ PUBMED:10958635 , PUBMED:10973054 , PUBMED:15082783 ]. It appears in several translation factors and is found in:

  • One copy in plant and animal eIF4G 1 and 2 (DAP-5/NAT1/p97)
  • Two copies in the animal programmed cell death protein 4 (PDCD4) or MA-3 that is induced during programmed cell death and inhibits neoplastic transformation
  • Four tandem-repeated copies in a group of uncharacterised plant proteins

The MI domain consists of seven alpha-helices, which pack into a globular form. The packing arrangement consists of repeating pairs of antiparallel helices packed one upon the other such that a superhelical axis is generated perpendicular to the alpha-helical axes [ PUBMED:17060447 ].

The MI domain has also been named MA3 domain.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(22)
Full
(10178)
Representative proteomes UniProt
(18119)
RP15
(1558)
RP35
(4557)
RP55
(8325)
RP75
(11158)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(22)
Full
(10178)
Representative proteomes UniProt
(18119)
RP15
(1558)
RP35
(4557)
RP55
(8325)
RP75
(11158)
Alignment:
Format:
Order:
Sequence:
Gaps:
Download/view:

Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(22)
Full
(10178)
Representative proteomes UniProt
(18119)
RP15
(1558)
RP35
(4557)
RP55
(8325)
RP75
(11158)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Alignment kindly provided by SMART
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: SMART
Number in seed: 22
Number in full: 10178
Average length of the domain: 110.20 aa
Average identity of full alignment: 22 %
Average coverage of the sequence by the domain: 14.66 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.2 23.2
Trusted cut-off 23.2 23.2
Noise cut-off 23.1 23.1
Model length: 113
Family (HMM) version: 19
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the MA3 domain has been found. There are 47 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

Loading structure mapping...

AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JY73 View 3D Structure Click here
A0A0P0WHV8 View 3D Structure Click here
A0A0P0Y905 View 3D Structure Click here
A0A0R0EZ81 View 3D Structure Click here
A0A0R0FBT0 View 3D Structure Click here
A0A0R0FBT0 View 3D Structure Click here
A0A0R0FBT0 View 3D Structure Click here
A0A0R0FBT0 View 3D Structure Click here
A0A140LGN9 View 3D Structure Click here
A0A1D6E703 View 3D Structure Click here
A0A1D6E839 View 3D Structure Click here
A0A1D6E839 View 3D Structure Click here
A0A1D6E839 View 3D Structure Click here
A0A1D6E839 View 3D Structure Click here
A0A1D6EXV2 View 3D Structure Click here
A0A1D6FVI7 View 3D Structure Click here
A0A1D6GIN3 View 3D Structure Click here
A0A1D6HE28 View 3D Structure Click here
A0A1D6IEV2 View 3D Structure Click here
A0A1D6IW19 View 3D Structure Click here
A0A1D6J268 View 3D Structure Click here
A0A1D6JBC7 View 3D Structure Click here
A0A1D6LEN8 View 3D Structure Click here
A0A1D6LEN8 View 3D Structure Click here
A0A1D6LEN8 View 3D Structure Click here
A0A1D6LEN8 View 3D Structure Click here
A0A1D8PSJ3 View 3D Structure Click here
A0A286YA82 View 3D Structure Click here
A0A2R8QH90 View 3D Structure Click here
A2AK42 View 3D Structure Click here
A2AK44 View 3D Structure Click here
A3KQB2 View 3D Structure Click here
A4I5E6 View 3D Structure Click here
A4IDT8 View 3D Structure Click here
A8DZ29 View 3D Structure Click here
B9FXV5 View 3D Structure Click here
C0HFC3 View 3D Structure Click here
C0HFC3 View 3D Structure Click here
C0HFC3 View 3D Structure Click here
C0HFC3 View 3D Structure Click here
C7G046 View 3D Structure Click here
D3ZEL0 View 3D Structure Click here
D3ZU13 View 3D Structure Click here
F1LN59 View 3D Structure Click here
F1LY38 View 3D Structure Click here
F1QBM2 View 3D Structure Click here
F1QBM2 View 3D Structure Click here
F1R101 View 3D Structure Click here
F1R9I0 View 3D Structure Click here
F4ICW3 View 3D Structure Click here
I1JGR4 View 3D Structure Click here
I1JWB5 View 3D Structure Click here
I1JXE8 View 3D Structure Click here
I1JXE8 View 3D Structure Click here
I1JXE8 View 3D Structure Click here
I1JXE8 View 3D Structure Click here
I1K072 View 3D Structure Click here
I1K072 View 3D Structure Click here
I1K072 View 3D Structure Click here
I1K072 View 3D Structure Click here
I1KDI8 View 3D Structure Click here
I1KJH0 View 3D Structure Click here
I1M094 View 3D Structure Click here
I1MT11 View 3D Structure Click here
I1N2B5 View 3D Structure Click here
I1N8B0 View 3D Structure Click here
K7K2V9 View 3D Structure Click here
K7K701 View 3D Structure Click here
K7K701 View 3D Structure Click here
K7K701 View 3D Structure Click here
K7K701 View 3D Structure Click here
K7KEA2 View 3D Structure Click here
K7L9V4 View 3D Structure Click here
K7LAK0 View 3D Structure Click here
K7MF34 View 3D Structure Click here
K7MGM2 View 3D Structure Click here
K7MHM8 View 3D Structure Click here
K7MHM8 View 3D Structure Click here
K7MHM8 View 3D Structure Click here
K7MHM8 View 3D Structure Click here
K7TQJ7 View 3D Structure Click here
M0R6J5 View 3D Structure Click here
M0RD03 View 3D Structure Click here
O13971 View 3D Structure Click here
O43432 View 3D Structure Click here
O80548 View 3D Structure Click here
O80548 View 3D Structure Click here
O80548 View 3D Structure Click here
O80548 View 3D Structure Click here
O82233 View 3D Structure Click here
P53333 View 3D Structure Click here
P78344 View 3D Structure Click here
Q04637 View 3D Structure Click here
Q06132 View 3D Structure Click here
Q08C72 View 3D Structure Click here
Q0JCA4 View 3D Structure Click here
Q0JCA4 View 3D Structure Click here
Q0JCA4 View 3D Structure Click here
Q0JCA4 View 3D Structure Click here
Q10PT6 View 3D Structure Click here
Q10PT6 View 3D Structure Click here
Q10PT6 View 3D Structure Click here
Q10PT6 View 3D Structure Click here
Q17336 View 3D Structure Click here
Q1L8Y5 View 3D Structure Click here
Q1L8Y5 View 3D Structure Click here
Q1LY17 View 3D Structure Click here
Q2QUQ9 View 3D Structure Click here
Q3UFM5 View 3D Structure Click here
Q4D1X0 View 3D Structure Click here
Q4DFG5 View 3D Structure Click here
Q4E0V1 View 3D Structure Click here
Q53EL6 View 3D Structure Click here
Q53EL6 View 3D Structure Click here
Q54PG9 View 3D Structure Click here
Q553R3 View 3D Structure Click here
Q55G70 View 3D Structure Click here
Q59XY0 View 3D Structure Click here
Q5C9Z4 View 3D Structure Click here
Q61823 View 3D Structure Click here
Q61823 View 3D Structure Click here
Q62448 View 3D Structure Click here
Q67Z79 View 3D Structure Click here
Q6K641 View 3D Structure Click here
Q6NZJ6 View 3D Structure Click here
Q6YPF2 View 3D Structure Click here
Q6YPF2 View 3D Structure Click here
Q6YPF2 View 3D Structure Click here
Q6YPF2 View 3D Structure Click here
Q76E23 View 3D Structure Click here
Q80XI3 View 3D Structure Click here
Q84PB3 View 3D Structure Click here
Q8C5N3 View 3D Structure Click here
Q8I540 View 3D Structure Click here
Q8IKQ7 View 3D Structure Click here
Q8IKQ7 View 3D Structure Click here
Q8IKQ7 View 3D Structure Click here
Q8W4Q4 View 3D Structure Click here
Q8W4Q4 View 3D Structure Click here
Q8W4Q4 View 3D Structure Click here
Q8W4Q4 View 3D Structure Click here
Q93ZT6 View 3D Structure Click here
Q94BR1 View 3D Structure Click here
Q94BR1 View 3D Structure Click here
Q94BR1 View 3D Structure Click here
Q94BR1 View 3D Structure Click here
Q9HCG8 View 3D Structure Click here
Q9JID1 View 3D Structure Click here
Q9JID1 View 3D Structure Click here
Q9P6R9 View 3D Structure Click here
Q9SAG7 View 3D Structure Click here
Q9STL9 View 3D Structure Click here
Q9STL9 View 3D Structure Click here
Q9STL9 View 3D Structure Click here
Q9STL9 View 3D Structure Click here
Q9SUH8 View 3D Structure Click here
Q9U255 View 3D Structure Click here
Q9VCH1 View 3D Structure Click here
Q9VJ87 View 3D Structure Click here
Q9VY91 View 3D Structure Click here
Q9VY91 View 3D Structure Click here
Q9W020 View 3D Structure Click here