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123  structures 1459  species 0  interactions 9508  sequences 437  architectures

Family: HEAT (PF02985)

Summary: HEAT repeat

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "HEAT repeat domain". More...

HEAT repeat domain Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

HEAT repeat Provide feedback

The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see PF00514).

Literature references

  1. Andrade MA, Bork P; , Nat Genet 1995;11:115-116.: HEAT repeats in the Huntington's disease protein. PUBMED:7550332 EPMC:7550332

  2. Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D; , Cell 1999;96:99-110.: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. PUBMED:9989501 EPMC:9989501


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR000357

The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins, including the four name-giving proteins huntingtin, elongation factor 3 (EF3), the 65 Kd alpha regulatory subunit of protein phosphatase 2A (PP2A) and the yeast PI3-kinase TOR1 [ PUBMED:7550332 ]. Arrays of HEAT repeats consists of 3 to 36 units forming a rod-like helical structure and appear to function as protein-protein interaction surfaces. It has been noted that many HEAT repeat-containing proteins are involved in intracellular transport processes.

In the crystal structure of PP2A PR65/A [ PUBMED:9989501 ], the HEAT repeats consist of pairs of antiparallel alpha helices [ PUBMED:7550332 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan TPR (CL0020), which has the following description:

Tetratricopeptide-like repeats are found in a numerous and diverse proteins involved in such functions as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding.

The clan contains the following 176 members:

Adaptin_N Alkyl_sulf_dimr ANAPC3 ANAPC5 ANAPC8 APC_rep API5 Arm Arm_2 Arm_3 Arm_vescicular Atx10homo_assoc B56 BAF250_C BTAD CAS_CSE1 ChAPs CHIP_TPR_N CID CLASP_N Clathrin Clathrin-link Clathrin_H_link Clathrin_propel Cnd1 Cnd3 Coatomer_E Cohesin_HEAT Cohesin_load ComR_TPR COPI_C CPL CRM1_C CRM1_repeat CRM1_repeat_3 Cse1 CTK3 DHR-2 DIL DNA_alkylation Dopey_N Drf_FH3 Drf_GBD DUF1822 DUF2019 DUF2225 DUF3385 DUF3458_C DUF3808 DUF3856 DUF4042 DUF5588 DUF5691 DUF6340 DUF6377 DUF924 EAD11 EST1 EST1_DNA_bind FAT Fis1_TPR_C Fis1_TPR_N Foie-gras_1 GUN4_N HAT HEAT HEAT_2 HEAT_EZ HEAT_PBS HEAT_UF HemY_N HrpB1_HrpK HSM3_C HSM3_N IBB IBN_N IFRD Importin_rep Importin_rep_2 Importin_rep_3 Importin_rep_4 Importin_rep_5 Importin_rep_6 Insc_C KAP Leuk-A4-hydro_C LRV LRV_FeS MA3 MIF4G MIF4G_like MIF4G_like_2 MMS19_C Mo25 MRP-S27 Mtf2 NARP1 Neurochondrin Nipped-B_C Nro1 NSF Paf67 ParcG PC_rep PHAT PI3Ka PknG_TPR PPP5 PPR PPR_1 PPR_2 PPR_3 PPR_long PPTA Proteasom_PSMB PUF Rapsyn_N RIX1 RNPP_C RPM2 RPN7 Sel1 SHNi-TPR SNAP SPO22 SRP_TPR_like ST7 Suf SusD-like SusD-like_2 SusD-like_3 SusD_RagB SYCP2_ARLD TAF6_C TAL_effector TAtT Tcf25 TIP120 TOM20_plant TPR_1 TPR_10 TPR_11 TPR_12 TPR_14 TPR_15 TPR_16 TPR_17 TPR_18 TPR_19 TPR_2 TPR_20 TPR_21 TPR_22 TPR_3 TPR_4 TPR_5 TPR_6 TPR_7 TPR_8 TPR_9 TPR_MalT TTC7_N UNC45-central Upf2 V-ATPase_H_C V-ATPase_H_N Vac14_Fab1_bd Vitellogenin_N Vps39_1 W2 WSLR Wzy_C_2 Xpo1 YcaO_C YfiO Zmiz1_N

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(428)
Full
(9508)
Representative proteomes UniProt
(18270)
RP15
(1626)
RP35
(4331)
RP55
(7751)
RP75
(10491)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(428)
Full
(9508)
Representative proteomes UniProt
(18270)
RP15
(1626)
RP35
(4331)
RP55
(7751)
RP75
(10491)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(428)
Full
(9508)
Representative proteomes UniProt
(18270)
RP15
(1626)
RP35
(4331)
RP55
(7751)
RP75
(10491)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Reference [2]
Previous IDs: none
Type: Repeat
Sequence Ontology: SO:0001068
Author: Griffiths-Jones SR
Number in seed: 428
Number in full: 9508
Average length of the domain: 30.60 aa
Average identity of full alignment: 27 %
Average coverage of the sequence by the domain: 3.42 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.5 17.6
Trusted cut-off 23.5 17.6
Noise cut-off 23.4 17.5
Model length: 31
Family (HMM) version: 24
Download: download the raw HMM for this family

Species distribution

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Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the HEAT domain has been found. There are 123 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JV05 View 3D Structure Click here
A0A0P0W1W1 View 3D Structure Click here
A0A0R0ESB5 View 3D Structure Click here
A0A0R0GJS0 View 3D Structure Click here
A0A0R0JTN1 View 3D Structure Click here
A0A0R4IFI0 View 3D Structure Click here
A0A1D6E6C0 View 3D Structure Click here
A0A1D6F946 View 3D Structure Click here
A0A1D6HNA8 View 3D Structure Click here
A0A1D6IHP1 View 3D Structure Click here
A0A1D6J9Y7 View 3D Structure Click here
A0A1D6JIW5 View 3D Structure Click here
A0A1D6JWX6 View 3D Structure Click here
A0A1D6KE00 View 3D Structure Click here
A0A1D6L0X5 View 3D Structure Click here
A0A1D6LKF6 View 3D Structure Click here
A0A1D6ME19 View 3D Structure Click here
A0A1D6QC47 View 3D Structure Click here
A0A1D6QT92 View 3D Structure Click here
A0A1P8B4P1 View 3D Structure Click here
A0A286YB17 View 3D Structure Click here
A0A2R8QJE9 View 3D Structure Click here
A0A2R8RYR9 View 3D Structure Click here
A0A2R8RZX0 View 3D Structure Click here
A0A2R8RZX0 View 3D Structure Click here
A4HT97 View 3D Structure Click here
A4HWJ0 View 3D Structure Click here
A5PMV7 View 3D Structure Click here
A5PMV7 View 3D Structure Click here
A5PMV7 View 3D Structure Click here
A5PMV7 View 3D Structure Click here
A8WFS2 View 3D Structure Click here
B3CJ34 View 3D Structure Click here
B8A5E7 View 3D Structure Click here
B8JHR9 View 3D Structure Click here
B9FDR3 View 3D Structure Click here
C0P3E1 View 3D Structure Click here
D3ZDU2 View 3D Structure Click here
D3ZSM9 View 3D Structure Click here
D4A2D7 View 3D Structure Click here
D4A781 View 3D Structure Click here
E0CZ22 View 3D Structure Click here
E7F948 View 3D Structure Click here
F1M949 View 3D Structure Click here
F1R8B4 View 3D Structure Click here
F4IK92 View 3D Structure Click here
G3V682 View 3D Structure Click here
I1J4H2 View 3D Structure Click here
I1J5G7 View 3D Structure Click here
I1JDU7 View 3D Structure Click here
I1JPB4 View 3D Structure Click here
I1JZV3 View 3D Structure Click here
I1KCM0 View 3D Structure Click here
I1KIV5 View 3D Structure Click here
I1KJQ8 View 3D Structure Click here
I1KSC8 View 3D Structure Click here
I1KUM4 View 3D Structure Click here
I1L4D3 View 3D Structure Click here
I1L8J7 View 3D Structure Click here
I1LEY1 View 3D Structure Click here
I1LF63 View 3D Structure Click here
I1LYS8 View 3D Structure Click here
I1MDN4 View 3D Structure Click here
I1ML09 View 3D Structure Click here
I1N8A0 View 3D Structure Click here
I1N9Y3 View 3D Structure Click here
I1NF81 View 3D Structure Click here
I1NFG9 View 3D Structure Click here
K7K632 View 3D Structure Click here
K7KKT7 View 3D Structure Click here
K7L1A1 View 3D Structure Click here
K7M6L4 View 3D Structure Click here
K7MKS9 View 3D Structure Click here
K7V7I6 View 3D Structure Click here
O00410 View 3D Structure Click here
O00410 View 3D Structure Click here
O13864 View 3D Structure Click here
O14089 View 3D Structure Click here
O60100 View 3D Structure Click here
O60518 View 3D Structure Click here
O74476 View 3D Structure Click here
P30153 View 3D Structure Click here
P30153 View 3D Structure Click here
P30153 View 3D Structure Click here
P30154 View 3D Structure Click here
P30154 View 3D Structure Click here
P36179 View 3D Structure Click here
P36179 View 3D Structure Click here
P38217 View 3D Structure Click here
P38217 View 3D Structure Click here
P38217 View 3D Structure Click here
P38873 View 3D Structure Click here
Q06142 View 3D Structure Click here
Q06708 View 3D Structure Click here
Q09543 View 3D Structure Click here
Q09543 View 3D Structure Click here
Q0WML1 View 3D Structure Click here
Q10105 View 3D Structure Click here
Q14008 View 3D Structure Click here
Q38845 View 3D Structure Click here
Q38950 View 3D Structure Click here
Q38951 View 3D Structure Click here
Q3V0U9 View 3D Structure Click here
Q4CR90 View 3D Structure Click here
Q4CSP3 View 3D Structure Click here
Q4CY81 View 3D Structure Click here
Q4CZ83 View 3D Structure Click here
Q4DIA8 View 3D Structure Click here
Q4QQT4 View 3D Structure Click here
Q4QQT4 View 3D Structure Click here
Q4QQT4 View 3D Structure Click here
Q54EW3 View 3D Structure Click here
Q54QR9 View 3D Structure Click here
Q54TV3 View 3D Structure Click here
Q54TV3 View 3D Structure Click here
Q54TV3 View 3D Structure Click here
Q54TV3 View 3D Structure Click here
Q54WR2 View 3D Structure Click here
Q5ADN1 View 3D Structure Click here
Q5XI34 View 3D Structure Click here
Q642H5 View 3D Structure Click here
Q642H5 View 3D Structure Click here
Q6K4K9 View 3D Structure Click here
Q6P6Y1 View 3D Structure Click here
Q6PJG6 View 3D Structure Click here
Q6PJG6 View 3D Structure Click here
Q6ZL37 View 3D Structure Click here
Q76MZ3 View 3D Structure Click here
Q7PLL6 View 3D Structure Click here
Q7PLL6 View 3D Structure Click here
Q7TNP2 View 3D Structure Click here
Q7TNP2 View 3D Structure Click here
Q7TNP2 View 3D Structure Click here
Q7YWN2 View 3D Structure Click here
Q7Z460 View 3D Structure Click here
Q86WZ0 View 3D Structure Click here
Q8BIV3 View 3D Structure Click here
Q8BKC5 View 3D Structure Click here
Q8C3R1 View 3D Structure Click here
Q8H0U4 View 3D Structure Click here
Q8I5G0 View 3D Structure Click here
Q8K2V1 View 3D Structure Click here
Q8K2V1 View 3D Structure Click here
Q8K4Q0 View 3D Structure Click here
Q8N122 View 3D Structure Click here
Q8NDA8 View 3D Structure Click here
Q8RWY6 View 3D Structure Click here
Q8TEX9 View 3D Structure Click here
Q8TF05 View 3D Structure Click here
Q8TF05 View 3D Structure Click here
Q8VI02 View 3D Structure Click here
Q8VI02 View 3D Structure Click here
Q8VI75 View 3D Structure Click here
Q8W498 View 3D Structure Click here
Q93VS8 View 3D Structure Click here
Q93ZH1 View 3D Structure Click here
Q95YF0 View 3D Structure Click here
Q9BIB8 View 3D Structure Click here
Q9LJY1 View 3D Structure Click here
Q9N5V3 View 3D Structure Click here
Q9UT08 View 3D Structure Click here
Q9UT08 View 3D Structure Click here
Q9VG59 View 3D Structure Click here
Q9VN44 View 3D Structure Click here
Q9Y7K2 View 3D Structure Click here
Q9ZU97 View 3D Structure Click here