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2  structures 1378  species 0  interactions 5339  sequences 53  architectures

Family: WES_acyltransf (PF03007)

Summary: Wax ester synthase-like Acyl-CoA acyltransferase domain

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

The Pfam group coordinates the annotation of Pfam families in Wikipedia, but we have not yet assigned a Wikipedia article to this family. If you think that a particular Wikipedia article provides good annotation, please let us know.

This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Wax ester synthase-like Acyl-CoA acyltransferase domain Provide feedback

This domain is found in wax ester synthase genes such as Q8GGG1. In these proteins this domain catalyses the CoA dependent acyltransferase reaction with fatty alcohols to form wax esters [1].

Literature references

  1. Kalscheuer R, Steinbuchel A;, J Biol Chem. 2003;278:8075-8082.: A novel bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase mediates wax ester and triacylglycerol biosynthesis in Acinetobacter calcoaceticus ADP1. PUBMED:12502715 EPMC:12502715


Internal database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004255

This entry represents the N terminus (approximately 170 residues) of a number of hypothetical plant proteins. O-acyltransferase WSD1 is a bifunctional wax ester synthase/diacylglycerol acyltransferase, which is involved in cuticular wax biosynthesis [ PUBMED:18621978 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan CoA-acyltrans (CL0149), which has the following description:

All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.

The clan contains the following 9 members:

2-oxoacid_dh AATase Carn_acyltransf CAT Condensation PapA_C Transferase Tri3 WES_acyltransf

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(15)
Full
(5339)
Representative proteomes UniProt
(17802)
RP15
(587)
RP35
(2359)
RP55
(5085)
RP75
(8786)
Jalview View  View  View  View  View  View  View 
HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(15)
Full
(5339)
Representative proteomes UniProt
(17802)
RP15
(587)
RP35
(2359)
RP55
(5085)
RP75
(8786)
Alignment:
Format:
Order:
Sequence:
Gaps:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(15)
Full
(5339)
Representative proteomes UniProt
(17802)
RP15
(587)
RP35
(2359)
RP55
(5085)
RP75
(8786)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_1896 (release 6.4)
Previous IDs: UPF0089;
Type: Domain
Sequence Ontology: SO:0000417
Author: Bateman A , Auchincloss A
Number in seed: 15
Number in full: 5339
Average length of the domain: 234.00 aa
Average identity of full alignment: 20 %
Average coverage of the sequence by the domain: 50.01 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 23.6 23.6
Trusted cut-off 23.6 23.6
Noise cut-off 23.5 23.5
Model length: 264
Family (HMM) version: 18
Download: download the raw HMM for this family

Species distribution

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Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the WES_acyltransf domain has been found. There are 2 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0P0V8R9 View 3D Structure Click here
A0A0P0WQG4 View 3D Structure Click here
A0A0R0HGL8 View 3D Structure Click here
A0A0R0IHH9 View 3D Structure Click here
A0A0R0JSX3 View 3D Structure Click here
A0A1D6MC15 View 3D Structure Click here
A0A1D6NFR2 View 3D Structure Click here
C6T8C1 View 3D Structure Click here
F4IU14 View 3D Structure Click here
F4KJ46 View 3D Structure Click here
I1KF12 View 3D Structure Click here
I1KG13 View 3D Structure Click here
I1L5Z1 View 3D Structure Click here
I1LS44 View 3D Structure Click here
I1N4C0 View 3D Structure Click here
K7KY24 View 3D Structure Click here
K7LXT3 View 3D Structure Click here
K7M2N6 View 3D Structure Click here
K7MUS2 View 3D Structure Click here
P9WKA3 View 3D Structure Click here
P9WKA5 View 3D Structure Click here
P9WKA7 View 3D Structure Click here
P9WKA9 View 3D Structure Click here
P9WKB1 View 3D Structure Click here
P9WKB3 View 3D Structure Click here
P9WKB5 View 3D Structure Click here
P9WKB7 View 3D Structure Click here
P9WKB9 View 3D Structure Click here
P9WKC1 View 3D Structure Click here
P9WKC3 View 3D Structure Click here
P9WKC5 View 3D Structure Click here
P9WKC7 View 3D Structure Click here
P9WKC9 View 3D Structure Click here
Q5KS41 View 3D Structure Click here
Q5QLE2 View 3D Structure Click here
Q93ZR6 View 3D Structure Click here
Q94CK0 View 3D Structure Click here
Q94EF2 View 3D Structure Click here
Q9C7H4 View 3D Structure Click here
Q9FFE8 View 3D Structure Click here
Q9FK89 View 3D Structure Click here
Q9M3B1 View 3D Structure Click here
Q9M3B2 View 3D Structure Click here
Q9M3B3 View 3D Structure Click here