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1  structure 477  species 0  interactions 5946  sequences 74  architectures

Family: OATP (PF03137)

Summary: Organic Anion Transporter Polypeptide (OATP) family

Pfam includes annotations and additional family information from a range of different sources. These sources can be accessed via the tabs below.

This is the Wikipedia entry entitled "Organic anion-transporting polypeptide". More...

Organic anion-transporting polypeptide Edit Wikipedia article

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This tab holds the annotation information that is stored in the Pfam database. As we move to using Wikipedia as our main source of annotation, the contents of this tab will be gradually replaced by the Wikipedia tab.

Organic Anion Transporter Polypeptide (OATP) family Provide feedback

This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. [1] initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.

Literature references

  1. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A; , Biochem Biophys Res Commun 2000;273:251-260.: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. PUBMED:10873595 EPMC:10873595


Internal database links

External database links

This tab holds annotation information from the InterPro database.

InterPro entry IPR004156

This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules) so a scheme of using digits for rat OATPs and letters for human ones was introduced [ PUBMED:10873595 ]. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. All characterized OATPs are predicted to have 12 transmembrane domains and are sodium-independent transport systems [ PUBMED:23506880 ].

Gene Ontology

The mapping between Pfam and Gene Ontology is provided by InterPro. If you use this data please cite InterPro.

Domain organisation

Below is a listing of the unique domain organisations or architectures in which this domain is found. More...

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Pfam Clan

This family is a member of clan MFS (CL0015), which has the following description:

The major facilitator superfamily (MFS) is one of the two largest families of membrane transporters found on Earth [1]. It is present ubiquitously in bacteria, archaea, and eukarya and includes members that can function by solute uniport, solute/cation symport, solute/cation antiport and/or solute/solute antiport with inwardly and/or outwardly directed polarity [1]. All permeases of the MFS possess either 12 or 14 transmembrane helices [1].

The clan contains the following 23 members:

Acatn ATG22 BT1 Folate_carrier FPN1 LacY_symp MFS_1 MFS_1_like MFS_2 MFS_3 MFS_4 MFS_5 MFS_Mycoplasma Nodulin-like Nuc_H_symport Nucleoside_tran OATP PTR2 PUCC Sugar_tr TLC TRI12 UNC-93

Alignments

We store a range of different sequence alignments for families. As well as the seed alignment from which the family is built, we provide the full alignment, generated by searching the sequence database (reference proteomes) using the family HMM. We also generate alignments using four representative proteomes (RP) sets and the UniProtKB sequence database. More...

View options

We make a range of alignments for each Pfam-A family. You can see a description of each above. You can view these alignments in various ways but please note that some types of alignment are never generated while others may not be available for all families, most commonly because the alignments are too large to handle.

  Seed
(219)
Full
(5946)
Representative proteomes UniProt
(10212)
RP15
(1433)
RP35
(2617)
RP55
(5088)
RP75
(6548)
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HTML View             
PP/heatmap 1            

1Cannot generate PP/Heatmap alignments for seeds; no PP data available

Key: ✓ available, x not generated, not available.

Format an alignment

  Seed
(219)
Full
(5946)
Representative proteomes UniProt
(10212)
RP15
(1433)
RP35
(2617)
RP55
(5088)
RP75
(6548)
Alignment:
Format:
Order:
Sequence:
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Download options

We make all of our alignments available in Stockholm format. You can download them here as raw, plain text files or as gzip-compressed files.

  Seed
(219)
Full
(5946)
Representative proteomes UniProt
(10212)
RP15
(1433)
RP35
(2617)
RP55
(5088)
RP75
(6548)
Raw Stockholm Download   Download   Download   Download   Download   Download   Download  
Gzipped Download   Download   Download   Download   Download   Download   Download  

You can also download a FASTA format file containing the full-length sequences for all sequences in the full alignment.

HMM logo

HMM logos is one way of visualising profile HMMs. Logos provide a quick overview of the properties of an HMM in a graphical form. You can see a more detailed description of HMM logos and find out how you can interpret them here. More...

Trees

This page displays the phylogenetic tree for this family's seed alignment. We use FastTree to calculate neighbour join trees with a local bootstrap based on 100 resamples (shown next to the tree nodes). FastTree calculates approximately-maximum-likelihood phylogenetic trees from our seed alignment.

Note: You can also download the data file for the tree.

Curation and family details

This section shows the detailed information about the Pfam family. You can see the definitions of many of the terms in this section in the glossary and a fuller explanation of the scoring system that we use in the scores section of the help pages.

Curation View help on the curation process

Seed source: Pfam-B_626 (release 6.5)
Previous IDs: OATP_C;
Type: Family
Sequence Ontology: SO:0100021
Author: Mifsud W , Bateman A
Number in seed: 219
Number in full: 5946
Average length of the domain: 424.90 aa
Average identity of full alignment: 26 %
Average coverage of the sequence by the domain: 79.44 %

HMM information View help on HMM parameters

HMM build commands:
build method: hmmbuild -o /dev/null --hand HMM SEED
search method: hmmsearch -Z 57096847 -E 1000 --cpu 4 HMM pfamseq
Model details:
Parameter Sequence Domain
Gathering cut-off 25.8 25.8
Trusted cut-off 25.8 25.8
Noise cut-off 25.7 25.7
Model length: 545
Family (HMM) version: 22
Download: download the raw HMM for this family

Species distribution

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Colour assignments

Archea Archea Eukaryota Eukaryota
Bacteria Bacteria Other sequences Other sequences
Viruses Viruses Unclassified Unclassified
Viroids Viroids Unclassified sequence Unclassified sequence

Selections

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This visualisation provides a simple graphical representation of the distribution of this family across species. You can find the original interactive tree in the adjacent tab. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the PDBe group, to allow us to map Pfam domains onto UniProt sequences and three-dimensional protein structures. The table below shows the structures on which the OATP domain has been found. There are 1 instances of this domain found in the PDB. Note that there may be multiple copies of the domain in a single PDB structure, since many structures contain multiple copies of the same protein sequence.

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AlphaFold Structure Predictions

The list of proteins below match this family and have AlphaFold predicted structures. Click on the protein accession to view the predicted structure.

Protein Predicted structure External Information
A0A0G2JWY3 View 3D Structure Click here
A0A0G2K9W9 View 3D Structure Click here
A0A0N4SU37 View 3D Structure Click here
A0A0N4SUD8 View 3D Structure Click here
A0A0R0FWP3 View 3D Structure Click here
A0A0R4IBD9 View 3D Structure Click here
A0A0R4ICL4 View 3D Structure Click here
A0A0R4IW35 View 3D Structure Click here
A0A2R8QE24 View 3D Structure Click here
A0A2R8QHY9 View 3D Structure Click here
A0A2R8RXR5 View 3D Structure Click here
B3DJD4 View 3D Structure Click here
D3ZZM7 View 3D Structure Click here
E7F2I7 View 3D Structure Click here
E7FFX7 View 3D Structure Click here
E9PVD9 View 3D Structure Click here
F1Q5M5 View 3D Structure Click here
F1Q9B1 View 3D Structure Click here
G3V0H7 View 3D Structure Click here
L7N264 View 3D Structure Click here
M0QWR8 View 3D Structure Click here
M0RAI5 View 3D Structure Click here
O35913 View 3D Structure Click here
O62421 View 3D Structure Click here
O88397 View 3D Structure Click here
O94956 View 3D Structure Click here
P46720 View 3D Structure Click here
P46721 View 3D Structure Click here
P70502 View 3D Structure Click here
Q00910 View 3D Structure Click here
Q1LV73 View 3D Structure Click here
Q20538 View 3D Structure Click here
Q4CQB9 View 3D Structure Click here
Q6ZQN7 View 3D Structure Click here
Q86UG4 View 3D Structure Click here
Q8BGD4 View 3D Structure Click here
Q8BXB6 View 3D Structure Click here
Q8C0X7 View 3D Structure Click here
Q8K078 View 3D Structure Click here
Q8R3L5 View 3D Structure Click here
Q8SY02 View 3D Structure Click here
Q91YY5 View 3D Structure Click here
Q924H6 View 3D Structure Click here
Q92959 View 3D Structure Click here
Q93550 View 3D Structure Click here
Q95ZT3 View 3D Structure Click here
Q96BD0 View 3D Structure Click here
Q99J94 View 3D Structure Click here
Q99N01 View 3D Structure Click here
Q99N02 View 3D Structure Click here
Q9D5W6 View 3D Structure Click here
Q9EP96 View 3D Structure Click here
Q9EPT5 View 3D Structure Click here
Q9EPZ7 View 3D Structure Click here
Q9ERB5 View 3D Structure Click here
Q9H2Y9 View 3D Structure Click here
Q9JHI3 View 3D Structure Click here
Q9JJL3 View 3D Structure Click here
Q9NPD5 View 3D Structure Click here
Q9NYB5 View 3D Structure Click here
Q9QXZ6 View 3D Structure Click here
Q9QYE2 View 3D Structure Click here
Q9QZX8 View 3D Structure Click here
Q9UIG8 View 3D Structure Click here
Q9VK82 View 3D Structure Click here
Q9VK84 View 3D Structure Click here
Q9VLB3 View 3D Structure Click here
Q9VVH9 View 3D Structure Click here
Q9W269 View 3D Structure Click here
Q9W270 View 3D Structure Click here
Q9W271 View 3D Structure Click here
Q9XWC5 View 3D Structure Click here
Q9Y6L6 View 3D Structure Click here
X5LPS1 View 3D Structure Click here
X5LV99 View 3D Structure Click here